mary ellen perry, ph.d., program leader office of strategic coordination division of program...
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Mary Ellen Perry, Ph.D., Program LeaderOffice of Strategic CoordinationDivision of Program Coordination, Planning, and Strategic InitiativesNIH Office of the Director
Special NIH Funding Opportunities
27 NIH Institutes and Centers27 NIH Institutes and Centers
Clinical Center
International Center
National Institute of Biomedical Imagingand Bioengineering
National Institute of Deafness and
Communications Disorders
National Institute of Diabetes and Digestive and Kidney Diseases
NIAMSNational Institute of Arthritis andMusculoskeletal and Skin Diseases
The Office of the Director (OD)
Francis S. Collins, M.D., Ph.D.NIH Director
Strategic Priorities1.High-throughput Technologies
2.Translational Medicine
3.Science for Health Care Reform
4.Global Health
5.Reinvigorating and Empowering the Biomedical Research Community
Established:
the Common Fund to support cross-cutting, trans-NIH programs
the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI)
In FY2010, the Common Fund was $544M.
The Common Fund currently supports a series of short term, high impact, trans-NIH programs, some of which were previously called Roadmap programs.
James M. Anderson, M.D., Ph.D.DPCPSI Director
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2009 BC
Five Special Funding Opportunities
Eureka!
Reinvigorating and Empowering the Biomedical Research Community
We must develop ways to liberate our brightest minds to
pursue high-risk, high-reward ideas during their most creative years.
Nature, Vol.467, 7 October 2010.
Age
Per
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f T
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lAge Distribution of R01-equivalent Principal Investigators
All Investigators First-Time Investigators
Average Age
All Investigators 51.0
First-Time Investigators 42.6
FY2007 Data
How can we shorten the time to first grant?How can we shorten the time to first grant?
GRADUATE/GRADUATE/MEDICALMEDICALSTUDENTSTUDENT
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SENIORSENIOR
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GRADUATE/GRADUATE/MEDICALMEDICALSTUDENTSTUDENT
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Early Independence Award Program
• Graduate students and clinicians within one year of degree
• Up to $250K DC/year for five years, plus F&A
• Talented young scientists who have the intellect, scientific creativity, drive and maturity to flourish independently without the need for traditional post-doctoral training
• FOA RM10-019
• January 21, 2011 receipt12
http://nihroadmap.nih.gov/
Transformative R01 program places the emphasis on creative ideas - projects with the potential to create or overturn paradigms (62 awards since 2009).
Pioneer Awards support individual scientists of exceptional creativity who propose pioneering approaches to major challenges in biomedical and behavioral research (98 awards since 2004).
New Innovator program addresses two important goals: stimulating highly innovative research and supporting promising new investigators (167 awards since 2007).
Reinvigorating and Empowering the Biomedical Research Community
http://nihroadmap.nih.gov/
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New Innovator Award
• Unusually creative investigators with a highly innovative research idea
• $300K DC/year for five years, plus F&A
• New and early stage investigators
• FOA RM10-009
• Due date September 20, 2010
452 applications
http://nihroadmap.nih.gov/
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Benjamin Garcia
Princeton University
Novel Methodology for Quantitative High-throughput Cancer Epigenetics
Conor Evans
Massachusetts General Hospital/Harvard Medical School
Imaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian Cancer
Jianjun Cheng
University of Illinois at Urbana-Champaign
Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates
New Innovators in cancer research
Monica Guzman
Cornell University /Weill Medical College
Selection of Novel Therapies to Ablate Chemoresistant Myeloid Leukemia Stem Cells
http://nihroadmap.nih.gov/
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Pioneer Award Program
• Any qualified investigator
• $500K DC/year for five years, plus F&A
• Individual scientists of exceptional creativity who propose pioneering and possibly transforming approaches to addressing major biomedical or behavioral challenges
• FOA RM10-008
• Due date September 13, 2010
http://nihroadmap.nih.gov/
240 applications
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Some Pioneers of interest
Michael Roukes
California Institute of Technology
Nanoscale Tools to Push Biomedical Frontiers
Susan Rosenberg
Baylor College of Medicine
Forward Genomics of Damage Control: An Undiscovered Class of Cancer Genes
Leona Samson
Massachusetts Institute of Technology
Developing Novel Methods to Measure DNA Repair Capacity in Human Populations
Joseph Nadeau
The Institute for Systems Biology
Lamarck Redux: Transgenerational Genetic Effects on Phenotypes and Disease
http://nihroadmap.nih.gov/
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Transformative RO1
• Anyone with a project to overturn or create a paradigm
• Up to $25M TC for five years
• “Out of the box” ideas
• FOA RM10-010
• October 27, 2010 receipt
http://nihroadmap.nih.gov/
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Some TRO1 projects of interest
GEORGE COUKOS
University of Pennsylvania
Transformative Personalized Vascular Disrupting Cancer Immunotherapy
RICHARD FLAVELLMADHAV DHODAPKARMARKUS MANZ
Yale University and University Hospital Zurich
Understanding Hematopoietic Neoplasias Using Humanized Mice
http://nihroadmap.nih.gov/
Transformative R01 Program places the emphasis on creative ideas—projects with the potential to create or overturn paradigms. (62 awards since 2009).
Pioneer Awards support individual scientists of exceptional creativity who propose pioneering approaches to major challenges in biomedical and behavioral research (98 awards since 2004).
New Innovator Program address two important goals: stimulating highly innovative research and supporting promising new investigators (167 awards since 2007).
Reinvigorating and Empowering the Biomedical Research Community
We WILL have all 3competitions again next year!
Look for announcements next spring.
http://nihroadmap.nih.gov/
Trans-NIH but not Common Fund
Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) Program
• Open to anyone with a high impact project
• “Exceptionally innovative research on novel hypotheses or difficult problems, solutions to which would have an extremely high impact on biomedical or bio-behavioral research”
• Up to $800K DC for four years, plus F&A
• FOA GM10-009
• November 24, 2010 receipt
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Institutes participating in EUREKA awards
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Ravi Bellamkonda, Ph.D.Georgia Institute of Technology
“Our plan is to deliver the tumor to the drug -- by directing tumor cells to a specially engineered gel that can be removed or designed to kill the cells -- rather than the current strategy of delivering the drug to the tumor, which is problematic due to the irregular vasculature and poor diffusivity of the tumor tissue,” explained Bellamkonda, who is also a Georgia Cancer Coalition Distinguished Scholar.
NCI Eureka awardee 2010
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Summary Special Opportunities
Early Independence Award Graduate student or new clinician
New Innovator New PI/ESI with innovative project
Pioneer Very creative investigator
TR01 Person with paradigm – disrupting idea
Eureka award Person with a very innovative project
Program Eligibility
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For more information:
Contact information:
Today’s talk – Mary Ellen Perry [email protected]
Pioneer, TR01, New Innovators, Early Independence Award – Ravi Basavappa [email protected]
Eureka awards – Judy Mietz [email protected]
Common Fund – Ellie Murcia [email protected]
http://nihroadmap.nih.gov/