Organized byHacettepe University

Medicinal Chemistry ResearchDevelopment & Application Center

May 27-29, 2011WOW Topkapı PalaceAntalya-TÜRKİYE

www.drd.hacettepe.edu.tr

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Dear Colleagues,

I would like to invite you to attend and contribute to the International Symposium on Drug Research and Development “From Chemistry to Medicine” DRD 2011 and New Horizons and Job Opportunities for Young Scientists which is organized by Hacettepe University, Medicinal Chemistry Research, Development and Application Center (MAGUM).

MAGUM, a subunit of Hacettepe University, was established in 1996 for the purpose of realization of the drug design, structure-activity relationships, synthesis, analysis and molecular quality control of synthetic and natural drugs and drug raw materials in medicinal chemistry area with cooperation of departments of Faculty of Pharmacy, Faculty of Medicine and other facul-ties to improve outputs of drug research, development and application by multidisciplinary collaboration approaches.

The high quality performed scientific International Symposium on Drug Research and Development “From Chemistry to Medicine” organized by MAGUM every two years. In addition to DRD 2011 symposium, which will be held on May 27-29, 2011, New Horizons and Job Opportunities for Young Scientists” was also planned to conduct by MAGUM.

The mission of “International Symposium DRD 2011 and New Hori-zons and Job Opportunities for Young Scientists” will be to provide a sci-entific forum by the invitation of distinguished scientists having national / international reputation in their areas, so the most recent advances will be discussed and evaluated interactively and the exchange of interdisciplinary knowledge from chemistry to medicine. The format of the scientific program will also include oral and poster presentations on the concerning scientific topics in addition to the invited lectures.

Members of the organizing committee and I cordially invite you to join us at DRD 2011 in Antalya, May 27-29, 2011. It is important to note that symposium venue Antalya is very famous with its archaeological and natural riches and known as one of the most popular region of Turkish Riviera.

We are looking forward to see you in Antalya,Turkey.With our kind regards,

Prof. Dr. Ünsal ÇALIŞChair

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Honorary ChairProf. Uğur ERDENER, M.D.

President of Hacettepe University

Organizing CommitteeÜnsal ÇALIŞ, Ph.D. (Chair)

Selma SARAÇ, Ph.D.

Sedef KIR, Ph.D.

Gülberk UÇAR, Ph.D.

Funda Nuray YALÇIN, Ph.D.

S. Kutay DEMİRKAN, Pharm.D.

Prof. Melih ALTAN, Ph.D. (Ankara University, Türkiye) Prof. Metin BALCI, Ph.D. (Middle East Technical University, Türkiye)

Prof. Erden BANOĞLU, Ph.D. (Gazi University, Türkiye)Prof. A Ahmet BAŞARAN, Ph.D. (Hacettepe University, Türkiye)Prof. Erdem BÜYÜKBİNGÖL, Ph.D. (Ankara University, Türkiye)Prof. Zeliha BÜYÜKBİNGÖL, Ph.D. (Ankara University, Türkiye)

Prof. Sevim DALKARA, M.D. (Hacettepe University, Türkiye) Prof. Katerina GORACINOVA, Ph.D. (University of Sts Cyrill and Methodius, Macedonia)

Prof. Arzum Erdem GÜRSAN, Ph.D. (Ege University, Türkiye) Prof. Selçuk GEÇİM, Ph.D. (Hacettepe University, Türkiye)Prof. Emin KANSU, M.D. (Hacettepe University, Türkiye)Prof. Hakan ORER, M.D. (Hacettepe University, Türkiye) Prof. Seçkin ÖZDEN, Ph.D. (Ankara University, Türkiye) Prof. Yekta ÖZER, M.D. (Hacettepe University, Türkiye)

Prof. Serhat ÜNAL, M.D. (Hacettepe University, Türkiye)Prof. Metin TÜLÜ, Ph.D. (Yıldız Technical University, Türkiye) Prof. Kemal YELEKÇİ, Ph.D. (Kadir Has University, Türkiye)Prof. Nurşen ÜNLÜ, Ph.D. (Hacettepe University, Türkiye)

ORGANIZING COMMITTEE

ADVISORY BOARD

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World of Wonders (WOW) Resort Hotel, besides being a unique holiday paradise, is the special and privileged preference of business world by being a perfect host for congress organizations.

WOW Topkapi Palace and WOW Kremlin Palace Hotels, which are both located in Lara region which is the tourism center of Mediterranean, 20 km to Antalya International Airport and 20 km to Antalya City Center, with their au-thentic palace architectures, natural beauties, sea, sun, quality service and full equipped halls, offer a first class service for efficient company meetings.

Our guests, as soon as they arrive at the WOW Topkapi Palace and WOW Kremlin Palace, will have the opportunity of favoring the very rich and comprehensive services of all included concept as well as full and efficient congress period. They will get rid of the tiredness of meetings by getting use of all the activities of the hotel, by relaxing and having fun.

IMPORTANT DATESDeadline for TUBITAK support (only Turkish participants) : January 10, 2011Deadline for abstract submission : March 18, 2011Deadline for early registration and accommodation : March 18, 2011Notification on acceptance of the abstracts : March 18, 2011

SOCIAL PROGRAMMEMay 27, 2011, Friday 18.00-20.00 : Welcome ReceptionMay 27, 2011, Friday, Tuesday 20.00-24.00 : Special Turkish Night & DinnerMay 28, 2011, Saturday, 20.00-24.00 : Gala Dinner

CANCELLATIONSIn case of cancellation of registrations and hotel reservations until

March 18, 2011, 50% of total fee will be refunded. Cancellation request will not be able to accept after this date. All refunds will be done after the con-gress.

TRANSPORTATIONUpon request from DMR Tourism, the transportation service will be

available for the participants in May 27 and May 29, 2011 from Antalya airport to WOW Topkapı Palace and back, the price is 60 EURO per person. (18% V.A.T. is not included). For special transportation requests, please contact DMR Tourism.

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LEMay 27, 2011

FridayMay 28, 2011

SaturdayMay 29, 2011

Sunday

09:00 -10:30Session II

Current Approaches for Development of Novel Drug Delivery Systems

Session VRecent

Biochemical Approaches

to Drug Development

10:30 -11:00 Coffee Break - Exhibition

11:00 -12:30 Registration

Session III-A

Experiences and Expectations of Clinicians:

Diabetic Agents

Session III-B

Selected Oral Presentations

on Research and Development in Pharmaceutical

Sciences

Session VI

Organic Synthesis and Analysis of Pharmaceutical

Molecules

12:30 -14:00 Lunch

14:00 -14:30 Poster - Exhibition

Poster Discussion&

ExhibitionSEARCH

CONFERENCE

Visualising the Future of Drug

R & D : Policies,

Priorities and Strategies

14:30 -16:00OPENING

CEREMONY

Opening Lectures

PANEL

New Horizons and Job Opportunities

for Young Scientists

16:00 -16:30 Coffee Break - Exhibition Closing Remarks

16:30 -18:00

Session I

New Trends and Methods in Drug

Research and Development

Session IV

Interview Fear in Job Applications

Social Programme

Welcome Reception

18:00 -19:00

Special Turkish Dinner

19:00 -24:00

Gala Dinner

20:00 -24:00

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14.30-16.00 OPENING CEREMONY Opening Lectures Engineering Versatile Nano-carriers for Therapeutic Delivery Woei Ping Cheng, University of Hertfordshire, United Kingdom The Use of Novel Enabling Techniques to Overcome Drug Solubility Issues Firas Elsaleh, ISP-International Specialty Products, Germany16.00-16.30 Coffee Break16.00-16.30 Coffee Break

16.30-18.00 SESSION I New Trends and Methods in Drug

Research and Development (All presentations will be in English)

Chairpersons : Rümeysa Demirdamar, Near East University, Turkish Republic of

Northern Cyprus Nur Onar, Ondokuz Mayıs University, Türkiye

New Trends in Pharma: The Growth of Generics Ferhat Farshi, Abdi İbrahim Pharmaceutical R&D Center, Türkiye In Silico Design of Novel and Highly Selective Monoamine Oxidase A and B

Inhibitors: Evaluation of Computational and Experimental Inhibition Values Kemal Yelekçi, Kadir Has University, Türkiye Nanomaterial Based Sensor Technology for Electrochemical

Monitoring Drug-DNA Interactions Arzum Erdem Gürsan, Ege University, Türkiye18.00-20.00 WELCOME RECEPTION Sponsored by

MAY 28, 201109.00-10.30 SESSION II Current Approaches for Development of Novel Drug Delivery

Systems (All presentations will be in English)

Chairpersons : Nurşen Ünlü, Hacettepe University, Türkiye Sema Çalış, Hacettepe University, Türkiye

Novel Excipients From Scratch to Launch Nils Rottmann, BASF - The Chemical Company, Germany

Colloidal Carriers for Anticancer Drug Delivery – Formulation Approaches Katerina Goracinova, University of Sts Cyrill and Methodius, Macedonia Novel Nano-carriers Based on Self-assembling Polymers: A New

Opportunity for Improving Treatment of Diseases Woei Ping Cheng, University of Hertfordshire, United Kingdom

10.30-11.00 Coffee Break

Sponsored by

Sponsored by

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E11.00-12.30 SESSION III-A Experiences and Expectations of Clinicians: Diabetic Agents (All presentations will be in Turkish) Chairperson: Gülberk Uçar, Hacettepe University, Türkiye Insulin Therapy & Routes of Administration Ercan Tuncel, Uludağ University, Türkiye Oral Diabetic Therapy Nilgün Güvener Demirağ, Başkent University, Türkiye New Antidiabetic Agents Bülent Okan Yıldız, Hacettepe University, Türkiye12.30-14.00 LUNCH11.00-12.30 SESSION III-B Selected Oral Presentations on Research and Development in

Pharmaceutical Sciences

(All presentations will be in English)

Chairpersons : Arzum Erdem Gürsan, Ege University, Türkiye Katerina Goracinova, University of Sts Cyrill and Methodius, Macedonia

Monitoring Reovirus entry and endosomal trafficking in live non-polarized and polarized cells by single viral particle tracking

Comert Kural, Harvard Medical School, USA Computational study of the conformational interconversion of

4,5-dimethyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one Sajid Jahangir, Karl Franzens University, Austria Determination of Antioxidant Activity of Some Biologically

Importantant Samples Through Cyclic Voltammetry Haji Muhammad, Federal Urdu University of Arts, Science and

Technology, Pakistan Synthesis of Folate-PEG-Doxorubicin Conjugate, Radiolabelling With

Technetium-99m and Research Into Its Applications as An Imaging Agent in Cancer

Güliz AK, Ege University, Türkiye Bioengineering Technique Used To Study The Effects Of Grapefruit

Extract Containing Emulsion On Human Skin Mechanical Parameters Naveed Akhtar, The Islamia University of Bahawalpur, Pakistan Study On A Commercial Anthelmentic Combination Efficacy Against

Fasciola Spp, Dicrocoelium Dendriticum And Moniezia Spp In Small Ruminants In Urmia, Iran

Sohrab Rasouli, Islamic Azad University, Iran Heavy Metals Toxicity In Root Vegetables Irrigated By Industrial Waste

Water Karachi Kousar Yasmeen, Federal Urdu University of Arts, Pakistan Formulation And Characterization Of Two Bleach Creams Of Mulberry Extract

And Comparison Of Their Effects On Human Skin Melanin And Erythema Fatima Rasool, The University of the Punjab, Pakistan

Supported by

İLADER

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12.30-14.00 Lunch

14.00-14.30 Poster Discussion & Exhibition

14.30-16.00 SESSION IV Interview Fear in Job Applications (All presentations will be in Turkish) Chairperson : Buket Aksu, Santa Farma Pharmaceutical Company, Türkiye

Getting Ready for Interview and Get Over Your Fear Nesrin Dilbaz, Ankara Numune Research And Training Hospital, Türkiye Personal Behaviors During Job Interview Aykut Bora, Bilim Pharmaceutical Company, Türkiye Requirements of Scientific Background for Job Applications in Drug

Research and Development A. Atilla Hıncal, İDE Pharmaceutical Consultancy, Türkiye

16.00-16.30 Coffee Break & Exhibition

16.30-18.00 PANEL New Horizons and Job Opportunities for Young Scientists (All presentations will be in Turkish) Moderator : Selçuk Geçim, Hacettepe University, Türkiye

Tarık Çelik, The Turkish Academy of Sciences TÜBA, Türkiye Tayfun Öner Small & Medium Enterprises Development Organization

KOSGEB, Türkiye Murat Yıldız, Republic of Turkey Ministry of Industry and Trade, Türkiye

Rıza Alagöz, Republic of Turkey Ministry of Industry and Trade, Türkiye Tuğba Arslan Kantarcıoğlu, The Scientific & Technological Research

Council of Türkiye- TÜBİTAK Emel Önder Fırat

The Scientific & Technological Research Council of Türkiye- TÜBİTAK A.Tuncay Teksöz, Pfizer Inc. Pharmaceutical Company, Türkiye Ferhat Farshi, Abdi İbrahim Pharmaceutical R&D Center, Türkiye Sami Türkoğlu, Ulkar Holding, Türkiye

20:00-24:00 Gala Dinner

Supported by

İLADER

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Sponsored by

MAY 29, 2011 09.00-10.30 SESSION V Recent Biochemical Approaches to Drug

Development (All presentations will be in English) Chairpersons : Zeliha Büyükbingöl, Ankara University, Türkiye Filiz Hıncal, Hacettepe University, Türkiye

How to Change an Enzyme into a Cytotoxic Agent: Mechanisms of Targeting Top2 in Cancer

John L. Nitiss, St. Jude Children’s Research Hospital, Memphis-USA Enhanced Survival and Paracrine Activity of Bone Marrow Mesenchimal Stem Cells: Impact on Cell Therapy of Ischemic Syndromes.

Angelo Parini, Inserm Institut, France Serotonergic Control of Cardiovascular Function Nathalie Pizzinat, University of Toulouse, France

10.30-11.00 Coffee Break

11.00-12.30 SESSION VI Organic Synthesis and Analysis of Pharmaceutical

Molecules (All presentations will be in English)

Chairpersons : Tuncel Özden, Gazi University, Türkiye Erdem Büyükbingöl, Ankara University, Türkiye

Bisacylazides: A New Milestone for the Synthesis of Various Heterocycles

Metin Balcı, Middle East Technical University, Türkiye Dendrimers as Potential Drug Carriers: Microwave-Assisted

Synthesis of Pamam Type Dendrimers Metin Tülü, Yıldız Technical University, Türkiye A Novel Polymorph of Zoledronic Acid And Process For Its Preparation Bekir Karlığa, Deva Holding API R&D, Türkiye Synthesis of Ezetimibe: A Selective Cholesterol Absorption Inhibitor Esen Bellur Atıcı, Deva Holding API R&D, Türkiye

12.30-14.00 Lunch

14.00-16.00 SEARCH CONFERENCE Visualising The Future of Drug R & D:

Policies, Priorities and Strategies (All presentations will be in Turkish) Moderator: İsmail Üstel, Consultant, Türkiye

16.00-16.30 Closing Remarks

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May 27, 2011, Friday18:00-19:00

Welcome Reception

May 27, 2011, Friday19:00-24:00

Special Turkish Dinner

May 28, 2011, Saturday20:00-24:00Gala Dinner

Sponsored by

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Registration fee includes; attendance to scientific sessions, coffee breaks, lunches, social programme (opening cocktail and gala dinner) and scientific documents.

Before March 18, 2011 After March 18, 2011

Student* 125 € 150 €

Senior Academic 150 € 175 €

Company Delegate 350 € 400 €* Master and PhD student, post-doctorates and participants from Re-

search and Development Departments.

ACCOMMODATION & REGISTRATIONAccommodation & registration package includes; 2 nights accommo-

dation (all inclusive) between May 27 - 29, 2011, scientific sessions, coffee breaks, lunches, social programme (opening cocktail and gala dinner) and scientific documents.

WOW TOPKAPI PALACE

(ACCOMMODATION & REGISTRATION)

Before March 18, 2011 After March 18, 2011

Single Room

Per Person

in Double Room

Single Room

Per Person

in Double Room

Stundent* 250 € 175 € 275 € 200 €

Senior Academics 300 € 200 € 350 € 225 €

Company Delegate 600 € 400 € 650 € 450 €* Master and PhD student, post-doctorates and participants from Re-

search and Development Departments.

Please note that, registrations and reservations will be confirmed by DMR Tourism after you send the registration form in our website (www.drd.hacettepe.edu.tr) via fax (+90.312 442 04 10).

PAYMENT OF REGISTRATION & ACCOMMODATION FEESIsbank Ankara Başkent Branch - DMR TurizmEuro Account : 4398 - 0001900 IBAN: TR760006400000243980001900TL Account : 4398 - 0002347 IBAN: TR730006400000143980002347

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NPlease, read carefully these guidelines for Abstract writing.

All abstracts written according to the “Guidelines for Abstracts” should only be submitted to scientific secretary (Prof. Selma Saraç or Prof. Sedef Kır) as a Word file via e-mail no later than March 18, 2011:

Prof. Selma SARAÇ, Ph. D. (Scientific Secretary)E-mail: sesarac@hacettepe.edu.trProf. Sedef KIR, Ph. D. (Scientific Secretary)E-mail: sekir@hacettepe.edu.tr

GUIDELINES FOR ABSTRACTSDeadline for abstract submission: March 18, 2011

• Abstracts should only be submitted to scientific secretary (Prof. Selma Saraç, sesarac@hacettepe.edu.tr or Prof. Sedef Kır, sekir@hacetepe.edu.tr) as a Word file via e-mail no later than March 18, 2011.

• All abstracts must be written in English according to the rules de-tailed below.

• Only the abstracts of registered presenting authors will be includ-ed in the program and book of abstracts.

• Abstracts will be accepted either as a poster or a oral presentation.• Poster presentations must be prepared as 70 cm x 90 cm.• Notification on acceptance of the abstracts will be e-mailed until

March 28, 2011.• Paper size and margins: A4 (21x 29.7 cm) with margin: 2.5 cm,

single-spaced.• Title: In bold type, capital letters, 12 pt Times New Roman, centred• Name of author and co-authors: 11 pt Times New Roman, cen-

tred, bold, italics, without degrees, the name of the presenting author should be underlined.

• Affiliations: Full address of the author and co-authors on separate lines (no spacing between the lines) including e-mail address of the present-ing author in parentheses, 10 pt Times New Roman, italics, centred

• Abstract: Brief description of the paper not exceeding one page. The main body of the paper 11 pt Times New Roman, normal. Up-per and lower case letters. Right and left justified.

• Tables must be numbered by Arabic numbers and then brief and concise title is given, 10 pt Times New Roman. Tables should be produced directly in the text.

• Figures must be supplied only in the format jpg.• References should be numbered consecutively in the text and

listed at the end.

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Prof. Selma SARAÇ, Ph. D.Hacettepe University, Faculty of PharmacyDepartment of Pharmaceutical Chemistry06100 Ankara-TÜRKİYEPhone (Fax) : +90 312 305 30 15sesarac@hacettepe.edu.tr

Prof. Sedef KIR, Ph. D.Hacettepe University, Faculty of PharmacyDepartment of Analytical Chemistry06100 Ankara-TÜRKİYEPhone : +90 312 305 21 63sekir@hacettepe.edu.tr

OFFICIAL SYMPOSIUM AGENCY

DMR Congress Organization Services Tourism Inc.Hollanda Cad. 696. sok. 22/9-1006550 Yıldız Çankaya - Ankara, TURKEYPhone : +90 312 442 01 50Fax : +90 312 442 04 10www.dmrturizm.com.tronur.arda@dmrturizm.com.tr