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Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts, Gregory J. Heffron, Matthew G. Vander Heiden, Renliang Yang, Fupeng Li, Jason W. Locasale, Hadar Sharfi, Bo Zhai, Ricard Rodriguez-Mias, Harry Luithardt, Lewis C. Cantley, George Q. Daley, John M. Asara, Steven P. Gygi, Gerhard Wagner, Chuan-Fa Liu, Junying Yuan Cell Volume 146, Issue 4, Pages 607-620 (August 2011) DOI: 10.1016/j.cell.2011.06.050 Copyright © 2011 Elsevier Inc. Terms and Conditions

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Page 1: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival 

Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts, Gregory J. Heffron, Matthew G. Vander Heiden, Renliang Yang, Fupeng Li, Jason W. Locasale, Hadar Sharfi, Bo Zhai, Ricard Rodriguez-Mias, Harry Luithardt, Lewis C. Cantley, George Q.

Daley, John M. Asara, Steven P. Gygi, Gerhard Wagner, Chuan-Fa Liu, Junying Yuan 

Cell Volume 146, Issue 4, Pages 607-620 (August 2011)

DOI: 10.1016/j.cell.2011.06.050

Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure 1

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure 2

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure 3

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure 4

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure 5

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure 6

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 8: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure 7

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 9: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure S1

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 10: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure S2

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 11: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure S3

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 12: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Figure S4

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 13: Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival Caroline H. Yi, Heling Pan, Jan Seebacher, Il-Ho Jang, Sven G. Hyberts,

Cell 2011 146, 607-620DOI: (10.1016/j.cell.2011.06.050) Copyright © 2011 Elsevier Inc. Terms and Conditions

http://www.elsevier.com/termsandconditions

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