Metrology in Chemistry-

the need for Hong Kong

by

Dr C S MOK

Government Laboratory

World Metrology Day Seminar , 24 May 2012

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Scientific Measurements-social and regulatory functions

Provide information to

Meet the needs of trade

Consistency in measurement - removal of technical trade barriers

Protection of

Public health and safety

Consumers' interests

Government revenue

Environment

Enforcement of regulations and ordinances

Chemical measurements- Applications

Pharmaceuticals

Foods

Environment

Legal Measure

Herbal Medicine Commodities

Toys

Forensic examination

Trade

Metrology

science of measurement and its application

includes all theoretical and practical aspects of measurement, whatever the measurement uncertainty and field of application.

(JCGM 200:2012, International vocabulary of metrology — Basic and general

concepts and associated terms – Reproduced with permission)

Metrological traceability

property of a measurement result whereby the

result can be related to a reference through a

documented unbroken chain of calibrations, each

contributing to the measurement uncertainty

(JCGM 200:2012, International vocabulary of metrology — Basic and general

concepts and associated terms – Reproduced with permission)

Essential for maintaining confidence in the measurement

Bureau of Weights and Measures (BIPM)

a) Laboratory accreditation relies on an international system of measurement under the Meter Convention. The BIPM, set up by the metre convention, has the mandate to establish equivalence of measurements among nations. National Metrology Institutes (NMIs)maintain the measurement standards of a nation.

b) Under the Mutual Recognition Arrangement (MRA) of the International Committee for Weights and Measures (CIPM), all signatories agree to recognize each other’s national measurement standards.

c) The Consultative Committee for Amount of Substance – Metrology in Chemistry (CCQM) under the CIPM looks after establishment of equivalence of chemical measurements among national laboratories.

d) Regional metrology organizations such as the Asia Pacific Metrology Program( APMP ) co-ordinate metrology activities in the region.

e) The National Metrology Institute maintains and disseminates traceability to the SI through calibrations and other services.

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CIPM Mutual Recognition Arrangement (MRA)

This Mutual Recognition Arrangement is a response to a growing

need for an open, transparent and comprehensive scheme to give users reliable quantitative information on the comparability of national metrology services and to provide the technical basis for wider agreements negotiated for international trade, commerce and regulatory affairs. (© BIPM – Reproduced with permission)

Designated institute to CIPM-MRA – role & function

To establish metrological-based competencies

and measurement capability that are

Internationally vetted and recognized

To provide calibration and measurement services

and disseminate traceability to local laboratories

through establishment of standards and production of

Certified Reference Materials

Example: MiC Infrastructure on Mainland China

State Council

State Administration of Quality Supervision, Inspection and Quarantee (AQSIQ)

Certification and Accreditation

Administration of China (CNCA) National Institute of Metrology (NMI)

Provincial Bureau of Quality & Technical Supervision

China National Accreditation Service

for Conformity Assessment (CNAS)

Chemical Metrology Legal

Accreditation (CMA) metrology Certification &

Laboratory accreditation

in accordance with the Law on Metrology of P.R. China (1986)

National standards Certified reference materials Standard methods

&

GL has assume the role of a reference laboratory apart from just providing testing service since becoming a Designated Institute for HONG KONG, CHINA in 2005 to meet the international development on harmonization of measurement standards

Mar 1993

Nov 2004

May 2005

Aug 2006

Dec 2008

Nov 2010

Founding member of

CITAC

Full member of APMP

Designated Metrology Institute

under CIPM MRA

Accredited Proficiency

Testing Provider

First peer

review

Accredited

Reference

Material

Producer under

HOKLAS

METROLOGY IN CHEMISTRY ACTIVITIES

Participate and organize inter-comparison

programmes in CCQM and RMO-APMP

Provide proficiency testing (PT) schemes

Reference materials production

Promotion of MiC

Attend CCQM, APMP, CITAC, APEC and

APLMF meetings

Calibration and Measurement Capabilities

With support of the results obtained from key comparisons organized by international metrology organizations, national metrology institutes or designated institutes are eligible to apply a Calibration and Measurement Capabilities (CMCs) claim.

To be included in the Appendix C of the Key Comparison Database (KCDB) under the Mutual Recognition Arrangement of the International Committee for Weights and Measures (CIPM MRA). (© BIPM – Reproduced with permission)

Calibration and Measurement Capabilities (CMC) Claims

Metals in bovine liver

Cadmium in shellfish

PAHs in soil / Particulate matters

PCBs in mussel tissue extract

Malachite green in fish

High purity organic compounds

pH buffer solution

CMCs are internationally recognized as the best measurement capability that a metrology institute could possess. With the CMCs claim, the institute can disseminate traceability to its customers through services such as

1. Provision of calibrations or reference value 2. Provision of certified reference materials (CRMs) CMC Claims in GL (representing Hong Kong)

MiC activities in Hong Kong

CRM production Melamine pure standard OC pesticides in tea Metals in herb Melamine in milk

Inter-comparison CCQM-K89 – metals in herb CCQM-K95 – organochlorine pesticide in green tea APMP.QM-S5 – metals in seafood

Proficiency testing program collaboration with APLAC and APMP-DEC PT for APEC capability building project

e.g. 1

Malachite green in fish (Aug 2005) • organized technical seminar for local laboratories in Sep 2005

• sought accreditation in December 2005

• routine analysis of 400 samples per year

• organized PT programme (APLAC T058) in 2008

• participated in CCQM P-88 in 2007, CCQM-K85 in 2010

• approved CMC Claim in July 2010

MG

LMG MG

Development of Testing Services

An example

An APMP Supplementary

Comparison (APMP.QM-S5):

Elements in seafood

APEC PT programme

TCQM/DEC PT

programme

APLAC PT programme

(food safety inspection labs)

(expert labs. from developing economies)

(accredited field labs.)

Ref. values

NMIs/DIs

from

APMP

NMIs/DIs

from

other

RMOs

A CCQM Key Comparison

(CCQM K-95): Pesticides in

green tea

TCQM/DEC PT

programme

APLAC PT programme

(accredited field labs.)

Ref. values

NMIs/DIs

from

CCQM

NMIs/DIs

from

other

RMOs

(expert labs. from

developing economies)

Registration deadline : 31 Sep

2011

Sample delivery : Nov 2011

Results submission : 28 Feb

2012

Proficiency Testing Programme - Ketamine/norketamine in hair

Increase in ketamine abuse

PT on quantitative analysis of ketamine in hair not available

First PT program organized by GL for forensic laboratories

“Determination of ketamine in hair (GLHK1001)”

8 laboratories worldwide participated

APMP.QM-P20 under preparation

GL as a Reference Laboratory

Participated in over 30 key /supplementary comparisons/pilot studies organized by CCQM , APMP and other regional bodies, parameters covering pesticides, veterinary drugs residues, trace elements, PAHs, PCBs, DNA quantification, pH, hormone, preservatives

Has organized 4 CCQM key comparisons, 2 supplementary comparison, and 6 pilot studies

Accredited as reference materials producer (2010) and proficiency testing schemes provider (2006)

Prepared 3 certified reference materials and organized over 20 proficiency testing programmes since 2000

Since 1987

Organized PT to establish comparability of measurement ……

toxic elements in herb (2005)

organochlorine pesticide in herb (2006)

heavy metals in seawater shrimp (2007)

malachite green in eel (2007)

OC pesticide in ginseng (2008)

melamine in milk (2008)

heavy metals in herb (2008)

PAHs in sediment (2009)

melamine in fish feed (2009)

melamine in milk powder (2009)

Sudan dyes in chilli powder (2009)

Organochlorine pesticides in green tea (2010)

Heavy metals in crustacean seafood (2011)

Ketamine in hair (2011)

PAHs in sediment (2011)

Essential and trace elements in bovine liver (2011)

137Cs in Milk Powder (2011)

Aflatoxin B1 in peanut oil (2011)

Organochlorine pesticides in green tea (2011)

Essential and trace elements in seafood (2011)…..

Looking forward

Effective and sustainable development of

metrology in chemistry is needed to support of

the testing and certification sectors in HK. There

is a need for Hong Kong to produce more CRMs

and organize more PTs to meet the specific

needs of HK.

THANK YOU