45th MiaMi Pediatric NePhrology SeMiNar aNd 5th reNal Pathology courSeMARCH 8 - 11, 2018

FOR MORE INFORMATION CALL 305-243-6716VISIT US AT WWW.PEDIATRICS.MED.MIAMI.EDU/NEPHROLOGY/SEMINAR

MIAMI BEACH, FL The Alexander

ALL SUITE OCEAN FRONT RESORT5225 Collins Avenue • Miami Beach, FL 33140

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PROGRAM PEDIATRIC NEPHROLOGY SEMINAR 2018

WEDNESDAY, MARCH 7, 20186:00-8:00 P.M. REGISTRATION

THURSDAY, MARCH 8, 2018 CELEBRATING WORLD KIDNEY DAY

PEDIATRIC RENAL PATHOLOGY COURSE: CURRENT CLASSIFICATION SYSTEMSDirector: David B. Thomas, M.D.Co-Directors: Surya Seshan, M.D. and Laura Barisoni, M.D.

7:00-8:00 A.M. REGISTRATION. Continental Breakfast.8:00-8:10 A.M. INTRODUCTION. Opening Remarks. Gastón E. Zilleruelo, M.D. David B. Thomas, M.D.

SESSION 1: INTRODUCTION TO RENAL PATHOLOGY Moderator: Surya Seshan, M.D.

8:10-8:40 A.M. Processing and Reporting of Renal Biopsies David B. Thomas, M.D.8:40-9:10 A.M. Algorithmic Approach to Renal Diseases Laura Barisoni, M.D. 9:10-9:30 A.M. Discussion

SESSION 2: KIDNEY LIMITED GLOMERULAR DISEASES Moderator: David B. Thomas, M.D.

9:30-10:10 A.M. New Classification of Podocytopathies (MCD-FSGS) Laura Barisoni, M.D.10:10-10:30 A.M. BREAK10:30-10:50 A.M. Congenital and Infantile Nephrotic Syndrome Surya Seshan, M.D.10:50 -11:20 A.M. Membranous GN Laura Barisoni, M.D. 11:20-11:40 A.M. IgM and C1Q Nephropathy David B. Thomas, M.D.11:40-12:10 P.M. MPGN/DDD/C3 Nephropathy Laura Barisoni, M.D. 12:10-12:30 P.M. Discussion

SESSION 3: LUNCHEON SESSION

12:30-1:30 P.M. Role of the Pathologist in Vasculitis/TMA David B. Thomas, M.D.

SESSION 4: SYSTEMIC DISEASES & TRANSPLANT PATHOLOGY Moderator: Laura Barisoni, M.D.

1:30-2:00 P.M. Lupus Nephritis Surya Seshan, M.D.2:00-2:30 P.M. IgA /HSP Surya Seshan, M.D.2:30-3:00 P.M. Collagen Type III, IV, Fibronectin Lesions David B. Thomas, M.D. 3:00-3:30 P.M. Banff classification and evaluation of transplant renal biopsies Surya Seshan, M.D.3:30-3:40 P.M. Discussion3:40-4:00 P.M. BREAK

SESSION 5: CLINICAL-PATHOLOGIC CORRELATIONS Moderators: David B. Thomas, M.D. and Wacharee Seeherunvong, M.D.

4:00-5:30 P.M. Case Presentations (including Transplant Pathology and TIN and Discussion)5:30-6:00 P.M. Competency Assessment Exam

FRIDAY, MARCH 9, 2018 PEDIATRIC NEPHROLOGY SEMINARSeminar Chair: Gastón E. Zilleruelo, M.D.Seminar Associate Chairs: Carolyn L. Abitbol, M.D. and Michael Freundlich, M.D.

7:00-8:00 A.M. REGISTRATION. Continental Breakfast.

SESSION 6: GENETICS AND PRECISION MEDICINE Moderators: Vera Koch, M.D. and Friedhelm Hildebrandt, M.D.8:00-8:20 A.M. Precision Medicine: Definitions and Significance Matthew G. Sampson, M.D.8:20-8:40 A.M. Precision Medicine in Monogenic Forms of FSGS and Cystic Kidney Diseases Friedhelm Hildebrandt, M.D.8:40-9:00 A.M. Alport Syndrome: From Bench to Bed Side Alessia Fornoni, M.D., Ph.D.9:00-9:20 A.M. Tuberous Sclerosis Complex John J. Bissler, M.D.9:20-9:40 A.M. CAKUT: When To Do Genetic Screening? Friedhelm Hildebrandt, M.D.9:40-10:10 A.M. Panel Discussion10:10-10:30 A.M. BREAK

SESSION 7: NEONATAL NEPHROLOGY Moderators: Carolyn L. Abitbol, M.D. and Julie Ingelfinger, M.D.10:30-10:50 A.M. Neonatal Nephrology and Prenatal Programming Julie Ingelfinger, M.D.10:50-11:10 A.M. Twin Pregnancy and Its Effect on the Kidneys Marissa DeFreitas, M.D.11:10-11:30 A.M. AKI in the NICU: Can we define it? Carolyn L. Abitbol, M.D.11:30-11:50 A.M. Predictor Markers in LUTO Disorders Chryso Katsoufis, M.D.11:50-12:10 P.M. Long Term Effects of Extreme LBW Carolyn L. Abitbol, M.D.12:10-12:30 P.M. Panel Discussion12:30-1:30 P.M. Meet the Professors Luncheon

SESSION 8: NEPHROLOGY FOR THE GENERAL PRACTITIONER Moderators: Michael Freundlich, M.D. and Uri S. Alon, M.D.1:30-1:50 P.M. RTA: Still a Problem? Uri S. Alon, M.D.1:50-2:10 P.M. Cystinosis: When to Recognize it? Craig B. Langman, M.D.2:10-2:30 P.M. Diagnosis and Management of TIN William E. Smoyer, M.D.2:30-2:50 P.M. Hypercalciurias: An Update Uri S. Alon, M.D.2:50-3:10 P.M. Vit D Deficient and Resistant Rickets Michael Freundlich, M.D.3:10-3:30 P.M. Panel Discussion3:30-3:50 P.M. BREAK

SESSION 9: HYPERTENSION AND ENDOCRINE NEPHROLOGY Moderators: Joseph T. Flynn, M.D., M.S. and Guido Filler, M.D., Ph.D.3:50-4:10 P.M. New Pediatric HTN Guidelines: An Overview Joseph T. Flynn, M.D., M.S.4:10-4:30 P.M. Salt and HTN: Are They Related? Julie Ingelfinger, M.D.

PROGRAM PEDIATRIC NEPHROLOGY SEMINAR 20184:30-4:50 P.M. Salt and FGF23: Are They Related? Michael Freundlich, M.D.4:50-5:10 P.M. Dual Angiotensin Blockade: Is it the Answer? Guido Filler, M.D., Ph.D.5:10-5:30 P.M. Panel Discussion5:30-6:00 P.M. Special Lecture: RAAS System: Past, Present and Future Leon Ferder, M.D., Ph.D.6:00-7:30 P.M. WELCOME RECEPTION

SATURDAY, MARCH 10, 20187:00-8:00 A.M. REGISTRATION. Continental Breakfast.

SESSION 10: NEW APPROACHES AND MANAGEMENT OF GLOMERULAR DISORDERS AND CKD Moderators: William E. Smoyer, M.D. and H. William Schnaper, M.D.8:00-8:20 A.M. Creatinine and Cystatin Based eGFR and CV risk in Children with CKD Susan Furth, M.D., Ph.D.8:20-8:40 A.M. Non-inflammatory Mechanisms in the Progression of CKD H. William Schnaper, M.D.8:40-9:00 A.M. New Management Approaches for TMA Craig B. Langman, M.D. 9:00-9:20 A.M. Nephrotic Syndrome: The Evolution of Its Treatment Frederick J. Kaskel, M.D., Ph.D.9:20-9:40 A.M. Onconephrology: A New Discipline? John J. Bissler, M.D.9:40-10:00 A.M. Panel Discussion10:00-10:30 A.M. BREAK AND VISIT EXHIBITS10:30-11:00 A.M. ASPN 50th Anniversary History Project Frederick J. Kaskel, M.D., Ph.D.11:00-11:20 AM The José Strauss Visiting Professor Award Gastón E. Zilleruelo, M.D.

SESSION 11: TRANSPLANT CLINICAL CHALLENGES Moderators: Jayanthi Chandar, M.D. and Richard N. Fine, M.D.11:20-11:40 A.M. Donor Options in Pediatric Kidney Transplant Jayanthi Chandar, M.D.11:40-12:00 P.M. Donor-Pair Exchange Programs: Is there a Benefit? Giselle Guerra, M.D.12:00-12:20 P.M. Generic Immunosuppression and Drug Interactions Guido Filler, M.D. Ph.D.12:20-12:40 P.M. The Future and Beyond in Kidney Transplantation Richard N. Fine, M.D.12:40-1:00 P.M. Panel Discussion1:00-2:00 P.M. Meet the Professors Luncheon

SESSION 12: WORKSHOP ON GROWTH AND NUTRITION IN CKD Moderators: Carolyn L. Abitbol, M.D. and John D. Mahan, M.D. 2:00-2:30 P.M. Hidden Renal Consequences of Obesity in Children with CKD Susan Furth, M.D., Ph.D. 2:30-2:50 PM Growth and Growth Hormone Therapy in Children with CKD John D. Mahan, M.D.2:50-3:10 P.M. Management of Anemia in Children with CKD Bradley A.Warady, M.D. 3:10-3:30 P.M. Management of Potassium in Infants with CKD Melvin Bonilla-Felix, M.D.3:30-3:40 P.M. BREAK 3:40-5:00 P.M. Case Studies and Discussion5:00-6:00 P.M. Medical Knowledge Competency Assessment

SUNDAY, MARCH 11, 20187:00-08:00 A.M. Registration. Continental Breakfast.

SESSION 13: DIALYSIS AND CRITICAL CARE NEPHROLOGY Moderators: Patrick Brophy, M.D. and Bradley A. Warady M.D.8:00-8:20 A.M. Critical Care Nephrology in the ICU: A New Specialty? Patrick Brophy, M.D.8:20-8:40 A.M. Modalities of Extracorporeal Therapy in the Management of AKI Timothy Bunchman, M.D.8:40-9:00 A.M. Nutritional Management of the Critically Ill Child Norma J. Maxhold, M.D. 9:00-9:20 A.M. Peritoneal Dialysis Access in Children: What we need to know Bradley A. Warady, M.D. 9:20-9:40 A.M. Panel Discussion9:40-10:00 A.M. BREAK

SESSION 14: SPECIAL SESSION: RECOGNIZING HEROES IN PEDIATRIC NEPHROLOGY Moderators: Gastón E. Zilleruelo, M.D. and Carolyn L. Abitbol, M.D.10:00-10:10 A.M. Welcome to Families and Special Invitees Gastón E. Zilleruelo, M.D. Carolyn L. Abitbol, M.D.10:10-10:30 A.M. Miracles Happen at Holtz: The Patient/Families Viewpoint 5 Testimonials10:30-11:00 A.M. When Clinical Research and Practice Merge Together: The Future George W. Burke III, M.D.11:00: 11:30 A.M. AWARDS CEREMONY/ Special Gifts11:30 A.M. ADJOURN

FIFTH ANNUAL PEDIATRIC CRITICAL CARE NEPHROLOGY WORKSHOP MARCH 11, 2018 | 1:00-5:00 PM - Holtz Children’s Hospital | Coordinator: Carolyn L. Abitbol, M.D.1:00-1:10 P.M. INTRODUCTION. Carolyn L. Abitbol, M.D. Medical Director, Pediatric Dialysis1:10-1:30 P.M. Developing a Program in Pediatric Dialysis Critical Care Evel Michel, DNP, ARNP, FNP-BC1:30-1:50 P.M. Continuous Renal Placement Therapies in Pediatric Critical Care Patrick Brophy, M.D.1:50-2:10 P.M. Adapted Vascular Access for Acute Dialysis in Small Patients Michael A. Nares, M.D.2:10-2:30 P.M Pharmacodynamics of CRRT: Intoxication & Hyperammonemia Timothy Bunchman, M.D.2:30-3:00 P.M. Workshop Stations: The Prisma Machine: Versatility Kelli Walker, ARNP, MSN3:00-3:30 P.M. Workshop Stations: CRRT: Blood Prime; Tandem ECMO & Transfers Chryso Katsoufis, M.D.3:30-4:00 P.M. Therapeutic Plasma Exchange: Indications & Applications Marissa Defreitas, M.D.4:00-4:30 P.M. Assessments of PD adequacy and developing a prescription Francisco J. Cano, M.D. Practical Skills in Management and Parental Training Wacharee Seeherunvong, M.D.4:30-5:00 P.M. Final Assessment & Certificates Carolyn L. Abitbol, M.D. and Carlos Cuervo, M.D.5:00 P.M. ADJOURN

A HANDS-ON WORKSHOP FOR LIVE CRRT WILL TAKE PLACE AT HOLTZ CHILDREN’S HOSPITAL AT THE END OF THE SEMINAR WITH AN ADDITIONAL FEE. FOR DETAILS AND INFORMATION SEE THE ADVANCED REGISTRATION FEES SECTION OF THIS BROCHURE.

Carolyn L. Abitbol, M.D. Professor of Pediatrics Division of Pediatric Nephrology, Medical Director, Pediatric Dialysis Unit, Fellowship Training Program Director, Associate Chair Pediatric Nephrology Seminar

Laura Barisoni, M.D. Professor of Pathology, Division Chief, Renal Pathology Service, Department of Pathology, Co- Director Renal Pathology Course

George W. Burke, III, M.D., FACS Professor of Surgery, Director, Kidney and Kidney/Pancreas Transplantation, The Joshua Miller MD Chair in Transplant Surgery

Jayanthi Chandar, M.D. Associate Professor of Clinical Pediatrics, Division of Pediatric Nephrology, Medical Director Pediatric Kidney Transplant Program

Sheila Coakley, R.N. Pediatric Dialysis Unit, Nicklaus Children’s Hospital

Carlos Cuervo, M.D. Voluntary Assistant Professor of Pediatrics, Division of Pediatric Nephrology

Marissa Defreitas, M.D. Assistant Professor of Clinical Pediatrics, Division of Pediatric Nephrology

Leon Ferder, M.D. Voluntary Associate Professor of Pediatrics, Division of Pediatric Nephrology

Michael Freundlich, M.D. Professor of Clinical Pediatrics, Division of Pediatric Nephrology Associate Chair Pediatric Nephrology Seminar

Alessia Fornoni, M.D., Ph.D. Professor of Medicine, Chief, Katz Family Division of Nephrology and Hypertension, Director, Peggy and Harold Katz Family Drug Discover Center

Giselle Guerra, M.D. Associate Professor of Clinical Medicine, Director of the Living Kidney Donor Program, Medical Director of Transplant Services

Beverly Jackson, R.N. Pediatric Dialysis Unit, Holtz Children’s Hospital

Chryso Katsoufis, M.D. Assistant Professor of Clinical Pediatrics, Division of Pediatric Nephrology

Evel Michel, DNP, ARNP, FNP-BC Nurse Educator,JHS Program Coordinator for: Daisy Certification, & Preceptor, Education & Development/Center for Nursing Excellence

Michael A. Nares, M.D. Director, Pediatric Intensive Care Unit, Holtz Children’s Hospital, Assistant Professor of Clinical Pediatrics, Division of Pediatric Critical Care Medicine

José Strauss, M.D. Emeritus Professor, Division of Pediatric Nephrology, Former Chairman Pediatric Nephrology Seminars

David B. Thomas, M.D. Professor of Pathology, Department of Pathology, Director Renal Pathology Course

Wacharee Seeherunvong, M.D. Associate Professor of Clinical Pediatrics, Division of Pediatric Nephrology

Marie Saintvil, R.N. Pediatric Dialysis Unit, Nicklaus Children’s Hospital

Marcia Young, R.N. Pediatric Dialysis Unit, Holtz Children’s Hospital

Kelli Walker, ARNP, MSNTherapy Development Specialist at Gambro

Gastón E. Zilleruelo, M.D. Professor of Pediatrics, Director, Division of Pediatric Nephrology, Chair, Pediatric Nephrology Seminar

Uri S. Alon, M.D. Professor of Pediatrics and Director of Research and Education, Section of Nephrology, Children’s Mercy Hospital and Clinics, University of Missouri, Kansas City, MO

Melvin Bonilla-Felix, M.D. Professor and Chair, Department of Pediatrics. University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

John J. Bissler, M.D. Chief of Pediatric Nephrology and Director of the Tuberous Sclerosis Center of Excellence, Le Bonheur Children’s Hospital, Professor, The University of Tennessee Health Science Center, Memphis, TN

Patrick Brophy, M.D. Director of Pediatric Nephrology, Children’s Hospital, Iowa City, IA President Elect American Society of Pediatric Nephrology (ASPN)

Timothy Bunchman, M.D. Professor and Chief of Pediatric Nephrology, Children’s Hospital of Richmond at VCU, Richmond, VA

Francisco J. Cano, M.D. Profesor Titular de Pediatria, Division of Pediatric Nephrology, Hospital Luis Calvo-Mackenna Children’s Hospital, Director Revista Chilena de PediatriaSantiago, Chile

Guido Filler M.D., Ph.D. Professor of Pediatrics, Department of Pediatrics. Children’s Hospital, London Health Science Centre University of Western Ontario, Canada

Richard N. Fine, M.D. Professor of Pediatrics, State University of N Y at Stony Brook, NY

Joseph T. Flynn, M.D. Dr. Robert O. Hickman Endowed Chair in Pediatric Nephrology, Professor of Pediatrics, University of Washington, Chief, Division of Nephrology, Seattle Children’s Hospital, Seattle, WA

Susan L. Furth, M.D., Ph.D. Professor of Pediatrics, Chief of Division of Nephrology, Children’s Hospital of Philadelphia, PA

Julie Ingelfinger, M.D. Professor of Pediatrics and Senior consultant I Pediatric Nephrology, Mass General Hospital for Children, Boston, MA

Friedhelm Hildebrandt, M.D. Chief Division of Nephrology, Boston Children’s Hospital, Professor of Pediatrics, Harvard Medical School, Boston, Mass

Frederick J. Kaskel, M.D., Ph.D. Professor and Vice Chair of Pediatrics, Director for Child Health Einstein/Montefiore Institute for Clinical and Translational Research, NY

Vera Koch, M.D. Professor of Pediatric Nephrology, Instituto da Crianza do Hospital das Clinicas, Universidad of Sao Paulo, School of Medicine, Brazil. Secretary General ALANEPE

Craig B. Langman, M.D. The Isac A. Abt M.D. Professor of Kidney Diseases, Feinberg School of Medicine, Northwestern University, Head Kidney Diseases, Lurie Children’s Hospital of Chicago, Chicago,IL

John D. Mahan, M.D. Professor, Department of Pediatrics, Program Director, Pediatric Residency Program, Program Director, Pediatric Nephrology Fellowship Program, Vice Chair for Education, The Ohio State University COM, Columbus, OH

Norma J. Maxvold, M.D. Associate Professor of Pediatrics, Specialty Critical Care Medicine, Children’s Hospital of Richmond at VCU, Richmond, VA

Matthew G. Sampson, M.D. Assistant Professor of Pediatrics, University of Michigan, Ann Arbor, Mi

William E. Smoyer, M.D. Director Center for Clinical and Translational Research. The Research Institute at Nationwide Children’s Hospital, Columbus, OH

H. William Schnaper, M.D. Professor of Pediatrics; Vice Chairman, Children’s Memorial Medical Center, Feinberg School of Medicine, Northwestern University, Chicago, IL

Surya Seshan, M.D. Professor of Pathology, Department of Pathology, The New York Hospital-Cornell Med. Ctr, New York, NY Renal Pathology Course Co-Director

Bradley Warady, M.D. Professor of Pediatrics, University of Missouri-Kansas City School of Medicine, Director Division of Pediatric Nephrology; Director of Dialysis and Transplantation, Children’s Mercy Hospital and Clinics, Kansas City, MO

GUEST FACULTY

LOCAL FACULTY

Flanked by the roaring Atlantic Ocean and rippling Intracoastal Waterway, the Alexander All Suite Ocean Front Resort is located in the heart of

Miami Beach. Attendees will enjoy late-winter in South Florida which is unlike that in any other part of the U.S. thanks to a subtropical climate and

strong Caribbean/Latin American influences. It’s just the right place for recharging your personal and professional perspectives in the company of

friends and colleagues. You won’t need your coat, boots, or umbrella, but a light jacket may feel good in Miami’s moonlit evening breezes and super-air

conditioned restaurants.

Room Rates: US $275.00 + US $10.00 Resort Fee and 14% tax-Single/Double Occupancy- European plan

(meals not included).

Room rates apply three day prior to, during and three days after the Seminar. Reservations must be received by February 12, 2018 to take advantage of

the above rate. Please use attendee code APEDIA when making your reservations for a discounted rate.

After this date, reservation requests will be considered on a space available basis.

Advanced Registration Fee:Renal Pathology Course ONLY US $125.00Pediatric Nephrology Seminar ONLY US $400.00Pediatric Renal Pathology Course and Pediatric Nephrology Seminar US $495.00CRRT Workshop on Sunday afternoon ONLY US $ 50.00Physicians in Training (except Grantees), Nurses and Allied Health Professionals* US $295.00

* Physicians in Training will need letter of verification from Chief of service.

* Tuition includes admission to scientific sessions, a course flash drive and continental breakfasts.

* After February 19, 2018 and (On-Site) US $550.00 for physician in practice and US $330.00 for others.

* ONLY PAYMENTS BY CREDIT CARD CAN BE ACCEPTED FOR ONSITE REGISTRATION.

Services for the Disabled:If special arrangements are required for an individual with a disability to attend this conference, please contact: Yvette Arauz, (305) 585-6726 and the Alexander All Suite Ocean Front Resort 1-800-327-6121 or (305) 865-6500 no later than February 19, 2018.

For Additional Information, contact:Department of PediatricsDivision of Pediatric NephrologyP.O. Box 016960 (M-714)Miami, FL 33101Tel. (305) 585-6726Email: pediatricnephrology@med.miami.edu

To register online, visit http://pediatrics.med.miami.edu/nephrology/seminar select conference you are attending and click register and pay.

Registration Cancellation PolicyRefunds will be made only if written notice of cancellation is received prior to February 19, 2018. A US $75.00 fee is charged to all refunds. After this date, no refunds will be made. In cases where a course is cancelled due to insufficient registrations, a full tuition refund will be made.

Hotel InformatIon

The Alexander ALL SUITE OCEANFRONT RESORT

5225 Collins Avenue, Miami Beach, FL 33140Tel: 1-800-327-6121 or (305) 865-6500

Email: reservations@alexanderhotel.com

PEDIATRIC NEPHROLOGY SEMINAR XLVRegistration Information

PROGRAM DIRECTOR: Gastón E. Zilleruelo, M.D. ASSOCIATE PROGRAM DIRECTORS:

Carolyn L. Abitbol, M.D. and Michael Freundlich, M.D.FOUNDED BY: José Strauss, M.D.

COURSE DESCRIPTIONThe Miami Pediatric Nephrology Seminar now in its 45th year is an unique international gathering of pediatric and adult nephrologists, pediatricians, internists, general practitioners, renal pathologists, neonatologists, pediatric urologists, transplant surgeons, nurses, nutritionists and allied health professionals from all over the United States and the world sponsored by the University of Miami, Leonard Miller School of Medicine and Holtz Children’s Hospital at Jackson Memorial Hospital. The content is basic, the approach is clinical. Conceptual and practical problems are featured in a balance of formal presentations followed by informal discussions. Topics covered relate research advances to the understanding of mechanisms of renal disease, pathological expressions and clinical diagnosis and management. All registrants have opportunities to be involved in a dynamic exchange of information, experience, and insight. Selection of topics, faculty and format are based on suggestions from past Seminar participants and current questions. The 45th Pediatric Nephrology Seminar and the preceding Renal Pathology Course will include a total of 14 Sessions from March 8-11, 2018. The Pre-Seminar Renal Pathology Course is an intensive, one full day comprehensive course focused on updated new classifications and covering all aspects of nephro-pathology starting with sample processing and transition to glomerular, tubular, cystic as well as systemic and metabolic disorders affecting pediatric and young adult patients finalizing with a clinico-pathologic correlations interactive Session. The Pediatric Nephrology Seminar will cover a wide range of topics including Genetics and Precision Medicine, Neonatal Nephrology, Nephrology for the General Practitioner, Hypertension and Endocrine Nephrology, New Approaches and Management of Glomerular Disorders and CKD, Transplant Clinical Challenges, Nutrition and Growth in CKD (Workshop), Dialysis/Critical Care Nephrology and an special Session dedicated to the Recognition of Challenging Patients as “Heroes” in Pediatric Nephrology. In addition, there will be an optional “hands-on” workshop dealing with CRRT and Critical Care Pediatric Nephrology at the end of the Seminar specifically developed for physicians in-training. All the topics selected have high clinical research relevance and have not been covered in this format by other conferences in recent years. The Seminar will feature 22 distinguished Guest Faculty and 21 Local Faculty who will provide expertise and cordial exchanges including several panel discussions and Meet the Professor Luncheons. We hope you will enjoy attending this newly structured scientific meeting.

CONFERENCES OBJECTIVES1. Diagnose and treat the most frequent conditions by identifying recent

discoveries in basic, translational and clinical research in selected areas of pediatric nephrology, and assessing its impact in research development and precision medicine.

2. Recognize and assess routine handling, processing and reporting of kidney biopsies with a systematic approach in the diagnosis of medical renal diseases and updated classifications.

3. Establish appropriate diagnosis and management of children with various medical renal diseases by assessing the histopathologic findings obtained from kidney biopsies.

4. Assess and utilize genetic diagnostic testing for use by the practitioner approach to children with inherited pediatric nephrology disorders.

5. Recognize the pathogenesis, diagnose complications and select appropriate management of neonates with kidney diseases.

6. Recognize common kidney disorders confronted by the general practitioner and discuss timely referral to the specialist.

7. Use recombinant growth hormone therapy in the management of children with growth impairment associated with chronic kidney disease (CKD) and assessment of nutrition abnormalities in children with this condition.

8 . More effectively manage children with hypertension, CKD, dialysis and transplant and its complications.

9. Evaluate pathogenesis, complications and management of infants and children with glomerular disorders and chronic kidney diseases.

10 Review practical protocols for the management of patients with extracorporeal therapies in the critical care setting.

Upon completion of the Seminar, participants should be able to define the various etiologies and physiologic conditions relating to these subjects,

select appropriate diagnostic procedures, understand that which may occur as a result of the disease process or treatment, and indicate appropriate therapy. In addition, those able to do basic or clinical research focused on pediatric nephrology challenges, will be stimulated by those knowledgeable about research issues and be informed about support sources. It is anticipated that the exchanges of knowledge occurring during this meeting, will help identify future research directions and new approaches and technologies that will eventually lead to a better understanding of these conditions and improved treatment and prevention strategies. It is expected that the Faculty will serve as role models for future generations of Pediatric Nephrologists and serve to stimulate interest in this field as a career choice. The Pediatric Nephrology Seminars have successfully addressed for over 44 years the issues of selecting the best faculty speakers, formal lectures of short duration followed by panel discussions and case-based presentations. Informal exchanges throughout the meeting allows for clear improvement in the professional gaps of the intended audience. The faculty, format and educational design will allow learners to give better patient care with regards to early detection of kidney disease in children or its complications (i.e growth hormone deficiency) and a more evidence based management of these conditions.

ACTIVITY LEARNING OBJECTIVESGoals for the Scientific Conference/Seminar.The purpose of the 45th Pediatric Nephrology Seminar and 5th Renal Pathology Course will be to review the current state/knowledge of selected relevant areas of research in Pediatric Nephrology with clinical practice implications. The specific aims of the proposed scientific Seminar are:

1. To review the current understanding of the diagnosis and management of various kidney disorders with a focus on clinical research, clinico-pathologic correlations, current approaches for the general practitioner in common kidney conditions,concepts on neonatal nephrology and hypertension, effects of nutrition, and recombinant growth hormone in chronic kidney disease, in-depth review on selected glomerulopathies, on-going challenges in critical care nephrology, chronic kidney disease, dialysis and transplantation, and new developments in genetic approaches to inherited disorders and precision medicine.

2. To identify the most critical and promising areas for future basic and clinical research efforts regarding Pediatric Nephrology.

3. To stimulate interest in Pediatric Nephrology as a career choice.

4. To provide role models for the next generation of Pediatric Nephrologists and a communication network for future collaboration and career support for retention of current trainees.

FACULTY DISCLOSURE AND CONFLICT OF INTEREST RESOLUTIONAll conflicts of interest of any individual(s) in a position to control the content of this CME activity will be identified and resolved prior to this educational activity being provided. Disclosure about provider and faculty relationships, or the lack thereof, will be provided to learners.

Pediatric Nephrology Seminar XLV and the Renal Pathology Course are an international forum for pediatric and adult nephrologists, pediatricians, internists, general practitioners, renal pathologists, neonatologists, pediatric urologists, transplant surgeons, nurses, nutritionists and allied health professionals to review selected relevant subjects and share new scientific materials.

ACCREDITATIONThe University of Miami Leonard M. Miller School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATIONThe University of Miami Leonard M. Miller School of Medicine designates this live activity for a maximum of 32.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This seminar has been planned and implemented in accordance with the essential areas and policies of the Florida Board of Nursing for Continuing Education Provider #50-2105. The University of Miami School of Nursing and Health Studies designates CEU credits for this live activity as well.