micro- and nanotechnologies for healthcare and biology at
TRANSCRIPT
MICRO- AND NANOTECHNOLOGIES
FOR HEALTHCARE AND BIOLOGY AT
CEA-LETI
• Promoting and developing Micro & Nano-
technologies for biology, healthcare and environment
• Create new technologies & develop integrated
innovative solutions for our industrial partners
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5 STRATEGIC DOMAINS…
Medical devices Lab-on-chip and µfactory
Wearable and implantable devices
& sensors
Microsystems for in vitro diagnostic,
environmental and industrial monitoring
Molecular imaging
Optical imaging
X and Ƴ-ray detectors
X, Ƴ-ray and optical detectors
for medical imaging and
security
Nanocarriers
Nanocarriers for diagnostics and drug
delivery
ADRESSING
SMEs AND START-UPs LARGE COMPANIES
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NANOCARRIERS,DRUG DELIVERY
Dye for in vitro Diagnosis and in vivo Imaging,
Photodynamic Therapy, Active Pharmaceutical
Ingredient encapsulation for Drug Delivery,
Chemotherapy, Vaccines and Cosmetic, Active Delivery
of siRNA, Protein Antigens Delivery
Lipidots®
Soybean Oil
and Wax Core
Shell Phospholipids
PEG surfactant
Lipophilic content: Imaging agent, Active Pharmaceutical Ingredient
Lipidot® dopped with
different dyes Lipidots® gel
OPTICAL MOLECULAR IMAGING
Diagnosis (Bacteria, Viruses, Skin / Tissues
Characterization, Biopsy Guidance… ), Therapy (Image
Guide Surgery, Skin Scrap Surgery), Biology (Cellular
Imaging, Bioproduction), Security & environment
(Chemical, Nanoparticles Detection…)
3D imaging
Skin analysis
Lensfree imaging
Prostate biopsy guidance Vascular imaging
Raman Analyzer Scattering image of
bacteria microcolony
Cell culture monitoring
Contact: [email protected] / [email protected] Contact: [email protected] / [email protected]
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X AND γ-RAY DETECTORS FOR
IMAGING
ASIC design
Detector / system
simulation
Material, technologies
& hybridization
Detection modules
Information
processing
Medical Imaging (Radiology, Computed Tomography,
Pre-clinical Imaging), Security (Explosive and Drug
Detection), Non-destructive testing (Weld Testing,
Counterfeit Identification), Environment (Sorting of
waste)
Information and
signal processing
CdTe / CdZnTe/CsI
CMOS ASICs
X g
Connectic
MEDICAL DEVICES
Diagnosis, Drug Delivery, Chronic Disease Monitoring
(respiratory, sleep, diabetes, epilepsy...), e-Health,
Activity Monitoring, Sport, Wellness, Rehabilitation,
Smart Textile, User Feeling Monitoring
µbiopsy system
EEG
µpump for drug delivery
Vagus nerve electrodes
Respiratory disease
Patch
Diabetes regulation loop
Contact: [email protected] Contact: [email protected] / [email protected]
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FOR IN VITRO DIAGNOSIS
LAB ON CHIP AND µFACTORIES
FOR ENVIRONMENTAL &
INDUSTRIAL MONITORING
Plasma Preparation, Sample Preparation for PCR or
immunoassay, Cell encapsulation, Chemical Synthesis,
cells insolation, Pathogen detection, Monophasic and
diphasic / digital fluidics
Solgel sensors
Encapsulation et µfab
Detection, Collection and Quantification of Bio and
Chemical Species, Gases, VOCs, Nanoparticles,
Drugs, Toxins, Virus, Pollens…
Conductivity sensor
Water analysis Personnal Aerocollector
Plasma extraction from whole
blood
Sample preparation cartridge
Microfluidic system
Field air sampler
Contact: [email protected] Contact: [email protected] / [email protected]
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• Develop innovative medical devices for patient use
• Satisfy increasing needs in safety and biocompatibility
evaluations
• Accelerate clinical proof-of-concept
CONCEIVE AND PROPOSE A NOVEL BIOMEDICAL RESEARCH
MODEL TO ACCELERATE THE DEVELOPMENT AND CLINICAL
VALIDATION OF INNOVATIVE MEDICAL DEVICES
CLINATEC’S MISSION
University, National Research
Institution
Research and
Technology
Organization Hospital
Engineers &
Technologist
Clinicians
Biologists
Contact: [email protected] / [email protected]