MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon

Cancer(Lynch Syndrome)Kevin Harris

Some Families are Predisposed to Colon Cancer

What Genes Cause HNPCC?

MLH1 Encodes a DNA Mismatch Repair Protein

Meiotic Pachytene Arrest is Observed in MLH1-Deficient Mice

MLH1 Mutants Lack MLH1 Protein and Make Many Replication Errors

Molecular Markers Confirm MLH1 Mutations in HNPCC Patients

Familial Non-Polyposis Colon Cancer (Lynch Syndrome) Leads to Other Cancers

Polyps Come in Many Forms

FAP HNPCC

With HNPCC Additional Screening Visits are Necessary

A Preemptive Strike Against Cancer

Sources

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