molecular biology - kocwcontents.kocw.net/kocw/document/2015/pusan/kimheuisoo/2.pdf ·...
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![Page 1: MOLECULAR BIOLOGY - KOCWcontents.kocw.net/KOCW/document/2015/pusan/kimheuisoo/2.pdf · 2016-09-09 · 학습 요약 정리-2 1.장수유전자 Sirtuin family에서, SIRT2-SIRT3이](https://reader031.vdocuments.net/reader031/viewer/2022011821/5eb7d105353c2130a8638424/html5/thumbnails/1.jpg)
Heui-Soo Kim
MOLECULAR BIOLOGY
PHYLOGENY LAB
http://www.primate.or.kr
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학 습 목 표
1.동물계통분류학 학문의 특성을 이해한다.
2.ARHGAP11B 유전자의 계통 및 진화의 중요성을 인식한다.
3.동물계의 위치 및 뿌리를 이해한다.
4.Sirtuin 유전자 패밀리의 특성과 계통관계를 이해한다.
5.이동성유전인자의 중요성을 논의한다
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ARHGAP11B Gene Makes Human Brain Bigger
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Human specific gene, ARHGAP11B, works in mice Play a key role in neocortex
expansion
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학습 요약 정리-1
1.동물계에서 인간만이 가지고 있는 유전자는 ARHGAP11B, PCDHY등이 있다. 2.ARHGAP11B유전자 기능은 대뇌피질의 확장에 있다. 3.인간과 가장 가까운 계통적 유연관계는 침팬지, 고릴라, 오랑우탄, 긴팔원숭이 순서다.
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다음 차시 예고…
1.장수유전자 Sirtuin family에서, 분자계통분류의 이모 저모?..… 2.분자계통분류에서 새로운 바이오마커는 무엇인가? 3.분자계통도의 작성에서 유사서열/이종상동서열의 중요성…
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동물계통분류학
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-개구리 피부 감염을 막는 슈딘-2
-슈딘-2가 췌장의 베타세포를 자극하여 인슐린 분비 촉진
- iPSC로 랑게르한스 섬 조직 만들어 인슐린 분비 가능 /인슐린 캡슐
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-벼룩의 레실린 유전자정보 이용하여, 인간의 질병 치료에 응용 인간의 손상된 동맥 내벽에서 탄성물질로 활약 가능 - Resilin은 flea의 발가락에서 점프하기 위해 발현하는 탄성 단백질 - 낙동강 수질검사-물벼룩이 담당 (수질오염의 주범인 조류를 먹어 치움)
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Sirtuins of parasitic protozoa: In search of function(s)
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0.2
Class I
Class II
Class III
Betaretrovirus
Gammaretrovirus
Epsilonretrovirus
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Long-range regulatory elements
(Enhancers, Repressors/
Silencers, Insulators)
Cis-regulatory elements
(Promoters, transcription
factor binding sites)
Gene regulation elements
(UTR, splicing signal,
poly A signal)
Gene [Exon and Intron]
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학습 요약 정리-2
1.장수유전자 Sirtuin family에서, SIRT2-SIRT3이 가까운 유연관계에 있고 SIRT1이 그 다음이다. 2.이동성유전인자가 분자계통분류의 새로운 바이오마커로 이용되고 있다. 3.분자계통도의 작성에서 유사서열인가, 이종상동서열인가를 잘 구분함이 중요하다.
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다음 차시 예고…
1.생물종다양성이란 무엇인가?
2.생물종다양성의 가치는 어느정도 될까? 3.생물종다양성은 질병과 어떻게 연결될까?
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