moller introduction - sos international hospital

Genuine, inspiring and passionate about omega-3

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About Moller’s Omega-3I. The history of Moller : since 1854- the

longest history.II. About the Quality : the purest & most

natural Omega-3 III. Excellent health care of Omega-3 and

clinical studies

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I. History

• Cod liver oil : over 1000 year ago

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• He introduced “medicine cod liver oil” in 1854 with an impressive quality and taste.

History

Pharmacist Peter Möller (1793 – 1869)

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• Raw material: liver of wild Arctic cod (Skrei) fished off Lofoten and Vesterålen , ones of the clearest waters on the Earth.

• Richness in the most important Omega-3 fatty acids DHA + EPA and vitamins D and A.

Raw material

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Widely international presense

Available in more than 20 countries One of the Best product of Omega-3 in the world

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Möller’s – leading omega-3 brand in many markets

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II. The QualityMöller’s – the purest &most natural omega-3

• Reason to believe Made of wild fish from the world’s purest

seas. Kept in its natural form as oil straight from the

fish. (Triglycerides) Processed gently to preserve all the natural

goodness.

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Highest freshness values

• For all Möller’s products we follow the strict standards and recommendations for oxidation values set by European Pharmacopoeia (Ph.Eur) and GOED (Global Organization for EPA and DHA Omega-3)

• Orkla Health has set internal requirements that are even stricter than the ones put forward by Ph. Eur. and GOED to secure the highest level of freshness.

Möller’s cod liver oil

Möller’s fish oil

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Möller's Oxidation values - Peroxide

Ph.Eur. limit Möller’s limit Möllers average value 2008-2010

Möller’s cod liver oil

Möller’s fish oil

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Möller's Oxidation values - Anisidine

Ph.Eur. limit Möller’s limit Möller’s average value 2008-2010

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Securing highest purity• To secure consumption safety of highest degree Moller

employs the art technologies to remove environmental toxins.• We analyse for contaminants regularly and all our results are

below the EU and Möller’s limits with good margin.

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Strict standards for microbiological activity• As of today, there exist no official government requirements

for the maximum allowed levels of microbiological activity in fish oil.

• However, Orkla Health makes sure that the microbiological activity is at a minimum:

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Moller Vietnam

Components 5ml Moller’s Tran Lemon

5ml Moller’s Tutti Fruit

2 capsules Mollers’s Dobbel

Omega 3 1100 mg 1200 mg 700 mg

DHA 600 mg 600 mg 600 mg

EPA 400 mg 400 mg

Other fatty acids 100 mg 200 mg 100 mg

Vitamin D 10 mcg 10 mcg 15 mcg

Vitamin A 250 mcg 250 mcg 250 mcg

Vitamin E 10 mg 10 mg 10 mg

Cod Liver Oil Fish Oil

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III. EXCELLENT HEALTH CARE Omega- 3 fatty acids are a general term for a group

of polyunsaturated fatty acids The longest, most flexible fatty acids among the

marine omega-3 fatty acids are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).

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Fatty acid Double bonds Sources

Linoleic acid n-6 Vegetable oils, margarines, grain

α-linolenic acid n-3 Green leaves, linseed, soybean and canola oil

EPA , DHA Marine animals, cod liver oil and fish oil

Food sources of Fatty acids

Source of oil

Saturates Monoenes N-3 N-6

Cod liver 16 51 27 2

Soy 16 23 8 53

Corn 13 27 1.3 58

Rape seed 6 64 9 20

Palm oil 51 39 0.5 10

Coconut 91 7 0 3

Fatty acid composition of vegetable oils, marine oils (% of fatty acids)

United States Department of Agriculture Provisional table on the content of omega-3 fatty acids and other fat components in selected foods.

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Every cell wall in our body has a double layer of phospholipids built from fatty acids.

All cells are constantly rebuilt and changing, and new building blocks are therefore required!

Need to supplement through dietary !

IMPORTANCE OF DIETARY INTAKE

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COD LIVER OIL ALSO CONTAINSVITAMIN D, A and E

• It is not cod liver oil if there is not vitamin (Norwegian pharmacopea).

• The combination is perfect and natural• Bring more benefits to our consumers

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- Reducing risk of atherosclerosis- Inhibition of thrombosis- Anti-arrhythmic effects- Arterial compliance

EPA + DHA AND HEART

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DHA AND VISION

• Supplementation with DHA enhance maturation of infant retina function and visional acuity.

• It is hypothesized that if dietary intake of DHA is increased among elderly, concentration of DHA will increase in retina and increase light sensitivity

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DHA AND BRAIN• Docosahexaenoic acid (DHA) is

the most abundant omega-3 fatty acid in the human brain, increasing in amount when the brain develops and grows, and decrease in amount as we age.

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Research on Möller’s cod liver oil

• During pregancy and lactation To enrich breastmilk with VLC n-3 Effects on brain development – IQ• Effects on risk factors for

Cardiovascular disease Incorporation of marine fatty acids

into blood cells Modulation of inflammtion Lowering of triglyceride levels Modulation of cholesterol levels Reduced platelet aggregation• Correlation studies :CLO intake and

depression

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Pregnancy and lactation• 4 published studies from the Institute for Nutrition research, University of Oslo,

Norway• 10ml Möller’s CLO throughout pregnancy and lactationResults: Supplementation with Möller’s CLO raises omega-3 content of breast-milk, thereby

increasing the supply of these fatty acids to the infant Supplementation with Möller’s CLO reduces maternal plasma lipids such as

triglycerides Supplementation with Möller’s CLO is associated with higher IQ at 4 years of age

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Studies from the Institute for Nutrition research University of Oslo, Norway

Pregnancy and lactation

HELLAND et al, 2008 HELLAND et al ,2003

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Intelligence• Mothers were supplemented with cod liver oil (or a control) during

pregnancy and lactation• Children of supplemented mothers had a higher IQ at 4 years of age

(average = 4.1 points higher)• DHA intake had the strongest correlation with intelligence

Maternal Supplementation with Very-Long-Chain n-3 FattyAcids during Pregnancy and Lactation AugmentsChildren’s IQ at 4 years of age, Pediatrics: 2003

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Research on Möller’s cod liver oilDuring

• During pregancy and lactation To enrich breastmilk with VLC n-3 Effects on brain development – IQ• Effects on risk factors for Cardiova

scular disease Incorporation of marine fatty acids

into blood cells Modulation of inflammation Lowering of triglyceride levels Modulation of cholesterol levels Reduced platelet aggregation• Correlation studies :CLO intake

and depression

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• GISSI study from 1999

Cardiovascular risk factors

From October, 1993, to September, 1995, 11 324 patients surviving recent (3 months) myocardial infarction Randomly assigned supplements of n-3 PUFA (1 g daily, n=2836), vitamin E (300 mg daily, n=2830), both (n=2830), or none (control, n=2828) for 3·5 years. Treatment with n-3 PUFA: significantly lowered the risk of the primary endpoint (death, non-fatal myocardial infarction, and stroke)

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Research on Möller’s cod liver oilDuring

• During pregancy and lactation To enrich breastmilk with VLC n-3 Effects on brain development – IQ• Effects on risk factors for Cardiova

scular disease Incorporation of marine fatty acids

into blood cells Modulation of inflammtion Lowering of triglyceride levels Modulation of cholesterol levels Reduced platelet aggregation• Correlation studies :

CLO intake and cognitive function, diabete and Metabolic syndrom.

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The Lund Cognitive Study• Aim: to test the effect of 5 weeks supplementation with omega-3 fatty

acids on cognition–Used Orkla Health’ PMET oil (Möller’s High Concentrate): 3g omega-3 FA per day–38 subjects, 50-70 years–Placebo-controlled, crossover design–Used cognitive tests to evaluate:• Working memory(WM)• Selective attention

Nilsson et al. Nutrition Journal 2012

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• Results:- Better performance in the

WM-test compared with placebo

- n-3 PUFA lowered plasma triacylglycerides and systolic blood pressure

The Lund Cognitive Study

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omega-3kontroll

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P<0,05

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omega-3kontroll

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resultat på den svåraste delen av testet(max 24p)

ab

Totalt (60 +160min): P=0,015

~8%skillnad

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Type 1 diabetes• 545 cases of

childhood- type 1 diabetes

• A significantly lower risk of type 1 diabetes (adjusted odds ratio: 0.74; 95% CI: 0.56, 0.99).

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Metabolic syndrom• Intervention with diet plus

omega-3 was associated with significant reduction in systolic (−12.2%) and diastolic (−8.2%) blood pressure, serum triglycerides concentration (−21.4%), and insulin resistance (−13.1%) (P<0.05), as well as a reduction in serum IL-6 concentration (−28.5%) (P=0.034).

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HOW MUCH OMEGA-3DO WE NEED?

• Nordic Nutrition Recommendations: 1 gram omega-3 every day.• Norwegian Health authorities recommend vitamin D to infants from 4 weeks

of age. Vitamin D supplement is preferably from cod liver oil.• Subjects with special needs can benefit from larger doses of omega-3.• Joint or heart problems: 2-3 grams of omega-3 daily (American Heart

Association).

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Global recommendations Organization Target Population Recommendation World Health Organization (WHO) General adult population n-3 PUFAs: 1-2% of energy/day

Food and Agriculture Organization of the United Nations (FAO)2

0-6 months DHA: 0.1-.018%E

6-24 months DHA: 10-12 mg/kg bw

2-4 years EPA + DHA: 100-150 mg



Pregnant/Lactating Women EPA + DHA: 0.3 g/d of which at least should be 0.2 g/d

European Food Safety Authority General Adult Population 250mg EPA+DHA /day

Pregnant & Lactating Women 100-200 mg DHA / day in addition to general adult requirements

Children 7-24 months 100 mg DHA / day

Children 2-18 years 250mg EPA+DHA /day

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Moller’s Values Since 1854 – The longest history. Leading omega-3 brand in

Denmark, Norway, Sweden, Finland and many other countries. The purest &most natural omega-3. The best Quality : exceed the European Pharmacopeia. Excellent health care.

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Thanks For Your Attention

Genuine, inspiring and passionate about omega-3

moller introduction - sos international hospital

Health & Medicine