morphological changes of ischemic heart … heart disease... · morphological changes of ischemic...
TRANSCRIPT
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MORPHOLOGICAL CHANGES OF ISCHEMIC HEART DISEASE
DR. K.SARITHAASSISTANT PROFESSORPATHOLOGY DEPT
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INTRODUCTION
• Ischemic heart disease (IHD) is the leading cause of death worldwide for both men and women (7 million total per year).
• IHD is the generic designation for a group of pathophysiologically related syndromes resulting from myocardial ischemia—an imbalance between the supply (perfusion) and demand of the heart for oxygenated blood.
• Ischemia -1)insufficiency of oxygen 2) reduces the availability of nutrients and the removal of metabolites
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ETIOPATHOGENESIS
1)Coronary atherosclerosis- fixed obstruction -90%cases
2)Super added changes in coronary atherosclerosis
3)Non atherosclerotic causes-10%
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ATHEROSCLEROSIS
athero = porridge; sclerosis = scarring
Atherosclerosis is a specific form of arteriosclerosis affecting primarily the intima of large and medium-sized muscular arteries and is characterised by fibrofatty plaques or atheromas.
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CORONARY ATHEROSCLEROSIS
1) Distribution-
Anterior descending branch of LCA>RCA>circumflex branch of LCA
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– 75% reduction cross sectional area coronary artery leads to MI
– Severest involvement -3 to 4 cms from coronary ostia near bifurcation of arteries-suggesting role of haemodynamic forces in atherogenesis
LOCATION
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SUPER ADDED CHANGES IN CORONARY ATHEROSCLEROSIS
• Lead to attacks of acute coronary syndromes
1)Acute changes in chronic atheromatous plaque• Plaque haemorrhage,fissuring,ulceration • Due to spasm,tachycardia,hypercholesteremia
2)Coronary artery thrombosis-• Initiation of thrombosis due to surface ulceration of fixed
chronic atheromatous plaque-----luminal obstruction• Lipid core is thrombogenic ---embolise to terminal
coronary branches---microinfarcts of myocardium
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NON ATHEROSCLEROTIC CAUSES Vasospasm Stenosis of coronary ostia-syphilitic aortitis Arteritis-vasculitic disorders Embolism Thrombotic diseases-hypercoagulability Trauma Aneurysms-extension of dissecting aortic
aneurysms into coronary artery Compression-primary or secondary tumor of
heart
3) Local platelet aggregation -- coronary artery spasm-- thromboxane A2
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ATHEROSCLEROSISATHEROSCLEROSIS
AFFECTS Elastic arteries :
Aorta , Carotid , Iliac
Medium sized muscular arteries : coronary & popliteal
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RISK FACTORS FOR ATHEROSCLEROSIS
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ROLE OF OXIDIZED LDL IN ATHEROGENESIS
1) Readily ingested by macrophages
2) Chemotactic for circulating monocytes
3) Increases monocyte adhesion
4) Inhibits motility of macrophages
5) Favours recruitment and retention of macrophages
6) Stimulates release of growth factors and cytokines
7) Cytotoxic to endothelial and smooth muscle cells
8) immunogenic
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ROLE OF MACROPHAGE IN ATHEROGENESIS
MACROPHAGE
IL-1 , TNF , and MCP-1
Increases adhesion of leukocytes
Toxic oxygen species
Oxidation of LDL
Growth stimulators & inhibitors
Modulate the proliferation of SMCsDeposition of ECM protiens
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ROLE OF ENDOTHELIAL CELL IN ATHEROGENESIS
• Increase in the permiability of the wall to
lipoprotiens
• Acceleration of lipoprotein accumulation.
• Permit platelet interaction with the vessel wall
• Subsequent release of growth factors
• Allow the formation of thrombus on the surface
• Neovascularization in the shoulders of fibrous caps
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PDGF NObFGF PGI2IL-1 IGF-1TGF ox LDLEndothelial cell
Antigens
PDGF EGFTGF α TGF βTxA2 IGF-1
PLASMA Angiotensin
LDL
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• FATTY STREAK
• ATHEROMATOUS PLAQUE
FIBROUS
FIBROFATTY
LIPID
FIBROLIPID PLAQUES
• COMPLICATED PLAQUE
MORPHOLOGY
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Fatty streak(collection of foamy macrophages in intima)
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NECROTIC CENTRE
FIBROUS CAP
MEDIA
Components of intimal atheromatous plaque
Smooth muscle cellsdense connective tissueMixture of macrophagessmooth muscle cells , T lymphocytes
Disorganised mass of lipid cholesterol clefts , foam celthrombus
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Gross-Atherosclerosis of aorta
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Pathogenic events and complications of atherosclerosis
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COMPLICATED ATHEROSCLEROSIS• CALCIFICATION
• ULCERATION
• FOCAL RUPTURE ( Atheroemboli )
• HEMORRHAGE
• SUPERIMPOSED THROMBOSIS
• ANEURYSMAL DILATATION
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COMPLICATED PLAQUE
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THROMBOEMBOLISM
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AORTIC ANEURYSM
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Effects of Myocardial Ischemia
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Pathogenesis of acute coronary syndromes
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Myocardial infarction
• Etiopathiogenesis1)Myocardial ischemia
2)Role of platelets
3)Tissue factor activates coagulation pathway-thrombus
4)Non atherosclerotic causes
5)Transmural vs Subendocardial infarcts
Also called as Heart Attack/ Myocardial Necrosis
Death of cardiac muscle due to prolonged ischemia
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PATHOGENESIS OF MI
1. CORONARY ARTERY OCCLUSION Disruption of plaque-platelets exposed to
subendothelial collagen,undergo adhesion,
aggregation,activation, release of potent aggregators .Vasospasm
stimulated.2.VASOSPASM3.EMBOLI --- atrial fibrillation,
--- vegetative endocarditis, --- paroxysmal emboli
4.UNEXPLAINED
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TIME GROSS MICRO 12 Hrs No changes Coagulation
necrosis :12-18hrs12-18Hrs Slight Pallor - - Neutrophilic infilt. - Contraction bands
- Myocytolysis 4---5 DAYS Pale,Firm,Well Macrophages defined10 DAYS yellow area Granulation tissue red purple zone4 weeks Collagen8 weeks Scar tissue
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12-18 Hrs
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12 to 18 hrs.
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12 to 18 hrs.3--4 days
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1 to 2 wks.
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8 wks
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TTC Test NBT Test
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Light microscopic changes in MI
Changes during first 24 hrs
Changes during first 72 hrs
Changes by the end of first week
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Light microscopic changes in MI
Coagulative necrosis with wavy fibres
Neutrophilic infiltrate3-4days
Phagocytocis of necrotic myocytes7-10days
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Light microscopic changes in MI
Granulation tissue-loose collagen,abundant capillaries
Well healed infarct-dense collagenous scar
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Old Myocardial infarct
Infarcted area shows ingrowth of inflammatory granulation tissue
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MI healed-Grey white thining at apex due to healed fibrous scarring
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Changes in early infarcts
1)Electron microscopic changes• Evident in less than 30 min on onset of infarction • Disappearance of perinuclear glycogen granules within
5min of ischemia• Swelling of mitochondria in 20-30min• Disruption of sarcolemma• Nuclear alterations –peripheral nuclear clumping2)Chemical and histochemical changes• Glycogen depletion• Increase in lactic acid• Loss of k+,increase in Na+• Influx of Ca++ into cells---irreversible injury
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Complications1. Arrhythmias(most common)
2. Congestive heart failure---40%deaths
3. Cardiogenic shock----10%deaths
4. Mural thrombosis and thromboembolism---12%deaths
5. Rupture----5%deaths(ventricular wall,iv septum,papillary muscle)
6. Acute Pericarditis----2nd day
7. Postmyocardial infarction syndrome/Dresslers syndrome---- 1-6weeks,autoimmune,fibrinous haemorrhagic pericarditis 8. Infarct extension and expansion
9. Ventricular aneurysm----5%deaths(late complication)
10. Progressive heart failure
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Complications
Anterior myocardial rupture Rupture of ventricular septum
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Complications
Complete rupture of necrotic papillary muscle Fibrinous pericarditis
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Complications
Antero apical infarct with wall thining and mural thrombus
Large apical left ventricular aneurysm
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Salvage in early infarcts and reperfusion injury
• Reversible -30min1. Thrombolytic therapy-tPA-relieves only thrombus 1. PTCA with stent-relives thrombus+underlying
plaque
3. CABG-restores flow in blocked vessels
Complication-myonecrosis-Ca++,ROS
Gross-haemorragic infarctMicro-contraction band necrosis
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Consequences of myocardial ischemia following reperfusion
Contraction bands and haemorrhage
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ENZYME CHANGES
• CK Sensitive but not specificRises in 2-4 HrsPeaks in 24 HrsNormal in 72 Hrs• CK-MB More specificRises in 4-8 HrsPeaks in 18 HrsNormal in 48-72 Hrs
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• LDH & AST-useful only after 48 Hrs• CARDIAC Troponin Troponin--I Troponin--TSensitivity similar to CK-MB
Elevated for 7-10 days
Marker for Unstable Angina
• SERUM MYOGLOBIN-preceedes CK-MB by 2-5 Hrs
Increases in 2-6 Hrs Peaks in 8-12 Hrs
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CHRONIC IHD• Seen in ELDERLY• Previous MI/ Bypass Surgery• Severe obstructive coronary artery disease with
or without acute or healed MI
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Chronic ischemic heart disease/myocardial fibrosis/ischaemic cardiomyopathy
• Appears postinfarction due to functional decompensation of hypertrophied noninfarcted heartPathogenesis:
Healing of minute areas of focal myocytolysis loss of myofibrils but nuclei remain intact
infiltrated by macrophages
replaced by proliferation fibroblasts and collagen
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Chronic ischemic heart disease-MORPHOLOGY
• Gross-enlarged and heavy due to left ventricular hypertrophy and dilatation
• Discrete scars-healed infarcts
• Mural endocardium-patchy,fibrous thickening,mural thrombi
• Micro-Myocardial hypertrophy Diffuse subendocardial vacuolisation Fibrosis
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Chronic ischemic heart disease-microscopy
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SUDDEN CARDIAC DEATH
•Unexpected death from cardiac cause either asymptomaticOr early onset symptoms within 1 hr. •Lethal arrthymias
•Critical stenosis>75% lumen compromised
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Lesions in Coronary artery in various forms of IHD
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NON ATHEROMATOUS CORONARY ARTERY DISEASE
1) Congenital anomalies
2) Spontaneous dissection of coronary arteries
3) Arterial bridging
4) Coronary aneurysms
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Spontaneous dissection of coronary arteries
Coronary aneurysms
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