mortality data from the basket late trial and premier registry

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w. Clinical trial results.org Mortality Data From the BASKET LATE Mortality Data From the BASKET LATE Trial Trial and PREMIER Registry and PREMIER Registry In the BASKET LATE Trial, cardiac death trended higher in the DES In the BASKET LATE Trial, cardiac death trended higher in the DES group than in the BMS group during the year following clopidogrel group than in the BMS group during the year following clopidogrel discontinuation (1.2% vs. 0%, p=0.09). discontinuation (1.2% vs. 0%, p=0.09). Data from the PREMIER registry looked exclusively at AMI patients who Data from the PREMIER registry looked exclusively at AMI patients who received DES and suggested that patients who discontinued thienopyridine received DES and suggested that patients who discontinued thienopyridine therapy early - within 30 days in this instance - were significantly therapy early - within 30 days in this instance - were significantly more likely to die over the next 11 months (p<0.0001). more likely to die over the next 11 months (p<0.0001). 1.2 0.0 0 1 2 DES BMS BASKET LATE Trial: Cardiac Death in DES vs. BMS (%) p=0.09 7.5 0.7 0 2 4 6 8 S topped thienopyridines S tayed on thienopyridines PREMIER Registry Data: All Cause Death According to Minimum 30 day thienopyridine Therapy Duration (%) p<0.0001 % patients % patients % patients % patients

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Mortality Data From the BASKET LATE Trial and PREMIER Registry. BASKET LATE Trial: Cardiac Death in DES vs. BMS (%) p=0.09. PREMIER Registry Data: All Cause Death According to Minimum 30 day thienopyridine Therapy Duration (%) p

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Page 1: Mortality Data From the BASKET LATE Trial  and PREMIER Registry

www. Clinical trial results.org

Mortality Data From the BASKET LATE Trial Mortality Data From the BASKET LATE Trial and PREMIER Registryand PREMIER Registry

Mortality Data From the BASKET LATE Trial Mortality Data From the BASKET LATE Trial and PREMIER Registryand PREMIER Registry

• In the BASKET LATE Trial, cardiac death trended higher in the DES group than in the In the BASKET LATE Trial, cardiac death trended higher in the DES group than in the BMS group during the year following clopidogrel discontinuation (1.2% vs. 0%, p=0.09).BMS group during the year following clopidogrel discontinuation (1.2% vs. 0%, p=0.09).

• Data from the PREMIER registry looked exclusively at AMI patients who received DES and Data from the PREMIER registry looked exclusively at AMI patients who received DES and suggested that patients who discontinued thienopyridine therapy early - within 30 days in suggested that patients who discontinued thienopyridine therapy early - within 30 days in this instance - were significantly more likely to die over the next 11 months (p<0.0001).this instance - were significantly more likely to die over the next 11 months (p<0.0001).

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DES BMS

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DES BMS

BASKET LATE Trial: Cardiac Death in DES vs. BMS (%)

p=0.09

7.5

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Stoppedthienopyridines

Stayed onthienopyridines

7.5

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Stoppedthienopyridines

Stayed onthienopyridines

PREMIER Registry Data: All Cause Death According to Minimum 30 day thienopyridine Therapy Duration (%)

p<0.0001

% p

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% p

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% p

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% p

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