motor proteins. one-state model with unequal forward and backward rates
TRANSCRIPT
![Page 1: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/1.jpg)
Motor Proteins
![Page 2: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/2.jpg)
![Page 3: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/3.jpg)
![Page 4: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/4.jpg)
![Page 5: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/5.jpg)
![Page 6: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/6.jpg)
![Page 7: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/7.jpg)
![Page 8: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/8.jpg)
![Page 9: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/9.jpg)
One-state model with unequal forward and backward rates
![Page 10: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/10.jpg)
Dwell time distribution for myosin V
![Page 11: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/11.jpg)
Expected velocity as function of force in one-state model.Comparison to myosin V experiment.
if pulling back makes forward rate go down
if pulling back makes backward rate go up
![Page 12: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/12.jpg)
Pushing by polymerization
![Page 13: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/13.jpg)
Listeria move inside a cell by inducing polymerization of actin
![Page 14: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/14.jpg)
![Page 15: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/15.jpg)
![Page 16: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/16.jpg)
Interpretation as a sloping potential
![Page 17: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/17.jpg)
Model with 2 states at each site.
![Page 18: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/18.jpg)
Velocity of kinesin as a function of ATP conc and load
![Page 19: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/19.jpg)
In two-state model dwell time distribution is not exponential
BA ttt )/exp(1
)( AAA
AA ttp
)/exp(1
)( BBB
BB ttp
)/exp()/exp(1
)()()(0
ABAB
t
ABAAA ttttptpdttp
measured for myosin V
![Page 20: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/20.jpg)
![Page 21: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/21.jpg)
![Page 22: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/22.jpg)
![Page 23: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/23.jpg)
![Page 24: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/24.jpg)
![Page 25: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/25.jpg)
![Page 26: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/26.jpg)
![Page 27: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/27.jpg)
![Page 28: Motor Proteins. One-state model with unequal forward and backward rates](https://reader036.vdocuments.net/reader036/viewer/2022062322/5697c0261a28abf838cd57d4/html5/thumbnails/28.jpg)
Wave motions in a swimming sperm cell.
Strokes in cilia on epithelial cells