Transcript
Motor Proteins
One-state model with unequal forward and backward rates
Dwell time distribution for myosin V
Expected velocity as function of force in one-state model.Comparison to myosin V experiment.
if pulling back makes forward rate go down
if pulling back makes backward rate go up
Pushing by polymerization
Listeria move inside a cell by inducing polymerization of actin
Interpretation as a sloping potential
Model with 2 states at each site.
Velocity of kinesin as a function of ATP conc and load
In two-state model dwell time distribution is not exponential
BA ttt )/exp(1
)( AAA
AA ttp
)/exp(1
)( BBB
BB ttp
)/exp()/exp(1
)()()(0
ABAB
t
ABAAA ttttptpdttp
measured for myosin V
Wave motions in a swimming sperm cell.
Strokes in cilia on epithelial cells