m.sc. semester i physical chemistry paper i (micro wave...

1

M.Sc. Semester – I Physical Chemistry

Paper – I

(Micro wave and IR Spectra)

Maximum Marks 50 Lectures : 40

Unit – I :

Basic features of Spectroscopy:

Electromagnetic radiations, Interaction of electromagnetic radiation with matter. Molecular

energy levels. Rotational, vibrational and electronic energy levels. Born Oppenheimer

approximation, Transition probability, transition moment, natural line width, and intensity of

spectral lines. Fourier Transform techniques.

Unit – II :

Rotational Spectra: Rotational modes of a molecule, selection rules for rotational spectra of diatomic molecules

using rigid rotator model, effect of isotopic substitution on the transition frequencies. Non - rigid

rotator. Rotational spectra of polyatomic molecules (Linear, spherical and symmetrical

molecules), Applications.

Unit – III :

Vibrational Spectra:

Vibrational energy of diatomic molecules, vibrational spectra using linear harmonic oscillator

model. Force constant and harmonicity. Theory of vibrational - rotational spectra. P, Q and R

lines in combination spectra. Vibrations of polyatomic molecules. Selection rules, normal modes

of vibration, group frequencies, factors affecting the band position and intensities. Applications,

and interpretation of spectra of simple molecules.

Unit – IV :

Raman Spectra:

Classical and Quantum theory of Raman effect, Pure rotational, vibrational, and vibrational -

rotational Raman spectra. Selection rule. Polarized & depolarized Raman lines, mutual exclusion

principle. Resonance Raman spectra. Applications.

Books Recommended:

1. J. M. Hollas; Modern Spectroscopy, 4th

edition (2004), John Wiley and Sons, Chichester.

2. K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th

Edn. (1986), John Wiley & Sons, New York.

3. W. Kemp, Organic Spectroscopy, 3rd

Edn. (1991), MacMillan, London.

4. R.M. Silverstein and F.X. Webster, Spectroscopic Identification of Organic Compounds, 6th

Edition (2003) John Wiley, New York.

5. D. L. Pavia, Gary M. Lampman, George S. Kriz; Introduction to Spectroscopy, 3rd

Edition,

(2001), Books / Cole, Thomson Learning.

2

Semester – I M.Sc. Physical Chemistry

Paper - II

(Physical States of Matter and Kinetics)


Unit – I :

Gaseous state: Distribution of molecular velocities. Maxwell - Boltzmann distribution law and its

derivation. Expressions for average, root mean square and most probable velocities with

calculation. Transport properties of gases, diffusion, thermal conductivity and viscosity.

Unit – II :

Solid state: Definition related to crystal structure (symmetry space lattice and space groups),

crystal objects and non - stoichiometry point defects. Non - stoichiometric compounds. Band

theory of solids. Heat capacity of solids (Einstein and Debye theory). Semi conductors, super

conductors, nanomaterials.

Unit – III :

Chemical kinetics: Dynamic chain reaction, H2-Br2; decomposition of ethane and acetaldehyde.

Photochemical combination of H2 - Br2, and H2 - Cl2 reactions. Oscillatory chemical

reactions. Kinetics of enzyme reactions. General features of fast reactions, study of fast

reactions; by flow method, relaxation method, flash photolysis and magnetic resonance

method.

Unit – IV :

Thermodynamics:

Equilibrium thermodynamics (classical), Brief review of laws of thermodynamics.

Partial molar properties, partial molar free energy, partial molor volume and partial molar

enthalpy and their determinations, concept of fugacity and determination of fugacity,

nonideal systems.

Books Recommended:

1. K. J. Laidler, Chemical Kinetics, Third Edition (1987), Harper & Row, New York.

2. P. W. Atkins, Physical Chemistry, Seventh Edition (2002), Oxford University Press, New

York.

3. D.A. Mc Quarrie and J.D. Simon, Physical Chemistry: A Molecular Approach, (1998) Viva

Books, New Delhi.

4. Thomas Engel, Philip Reid; Physical Chemistry; Pearson Education, 3rd

Edition, 2001.

3

M.Sc. Semester - I

Practical of Physical Chemistry

Maximum Marks 50 Duration - 4 Hrs.

Any one of the four practicals :

1. Chemical Kinetics: 20 Marks

1. Kinetics of ester hydrolysis in presence of acid.

2. To compare the strength of HCL and H2SO4 by studying the kinetics of hydrolysis of

ethyl acetate.

3. To study the saponification of ethylacetate with NaOH

4. To determine the rate constant of a reaction between acetone & iodine in presence of

mineral acid.

Any one of the three practicals :

2. Surface Tension: 15 Marks To determine the composition of the given solution by drop method by stalagmometre.

3. Viscosity: 15 Marks To determine the composition of a given mixture of two miscible liquids by

Viscometer.

4. Molecular weight determination: 15 Marks

To determine the molecular weight of a given substance by Rast method.

5. Viva-voice 10 Marks

6. Record 5 Marks

Books Recommended:

1. Experiments in Physical Chemistry: J. C. Ghosh, Bharti Bhawan

Publication, Patna.

2. Advanced Experimental Chemistry: Vol. I Physical J. N. Gurtu & R.

Kapoor, S. Chand & Comp.

3. Physical Chemistry Practical: B. D. Khosla (New Delhi)

4. Practical Physical Chemistry: S. R. Palit & S. K. De. Science BookAgency,

Calcutta

4

Semester - II

Paper – I (Physical Chemistry)

(Spectroscopy, X-ray and Electronic Diffraction)


Unit – I :

Electronic Spectra:

Atomic Spectra:

Energies of atomic orbitals, Vector representation of momenta & vector coupling.

Spectra of hydrogen atom and alkali metal atoms.

Unit – II :

Molecular Spectra:

Energy levels in molecules, and molecular orbitals. Principle of electronic spectra of

polyatomic molecules. Emission spectra, photophysical processes in electronically excited

molecules (radioactive and nonradiative), internal conversion. Spectra of transition metal

complexes, charge transfer spectra.

Unit – III :

X - ray Diffraction:

Principle of determination of molecular symmetry and molecular parameter, space

groups and their determination, analysis and assignment of space groups. Structre factor and

its relation to intensity and electron density distribution. Fourier series, Laue patterns,

Weissenberg method, Pattersion method. Difference between neutron and x-ray diffraction.

Unit – IV :

Electron Diffraction:

Principle, experimental techniques, scattering of electrons by gases. Scattering

intensity Versus scattering angles. Weirl equation and radial distribution method for

structural determination of simple gas phase molecules. Low energy electron diffraction

between limitations.

Books Recommended:

1. R. S. Drago, Physical Methods for Chemists, (1992), Saunders College Publishing,

Philadelphia.

2. G. Aruldhas, Molecular Structure and spectroscopy, (2001) Prentice Hall of India Pvt. Ltd.,

New Delhi.

3. C. N. Banwell and E. M. McCash, Fundamentals of Molecular Spectroscopy, 4th

edition

(1994), Tata McGraw Hill, New Delhi.

4. D. H. Williams and Ian Fleming; Spectroscopic Methods in Organic Spectroscopy, (4th

Edition) Tata McGrahill, 1989.

5

Semester - II

Paper - II (Physical Chemistry)

Thermodynamics and Electro Chemistry


Unit – I :

Thermodynamics : Excess function for nonideal solution activity and activity coefficient and their

determination. Thermodynamics of ideal and real gas and gaseous mixtures. Lewis - Randell

rule and its importance. Gibbs – Duhem - margueles equation and its applications.

Unit – II :

Non equilibrium thermodynamics: Thermodynamic criteria for non equilibrium states, entropy production and entropy

flow, fluxes and forces. Phenomenological equations, Onsagar’s reciprocity relations.

Unit – III :

Surface chemistry: Adsorption, surface tension, capillary action, pressure difference across curved

surface (Laplace equation), vapor pressures of droplets (Kelvin equation), Gibbs adsorption

isotherm. Estimation of surface area (BET equation), surface films on liquids, catalytic

activity at surfaces.

Micelles: Surface active agents, classification of surface active agents, critical micellar

concentration (CMC), factors affecting the CMC of surfactants.

Unit – IV :

Electrochemistry: Basic description of ion association, Wein’s effect and Debye - Falkenhagen effect,

effect of ionic strengths on the rate of ionic reaction; primary and secondary salt effects.The

structure of electrical double layer (Helmholtz, Gouy - Chapman and stern model) Butler -

Volmer equation, exchange current density. Tafel plots, polarizable and non -polarizable

interfaces corrosion, types of corrosion, corrosion monitoring and prevention.

Books Recommended:

1. J.O’M. Bockris and A. K. N. Reddy, Modern Electrochemistry, Vol. 2 A & B, Second

Edition (1998), Plenum Press, New York.

2. I.N. Levine, Physical Chemistry, 5th

Edition (2002),Tata McGraw Hill Pub. Co. Ltd., New

Delhi.

3. Y. Moroi; Micelles : Theoretical and Applied Aspects, (1992) Plenum Press, New York.

6

Semester - II

Practical of Physical Chemistry

Maximum Marks 50 Duration - 4 Hrs.

Any one of the two practicals : 20 Marks

1. Distribution Law: a. To determine the distribution coefficient of iodine between water and carbon tetra

chloride.

b. To determine the partition coefficient of benzoic acid between water and benzene.

c. Estimate the molecular weight of benzoic acid in benzene by distributing it between

water & benzene.

2. Colloidal and surface chemistry

a. To determine the adsorption of aqueous acetate acid by activated charcoal and study

the absorption.

b. Preparation of As2O3 and Fe (OH)3 solutions.

Any one of the two practicals : 15 Marks

3. Phase Diagram

a. To draw the phase diagram of the binary system and find the eutectic temperature.

b. To determine the transition temperature of given substance by thermometric method.

4. Solubility

a. To determine the solubility of a salt by gravimetric method.

b. To determine the solubility of an organic acid by titration method.

c. To determine the heat of solution of an organic salt by solubility method.

5. Viva-voice 10 Marks

6. Record 5 Marks

Books Recommended:

1. Experiments in Physical Chemistry: J. C. Ghosh, Bharti Bhawan Publication, Patna.

2. Advanced Experimental Chemistry: Vol. I Physical J. N. Gurtu & R. Kapoor, S.

Chand & Comp.

3. Physical Chemistry Practical: B. D. Khosla (New Delhi)

4. Practical Physical Chemistry: S. R. Palit & S. K. De. Science Book Agency, Calcutta

M.Sc.-III Semester (PHYSICALCHEMISTRY)

PAPER - I (Compulsory) (Spectroscopy and Dispersion Methods in Spectrometry)

Max Marks: 50 Lectures: 40

Unit-I Max Marks 5

Mossbauer Spectroscopy:

Basic principles of Mossbauer spectroscopy, Spectral parameters (isomer shift, quadrupole

interactions and magnetic interactions), Applications of M-B spectra in the study of iron and tin

complexes.

UNIT-II

Mass Spectroscopy:

Introduction, ion production, fragmentation and affecting factors, Molecular ion peak, Meta

stable ion peak, nitrogen rule, cleavage associated with common functional groups. McLafferty

rearrangement, Structural information of organic compounds by interpretation of simple mass

spectra.

UNIT-III

Optical Rotatory Dispersion (ORD):

Linearly and circularly polarized lights, Optical rotatory power, Different types of rotatory

dispersion curves. Application of ORD for the determination of absolute configuration of some

carbonyl compounds.

UNIT-IV

Circular Dichroism (CD): Principle, Definition, Nature of the CD curves, Cotton effect,

Application for the determination of absolute configuration of some carbonyl compounds.

Books Recommended:

1. Spectroscopic Methods in Organic Chemistry: D.H. William & Fleming, Tata McGraw.

2. Spectrometric Identification of Organic Compound: R.M. Silverastein, John Wiley.

3. Modern Spectroscopy: J.M.Hollas, 4th

edition (2004) John Wiley &Sons Ltd, New York.

4. Fundamental of Molecular spectroscopy: C.N.Banwell, 4th

edition (1994) TataMcGrawhill.

5.Physical Methods in Inorganic Chemistry: R.S.Drago, International edition (1971) Affiliated

East West Press, New Delhi.

M.Sc. III Semester (Physical Chemistry)

Paper - II

Thermodynamic (Reversible)

Maximum Marks 75 Duration - 3 hrs

UNIT - I

Thermodynamics of mixture:

Thermodynamics of ideal and real gases and gaseous mixtures. Fugacity of gaseous and

liquid mixtures. Lewis - Randall Rule and its importance.

UNIT - II

Thermodynamics of Solutions:

Thermodynamics of ideal and non - ideal binary solutions, Excess thermodynamics

functions for non - ideal solutions and their determination. Gibbs - Duhem - Margules

equation and its applications. Thermodynamics of polymer solution.

UNIT - III

Thermodynamics of Surfaces:

Thermodynamics of surfaces, Gibb’s adsorption isotherm. Surface films. Applications of

adsorption phenomena. Adsorption indicator and Chromatography.

UNIT - IV

Irreversible Thermodynamics:

Steady state and Cross - phenomena. Stability of steady states. Entropy production in

irreversible processes. Relation between forces and fluxes. Linear phenomenological

relations. Onsagar’s reciprocal Theory. Curie - Prigogine Theorem. Linear

thermodynamics theory of thermo - osmosis and reverse - osmosis.

UNIT - V

Phase Equilibrium:

Thermodynamic interpretation of phase diagram. Phase diagram of two component

systems. Simple eutectic systems (Bi - Co and Fe - C system). Systems exhibiting

complete miscibility in solid and liquid phases. Mixtures having congruent melting

points. Systems having partial miscibility in solid phases. Theory of phase diagram of

(Chloroform - acetic acid - water system and acetone - phenol - water system).

Books Recommended :

1. Samuel Glasstone; Thermodynamics for chemists, East - West Press.

2. J. C. Kuriacose and J. Rajaraman; Thermodynamics (Classical, statistical and

Irreversible), S. Nagin &Co.1986.

3. R. P. Rastogi and R.R.Mishra ; An Introduction to Chemical Thermodynamics, Vikas

Publication,1994..

4. I. Prigogine; Introduction to Thermodynamics of Irreversible processes,Springfield,1955.

5. P. A. Rock; Chemical Thermodynamics, Oxford University Press, 1983.

6. R.Brout; Phase Transitions, Mass Reading, 1965.


Edition, 2001.


Paper - III

Cells and Electrokinetics

Maximum Marks 75 Duration - 3 hrs

UNIT - I

Conduction in Non - aqueous Media:

Ion association and its effect on conduction. Diffusion of electrolytes. Measurement of

diffusion of coefficient. Diffusion in relation to conductance and viscosity.

UNIT - II

Concentration Cells:

Cells with and without transference, concentration cell involving mixture of

electrolytes. Amalgam cell, liquid Junction potential and its elimination. Membrane

potential and diffusion potential.

UNIT - III

Electro - kinetic phenomena:

Qualitative treatment of electro - osmosis, electrophroesis, streaming potential and

Streaming current. Formation of electrical double layer. Models of electrical double layer

& Zeta potential.

UNIT - IV

Electroanalytical Techniques and Electrodics:

Polarography, Overvoltage, Colorometry and amperometry. Tafel - plots, Butler - Volmer

equation, physical concept of equilibrium exchange current density and over potential.

Unit - V

Corrosion:

The mechanism of corrosion of Metals, corrosion - current and corrosion potential.

Electro - chemical corrosion theory. Estimation of corrosion rates. Corrosion prevention

and electrodeposition.

Books Recommended :



2. Samuel Glasstone; An Introduction to Electrochemistry, East West Press.

3. P. H. Rieger; Electro Chemistry, 2nd

Edition Chapman & Hall,1988.

4. D.R. Crow; Principles and Application of Electro Chemistry, Chapman and Hall,1988.


Edition, 2001.


Paper - IV

Quantum Chemistry(Basic)

Maximum Marks 75 Duration - 3 hrs.

UNIT - I

Origin of Quantum Theory:

Planck’s quantum theory of radiation, wave particle duality. Uncertainty principle and

operators.

UNIT - II

Postulates of Quantum Chemistry:

Schrodinger wave equation, physical significance of eigen wave function. Normalized

and orthogonal wave functions. Application of Schrodinger wave equation to simple

systems. Free particle in a box (one dimensional and three dimensional). Harmonic

oscillator, rigid rotator and hydrogen atom. Solution of r, θ and Φ parts. Angular

momentum, & spin, coupling of angular momentum including spin - orbit coupling.

UNIT - III

Approximation Methods:

The perturbation and variation methods and their application to Helium atom exchange

degeneracy electron spin wave function, symmetric and antisymmetric wave function.

Anti symmetry and exclusion principle.Term symbols and spectrographic states.

UNIT - IV Oppenheimer Approximation:

Hydrogen molecule in LCAO - MO and VB treatment of Hydrogen molecule. Idea of self -

consistent field (SCF).

UNIT - V

Huckel - Molecular Orbital Theory:

Huckel pi - electron theory and its applications to the calculations of bond - order,

delocalization energy, electron density to ethylene, butadiene, benzene and cyclobutadiene.

Books Recommended:

1. P. W. Atkins and R. S. Friedman, Molecular Quantum Mechanics, 3rd

edition (1997), Oxford

University Press. Oxford.

3. I. N. Levine, Quantum Chemistry, 5th

edition (2000), Pearson Education, Inc., New Delhi.

2. D. A. McQuarrie and J. D. Simon, Physical Chemistry: A Molecular Approach, (1998) Viva

Books, New Delhi.

4. A. K. Chandra, Introductory Quantum Chemistry, 4th

edition (1994), Tata McGraw Hill, New

Delhi.

5. M. Karplus and R. N. Porter, Atoms and Molecules (1970), Benjamin, London.


Edition, 2001.


Paper-V

Statistical Thermodynamics (Basic)


Unit - I

Classical Statistical Mechanics:

Fundamentals of statistical Mechanics, Phase space, Microstates, Microstates’, Ensemble

(canonical and microcanonical), statistical weight factor, probability distribution,

Liouville’s theorem.

Unit - II

Maxwell - Boltzmann distribution law, partition function, separation of partition functions.

Determination of vibrational, translational, rotational and electronic partition functions.

Relationship of partition functions to thermodynamic functions; such as internal energy,

enthalpy, free energy, entropy and chemical potential.

Unit - III

Third law and partition function. Study of monoatomic and diatomic molecule on the basis

of partition function. Sackur - Tetrode equation. Rotational energy and entropy,

vibrational energy and entropy, internal energy and entropy.

Unit - IV

Maxwell Distribution Law:

Maxwell distribution law of velocities from partition function. Average velocity and

average kinetic energy of the molecules. Partition functions for ideal crystals and ideal

gases. Relationship between partition function and equilibrium constant, some numerical

calculations. Ortho and para hydrogen. Heat capacities of solids. Limitations of

Boltzmann statistics.

Unit - V

Quantum Statistics:

Indistinguishability of identical particles. Bose - Einstein statistics and Fermi - Dirac,

Bose - Einstein and Maxwell - Boltzmann statistics. Calculation of Fermi - energy for free

electron in a metal.

Books Recommended:

1. B.K. Agarwal and M. Eisner, Statistical Mechanics, Wiley Eastern, New Delhi, 1988.

2. D.A. McQuarrie, Statistical Mechanics, Harper and Row Publishers, New York, 1976.

3. M.C.Gupta; Statistical Thermodynamics, New Age International, 2000.

4. Chandler; Introduction to Modern Statistical Mechanics, Oxford University Press,1987.

5. S. K. Ma; Statistical Mechanics, World Scientific, Philadelphia 1985.


Edition, 2001.

7. Benjamin Widom; Statistical Thermodynamics : A Concise Introduction for Chemists,

Cambridge University Press, 1st Edition, 2002.

M.Sc. III Semester Physical Chemistry

Paper -VI

Chemical Kinetics


Unit - I

Theories of Reaction Rates:

Collision Theory of reaction rates, steric factor. Arrhenius equation and collision

theory. Theory of absolute reaction rates. Thermodynamic formulation of reaction rates,

comparision of Eyring equation and Arrhenius equations. Comparision of transition state

theory and collision theory. Lindemann’s mechanism of unimolecular gaseous reaction.

Unit - II

Fast Reactions and Ionic reactions:

Study of kinetics of fast reactions by stopped - flow technique, relaxation methods and

magnetic resonance methods. Ionic reactions, salt effects (primary and secondary).

Unit - III

Complicating Factors in Reaction Kinetics and Oscillatory Reactions:

Kinetic study of parallel first order and two parallel first order reactions. Reversible or

opposing reactions and consecutive reactions. Oscillatory reactions.

Unit - IV

Nuclear Models and Radioactivity:

The shell model, liquid drop model and the collective model. Radioactive Decay (α and

β). Decay kinetics and radioactive equilibrium (Secular and Transient).

Unit - V

Nuclear Reaction and Nuclear Reactors: Q - values of Nuclear Reactions. Reaction cross - section, Nuclear fission and fusion.

Fission products and fission critical size of thermal reactor. Breeder reactor and

reprocessing of spent fuels.

Unit - VI

Radioactive Technique: Tracer technique, neutron activation analysis, rock - dating, radio carbon dating.

Counting technique such as G. M. counter, ionization counter and proportional counter.

Books Recommended:

1. K. J. Laidler; Chemical Kinetics, 3rd

Edition, Harper and Row,1987.

2. K. A .Connors; Chemical Kinetics, VCH, 1990.

3. Frost & Pearson; Kinetics and Mechanisms, Wiley, 1970.


Edition, 2001.

5. H. J. Arnikar; Essentials of Nuclear Chemistry, New Age International, rev. 4th

Edition,

2011.

6. G. Fridlander, J.W. Kennedy, E. S. Macias, and J. M. Miller, Nuclear & Radiochemistry, 3rd

Edition (1981), John Wiley, New York.

M.Sc. III Semester Physical Chemistry

Chemistry Practical

Maximum Marks - 150 Duration - 6 hrs

Any One Practical

1) Conductometric titration of a strong acid with a strong base.

2) Conductometric titration of a strong acid with a weak base.

3) Conductometric titration of a strong acid with a strong base.

4) Conductometric titration of a weak acid with a weak base.

5) Conductometric titration of a mixture of a strong acid and a weak acid with a strong base.

Any one Practical

1. To determine the order of saponification of ethyl acetate with NaOH.

2. To find the velocity constant of the hydrolysis of methyl acetate catalyzed by an

acid.

3. Kinetics of iodination of acetone by titrimetry.

Viva -

Record -

Seminar -

M.Sc. SEMESTER FOUR (Nuclear Resonance Spectrometry)

PHYSICAL CHEMISTRY

(Paper I (Compulsory)


Unit-I

Nuclear Magnetic Resonance spectroscopy:

Magnetic and non-magnetic nuclei, magnetic moment, nuclear spin, nuclear resonance,

population saturation, shielding of magnetic nuclei, chemical shift and its measurements, factors

affecting coupling constant, use of chemical shifts and spin spin coupling for structural

determination, spin decoupling, chemical exchange, effect of deuteration, nuclear magnetic

double resonance, nuclear over hauser effect (NOE) NMR studies of nuclei other than proton F19

,

P31

.

Unit-II 13

Carbon NMR spectroscopy:

General introduction, Peak assignment, Chemical shift, 13

C-H1 coupling (J Values), application

of 13

C magnetic resonance in structural determination.

Unit-III

Electron spin resonance spectroscopy:

Basic principles, Zero field splitting and Kramer’s degeneracy, factors affecting g-value, isotopic

& anisotopic hyperfine coupling constant. Application of ESR studies.

Unit-IV

Nuclear Quadrupole Resonance spectroscopy:

Quadrupole nuclei, quadrupole moments, electric field gradient, coupling constant, spliting,

Applications.

Books Suggested:

1.Spectroscopic Methods in Organic Chemistry: D.H. William & Fleming, Tata McGraw (2000)

2. Spectrometric Identification of Organic Compound: R.M. Silverastein, John Wiley (2000)


edition, John Wiley & Sons Ltd, New York (2004)


edition, TataMcGrawhill (1994)

5. Physical Methods in Inorganic Chemistry : R.S.Drago, International edition Affiliated East

West Press, New Delhi (1971)

M.Sc. Final

Semester IV PHYSICAL CHEMISTRY

PAPER - II

Thermodynamics(Irreversible)


UNIT - I

Irreversible Thermodynamics:

Steady state and Cross - phenomena. Stability of steady states. Entropy production in

irreversible processes. Relation between forces and fluxes. Linear phenomenological

relations.

UNIT - II

Onsagar’s reciprocal Theory. Curie - Prigogine Theorem. Linear

thermodynamics theory of thermo - osmosis and reverse - osmosis.

UNIT - III

Phase Equilibrium:

Thermodynamic interpretation of phase diagram. Phase diagram of two component

systems. Simple eutectic systems (Bi - Co and Fe - C system). Systems exhibiting

complete miscibility in solid and liquid phases.

UNIT - IV

Mixtures having congruent melting points. Systems having partial miscibility in solid

phases. Theory of phase diagram of (Chloroform - acetic acid - water system and

acetone - phenol - water system).

Books Recommended :

1. Samuel Glasstone; Thermodynamics for chemists, East - West Press.

2. J. C. Kuriacose and J. Rajaraman; Thermodynamics (Classical, statistical and

Irreversible), S. Nagin &Co.1986.

3. R. P. Rastogi and R.R.Mishra ; An Introduction to Chemical Thermodynamics, Vikas

Publication,1994..

4. I. Prigogine; Introduction to Thermodynamics of Irreversible processes,Springfield,1955.

5. P. A. Rock; Chemical Thermodynamics, Oxford University Press, 1983.

6. R.Brout; Phase Transitions, Mass Reading, 1965.


Edition, 2001.

M.Sc. Final


PAPER – III

Electrodics


UNIT - I

Electroanalytical Techniques and Electrodics:

Origin of polarography,Interpretation of polarography, Instrumentation, limiting

current, residual and charging current, diffusion current, migration current. Effect of

supporting electrlytes on limiting current. Diffusion coefficint and its evaluation, Iikovic

equation, its derivation and applications. Quasi reversible and irreversible processes.Half

wave potentials and their significance. Polarographic maxima and minima suppressors.

Overvoltage, Colorometry and amperometry.

UNIT - II

Butler - Volmer equation, physical concept of equilibrium exchange current density and

over potential, Tafel – plots.

Unit - III

Corrosion:

The mechanism of corrosion of Metals, corrosion - current and corrosion potential.

Electro - chemical corrosion theory.

UNIT - IV

Kinetics of corrosion:

Estimation of corrosion rates. Corrosion prevention and electrodeposition.

Books Recommended :



2. Samuel Glasstone; An Introduction to Electrochemistry, East West Press.

3. P. H. Rieger; Electro Chemistry, 2nd

Edition Chapman & Hall,1988.

4. D.R. Crow; Principles and Application of Electro Chemistry, Chapman and Hall,1988.


Edition, 2001.

M.Sc. Final


PAPER – IV

Quantum Chemistry(Advance)


UNIT - I

Approximation Methods:

The perturbation and variation methods and their application to Helium atom exchange

degeneracy electron spin wave function, symmetric and antisymmetric wave function.

Anti symmetry and exclusion principle.Term symbols and spectrographic states.

UNIT - II

Oppenheimer Approximation:

Hydrogen molecule in LCAO - MO and VB treatment of Hydrogen molecule. Simple

idea of self -consistent field (SCF) with example.

UNIT - III

Huckel - Molecular Orbital Theory:

Huckel pi - electron theory and its applications to the calculations of bond - order,

delocalization energy,

UNIT - IV

Electron density to ethylene, butadiene, benzene and cyclobutadiene.

Books Recommended:

1. P. W. Atkins and R. S. Friedman, Molecular Quantum Mechanics, 3rd

edition (1997), Oxford

University Press. Oxford.

3. I. N. Levine, Quantum Chemistry, 5th

edition (2000), Pearson Education, Inc., New Delhi.

2. D. A. McQuarrie and J. D. Simon, Physical Chemistry: A Molecular Approach, (1998) Viva

Books, New Delhi.

4. A. K. Chandra, Introductory Quantum Chemistry, 4th

edition (1994), Tata McGraw Hill, New

Delhi.

5. M. Karplus and R. N. Porter, Atoms and Molecules (1970), Benjamin, London.


Edition, 2001.

M.Sc. Final


PAPER – V

Statistical Thermodynamics(Advance)


Unit - I

Maxwell Distribution Law:

Maxwell distribution law of velocities from partition function. Average velocity, root

mean square velocity and most probable velocity. Average kinetic energy of the

molecules. Partition functions for ideal gases.

Unit - II

Relationship between partition function and equilibrium constant, some numerical

calculations. Ortho and para hydrogen. Population ratio determination of deuterium,

nitrogen, and oxygen. Limitations of Boltzmann statistics.

Unit - III

Quantum Statistics:

Indistinguishability of identical particles. Bose - Einstein and Fermi – Dirac statistics.

Comparison among Bose – Einstein, Fermi – Dirac and Maxwell - Boltzmann statistics.

Unit - IV

Partition functions for ideal crystals; Calculation of Fermi - energy for free electron in a

metal. Calculation of heat capacities of solids.

Books Recommended:

1. B.K. Agarwal and M. Eisner, Statistical Mechanics, Wiley Eastern, New Delhi, 1988.

2. D.A. McQuarrie, Statistical Mechanics, Harper and Row Publishers, New York, 1976.

3. M.C.Gupta; Statistical Thermodynamics, New Age International, 2000.

4. Chandler; Introduction to Modern Statistical Mechanics, Oxford University Press,1987.

5. S. K. Ma; Statistical Mechanics, World Scientific, Philadelphia 1985.


Edition, 2001.

7. Benjamin Widom; Statistical Thermodynamics : A Concise Introduction for Chemists,

Cambridge University Press, 1st Edition, 2002.

M.Sc. Final


PAPER – VI

Nuclear Chemistry


Unit - I

Nuclear Models :

The shell model, liquid drop model and the collective model. Detail study of magic

number nuclei, their stability.

Unit - II

Radioactivity:

Radioactive Decay (α and β). Decay kinetics (consecutive first order and two parallel first

order reactions), and radioactive equilibrium (Secular and Transient).

Unit - III

Nuclear Reaction and Nuclear Reactors: Q - values of Nuclear Reactions. Reaction cross - section, Nuclear fission and fusion.

Fission products and fission critical size of thermal reactor. Breeder reactor and

reprocessing of spent fuels.

Unit - IV

Radioactive Technique: Tracer technique, neutron activation analysis, rock - dating, radio carbon dating.

Counter technique such as G. M. counter, ionization counter and proportional counter.

Books Recommended:

1. K. J. Laidler; Chemical Kinetics, 3rd

Edition, Harper and Row,1987.

2. K. A .Connors; Chemical Kinetics, VCH, 1990.

3. Frost & Pearson; Kinetics and Mechanisms, Wiley, 1970.


Edition, 2001.

5. H. J. Arnikar; Essentials of Nuclear Chemistry, New Age International, rev. 4th

Edition,

2011.

6. G. Fridlander, J.W. Kennedy, E. S. Macias, and J. M. Miller, Nuclear & Radiochemistry,

3rd

Edition (1981), John Wiley, New York.

M.Sc. Final

Semester IV

PHYSICALChemistry (Practical)

Maximum Marks - 150 Duration - 6 hrs

Any one Practical 50 Marks.

1. Titration of a strong acid with a strong base pH metrically.

2. Titration of a strong acid with a weak base pH metrically.

3. Titration of a weak acid with a strong base pH metrically.

4. Titration of a mixture of a strong acid and a weak acid with a strong base pH metrically.

Any one Practical 30 Marks.

1. Determination of the enthalpy of ionization of acetic acid.

2. Determination of solubility product of AgCl from E.M.F. measurements.

3. Titration of CH3COOH with NaOH potentiometrically.

Viva - 25 Marks

Record - 15 Marks

Seminar - 30 Marks

M.Sc. Inorganic Chemistry

Paper-III

I semester

(Bonding and Stereochemistry of Transition Metal)

Maximum Marks-50 Lectures- 40

UNIT-I

Stereochemistry and Bonding in Main Group Compounds: VSEPR

Theory,Walsh diagram (tri, tetra and penta atomic molecules), dπ-pπ bonds, bent’s

rule, energetic of hybridization, some simple reactions of covalently bonded

molecules.

UNIT-II

Structures of 2 to 8 coordinate metal complexes: Cation-anion ratio in various

polyhedral, hybrid orbitals and preferred condition of formation of the complexes of

following geometries:

C.N.2-Linear

C.N.3- Trigonal planar, Trigonal pyramidal

C.N.4- Tetrahedral, Square planar

C.N.5- Trigonal bipyramidal, Square pyramidal, pentagonal

UNIT-III

C.N.6- Octahedral, Trigonal prism

C.N.7- Pentagonal bipyramidal, Capped octahedral, Capped trigonal prism

C.N.8- Cubic, Tetragonal antiprismatic, Dodecahedral, Hexagonal bipyramidal and

Bicapped trigonal prism, stereochemical non-rigidity in four to eight coordinate

complexes.

UNIT-IV

Stereoisomerism in six coordinate octahedral complexes (Ma3bcd, Ma2bcde,

Mabcdef and complexes containing bi- and ter- dentate ligands). Intermolecular

and intramolecular rearrangements (Bailar and Ray Dutta Twist only). Mechanism

of racemisation in tris (chelate) octahedral complexes. Methods of resolution of

optical isomers.

Books Recommended

1. F.A. Cotton and G. Wilkinson; Advanced Inorganic Chemistry; 6th Edn. (1999), John Wiley &

Sons, New York.

2. James E. Huheey; Inorganic Chemistry; 4th Edn. (1993), Addison-Wesley Pub. Co., New York.

3. G. L. Miessler and Donard A. Tarr; Inorganic Chemistry; Pearson Education Ltd.

4. D. Shriver, M. Weller, T. Overton, J. Rourke, F. Amstrong; Inorganic Chemistry; 6th

,W. H. Freenan

and Company.

5. W.W.Portefield, M.A Reading ; Inorganic Chemistry; A unified Approach; Addison Wesley; 1984.

6. James E. House; Inorganic Chemistry; 2nd

Edn. Elsevier.

7. Geoffrey A. Lawrance; Introdution to Coordination Chemistry; Wiley.

8. Catherine E. Housecroft and Alan G. Sharpe; Inorganic Chemistry; 2nd

Edn, Pearson Edu. Ltd.

(2005).

9. James E. House and Kathleen A. House; Descriptive Inorganic Chemistry; 2nd

Edn, Elsevier.(2010).

10. R. J. Gillespie and Paul L. A. Popelier; Chemical Bonding and Molecular Geometry; Oxford

University Press (2001).

11. Wai Kee Li, Gong Du Zhou and Thomous Chang Wai Mak; Advance Structural Inorganic

Chemistry; Oxford University Press.

12. Keith F. Purcell and John C. Kotz; Inorganic Chemistry; W. B. Sauders Company (1987), Hong

Kong.

13. D. F. Shriver and P. W. Atkins; Inorganic Chemistry; 3rd Edn. (1999), ELBS, London.


Chemistry Paper-IV

I semester

Chemistry of main group elements


UNIT-I

Bond enthalpy concept and interpretation of the following on the basis of bond

enthalpy data: Thermodynamic stability of XeFn, XeOn; P4 over P2; N2 over N4;

over S2; single bonded structure containing extended arrays of B-O-B of B2O3

molecule; N4O6 over N2O3.

UNIT-II Inorganic solids: Lattice energy and its interpretive uses, explanations for non-

existence of TiCl2, and NH5, stabilization of high oxidation state of metals by

fluorine and oxygen, stabilization of low oxidation states of metals by large anions,

solids electrolytes.

UNIT-III

Preparation, structure, bonding and technical application of

(a) polyether complexes of alkali and alkaline earth metals

(b) thiazyl and its polymers, tetrasulphur dinitride

(c) Polyphasphazenes

UNIT-IV

Polyhedral Boranes: Higher boranes, carboranes, metallo-boranes and metallo-

carboranes –Structure and Bonding in the light of Wade’s and Jemmis Rules. Structure and bonding of

(a) Borane anions

(b) Silicones and silicates

Books Recommended


Sons, New York.




,W. H. Freenan

and Company.


6. James E. House; Inorganic Chemistry;2nd

Edn, Elsevier.

7. Geoffrey A. Lawrance; Introdution to Coordination Chemistry; John Wiley & Sons, New York.



(2005).



10. Wai Kee Li, Gong Du Zhou and Thomous Chang Wai Mak; Advance Structural Inorganic

Chemistry; Oxford University Press.

11. Keith F. Purcell and John C. Kotz; Inorganic Chemistry; W. B. Sauders Com. (1987), Hong Kong.

12. N. N. Greenwood and A. Earnshaw, Chemistry of the Elements, 2nd Edn. (1997), Butterworth

Heinemann, London.


I semester

Practical

Maximum Marks - 50 Duration 5 hrs

Exercise No. 1

Quantitative analysis of an inorganic mixture of seven radicals including Ti, W, Mo, Te, V,

Be, U, Ti, Zr, Th, Ce, and Li Semi micro analysis

Exercise No. 2

Chromatographic separation of the metal ions given in any of the following exercise:

1) Pb+2

, Ag+, Hg2

+2

2) Co+2

, Ni+2

, Cu+2

3) Fe+3

, Cr+3

, Al+3

4) Ba+2

, Sr+2

, Ca+2

Viva

Records

Total Marks

Books Recommended:

1. J. Bassett, R.C. Denney, G.H. Zeffrey and J Mendham;Vogel’s text book of quantitative analysis

2. R. L. Peesok, L. D. Shields, T. Cairns; Modern Methods of Chemical Analysis: 2nd

ed. John Wileys

1997.


Paper-III

II semester

Transition Metal Chemistry


UNIT-I

Kinetic and mechanism of substitution reaction: Nature of substitution reaction,

energy profile of reaction, Kinetics of octahedral, tetrahedral and square planar

complexes in terms of VBT and CFT, inert and labile complexes, acidic hydrolysis,

factors affecting acid hydrolysis, base hydrolysis, conjugate base mechanism, direct

and indirect evidences in favour of conjugate mechanism, anion reaction, reactions

without metal ligand bond cleavage.

UNIT-II

Substitution reactions in square planar complexes, Trans effect, mechanism of the

substitution reactions.

UNIT-III

Redox reaction, Electron transfer reactions, Mechanism of one electron transfer

reactions (inner and outer sphere mechanism), factor affecting the rates of direct

electron transfer reactions, cross reaction and the Mareus-Hash theory, two electron

transfer reactions.

UNIT-IV

Metal ligand equilibrium in solution: Stepwise and overall formation constants

and their relation, trends in stepwise constants, factors affecting the stability of

metal complexes with reference to the nature of metal ion and ligand, chelate effect

and its thermodynamic origin, determination of stability constants by pH metric and

spectroscopic methods.

Books Recommended


Sons, New York.




,W. H. Freenan

and Company.



, Elsevier.




(2005).



10. D. F. Shriver and P. W. Atkins; Inorganic Chemistry, 3rd Edn. (1999), ELBS, London.

11. F. A. Cotton and G. Wilkinson; Advanced Inorganic Chemistry,; 6th Edn. (1999), John Wiley &

Sons, New York.


Chemistry Paper-IV

II semester

Bonding in Transition Metal


UNIT-I Metal ligands bonding in Transition metal complexes: Crystal field splitting

diagram in tetragonal, square-planar, trigonal bipyramidal and square pyramidal

geometries, limitations of CFT, spectrochemical series, Thermodynamic and

structural effect; site selection in spinels, experimental evidences for metal-ligand

orbital overlap.

UNIT-II

Molecular Symmetry: Symmetry elements, symmetry operations, point group of

molecules, dipole moment, optical activity and its relation with molecular

symmetry.

UNIT-III

Energy levels in an atom; Relation between electronic configuration and energy

terms, Hund’s rules and ground state energy terms, inter electronic repulsion

parameter. Variation of Racah parameter (B and C) in different transition series,

spin orbital coupling parameters.

UNIT-IV

Superconductivity: Zero resistance and transition temperature, superconductivity,

and periodic table, magnetic properties, theory of superconductivity(BSC Theory),

Organic superconductors and high temperature superconductors.

Books Recommended


Sons, New York.




,W. H. Freenan

and Company.



, Elsevier.




(2005).



10. David J. Willock; Molecular Symmetry; John Wiley.

11. Yngave Ohrn; Elements of Molecular Symmetry; John Wiley.

12. R. S. Drago; Physical Methods in Inorganic Chemistry; International Edu. (1971), Affiliated East-

West Press, New Delhi.

13. K. Veera Reddy; Symmetry and Spectroscopy of Molecules; New Age International Pvt. Ltd., New

Delhi (1999).

14. F. A. Cotton; Chemical Application of Group Theory; John Wiley.

15. Robert L. Carter; Molecular Symmetry and Group Theory; John Wiley.



II semester

Practical

Maximum Marks - 50 Duration 5 hrs

Exercise No. 1

Either both gravimetric or one gravimetric and one volumetric estimation of the ions Ag+,

Cu++, Ni++

, Zn++

, Fe++

, Ba++

, Ca++

Exercise No. 2

Volumetric determination of any one of the following exercise:

1) Chloride and Iodide in admixture

2) Bromide and Iodide in admixture

3) NO3-

by Ce(IV) or MnO4- oxidation

4) Arsenic (III) by BrO3- oxidation

5) Ammonia in an ammonium salt OBr- oxidation

Viva

Records

Total Marks

Books Recommended: 1. J. Bassett, R.C. Denney, G.H. Zeffrey and J Mendham; Vogel’s text book of quantitative analysis


ed. John Wileys,

1997.

M.Sc.-III Semester (INORGANIC CHEMISTRY)

PAPER - I (Compulsory) (Spectroscopy and Dispersion Methods in Spectrometry)

Max Marks: 50

Lectures: 40

Unit-I Max

Marks 5


Basic principles of Mossbauer spectroscopy, Spectral parameters (isomer shift, quadrupole

interactions and magnetic interactions), Applications of M-B spectra in the study of iron

and tin complexes.

UNIT-II

Mass Spectroscopy:

Introduction, ion production, fragmentation and affecting factors, Molecular ion peak,

Meta stable ion peak, nitrogen rule, cleavage associated with common functional groups.

McLafferty rearrangement, Structural information of organic compounds by interpretation

of simple mass spectra.

UNIT-III


Linearly and circularly polarized lights, Optical rotatory power, Different types of rotatory

dispersion curves. Application of ORD for the determination of absolute configuration of

some carbonyl compounds.

UNIT-IV

Circular Dichroism (CD): Principle, Definition, Nature of the CD curves, Cotton effect,

Application for the determination of absolute configuration of some carbonyl compounds.

Books Recommended:






edition (1994)

TataMcGrawhill.

5. Physical Methods in Inorganic Chemistry: R.S.Drago, International edition (1971)

Affiliated East West Press, New Delhi.


Semester III

Paper II

Application of Symmetry and Electronic Spectra

Maximum Marks-50 Lectures -40

UNIT-I

Symmetry species of metal orbital:

Effects of weak crystal fields on free ion terms in octahedral, square planar and

tetrahedral symmetries, Orgel diagrams, mixing of terms, definitions of Dq and

factors affecting in its magnitude, medium and strong field approximation in Oh

point group.

UNIT-II

Transition from weak to strong field and correlation diagram for only d2

case, non

crossing rule,Tanabe Sugano diagrams.

UNIT-III

Electronic spectra of Complexes:

Interpretation of spectra of aqueous solution of [M(H2O)6]n+

, Calculation of Dq, B

and β0 parameters, spectra of spin free and spin paired MA6.

UNIT-IV

Jahn Teller distortion and its effect on electronic spectra.

Books Recommended


Sons, New York.




,W. H. Freenan

and Company.



, Elsevier.




(2005).








Kong.


Delhi (1999).



17. B.N. Figgis; Introduction to Ligand Fields; Wiley Eastern Ltd. New Delhi (1976).


Semester III

Paper III

Symmetry and Group Theory

Maximum Marks-50 Lectures -40 UNIT-I

Definition and theorems of group theory, the defining properties of group and group

multiplication tables, cyclic groups, sub groups, classes of operation and their

determination by Similarity transformation and gener rules. Matrix representation

of symmetry elements and point groups, matrices of C3v and C4v point groups,

transformation matrices

UNIT-II

Character table, reducible and irreducible representations. Decomposition of

reducible representation into irreducible ones.

UNIT-III

Projection operations, general theorems of representations, theory and

consequences of the great Orthogonality theorem (derivation not required).

Derivation of character tables for C2v, C3v and C3 point groups, direct products of

representation.

UNIT-IV

Symmetry operation and identification of the point groups of the complex of

following geometries

(a) Octahedral: Ma6, Ma5b, cis and trans Ma4b2, fac and mer-Ma3.

(b) Tetrahedral: Ma4, Ma3b and Ma2b2.

(c) Planar: Ma4, Ma3b, Ma2b2 and Mabcd.

Books Recommended




,W. H. Freenan

and Company.



(2005).










Kong.


Delhi (1999).



14. B.N. Figgis; Introduction to Ligand Fields; Wiley Eastern Ltd. New Delhi (1976).


Semester III

Paper IV

Organometallic Chemistry


UNIT-I

Alkyl and aryls of Transition Metals: Types, general synthetic routes, stability

and decomposition pathways.

UNIT-II

Fluxional organometallic compounds: Fluxionality and dynamics equilibria in

compounds such as allyl and dienyl complexes

UNIT-III

Compounds of transition Metal – Carbon Multiple bonds; Low valent carbenes

and carbynes, synthesis, nature of bond and structural characteristics.

UNIT-IV

Transition metal π-complexes:

(a) Preparation, important reactions relating on the ligands, structural features and

bonding of alkenes, alkynes, dienes, dienyls and arene complexes.

(b) Ligands behaviour of C3Ph3+, C4H4

2-, C5H5

- C6H6, C7H7

+ and C8H8

2- in

different Organometallic compounds.

Books Recommended


Sons, New York.




, Elsevier.



(2005).




Kong.

8. R. H. Crabtree; The Organometallic Chemistry of Transition Metals; John Wiley.

9. Ch. Elschenbroich and A. Salzer; Organometallics; VCH.

10. J.P. Collman, L.S. Hegedus, J.R. Norton and R.G. Fink; Principles and Applications of

Organotransition metal Chemistry,; Univ. Sci. Books, Mill Valley. California.

11. R. C. Mehrotra and A. Singh; Organometallic Chemistry A unified approach; Wiley Eastern, (1991).

12. E. W. Abel, F. G. A. Stone and G.Wilkinson; Comprehensive Organometallic Chemistry;

Pergamon,1982.

13. K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th Edn.

(1986), John Wiley & Sons, New York.


Semester III

Paper V

Environmental and Bioinorganic Chemistry


UNIT-I

Scope of essential and Trace Element in Biological systems, Role of metal ions in

Biological processes (Metal binding sites, Metal binding groups, stereochemistry

and oxidation state).

UNIT-II

Nitrogenase: The biochemistry of nitrogen fixation, molybdenum nitrogenase ,

dinitrogen complexes and their reactivity.

UNIT-III

Metal in pollution & medicine: pollution caused by Cd, Hg, & Pb compounds.

UNIT-IV

Metal in medicine; Metal deficiency and diseases, toxic effects of metals, metals

used for diagnosis and chemotherapy with particular reference to anticancer drugs.

Books Recommended


Sons, New York.




,W. H. Freenan

and Company.



(2005).


7. M. N. Hughes; Inorganic Chemistry of Biological Processes, 2nd

Edn.(1981), John-Wiley & Sons,

New York.

8. W. Kaim and B. Schwederski; Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life,

An Introduction and Guide; Wiley, New York (1995).

9. S. J. Lippard and J. M. Berg; Principles of Bioinorganic Chemistry; University Science Books

(1994).

10. I. Bertini, H. B. Grey, S. J. Lippard and J. S. Valentine; Bioinorganic Chemistry; Viva Books Pvt.

Ltd. New Delhi (1998)


Semester III

Paper VI

Analytical Chemistry


UNIT-I

Thermal Analysis: Theory, Methodology, Instrumentation and Applications of

Thermo gravimetric analysis (TGA), Differential thermal analysis (DTA),

Differential scanning calorimetry (DSC) and thermometric titrations.

UNIT-II

Theory and instrumentation of polarography. Quantitative applications. Atomic

absorption spectrophotometry, X-ray fluorescence, Flame Photometry, fluorometry,

nephelometry and turbidimetry. UNIT-III

Modern voltametric methods: Samples polarography, pulse polarography, fast

linear sweep polarography, cyclic voltametry, AC polarography and stripping

voltametry.

UNIT-IV

Acid-base Equilibria & Buffer solutions: General concept of acid base

equilibrium water. Determination of PH and PH calculations for aqueous solutions of

weak acid, weak base, salts of weak acid and weak base, Protolysis curve, buffer

and buffer capacity.

Books Recommended


, Elsevier.




(2005)

4. D. A. Skoog and D. N. West; Fundamentals of Analytical Chemistry; 7th

ed.1969.


ed. John Wileys

1997.

6. A. l. Vogel.; A Text Book of quantitative Inorganic Analysis;

7. S. M. Khopkar; Analytical Chemistry; 2nd

ed.


Semester III

Inorganic Chemistry Practical

Maximum Marks-150 Duration -15 hrs

Exercise No. 1

Preparation of the complex compounds of chromium, manganese, iron,

cobalt, nickel, zinc and copper and their characterization by IR, UV / Vis

spectroscopic techniques.

Exercise No. 2

Synthesis of a series of Ni (II) complexes (with ligands of varying ligand

Field strength), electronic spectral interpretation and calculation of various

ligand-field parameters.

Exercise No. 3

Table work;

Analysis of Electronic Spectra of transition metal complexes at least for one system [dn

(Oh) or (Td)] and calculation of Crystal Field parameters, interelectronic repulsion

parameter and bonding parameter.

Exercise No. 4

Measurement of PH of the solution, simple electrometers titration and calorimetry,

Simple exercises involving chromatographic analysis.

Exercise No. 5

Determination of ferrous ammonium sulfate potentiometrically with standard ceric

sulfate solution (Direct and back titration).

Exercise No. 6

Determination of concentration of halide ion(s) in the given solution

potentiometrically.

Exercise No. 7

Conductometric titration of

(i) strong acid, monobasic weak acid or polybasic weak acid with strong

base

(ii) zinc with EDTA, and

(iii) KCl vs AgNO3

Exercise No. 8

To obtain the protolysis curves involving cases of weak acid, mixture of

acids and polybasic acid employing a pH meter and determine the amount

of the respective acid (in ppm) in the given solution

Viva

Record

Total Marks

Books Recommended:


ed. John Wileys

1997.

2. A. l. Vogel; A Text Book of quantitative Inorganic Analysis;

3. S. M. Khopkar ; Analytical Chemistry; 2nd

ed.

4. J. Bassett, R.C. Denney, G.H. Zeffrey and J Mendham;Vogel’s text book of quantitative analysis


INORGANIC CHEMISTRY

Paper I (Compulsory)


Unit-I


Magnetic and non-magnetic nuclei, magnetic moment, nuclear spin, nuclear resonance,

population saturation, shielding of magnetic nuclei, chemical shift and its measurements,

factors affecting coupling constant, use of chemical shifts and spin spin coupling for

structural determination, spin decoupling, chemical exchange, effect of deuteration, nuclear

magnetic double resonance, nuclear over hauser effect (NOE) NMR studies of nuclei other

than proton F19

, P31

.

Unit-II 13



C-H1 coupling (J Values),

application of 13

C magnetic resonance in structural determination.

Unit-III


Basic principles, Zero field splitting and Kramer’s degeneracy, factors affecting g-value,

isotopic & anisotopic hyperfine coupling constant. Application of ESR studies.

Unit-IV


Quadrupole nuclei, quadrupole moments, electric field gradient, coupling constant, spliting,

Applications.

Books Suggested:

1. Spectroscopic Methods in Organic Chemistry: D.H. William & Fleming, Tata McGraw

(2000)

2. Spectrometric Identification of Organic Compound: R.M. Silverastein, John Wiley

(2000)


edition, John Wiley & Sons Ltd, New York

(2004)


edition, TataMcGrawhill

(1994)

5. Physical Methods in Inorganic Chemistry : R.S.Drago, International edition

AffiliatedEast West Press, New Delhi (1971)


Semester IV

Paper II

Co-ordination Chemistry


UNIT-I

Molecular orbital Theory:

symmetry consideration for the formation of σ and π molecular orbitals in Oh

and Td points groups, molecular orbital energy level diagrams of Oh, Td and

Sq planar complexes, discussion of metal ligand interaction.

UNIT-II

Magnetic properties of complexes:

Dia, para, ferro and antiferromagnetism, spin crossover, correlation of magnetic

susceptibility with effective magnetic moment, spin formula, µs+1 formula.

Temperature independent k paramagnetic behaviour. Quenching of orbital

angular momentum by ligand fields. The magnetic properties of complexes with

A, E and T ground terms. Electron delocalization and the magnetic properties of

complexes with A, E and T ground terms.

UNIT-III

Metal clusters and metal-metal bonds:

Condition of formation of metal-metal bond, Metal halide,

carbonyl Clusters and chalcogenide clusters.

UNIT-IV

Parallels between Main Group and Organometallic Chemistry

Isolobal concept (Hoffman) in Organometallic and metal-cluster chemistry.

Books Recommended


Sons, New York.




,W. H. Freenan

and Company.





(2005).




Kong.


11. N. N. Greenwood and A. Earnshaw; Chemistry of the Elements, 2nd Edn. (1997), Butterworth

Heinemann, London.

12. K. Nakamoto; Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th Edn.



Semester IV

Paper III

Molecular Symmetry


UNIT-I

Symmetry aspects of valance bond and molecular orbital theories.

UNIT-II

Application of Symmetry aspects in the formation of AX2 (planer) and AX4

(tetrahedral and square planar) hybrid orbitals.

UNIT-III

Molecular orbital treatment of A2 and AXn (n=1,2 and 3) type molecules. Hückel

molecular orbital treatment of simple and conjugated polyenes.

UNIT-IV

Symmetry treatment and normal modes of vibration: polyatomic molecules of AX2

and AX3 type.

Books Recommended


Sons, New York.










Delhi (1999).

9. F. A. Cotton; Chemical Applications of Group Theory, 3rd Edn. (1999), John Wiley & Sons, New

York

10. Robert L. Carter; Molecular Symmetry and Group Theory; John Wiley & Sons, New York.


Semester IV

Paper IV

Bonding and Applications of Organometallic Compounds


UNIT-I

M.O. approach of bonding in ferrocene and bis (benzene) chromium.

UNIT-II

Inorganic π – acid ligands: Transition metal Compounds of dioxygen, dinitrogen

nitrosyl, tertiary phosphine and arsines as ligands.

UNIT-III

Metal carbonyl compounds: Nature of M-C and C-O bonds. Preparation,

properties and structure of platinum metal carbonyls, substitution reactions using

σ-donor, σ-donor & π-acceptor and π-donor ligands.

UNIT-IV

Catalysis involving Organometallic compounds:

Olefin hydrogenation, Oxo reaction, Fischer Tropsch process, Wacker process,

Polymerisation and oligomerisation of olefin and acetylenes

Asymmetric Catalysis: General features of chiral ligands and complexes; Mechanisms

and Catalytic cycles in hydrogenation, isomerization, epoxidation and catalytic

reactions of C-C bond formation.

Books Recommended


Sons, New York.




,W. H. Freenan

and Company.

5. W.W. Portefield, M. A Reading ; Inorganic Chemistry; A unified Approach; Addison Wesley;

1984.


Kong.


8. J.E. Huheey, Keiter and Keiter, Inorganic Chemistry,

9. R. H. Crabtree; The Organometallic Chemistry of Transition Metals; John Wiley.

10. Ch. Elschenbroich and A. Salzer; Organometallics; VCH.

11. J.P. Collman, L.S. Hegedus, J.R. Norton and R.G. Fink; Principles and Applications of

Organotransition metal Chemistry,; Univ. Sci. Books, Mill Valley. California.

12. R. C. Mehrotra and A. Singh; Organometallic Chemistry A unified approach; Wiley Eastern, (1991).

13. K. Nakamoto; Infrared and Raman Spectra of Inorganic and Coordination Compounds; 4th Edn.



Semester IV

Paper V

Bioinorganic Chemistry


UNIT-I

Mechanism of action of the following:

Non-redox metalo enzymes (carboxy peptidase and carbonic anhydrase).

(a) Oxygen carrier and storage proteins (heamoglobin, myoglobin, heamerythrin

and heamocyanins).

UNIT-II

Redox metalo proteins and enzymes: Cytochromes, ruberedoxin ferreodoxins,

copper containing proteins and enzymes with special references to

superoxidedismutase, xanthine oxidase, vitamins B12 & B12 coenzymes.

UNIT-III

Metal ion transport and storage: transferrin, ferritin and bacterical siderophores, Na

and K transport.

UNIT-IV

Photosynthesis: chlorophyll, role of principal photosynthetic pigments, chemistry of

photosynthesis and translocation of foods materials.

Books Recommended


Sons, New York.




Kong.

5. W. Kaim and B. Schwederski; Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life,

An Introduction and Guide; Wiley, New York (1995).

6. S. J. Lippard and J. M. Berg; Principles of Bioinorganic Chemistry; University Science Books

(1994).

7. I. Bertini, H. B. Grey, S. J. Lippard and J. S. Valentine; Bioinorganic Chemistry; Viva Books Pvt.

Ltd. New Delhi (1998)

8. J.E. Huheey, Keiter and Keiter, Inorganic Chemistry,

9. M. N. Hughes; Inorganic Chemistry of Biological Processes; 2nd Ed.(1981), John-Wiley & Sons,

New York.


Semester IV

Paper VI

Environmental and Analytical Chemistry


UNIT-I

Environment pollution:

Air pollution: general idea of atmosphere and pollutants, green house effect,

primary and secondary pollutants, sources and analysis of CO, SOX, NOX,

hydrocarbons, particulates.

UNIT-II

Water pollutants: sources and their analysis (Pb, As, Cd pesticides and detergent),

water quality parameter’s (DO, BOD, COD, TOC, Total N, Total S, Total P and

Chlorine). Analysis of toxic heavy metals, Cd, Cr, As, Pb, Cu, Separation of Co,

Cu, Mg, Mn, Fe, analysis of SO4-2

, PO43-

, NO3- , NO2

-

UNIT-III

Pesticide, residue analysis soil pollution, Sources of pesticides residue in the

Environment, pesticides degradation by natural forces, effect of pesticide residue on

life, Analytical techniques for pesticides residue analysis.

UNIT-IV Radiation pollution- Classification and effects of radiation, effects of ionizing

radiation on man, Effects of non ionizing radiation on life, radioactivity and

Nuclear fallout, protection and control from radiation.

Books Recommended




,W. H. Freenan

and Company.


, Elsevier.

5. G.W. Vanloon, S.J. Duffer; Environmental Chemistry - A Global Perspective; Oxford University

Press (2000).

6. F.W. Fifield and W. P. J. Hairens; Environmental Analytical Chemistry; 2nd Edition (2000), Black

Well Science Ltd

7. Colin Baird; Environmental Chemistry; W.H. Freeman and Company, New York (1995).

8. A.K. De; Environmental Chemistry; 4th Edition (2000), New Age International Private Ltd., New

Delhi.

9. D.A. Skoog and D.M. West, Fundamental of Analytical Chemistry, International Edition, 7th

Edition

10. (1996), Saunders College Publishing, Philadelphia, Holt, London.

11. R.L. Pecsok, L.D. Shields, T. Cairns and L.C. McWilliam; Modern Methods of Chemical Analysis;

2nd


12. D.A. Skoog; Principles of Instrumental Analysis; 5th Edition (1998), Saunders College of

Publishing, Philadelphia, London.


Semester IV

Inorganic Chemistry Practical

Max Marks: 130 + 20=150 12 Hrs

Exercise No. 1

Complete analysis of dolornite cement, brass, stainless-steel, bronze

and white metal.

Exercise No. 2

Estimation of silver, copper, lead, aluminum, manganese, calcium,

chloride ion, oxalate ion.

Exercise No. 3

[At least four exercises, two gravimetric and two volumetric in the

mixed solution].

(i) Cu, Ni, Zn (ii) Ag, Cu, Ni (iii) Cu, Ni, Mg

Exercise No. 4

Photometric Titrations: (a) Cu Vs EDTA (b) Fe Vs EDTA using salicylic

acid

Exercise No. 5

Potentiometric Titrations: (a) FAS vs K2Cr

2O

7 (b) FAS vs. KMnO

4

Exercise No. 6

Conductometric Titrations: (a) NaOH vs. HCl (b) NaOH vs. Boric acid

Viva

Record

Total Marks 130

Seminar 20

Books Recommended:


ed. John Wileys

1997.

2. A. l. Vogel; A Text Book of quantitative Inorganic Analysis;

3. S. M. Khopkar ; Analytical Chemistry; 2nd

ed.

4. J. Bassett, R.C. Denney, G.H. Zeffrey and J Mendham;Vogel’s text book of quantitative analysis.

M.Sc. SEMESTER ONE

Paper V Organic Chemistry

(Aromaticity and Reaction Mechanism)


Unit I

Aromaticity

Concept of aromaticity and Hückel’s rule, antiaromaticity, non aromaticity, homoaromaticity, aromaticity in

non-benzenoid compounds (tropone, tropolone, azulene, annulene, sydnones, ferrocene and fullerene)

Unit II

Reaction intermediates:

Non classical and bridgehead carbocations, stability and reactions involving non classical and bridge head

carbocations.

Carbenes: Generation, stereochemical consideration, structures and reactions involving carbenes and

carbenoids (Arndt-Eistert reaction)

Nitrenes: Generation, stereochemical consideration and rearrangements (Hoffman Bromamide, Lössen and

Curtius).

Unit III

Aromatic electrophilic reaction

The Arenium ion mechanism (nitration, sulphonation, halogenations, Friedel-Craft alkylation and acylation),

orientation and reactivity in monosubstituted benzene rings, ortho/para ratio, Ipso attack.

Effect of structure on reactivity

Quantitative treatment of reactivity in substrate and electrophiles, Hammett equation and its modification: the

Taft treatment of polar and steric effects in aliphatic compounds).

Unit IV

Aromatic nucleophilic substitution The Aromatic S

N1, S

N2 and benzyne mechanisms. Reactivity – effect of substrate structure, leaving group,

and attacking nucleophile.

Books recommended:

1. M.B. Smith & Jerry March, March’s Advanced Organic Chemistry, 5th

Edition (2001), John Wiley & Sons,

New York.

2. Peter Sykes, A Guide book to Mechanism in Organic Chemistry, 6th

Edition (1997), Orient Longman Ltd.,

New Delhi.

3. S.M. Mukherjee and S.P. Singh, Reaction Mechanism in Organic Chemistry, 1st

Edition (1990), Macmillan

India Ltd., New Delhi.

4. T.H. Lowry and K.S. Richardson, Mechanism and Theory in Organic Chemistry, 3rd

Edition (1998),

Addison – Wesley Longman Inc. (IS Edition)

5. R.T. Morrison and R.N. Boyd, Organic Chemistry, 6th

Edition (2003), Prentice- Hall of India, New Delhi.

6. P.S. Kalsi, Organic Reactions and Their Mechanisms, 1st

Edition (1996), New Age International Pub., New

Delhi.

M.Sc. SEMESTER ONE

Paper VI Organic Chemistry

(Carbohydrates and Natural Products)


Unit I

Carbohydrates

Disaccharides (Maltose, Lactose, Sucrose), structure elucidation and its synthesis

Polysaccharides (Starch, Cellulose), structure elucidation

Unit II

Ureides and Purines (Structure determination and its synthesis)

Ureides: Alloxan and Allantoin

Purines: Uric acid, xanthenes bases, caffeine, theobromine, theophynine,

Unit III

Terpenoids

Classification, isoprene rule, general methods for structural determination

Stucture and synthesis of acyclic (citral, geraniol), monocyclic (α-terpineol, carvone, limonene) terpenoids

Unit IV

Molecular recognition and supramolecular chemistry

Molecuar recognition: Definition, complementarity and preorganization, crowns, cryptands and spherands,

molecular recognition with a large ion-dipole component, large ion pairing component, large hydrogen bonding

component, large hydrophobic component (cyclodextrins, cyclophanes)

Supramolecular chemistry: Definition, assembly of complex architectures, self assembly via coordination

compounds, via hydrogen bonding, catenanes, rotaxanes, knots

Books recommended:

1. I. L. Finar, Organic Chemistry, Vol. 2, Pearson India

2. J. Clayden, N. Greeves, S. Warren, P. Wothers, Organic Chemistry, Oxford University Press.

3. K. C. Nicolaou, J. S. Chen, Classics in Total Synthesis III, Wiley-VCH.

4. E. V. Anslyn, D. A. Dougherty, Modern Physical Organic Chemistry, University Science Books.

M.Sc. SEMESTER ONE

PRACTICAL : ORGANIC CHEMISTRY

MAXIMUM MARKS-50 TIME: 5Hrs

1. Separation and identification of Organic mixture (binary)

2. Estimation

Estimation of amino acids

3. Viva-voice

4. Record

Books Suggested:

1. Experiments & Techniques in organic Chemistry: D.Pesto, C.Johnson & M. Miller, Prentice Hall.

2. Micro and macro scale organic experiments: K.I. Iolliamzon & D.C.Heath

3. Vogel’s text book of practical organic Chemistry: A.R.Tatchell, John William.

4. Systematic qualitative analysis organic: H. Middleton and Adward Arnold.

M.Sc. SEMESTER TWO (Reaction Mechanism and Stereochemistry)

Paper V (Organic Chemistry)


Unit-I

Nucleophilic aliphatic substitution reaction

Mechanism and stereochemistry of the reactions - SN1, SN

2, SN

i, SN

1’ and SN

2’

Structural and solvent effect on reactivity and rate (effect of R, Nu, Leaving group and solvent).

Addition to carbon-oxygen double bond(C=O), Cram’s rule, Mechanism of Aldol, Perkin, Wittig reaction,

Knoevenagal, Claisen and Cannizzaro reactions.

Unit-II

Elimination Reaction: E1, E2, E1cb, mechanism, stereochemistry and orientation, Saytzeff’s and Hoffmann’s rule.

Elimination vs substitution, Pyrolytic elimination.

Unit-III

Stereochemistry: Elements of symmetry (Alternating axis of symmetry), Enantiotropic, diastereotopic and homotopic groups,

chirality and prochirality, D/L and R/L system, Asymmetric synthesis, Erythreo and Threo isomers,

Interconversion of Fischer,Newmann and Sawhorse projection formula. Theory of racemisation and

resolution, E-Z isomerism in acyclic and cyclic system (C3 to C5).

Unit-IV

Stereochemistry of biphenyl and related compounds. Stereochemistry of biphenyls, allenes and spiranes (configuration, optical activity absolute configuration),

Racemisation of biphenyls. Stereochemistry due to restricted rotation in compounds other than biphenyls.

Molecular overcrowding.

Books suggested:

1. T.H.Lowry & K.S.Richardson: Mechanism and Theory in Organic Chemistry, 3rd

edition (1998)

Addison-Wesley-Longman Inc.

2. March’s Advanced organic chemistry : M. B. Smith and Jerry March, 5th

Edi. (2001) John Wiley &

Sons. New York.

3. Stereochemistry of Organic Compounds: E.L.Eliel and S.H.Wilen, (1994) Wiley Intrescience, New

York.

4. Stereochemistry of Organic Compounds : D.Nasipuri, 2nd

Edition (1994) Wiley Eastern Ltd, New

Delhi.

5. A Guide Book to Mechanism in Organic Chemistry : Peter Sykes, 6th

edition (1997) Orient-Longman

Ltd, New Delhi.

6. Organic Reaction and their Mechanism : P.S.Kalsi, 1st Edition (1996) New Age International Pub.,

New Delhi.

M.Sc. SEMESTER TWO (Natural Product Chemistry)

Paper VI (Organic Chemistry)


Unit-I

Alkaloids

General methods for determining structure of Alkaloids

Occurence, Biological importance and chemistry of Quinine and Ephederin.

Unit-II

Occurence, Biological importance and chemistry of Nicotine, Atropine.

Unit-III

Vitamins Structure and physiological function of Vitamin-A and Vitamin-C.

UNIT-IV

Hormones Structure and function of T3, T4 and TSH, Adrenalin.

Books suggested:

1. I.L.Finar: Vol.II, 5th

edition (1975) Longman Ltd, New Delhi.

2. J.W.Apsimon : Total Synthesis of Natural Products,Vol.1-6,Wiley-Interscience

Publications, New York.

3. K.C.Nicolaou:Classics in Total Synthesis of Natural Products,Vol I&II

4. S.V.Bhatt, B.A.Nagasampagi, M.Sevakumar : Chemistry of Natural Products,Springer-2005.

5. G.R.Chatwal: Organic chemistry of Natural Products - Vol II, Himalaya publishing House.

M.Sc. SEMESTER TWO

(Practical Organic Chemistry)

Max Marks: 50 TIME : 5Hrs

Preparation:

1. Preparation of sym-tribromobenzene from aniline.

2. Preparation of 2,4-Dinitrophenyl hydrazine from chlorobenzene

3. Preparation of p-nitro acetanilide from aniline

4. Preparation of p-bromo acetanilide from aniline

5. Preparation benzpinacolone from benzophenone. (Pinacole-Pinacolone rearrangement).

Extraction and Isolation:

1. Extraction of alkaloids from natural sources

2. Isolation of chlorophyll from plant leaves

Viva-voice

Record

Books suggested:

1. Experiments & Techniques in Organic Chemistry: D.Pesto, C.Johnson & M. Miller, Prentice Hall.

2. Micro and Macro Scale Organic Experiments: K.I. Iolliamzon & D.C.Heath.

3. Vogel’s Text Book of Practical Organic Chemistry: A.R.Tatchell, John William.

4. Systematic Qualitative Analysis Organic: H. Middleton and Adward Arnold.

M.Sc. SEMESTER THREE (Spectroscopy and Dispersion Methods in Spectrometry)

Paper I (Compulsory) Organic Chemistry


Unit-I Max Marks 5


Basic principles of Mossbauer spectroscopy, Spectral parameters (isomer shift, quadrupole interactions and

magnetic interactions), Applications of M-B spectra in the study of iron and tin complexes.

UNIT-II

Mass Spectroscopy:

Introduction, ion production, fragmentation and affecting factors, Molecular ion peak, Meta stable ion peak,

nitrogen rule, cleavage associated with common functional groups. McLafferty rearrangement, Structural

information of organic compounds by interpretation of simple mass spectra.

UNIT-III


Linearly and circularly polarized lights, Optical rotatory power, Different types of rotatory dispersion curves.

Application of ORD for the determination of absolute configuration of some carbonyl compounds.

UNIT-IV

Circular Dichroism (CD): Principle, Definition, Nature of the CD curves, Cotton effect, Application for the

determination of absolute configuration of some carbonyl compounds.

Books Recommended:






edition (1994) TataMcGrawhill.

5.Physical Methods in Inorganic Chemistry: R.S.Drago, International edition (1971) Affiliated East West

Press, New Delhi.

M.Sc. SEMESTER THREE (Protecting Groups and Rearrangement)

ORGANIC CHEMISTRY

Paper II


Unit-I

Neighbouring Group Effect

N, S and negatively charged O acting neighbouring group.

Neighbouring group participation by σ and π bonds.

Unit-II

Principle of protection of alcohol, carbonyl and amine group.

Protection of alcohol: Ether, Acetal, Ester protecting group.

Unit-III

Principle of protection of aldehydes and ketones: ketals. acetals, dithio ketals, dithio acetals.

Protection of amines : N-alkyl, N – acyl, N – Silyl, N – Carbamate Protecting Group

Unit-IV

Molecular Rearrangement:

Pinacol-Pinacolone and Wagner-Meerwein rearrangements, Sommelet-Hauser rearrangements,

Beckmann, Benzidine, Dienone-phenol and Fries rearrangement.

Books Suggested:

1. March’s Advanced organic chemistry : M. B. Smith and Jerry March, 5th


Sons New York.

2. Organic Chemistry and acid Base approach: M. B. Smith, 1st Edi. (2011) CRS Press India.

3. A Guide book to mechanism to in organic chemistry : Peter Sykes, 6th

Edi (1997). Orient Longman

Ltd, New Delhi.

4. Organic Synthesis: Disconnection approach, S. Warren (1982) Wiley New York.

5. Organic Chemistry: J. Clayden, N. Greeves, S. Warren and P. Wothers (2001) Oxford Univ. Press

Oxford.

M.Sc. SEMESTER THREE (Reactions and Oxidations)

ORGANIC CHEMISTRY

Paper III


Unit-I

Aldol Condensation and related reactions

Aldol reaction, Claisen-Schmidt, Dieckmann, Mannich and Reformatsky reaction. Stobbe and Darzen

reactions.

Unit-II

Oxidation with Chromium and Manganese Compound:

Oxidation of alcohols, aldehydes and C-C double bonds.

Unit-III

Oxidation with Peracids:

Oxidation of carbon-carbon double bonds (sharpless asymmetric epoxidation), carbonyl compounds (Baeyer

Villiger reaction), allylic carbon-hydrogen bonds.

Unit-IV

Other methods of oxidation

Oxidation with periodic acid, lead tetraacetate and selenium dioxide, oppenauer oxidation.

Books Suggested:

1. March’s Advanced organic chemistry: M. B. Smith and Jerry March, 5th


Sons New York.

2. Organic Synthesis: M. B. Smith, (1995) Mc Graw Hill Inc., Newyork.

3. Organic Chemistry: J. Clayden, N. Greeves, S. Warren and P. Wothers 2001 Oxford Univ Press

Oxford.

4. Organic Chemistry : L.G Wade, M.S. Singh: Pearson Edu. 6th

Edi (2011).

5. Organic Chemistry: T. W. G. Solomons, C. B Fryhle, Sasnyder Wiley India Pvt. Ltd. (2015) 11th

Edi.

M.Sc. SEMESTER THREE (Disconnection Approach and Stereo Chemistry)

ORGANIC CHEMISTRY

Paper IV


Unit-I

An introduction to synthon and Synthetic equivalents

Unit-II

Functional group interconversions, the importance of the order of events in organic synthesis. One group C-X

and two group disconnections, Chemo selectivity, Reversal of Polarity, Cyclisation reactions, Amine

Synthesis

Unit-III

Conformations:

Conformation and reactivity in cyclohexanes(SN1,SN

2,E1 and E2 reactions).

UNIT-IV

Conformation of decalin and decalol

Books Suggested:



Sons New York

2. Organic Chemistry: J. Clayden, N. Greeves, S. Warren and P. Wothers (2001) Oxford Univ Press

Oxford.

3. Organic Chemistry and acid Base approach: M. B. Smith, 1st Edi. (2011) CRS Press India.

4. Organic Chemistry: I.L.Finar, Vol.II, 5th

edition (1975) Longman Ltd, New Delhi.

5. Organic Synthesis: Disconnection approach, S. Warren (1982) Wiley New York.

M.Sc. SEMESTER THREE (Terpenoids and Vitamine)

ORGANIC CHEMISTRY

Paper V


Unit-I Bicyclic monoterpenoids (α-Pinene, Camphor).

Bicyclic sesquiterpeneoids (α-Cadinene).

Unit-II

Diterpenoids(Abietic acid), Triterpeneoids(squalene).

Unit-III Vitamin B1 and B2, Biotin, Vitamin D

Unit-IV Vitamin E (Tocopherols α, β, γ and δ), Vitamin B6, Biological importance.

Books Suggested:

1. S.W.Pelletier: Chemistry of Alkaloids(1970) Van Nostrand Reinhold Co.,New York.

2. Organic Chemistry. I.L.Finar: Vol.II,5th

edition(1975)Longman Ltd,New Delhi.

3. J.W.Apsimon : Total Synthesis of Natural Products,Vol.1-6,Wiley-Interscience Publications,

New York.

4. K.C.Nicolaou:Classics in Total Synthesis of Natural Products, Vol. I&II.

5. S.V.Bhatt, B.A.Nagasampagi, M.Sevakumar : Chemistry of Natural products,Springer-2005.

6. G.R.Chatwal: Organic chemistry of Natural Products - Vol II, Himalaya publishing House.

M.Sc. SEMESTER THREE (Antibiotics and Insecticides)

ORGANIC CHEMISTRY

Paper VI


Unit-I

ANTIBIOTICS:

Definition, classification and importance of antibiotics, PENICILLINES: Introduction, constitution,

Mechanism of action Elementary idea about β-lactam antibiotics. STREPTOMYCIN: Introduction

constitution, mechanism of action. CHLOROAMPHENICOL: chloromycetin (introduction, constitution,

mechanism of action). TETRACYCLINES: Introduction, terramycin (constitution, clinical properties).

Unit-II

INSECTICIDES:

Introduction, Halogenated Insecticides, Elementary idea about (DDT, DDD, DFDT, Perethane, Dilane, BHC,

Chlordane, Heptachlor.

Unit-III

ORGANOPHOSPHORUS: OMPA, Parathion, Paraoxan Insecticides, Diazinon, Malathion : Simple idea.

Unit-IV

HERBICIDES:

A general introduction. 2,4-D and related compounds. Carbamates (aromatic,thiol and sulphonyl).

Organophosphorus herbicides.

Books Suggested :

1. Medicinal Chemistry : A.Burger. Vol.I-III (1995) Wiley Interscience Publications,New York.

2. Principle of Medicinal Chemistry :W.O.Foye, 3rd Edition(1989), Lea & Febiger/Varghese Publishing

House, Bombay

3. The Organic Chemistry of Drug Synthesis :D.Lednicer and L.A.Mitscher, Vol.I-III, Wiley

Interscience.

4. Medicinal Chemistry : A.Kar (1993) Wiley Eastern Ltd, New Delhi.

5. I.L.Finar: Vol.II, 5th

edition (1975) Longman Ltd,New Delhi.

M.Sc. SEMESTER THREE (Organic Chemistry Practical)

Max Marks: 150 Duration: 6 hours

1. Separation and identification of organic mixture containing upto three components.

2. Estimation of N, S and halogens.

Viva

Record

Total Marks 150

Note: There will be a board of two examiners in M.Sc.III semester examination for each branch. The external

examiner of the board will be of same branch from outside and the internal examiner of the same branch will

be from the college where the practical examination will be conducted.


ORGANIC CHEMISTRY

Paper I (Compulsory)


Unit-I


Magnetic and non-magnetic nuclei, magnetic moment, nuclear spin, nuclear resonance, population saturation,

shielding of magnetic nuclei, chemical shift and its measurements, factors affecting coupling constant, use of

chemical shifts and spin spin coupling for structural determination, spin decoupling, chemical exchange, effect

of deuteration, nuclear magnetic double resonance, nuclear over hauser effect (NOE) NMR studies of nuclei

other than proton F19

, P31

.

Unit-II 13



C-H1 coupling (J Values), application of

13C

magnetic resonance in structural determination.

Unit-III


Basic principles, Zero field splitting and Kramer’s degeneracy, factors affecting g-value, isotopic & anisotopic

hyperfine coupling constant. Application of ESR studies.

Unit-IV


Quadrupole nuclei, quadrupole moments, electric field gradient, coupling constant, spliting, Applications.

Books Suggested:

1.Spectroscopic Methods in Organic Chemistry: D.H. William & Fleming, Tata McGraw (2000)

2. Spectrometric Identification of Organic Compound: R.M. Silverastein, John Wiley (2000)


edition, John Wiley & Sons Ltd, New York (2004)


edition, TataMcGrawhill (1994)

5. Physical Methods in Inorganic Chemistry : R.S.Drago, International edition Affiliated East West Press,

New Delhi (1971)

M.Sc. SEMESTER FOUR (Pericyclic Reactions and Photochemistry)

ORGANIC CHEMISTRY

Paper II


Pericyclic Reactions:

Unit-I

Symmetry properties of molecular orbitals, Woodward-Hofmann rule, Electrocyclic reactions (cyclobutene-

butadiene and cyclohexadiene-hexatriene interconversions).

Unit-II

1. Cycloaddition reactions [2+2] and [4+2].

2. Sigmatropic rearrangements [1,3],[1,5] and [3,3], Claisen and Cope rearrangements.

3. Analysis of these reaction by correlation diagram, FMO and PMO methods.

Unit-III

Principles of photochemistry (Photochemical energy, electronic excitation, excited states, energy transfer).

Photochemistry of carbonyl compounds ( Photoreduction, Norrish type I & II reactions, Paterno Buchi

reactions.).

Unit-IV

Photochemistry of Olefins(cis-trans isomerisation of butadiene). Photochemistry of arenes.

Photorearrangement of cyclohexadienones, di-pi methane rearrangement.

Books Suggested:


Edi.(2001) John Wiley &

Sons New York .

2. Pericyclic Reactions:S.M.Mukherjee and S.P.Singh,MacMillan India,New Delhi.

3. Pericyclic Reactions : I.Fleming (1999) Oxford University Press, Oxford.

4. Aspects of Organic Photochemistry : W.M.Horspool, Academic Press, New York.

5. Introduction to Organic Photochemistry : J.D.Coyle, Wiley-Blackwell(1986).

6. Molecular Reactions and Photochemistry : C.H.Depuy and O.L.Chapman, 2nd

edition (1988) Prentice

Hall,New Delhi.

7. Photochemistry: C.E.Wayne and R.P.Wayne, Oxford Chemistry (1996) Primers.

M.Sc. SEMESTER FOUR (Reagents and Name Reactions)

ORGANIC CHEMISTRY

Paper III


Unit-I

CATALYTIC HYDROGENATION: Reduction of functional groups,mechanism and stereochemistry.

Homogeneous Hydrogenation[Hydrogen transfer (Wilkinson’s catalyst) and hydride transfer].

Unit-II

METAL HYDRIDE REDUCTIONS: ( LiAlH4,NaBH4) Reduction of aldehydes,ketones and other

functional groups,stereochemistry of ketone reduction ,Hydroboration reactions.

REDUCTION BY DISSOLVING METALS : Clemmensen and Birch reduction.

REDUCTION WITH HYDRAZINES: Wolf-Kishner reduction.

REDUCTION WITH ALKOXIDE: Meerwein-Ponndrof-Verley reduction

Unit-III

SELECTIVE ORGANIC NAME REACTIONS: Favorskii reaction, Ene reaction, Stork-enamine

reaction, Shapiro reaction, Woodward and Prevost hydroxylation, Peterson synthesis, Hofmann-Loffler-

Freytag reaction

Unit-IV

REAGENTS IN ORGANIC SYNTHESIS : Use of following reagents in organic synthesis and

functional group transformation, Gilman reagent(Lithium dialkyl copper). Lithium diisopropyl amide(LDA)

,Dicyclohexyl Carbodiimide (DCC),1,3-Dithiane(reactivity umpolung) Trimethylsilyliodide ,Tri-n-buty tin

hydride ,DDQ, Phase Transfer catalyst, Crown ethers ,Merrifield resin, Heck reaction, Suzuki Coupling

,Mukaiyama reaction

Books Suggested:

1.March’s Advanced organic chemistry : M. B. Smith and Jerry March, 5th

Edi. 2001 John Wiley & Sons

Newyork

2.Organic Chemistry and acid Base approach: M. B. Smith, 1st Edi 2011 CRS Press India.

3.Modern Synthetic Reactions:H.O.House,2nd

Edition(1972),Benjamin/Cummings Publishing

Company,Californaia.

4. Organic Chemistry: J. Clayden, N. Greeves, S. Warren and P. Wothers 2001 Oxford Univ Press Oxford.

5.Organometallic reagents in Synthesis:P.R.Jenkins(1992) Oxford University Press,

M.Sc. SEMESTER FOUR (Free Radicals, Heterocyclic Chemistry and Spectroscopy)

ORGANIC CHEMISTRY

Paper IV


Unit-I :

FREE RADICALS: Generation,structure and stability,Radical effect. Reactions [fragmentation,

substitution,Addition and Oxidation].

HETEROCYCLIC COMPOUNDS:

Unit-II :

Nomenclature of heterocyclic compounds containg one,two and three Hetero atoms. Chemistry of- Three

membered ring- Aziridines and Four membered ring- Azetidines

Unit-III:

Chemistry of -Five membered ring (AZOLES),pyrazole, Imidazole, Oxazole and Thiazole.

Six membered ring(DIAZINE GROUP),Pyrimidine.

Unit-IV

SPECTROSCOPY:

Applications of UV,IR,NMR and Mass spectrometry in elucidation of structures of organic compounds.

Books Suggested:

1. T.L.Gilchrist:Heterocyclic Chemistry,3rd

edition(1997),Addison-Wesley Longman Ltd.,England

2. R.K.Bansal:Heterocyclic Chemistry;Synthesis,Reactions and Mechanism,3rd

edition(1999),New Age

International Publisher,New Delhi

3.A.R.Katritzky and A.F.Pozharskii:Handbook of Heterocyclic Chemistry,2nd

Edition(2000),Pergamon

Press,Oxford.

4.T.H.Lowry & K.S.Richardson:Mechanism and Theory in Organic Chemistry,3rd

edition,(1998),Addison-

Wesley-Longman Inc

M.Sc. SEMESTER FOUR (Steroids and Natural Products)

ORGANIC CHEMISTRY

Paper V


Unit-I :

STEROIDS: Diel’s Hydrocarbon,Cholesterol

Unit-II :

SEX HORMONES: Oestrone,testosterone ,progesterone,cortisone

Unit-III :

NATURAL PIGMENTS: General nature and classification.Carotenoids( β-carotene).Anthocyanidins and

Anthocyanins(Cyanidin,Cyanin). Flavones and Flavonols (Flavone,Flavonol &Quercitin).

Unit-IV :

ALKALOIDS: Opium alkaloids(Morphine).Rauwolfia alkaloids(Reserpine), Coca alkaloids(Cocaine).

Books Suggested:

1. S.W.Pelletier:Chemistry of Alkaloids,(1970)Van Nostrand Reinhold Co.,New York. Organic

Chemistry.

2. I.L.Finar: Vol.II,5th


3. J.W.Apsimon:Total Synthesis of Natural Products,Vol.1-6,Wiley-Interscience Publications,New York.

4. K.C.Nicolaou:Classics in Total Synthesis of Natural Products,Vol I&II

5. S.V.Bhatt,B.A.Nagasampagi,M.Sevakumar:Chemistry of Natural products,Springer-2005.

6. G.R.Chatwal: Organic chemistry of Natural Products-Vol II,Himalaya publishing House

M.Sc. SEMESTER FOUR (Medicinal Chemistry)

ORGANIC CHEMISTRY

Paper VI


DRUGS :

Unit-I :

Introduction,characteristics of drug, classification of drugs. ANTIMALARIALS: Pamaquine, quinacrine,

chlroquine, poludrine, Santoquine: Simple idea. ANTICANCER AGENTS: Introduction, Chemotherapy of

cancer, alkylating agents, Antimetabolites.

Unit-II :

ANTITUBERCULAR AGENTS: Cycloserine, ethambutol: Simple idea. ANTIBACTERIALS: sulpha drugs

(sulphanilamide, sulphapyridine, sulphathiazole, sulphadiazine,, sulphaguanidine, prontosil), Simple idea.

Unit-III:

FUNGICIDES: Definition. protectant fungicides.DITHIOCARBAMATES AND RELATED COMPOUNDS:

Thiram, Ziram, Ferbam, Nabam, Zineb-Maneb. HALOGENATED PHENOLS: Pentachlorophenol,

dichlorophen. QUINONES: Dichlone, Chloranil

Unit-IV :

RODENTICIDES: SYNTHETIC ORGANIC RODENTICIDES: ANTU,Warfarin,Coumochlor,

Dicoumarin

Books Suggested :

1. Medicinal Chemistry : A.Burger.vol.I-III(1995)Wiley Interscience Publications,New York.

2. Principle of Medicinal Chemistry :W.O.Foye, 3Edition(1989),Lea&Febiger/Varghese Publishing

House,Bombay

3. The organic Chemistry of Drug Synthesis :D.lednicer and L.A.Mitscher,Vol.I-III,Wiley Interscience.

4. Medicinal Chemistry : A.Kar(1993)Wiley Eastern Ltd,New Delhi

5. .I.L.Finar: Vol.II,5th


M.Sc. SEMESTER FOUR

ORGANIC CHEMISTRY (Practical)

Max Marks: 130 + 20=150 12 Hrs

Ques 1. Preparion of compounds involving not more than three stages.

Ques 2. Simple experiments on paper or thin layer chromatography.

OR

Interpretation of IR and PMR spectra of simple organic compound, hydrocarbons, carbonyl compounds,

hydroxyl compounds amines, acids and derivatives.

Interpretation of IR Spectra of synthesized compound in the lab.

Viva

Record

Total Marks

Seminar 20

Note: There will be a board of two examiners in M.Sc.Final examination for each branch. The external

examiner of the board will be of same branch from outside and the internal examiner of the same branch will be

from the college where the practical examination will be conducted.

m.sc. semester i physical chemistry paper i (micro wave...

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