multisensory convergence traditionally, represented by inputs from more than one sensory modality,...
Post on 20-Dec-2015
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Multisensory convergence
• Traditionally, represented by inputs from more than one sensory modality, each of which can independently activate the target neuron. (50 yr)
• Recently, multisensory neuron excited to suprathreshold levels by only one sensory modality, yet inputs from a second modality can significantly modulate these responses through facilitation or suppression (25 yr)
Subthreshold multisensory effects may be a general feature
Cat Auditory Cortex and FAES
Auditory field of the anterior ectosylvian sulcus (FAES)
• Prefer complex sounds /c multiple frequencies & sensitivity to sound location
• Reversible deactivation of leads to deficits in sound localization
• Bimodal neurons identified largely along shared borders
• Nonbimodal forms of multisensory processing in visual and somatosensory cortices. Allman 2007
Courtesy of Stein 2008
Somatosensory: SIV Visual: anterior ectosylvian visual (AEV)
Hypothesis
• Subthreshold-processing patterns might be ubiquitous to multisensory systems
• Multisensory processing is subserved by not just bimodal neurons, but by a range of multisensory convergence patterns.
Methods
• Craniotomy to expose auditory cortex (deep anesth. pentobarbital)
• a glass-insulated tungsten electrode was inserted vertically and advanced into the FAES (shallow anesth. with ketamine + acepromazine, still some reflex kept)
• Visual cues: moving light or dark bars projected onto a translucent hemisphere
• Auditory cues: clicks, claps, whistles, & hisses• Somatosensory stimuli: air puffs, brushes, taps to the
body surface, as well as compression of deep tissues and joint rotation.
FAES & the sensory responses
Auditory neurons: 70% (135/193)
Visual: 13.5% (26/193) ventrally (AEV)
A+V (bimodal): 14.5% (28/193)
2% unresponsive
No other sensory convergence (v+s)
FAES+AEV Bimodal: neurons response independentlyto separate visual and auditory stimulation Subthreshold multisensory neurons: response to only one modality but influenced by other modality
Response of FAES neurons to auditory, visual, and combined auditory–visual stimulation
16.5% of all neurons
Within FAES
Multisensory influences on auditory processing in FAES
MS: multisensory, bimodal & subthreshold
Conclusion
• Neurons in auditory FAES exhibit both bimodal and subthreshold forms of multisensory convergence and processing.
• Subthreshold multisensory neurons produce response levels intermediate to those elicited in bimodal (multisensory convergence) or in unimodal neurons (no convergence).