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Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman, Keiran Raine, David Jones, Jonathan Hinton, John Marshall, Lucy A. Stebbings, Andrew Menzies, Sancha Martin, Kenric Leung, Lina Chen, Catherine Leroy, Manasa Ramakrishna, Richard Rance, King Wai Lau, Laura J. Mudie, Ignacio Varela, David J. McBride, Graham R. Bignell, Susanna L. Cooke, Adam Shlien, John Gamble, Ian Whitmore, Mark Maddison, Patrick S. Tarpey, Helen R. Davies, Elli Papaemmanuil, Philip J. Stephens, Stuart McLaren, Adam P. Butler, Jon W. Teague, Göran Jönsson, Judy E. Garber, Daniel Silver, Penelope Miron, Aquila Fatima, Sandrine Boyault, Anita Langerød, Andrew Tutt, John W.M. Martens, Samuel A.J.R. Aparicio, Åke Borg, Anne Vincent Salomon, Gilles Thomas, Anne- Lise Børresen-Dale, Andrea L. Richardson, Michael S. Neuberger, P. Andrew Futreal, Peter J. Campbell, Michael R. Stratton Cell Volume 149, Issue 5, Pages 979-993 (May 2012) DOI: 10.1016/j.cell.2012.04.024 Copyright © 2012 Elsevier Inc. Terms and Conditions

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Page 1: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Mutational Processes Molding the Genomes of 21 Breast Cancers 

Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman, Keiran Raine, David Jones, Jonathan Hinton, John Marshall, Lucy A. Stebbings, Andrew Menzies, Sancha Martin, Kenric Leung, Lina Chen, Catherine Leroy,

Manasa Ramakrishna, Richard Rance, King Wai Lau, Laura J. Mudie, Ignacio Varela, David J. McBride, Graham R. Bignell, Susanna L. Cooke, Adam Shlien, John Gamble, Ian Whitmore, Mark Maddison, Patrick S. Tarpey, Helen R. Davies, Elli Papaemmanuil, Philip J. Stephens, Stuart McLaren, Adam P. Butler, Jon W. Teague, Göran Jönsson, Judy E. Garber, Daniel Silver, Penelope Miron, Aquila

Fatima, Sandrine Boyault, Anita Langerød, Andrew Tutt, John W.M. Martens, Samuel A.J.R. Aparicio, Åke Borg, Anne Vincent Salomon, Gilles Thomas, Anne-Lise Børresen-Dale, Andrea L. Richardson, Michael S. Neuberger, P. Andrew Futreal, Peter J. Campbell,

Michael R. Stratton 

Cell Volume 149, Issue 5, Pages 979-993 (May 2012)

DOI: 10.1016/j.cell.2012.04.024

Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 2: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure 1

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 3: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure 2

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 4: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure 3

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 5: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure 4

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 6: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure 5

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 7: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure 6

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 8: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure 7

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 9: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure S1

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 10: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure S2

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 11: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Figure S3

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 12: Mutational Processes Molding the Genomes of 21 Breast Cancers Serena Nik-Zainal, Ludmil B. Alexandrov, David C. Wedge, Peter Van Loo, Christopher D. Greenman,

Cell 2012 149, 979-993DOI: (10.1016/j.cell.2012.04.024) Copyright © 2012 Elsevier Inc. Terms and Conditions