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National Center

7272 Greenville Avenue

Dallas, Texas 75231-4596

©2014, American Heart Association 7/14JN0146

Sponsored by the Council on Hypertension and the Council on Kidney in Cardiovascular Disease.

High Blood Pressure Research Scientific Sessions 2014

Final ProgramSeptember 9–12, 2014 | Hilton San Francisco Union Square | San Francisco, CA

For information on upcoming American Heart Association Scientific Conferences, visit my.americanheart.org.

Cardiovascular disease afflicts people of all races, ethnicities, genders, religions, ages, sexual orientations, national origins and abilities. The American Heart Association is committed to ensuring that our work force and volunteers reflect the world’s diverse population. We know that such diversity will enrich us with the talent, energy, perspective and inspiration we need to achieve our mission: building healthier lives, free of cardiovascular diseases and stroke.

Tuesday, September 9 Wednesday, September 10 Thursday, September 11 Friday, September 12

7:00 am 7:00 am Registration Opens

7:00–8:00 am How-To Session I: How to Create an Individual Development PlanFranciscan C

7:00–8:00 am How-To Session II: How to Build Support for Science: Lessons in Effective CommunicationsFranciscan C

8:00 am 8:00 am–4:30 pm Review of HypertensionOpen to all conference attendees. No addtional cost. Plaza

8:00–10:00 am Oral Session I

8:00–8:30 am Presentation of Lifetime Achievement Award and Council Distinguished Achievement AwardsGrand Ballroom B

8:30–10:00 am Concurrent A: Inflammation, Immunity and Cytokines Grand Ballroom B Concurrent B: Aldosterone, Its Receptors and Other Hormones Plaza A

8:00–10:00 am Oral Session VII

8:00–8:30 am Seldin Award LectureGrand Ballroom B

8:30–10:00 am Concurrent A: Renal Tubular TransportGrand Ballroom B Concurrent B: Vascular Biology Plaza A

8:00–10:00 am Oral Session X

8:00–8:30 am Dahl Award LectureGrand Ballroom B

8:30–10:00 am Concurrent A: Brain and Renin-Angiotensin Grand Ballroom B Concurrent B: Kidney and HypertensionPlaza A

10:00 am 10:00–10:30 amRefreshments and Exhibits Yosemite

10:00–10:30 amRefreshments and Exhibits Yosemite


10:30 am 10:30 am–12:00 pm Oral Session II

Concurrent A: Obesity and Metabolic Syndrome Grand Ballroom B Concurrent B: Angiotensin Action and SignalingPlaza A

10:30 am–12:30 pm Oral Session VIII

10:30–11:00 am Dustan Award LectureGrand Ballroom B

11:00 am–12:30 pm Concurrent A: Epigenetics and GeneticsGrand Ballroom B Concurrent B: Obesity and Diabetes Plaza A

10:30 am–12:00 pm Oral Session XI

Concurrent A: Pregnancy and PreeclampsiaGrand Ballroom B Concurrent B: Vascular RemoldelingPlaza A

NOON 12:00–12:30 pm Lunch Break

NOONAdjourn

12:30 pm 12:30–1:30 pm Oral Session IIITop Trainee Oral AbstractsGrand Ballroom B

12:30–2:00 pm Annual Business Meeting and Awards Luncheon*Ticketed Event Imperial

1:00 pm

1:30 pm 1:30–3:00 pmPoster Session IIGrand Ballroom A2:00 pm 2:00–3:30 pm

Poster Session IIIGrand Ballroom A

3:00 pm 3:00–3:30 pm Oral Session IV Arthur C. Corcoran Memorial Lecture Grand Ballroom B

3:30 pm 3:30–4:00 pm Refreshments and Exhibits Yosemite

3:30–5:00 pm Oral Session IXConcurrent A: Oxidative StressGrand Ballroom B Concurrent B: Salt and HypertensionPlaza A

4:00 pm 4:00–5:15 pm Oral Session V Harry Goldblatt FinalistsAustralian HBPR Council Young InvestigatorGrand Ballroom B


5:15 pm 4:45–6:00 pm Oral Session VI

Concurrent A: Neurogenic Mechanisms Grand Ballroom B Concurrent B: Renin-Angiotensin SystemPlaza A

5:15–6:00 pm The Excellence Award in Hypertension Research LecturesGrand Ballroom B

5:30 pm 5:30–6:30 pm Opening and Keynote LectureGrand Ballroom B

6:00 pm

6:30 pm 6:30–9:30 PM Poster Session I and Reception: Trainee Poster Session and Competition Grand Ballroom A

7:00 pm 7:00–11:00 pm Trainee Advocacy Mixer *Entertainment portion open to all. Plaza B

7:30 pm 7:30–8:00 pm Conference-wide ReceptionFranciscan Room

8:00–10:00 pm Excellence Award in Hypertension Research Dinner *Ticketed Event Grand Ballroom B

8:00 pm

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PROFESSIONAL MEMBERSHIPmy.americanheart.org

“I have always valued membership in the Council for High Blood Pressure Research because of the opportunity it provides for meeting and interacting with leading national and international scientists involved in both laboratory and clinical investigations of the causes and consequences of hypertension.”

– Gregory Fink, PhD, FAHA

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©2014, American Heart Association 7/14DS8358

Stop by our High Blood Pressure Research booth by the registration area and receive a free gift (reversible fleece jacket or duffle bag) when you join or renew membership.

Become a part of our international community of more than 32,000 members…For more information, call (800) 787-8984 or (301) 223-2307 or email customer service at [email protected].

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Program at a Glance

How-To Sessions

Breaks

Legend

Ticketed Event

Oral Session

Poster Session

iNext year’s conference: Sept. 16–19, 2015 … visit my.americanheart.org for more information.

Letter From the Chair

Sept. 9, 2014

Dear Colleague,

On behalf of the Council on Hypertension and Council on the Kidney in Cardiovascular Disease, it is my pleasure to welcome you to the High Blood Pressure Research 2014 Scientific Sessions. This conference, focusing on recent advances in basic and clinical research on hypertension, is considered the premier scientific meeting on the subject in the world. The science submitted to this conference continues to bring us the most up to date developments on our understanding of: the causes of hypertension; its relationship to stroke, cardiac disease and kidney dysfunction; and the most effective means for detecting, evaluating and treating high blood pressure across diverse populations.

We hope that you take full advantage of all the excellent programming throughout the conference and enjoy your time here in San Francisco. We strive to create an atmosphere of enrichment for conference attendees. Please let us know if there is anything we can do to enhance your experience during your time here. We look forward to interacting with you during the next few days.

Christopher Wilcox, MD, PhDChair, High Blood Pressure Research Program CommitteeChief of Division of Nephrology & HypertensionDirector, Center for Hypertension, Kidney and Vascular HealthGeorgetown University

Become an AHA/ASA Professional Member and save up to $300 off next year’s registration.ii

1Next year’s conference: Sept. 16–19, 2015 … visit my.americanheart.org for more information.

Table of ContentsAbstracts .................................................................................... 32

Abstract Graders .......................................................................... 3

Author Index ............................................................................. 190

Conference Awards .................................................................... 12

Conference Highlights ................................................................... 9

Conference Policies .................................................................... 16

Faculty ........................................................................................... 4

General Information ..................................................................... 15

Hotel Map ..................................................................................... 7

Program Agenda ........................................................................ 17

Tuesday, September 9 ........................................................... 17

Wednesday, September 10.................................................... 20

Thursday, September 11 ....................................................... 24

Friday, September 12 ............................................................ 29

Program Committee ...................................................................... 2

Program Information ..................................................................... 8

Room Locator .............................................................................. 5

Speaker Resource Room ............................................................ 15

Questions and Information

If you have questions after reading this program, contact:

American Heart Association National Center, Dallas, TX

Telephone (888) 242-2453 (inside the United States) (214) 570-5935 (outside the United States)Fax (214) 373-3406 Email [email protected] my.americanheart.org

Professional Membership Customer ServiceLippincott, Williams & Wilkins Telephone (800) 787-8984 (inside the United States) Fax (301) 223-2327 (outside the United States)Email [email protected]

Become an AHA/ASA Professional Member and save up to $300 off next year’s registration.2

High Blood Pressure Research 2014 Scientific Sessions Program Committee

Christopher Wilcox, MD, PhD, Chair, High Blood Pressure Research Program Committee, Georgetown University,

Washington, D.C.

Daniel Battle, MD, Northwestern University, Feinberg School of Medicine, Chicago, IL

Ana Briones, PhD, Universidad Autónoma de Madrid, Madrid, Spain

Satoru Eguchi, MD, PhD, FAHA, Temple University School of Medicine, Philadelphia, PA

David Ellison, MD, FAHA, Oregon Health & Science University, Portland, OR

Gregory Fink, PhD, FAHA, Michigan State University, East Lansing, MI

John M. Flack, MD, MPH, FAHA, FACP, Wayne State University School Medicine, Detroit, MI

R. Ariel Gomez, MD, University of Virginia School of Medicine, Charlottesville, VA

Yoshitaka Hirooka, MD, PhD, FAHA, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

Bina Joe, MD, FAHA, University Toledo, Toledo, OH

Moshe Levi, MD, University of Colorado Denver, Aurora, CO

Augusto Montezano, MD, Institute of Cardiovascular and Medical Sciences, Glasgow, Scotland

Dominik Muller, PhD, Max-Delbruck Center and Clinical Experimental Research Center, Berlin, Germany

Ravi Nistala, MD, University of Missouri-Columbia, Columbia, MO

Pablo Ortiz, PhD, Henry Ford Hospital, Detroit, MI

Jennifer Pollock, PhD, University of Alabama Birmingham, Birmingham, AL

Sean D. Stocker, PhD, FAHA, Penn State College of Medicine, Hershey, PA

Colin Sumners, PhD, University of Florida, Gainesville, FL

Rhian M. Touyz, MD, PhD, FAHA, University of Glasgow, Glasgow, Scotland

Robert Unwin, PhD, UCL Medical School, London, UK

Mary Walker, PhD, University of New Mexico, Albuquerque, NM

Adam Whaley-Connell, DO, MSPH, FAHA, FACP, FASN, FASH, University of Missouri-Columbia, Columbia, MO

The American Heart Association is grateful to the members of the Council on Hypertension

Program Committee for their dedication and leadership in planning the program.

The American Heart Association is a national voluntary health organization whose mission is:

“Building healthier lives, free of cardiovascular diseases and stroke.”


Barbara Alexander

William Arendshorst

Michel Azizi

Michael Bader

Paula Barrett

Daniel Batlle

Kathleen Berecek

Anil Bidani

Henry Black

Ana Briones

K. Bridget Brosnihan

Nancy Brown

David Calhoun

Robert Carey

Dulce Casarini

Lisa Cassis

Alejandro Chade

Mark Chappell

Steven Crowley

Jan Danser

Katia De Angelis

Ralf Dechend

Donald DiPette

Debra Diz

Anna Dominiczak

Satoru Eguchi

Khalid Elased

Fernando Elijovich

Nicholas Ferreri

Greg Fink

Toshiro Fujita

John Funder

Kathyyn Gauthier

Celso Gomez-Sanchez

Ming Gong

Laura Gonzalez Bosc

Romer Gonzalez-Villalobos

Joey Granger

Roger Grekin

Diane Handy

Pamela Harding

Stephen Harrap

Lisa Harrison-Bernard

Yoshitaka Hirooka

John Imig

Raouf Khalil

Jose Krieger

Theodore Kurtz

Eric Lazartigues

Frans Leenen

Scott Levick

Ruisheng Liu

Thomas Lohmeier

James Luther

Dewan Majid

Franco Mantero

Mariela Mendez

Francis Miller

Kenneth Mitchell

Michael Moore

Dominik N Muller

Alberto Nasjletti

Genevieve Nguyen

Akira Nishiyama

Pablo Ortiz

John Osborn

Suresh Palaniyandi

Joon Park

Janos Peti-Peterdi

Ambra Pozzi

J. Howard Pratt

Morton Printz

Kamal Rahmouni

Mohan Raizada

Richard Re

Jane Reckelhoff

Michael Ryan

Kathryn Sandberg

Paul Sanders

Jennifer Sasser

Ernesto Schiffrin

Tatsuo Shimosawa

Curt Sigmund

Helmy Siragy

James Sowers

Jan Staessen

David Stec

Johannes Stegbauer

Colin Sumners

Zhongjie Sun

Stephen Textor

Rhian Touyz

Raymond Townsend

Paolo Verdecchia

Massimo Volpe

Richard Wainford

Donna Wang

Stephanie Watts

R. Clinton Webb

Michael Weber

Myron Weinberger

Matthew Weir

William Welch

Ulrich Wenzel

Adam Whaley-Connell

Robert Widdop

J Michael Wyss

Xueying Zhao

Irving Zucker

Abstract Graders

The program committee gratefully acknowledge these individuals for their assistance with the abstract grading process.


George Bakris, MD, University of Chicago Medicine, Chicago, ILDaniel Battle, MD, Northwestern University, Feinberg School of Medicine, Chicago, ILItalo Biaggioni, MD, Vanderbilt University, Nashville, TNDylan Burger, PhD, Kidney Research Centre, Ottawa, Ontario, CanadaLisa Cassis, PhD, University of Kentucky, Lexington, KYPhilip Clifford, PhD, University of Illinois at Chicago, Chicago, ILThomas Coffman, MD, Duke University Medical Center, Durham, NCRobin Davisson, PhD, FAHA, Cornell University, Ithaca, NYChristian Delles,MD, FRCP, University of Glasgow, Glasgow, United KingdomJussara do Carmo, PhD, University of Mississippi Medical Center, JacksonAnna Dominiczak, MD, Institute of CV and Molecular Science, Glasgow, ScotlandSatoru Eguchi, MD, PhD, FAHA, Temple University School of Medicine, Philadelphia, PAToshiro Fujita, MD, University of Tokyo, Tokyo, JapanElise Gomez-Sanchez, DVM, PhD, G. V. Montgomery VA Med Center, Jackson, MSJoey Granger, PhD, University of Mississippi Medical Center, Jackson, MSJustin Grobe, PhD, University of Iowa, Iowa City, IAFeng Han, PhD, Zhejiang University, Hangzhou, ChinaIris Jaffe, MD, PhD, Tufts Medical Center, Boston, MABina Joe, MD, University Toledo, Toledo, OHVyacheslav Korshunov, PhD, University of Rochester, Rochester, NYTheodore Kotchen, MD, FAHA, Medical College Wisconsin, Milwaukee, WIMingyu Liang, PhD, Medical College of Wisconsin, Milwaukee, WIMoshe Levi, MD, University of Colorado Helath Science, Denver, COAnalia Loria, PhD, University of Kentucky, Lexington, KY Fred Luft, MD, Max-Delbrück Center, Berlin, Germany Meena Madhur, MD, PhD, Vanderbilt University School of Medicine, Nashville, TNMariela Mendez, PhD, Henry Ford Hospital, Detroit, MIDominik Muller, PhD, Max-Delbruck Center and Clinical Experimental Research Center, Berlin, GermanyAkira Nishiyama, MD, PhD, Kagawa University Medical School, Kagawa, JapanRavi Nistala MD, MS, University of Missouri-Columbia, Columbia, MOSuzanne Oparil, MD, FAHA, University of Alabama Birmingham, Birmingham, TNFrederick Palm, PhD, University of Uppsala, Uppsala, SwedenBertram, Pitt, MD, University of Michigan School of Medicine, Ann Arbor, MIJennifer Pollock, PhD, University of Alabama Birmingham, Birmingham, ALMinolfa Prieto-Carrasquero, MD, PhD, Tulane University HSC, New Orleans, LAAlice Ra’anan, The American Physiological Society, Bethesda, MDAlta Schutte, PhD, North-West University, Potchefstroom, South AfricaDomenic Sica, MD , FAHA, Medical College Virginia, Richmond, VACurt Sigmund, PhD, University of Iowa Carver College of Medicine, Iowa City, IAJames Sowers, MD, University of Missouri, Kansas City, MOAndrew Spencer, PhD, Stanford University, Stanford, CASean Stocker, PhD, Penn State University College of Medicine, Hershey, PATheodora Szasz, PhD, Georgia Regents University, Augusta, GABernadette, Thomas, MD, Institute for Healthy Metrics and Evaluation, Seattle, WARhian, Touyz MD, PhD, Institute of Cardiovascular and Medical Sciences, Glasgow, United KingdomAaron Trask, PhD, The Research Institute at Nationwide Children’s Hospital, Columbus, OHRichard Wainford, PhD, LSU HSC, New Orleans, LAStephanie Watts, PhD, Michigan State University, East Lansing, MIMatthew Weir, MD, University of Maryland, Baltimore, MDJan Wysocki, MD, PhD, Northwestern University, Chicago, ILMatthew Zimmerman, PhD, University of Nebraska Medical Center, Omaha, NE

Faculty


Room Locator

Monday, September 8

All Conference Conference Registration Yosemite

All Conference Exhibits Yosemite

All Conference Speaker Resource Room Taylor Room

Tuesday, September 9

8:00 am–4:00 pm Reviews of the Field of Hypertension Plaza

5:30–6:30 pm Opening Remarks and Keynote Lecture Grand Ballroom B

6:30–9:30 pm Poster Session I (for Trainees) with Reception Grand Ballroom A

Wednesday, September 10

7:00–8:00 am How-To Session I: How to Create an Individual Development Plan Franciscan C

8:00–8:30 amOral Session I: Presentation of the Lifetime Achievement Award and Council Distinguished Achievement Awards

Grand Ballroom B

8:30–10:00 am Oral Session I Concurrent A: Inflammation, Immunity and Cytokines Grand Ballroom B

8:30–10:00 amOral Session I Concurrent B: Aldosterone, Its Receptors and Other Hormones

Plaza A

10:00–10:30 am BREAK — Refreshment and Exhibits Yosemite

10:30 am–12:00 pm Oral Session II Concurrent A: Obesity and Metabolic Syndrome Grand Ballroom B

10:30 am–12:00 pm Oral Session II Concurrent B: Angiotensin Action and Signaling Plaza A

12:00–12:30pm BREAK – Lunch on your own

12:30–1:30 pm Oral Session III: Top Trainee Oral Abstracts Grand Ballroom B

1:30–3:00 pm Poster Session II Grand Ballroom A

3:00–3:30 pm Oral Session IV: Arthur C. Corcoran Memorial Lecture Grand Ballroom B

3:30–4:00 pm BREAK — Refreshment and Exhibits Yosemite Foyer

4:00–5:15 pmOral Session V: Harry Goldblatt Award Finalists and Australian Council Young Investigator

Grand Ballroom B

5:15–6:30 pm Oral Session VI Concurrent A: Neurogenic Mechanisms Grand Ballroom B

5:15–6:30 pm Oral Session VI Concurrent B: Renin-Angiotensin System Plaza A

7:00–11:00 pmTrainee Advocacy Mixer (Entertainment portion open to all conference attendees)

Plaza B


Room Locator (continued)

Thursday, September 11

7:00–8:00 amHow-To Session III: How to Build Support for Science: Lessons in Effective Communication

Franciscan C

8:00–8:30 am Oral Session VII: Seldin Award Lecture Grand Ballroom B

8:30–10:00 am Oral Session VII Concurrent A: Renal Tubular Transport Grand Ballroom B

8:30–10:00 am Oral Session VII Concurrent B: Vascular Biology Plaza A


10:30–11:00 am Oral Session VIII: Dustan Award Lecture Grand Ballroom B

11:00 am–12:30 pm Oral Session VIII Concurrent A: Epigenetics and Genetics Grand Ballroom B

11:00 am–12:30 pm Oral Session VIII Concurrent B: Obesity and Diabetes Plaza A

12:30–2:00 pm Annual Business Meeting and Awards Luncheon *Ticketed Event Imperial

2:00–3:30 pm Poster Session III Grand Ballroom A

3:30–5:00 pm Oral Session IX Concurrent A: Oxidative Stress Grand Ballroom B

3:30–5:00 pm Oral Session IX Concurrent B: Salt and Hypertension Plaza A

5:00–5:15 pm BREAK — Refreshment and Exhibits Yosemite

5:15–6:00 pm The Excellence Award in Hypertension Research Lectures Grand Ballroom B

7:30–8:00 pmReception for Excellence Award in Hypertension Research (no ticket required; open to all conference attendees)

Imperial

8:00–10:00 pm Excellence Award in Hypertension Dinner *Ticketed Event Grand Ballroom B

Friday, September 12

8:00–8:30 am Oral Session X: Dahl Award Lecture Grand Ballroom B

8:30–10:00 am Oral Session X Concurrent A: Brain and Renin-Angiotensin Grand Ballroom B

8:30–10:00 am Oral Session X Concurrent B: Kidney and Hypertension Plaza A


10:30 am–12:00 pm Oral Session XI Concurrent A: Pregnancy and Preeclampsia Grand Ballroom B

10:30 am–12:00 pm Oral Session XI Concurrent B: Vascular Remodeling Plaza A

12:00 pm Adjourn


Hotel Maps

CONTINENTIALBALLROOM

MAINENTRANCE

TAYLOR ST.

O’FARRELL ST.MASON ST.

ELLIS ST.GARAGE

PLAZA

HEALTHCLUB

EXEC.CONFERENCE

CENTER

FEDEXKINKO’S

URBAN TAVERN

FRONT DESK

GIFTSHOP

WEST LOUNGE CALIFORNIA ROOMYOSEMITE123

A

25

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21 22 2324

BC

C

B

B

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67 8 9

A8

52 17

6

B

EXECUTIVEBOARDROOM

GREENROOM

LOMBARDMASON

POWELLSUTTER

TAYLORVAN NESS

IMPERIALBALLROOM

D

STARBUCKS

EASTLOUNGE

SOUTHLOUNGE

GRANDBALLROOM

B

A

NORTHLOUNGE

STAIRWAYDOWN TO

LOBBY LEVEL

MAINLOBBY

ELEVATORS

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2

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ELEVATORS ELEVATORS

FRANCISCAN

LOBBYUNION SQUARE ROOMS

4 3

GOLDEN GATE

Food & Beverages

Meeting & Conference Rooms

6th Floor

4th Floor

Ballroom Level

Grand Ballroom Level

Amenities


Program InformationConference Summary

The American Heart Association’s High Blood Pressure Research 2014 Scientific Sessions provides a critical forum to present the latest evidence in the optimal management of hypertension, obesity, metabolic syndrome and atherosclerosis. Considered one of the most important medical meetings on this subject in the world, the conference includes oral and poster presentations selected from abstracts submitted by clinical and basic researchers from more than 20 countries. These are all followed by discussions led by leading authorities. The conference will provide an educational program for physicians and research investigators that will enhance their knowledge, advance their skills and apprise them of the latest developments in research pertaining to hypertension and its relationship to stroke, cardiac disease, kidney function/renal diseases, obesity and genetics.

Conference Learning Objectives

After completing this program, participants will be able to:

• Discuss recent studies linking air pollution and other novel risk factors with hypertension and identify unmet needs for future research.

• Describe current research on the effect of APOL1 allele variants on kidney disease in African-Americans, unmet research needs and therapeutic implications.

• Describe knowledge and clinical gaps in the use of novel approaches to treat hypertension, and in new targets for clinical intervention.

• Discuss current knowledge and knowledge gaps regarding the relationship between obesity and hypertension.

• Describe the pathophysiology of diastolic heart failure and the implications for therapeutic interventions.

• Describe novel methods to measure and predict hypertension that can be used in research and clinical practice.

HypertensionPublishing the best high blood pressure–related articles, focused on basic science, clinical treatment, and

prevention of hypertension and related cardiovascular, metabolic, and renal diseases.

EDITOR-IN-CHIEFAnna F. Dominiczak, OBE, MD, FRCP, FRSE, FAHA, FMedSci

hyper.ahajournals.org

A subscription includes access to Hypertension online and on your iPad®.

Submit Your Manuscript

Watch Case Presentations

http://hype-submit.aha-journals.org

https://learn.heart.org/Catalog.aspx

TIME FROM SUBMISSION TO FIRST DECISION IS 2 WEEKS

NOW ONLINE: 3 VIDEOS FROM THE 2014 HYPERTENSION CLINICAL-PATHOLOGICAL CONFERENCE

Apple and iPad are trademarks of Apple Inc., registered in the U.S. and other countries. App Store is a service mark of Apple Inc.

An American Heart Association Journal


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Program Information (continued)

Conference Highlights

Opening Session and Keynote Lecture Please join us on Tuesday, Sept. 9 at 5:30 pm for the opening session of the High Blood Pressure Research 2014 Scientific Sessions. Dr Costantino Iadecola. Director of the Brain and Mind Research Institute, Weill Cornell Medical College will give a keynote address entitled “The Key Role of Hypertensive Microvascular Dysfunction in Stroke and Cognitive Impairment.” Be sure to join us for this session!

How-To Sessions A How To session will be offered on Wednesday, Sept. 10 and Thursday, Sept. 11 from 7:00–8:00 am. These are primarily designed to benefit trainees and early career attendees, but are open for all conference attendees. These informal and interactive sessions will provide in-depth information regarding various topics.

Wednesday, September 10

7:00–8:00 am How-To Session I: How to Create an Individual Development Plan Philip S. Clifford, PhD, University of Illinois Chicago, Chicago, Illinois Franciscan C

Thursday, September 11

7:00–8:00 am How to Build Support for Science: Lessons in Effective Communication Alice W. Ra’anan, American Physiological Society, Bethesda, Maryland Franciscan C

Reception and Poster Session featuring Trainees Tuesday, Sept. 9, 6:30–9:30 pm Grand Ballroom A The annual gathering takes place immediately following the keynote beginning at 6:30 pm. This year’s poster session will highlight presentations by trainees and feature an on-site poster competition. Be sure to join us for this session and engage conference poster presenters on their innovative research. No additional fee for this event.

Annual Business Meeting and Conference Awards Luncheon Thursday, Sept. 11, 12:30–2:00 pm Imperial Members and non-members are welcome during this luncheon, during which the business of the Council on Hypertension will be discussed. This event also includes a celebratory lunch to acknowledge the 2014 lecture award winners, the winners of the New Investigator Awards and the winner of the 2014 Harry Goldblatt New Investigator Award. The cost to attend this lunch is $35. If you did not pre-register for this event, please visit the conference registration desk to see if tickets are still available. Details regarding the 2014 award winners can be found on page 11 of this program.

Trainee/Early Career Focused Events Join us for events geared to early career attendees at the conference. Events include:

• Tuesday, Sept. 9 — Poster Session I featuring Trainees: 6:30–9:30 pm

• Wednesday, Sept. 10 and Thursday, Sept. 11 — How to Sessions: 7:00–8:00 am each day

• Wednesday, Sept. 10 — Trainee Advocacy Dinner and Mixer 7:00 pm The Trainee Advocacy Committee of the Council for High Blood Pressure Research is offering a dinner for trainees only, but all conference attendees are welcome to the entertainment portion of the mixer. Please note there is limited capacity and seating will be on a first-come, first-served basis.

Excellence Award in Hypertension Research Supported by a grant from Novartis Pharmaceuticals Corporation The events for this prestigious award begins with a lecture at 5:15 pm Thursday, Sept 11. Join us for a conference-wide reception 7:30–8:00 pm to honor this year’s recipients, Thomas Coffman, MD and Toshiro Fujita, MD, PhD. The annual dinner will begin at 8:00 pm. If you did not pre-register for this event, please visit the conference registration desk to see if tickets are still available.


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Exhibits Exhibits are located in the Yosemite Room beginning at 7:00 am Wednesday, Sept. 10. Please take a moment to visit our exhibitors. Refreshments will also be available in the Yosemite Room during breaks.

Exhibitor Hours:

• Wednesday, Sept. 10, 7:00 am–3:30 pm

• Thursday, Sept. 11, 7:00 am–5:30 pm


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The Council on Hypertension is pleased to present…

The Excellence Award in Hypertension ResearchSupported by a grant from Novartis Pharmaceuticals Corporation

Thursday, September 11, 2014

Life with Angiotensin ReceptorsThomas M. Coffman, MDProfessor and Chief, Division of Nephrology, Duke University, Durham, NC

Mechanisms of Salt-Sensitive HypertensionToshiro Fujita, MD, PhDProfessor at University of Tokyo, Tokyo, Japan

Lectures5:15 pm

Grand Ballroom B

Reception 7:30 pm

Imperial

Dinner 8:00 pm

Grand Ballroom BPre-registration or invitation only

(ticket required for entrance)



Conference Awards

Irvine Page — Alva Bradley Lifetime Achievement Award

Brian J. Morris, DSc, PhD, FAHA, School of Medicine, Sydney Medical School, Sydney, AustraliaThe Lifetime Achievement Award is named in honor of Dr. Irvine Page and Alva Bradley, who played prominent roles in establishing the National Foundation for High Blood Pressure Research in 1945. The foundation became the Council on Hypertension of the American Heart Association.

The Lifetime Achievement Award is presented each year to an individual who has had a lifetime of outstanding achievements in the field of hypertension and has served as a role model through service, research and teaching. In general, the recipient of this award must have had a career spanning at least 25 years. We are pleased to present this year’s award to Brian J. Morris, DSc, PhD, FAHA, Professor Emeritus, School of Medical Sciences and Bosch Institute, Sydney, Australia. The award will be presented on Wednesday, Sept. 10 at 8:00 am in Grand Ballroom B. Please join us for the presentation of this award.

Arthur C. Corcoran Memorial Lecture

Sadayoshi Ito, MD, PhD, Professor and Executive Vice President, Tohoku University, Sendai, JapanThe Arthur C. Corcoran Memorial Lecture was established in 1977 to honor Dr. Arthur C. Corcoran for his early application of clearance methods in both hypertensive patients and animals. The lecture will be presented by Sadayoshi Ito, MD, PhD on Wednesday, Sept. 10 at 3:00–3:30 pm. The Lewis K. Dahl Memorial Lecture

Bina Joe, PhD, FAHA, Professor, University of Toledo, Toledo, OH The Lewis K. Dahl Memorial Lecture was established in 1988 by the Council for Hypertension in honor of Dr. Dahl’s pioneering work on the relations between salt, the kidney and hypertension, and the establishment of a major genetically based experimental model of hypertension, the Dahl salt-sensitive rat. Bina Joe, PhD will present the lecture this year on Friday, Sept. 12 from 8:00–8:30 pm. The Harriet Dustan Award

Lilach O. Lerman, MD, PhD, Career Scientist/Professor of Medicine and Physiology, Mayo Clinic, Rochester, MNThe Harriet Dustan Award is designed to recognize women investigators who have made outstanding contributions in the field of hypertension. This award was established to honor the memory of Dr. Harriet Dustan, an outstanding clinician and investigator who was a tireless worker on behalf of the Council on Hypertension and the American Heart Association for more than 50 years. In addition to her numerous career achievements, Dr. Dustan served the AHA as president, chaired its Ethics and Research Committees, and was the founding editor-in-chief of Hypertension. This year’s honoree, Lilach O. Lerman, MD, PhD, will present her lecture on Thursday, Sept. 11 from 10:30–11:00 am.

The Donald Seldin Lecture

Alicia A. McDonough, PhD, Professor, Cell and Neurobiology, Keck School of Medicine of USC, Los Angeles, CAThe Donald Seldin Lecture was created to honor Dr. Donald Seldin, a pioneer and leader in the field of cardiovascular disease as it relates to kidney failure. This lecture continues to raise the awareness of AHA attendees about the rising epidemic of cardiovascular disease and mortality in patients with chronic kidney disease. We are pleased to announce the lecture will be presented by Alicia McDonough, PhD on Thursday, Sept. 11 from 8:00–8:30 am.

Mid-Career Award for Research Excellence

Iris Z. Jaffe, MD, PhD, Associate Professor of Medicine, Tufts Medical Center,Boston, MAThis award recognizes a mid-career investigator active in hypertension or cardiovascular research. This year’s winner Iris Z. Jaffe, MD, PhD was selected for her major contributions to the field of hypertension and will be honored at the awards luncheon taking place Thursday, Sept. 11 at 12:30 pm.

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Council Distinguished Achievement Awards

Distinguished Achievement Award recognizes individuals who have made major contributions to the affairs of a scientific council over a continuing period, and have made substantial professional contributions to the field represented by the council. This award was created in 1980 to recognize AHA/ASA members for significant, original and sustained scientific contributions to new knowledge, teaching and clinical care that have advanced the association’s mission “Building healthier lives, free of cardiovascular diseases and stroke.”

Council on Hypertension Distinguished Achievement Award

Jane F. Reckelhoff, PhD, Billy S. Guyton Distinguished Professor; Professor of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, MS

Dr Reckelhoff will be recognized at 8:30 am on Wednesday, Sept. 10 in Grand Ballroom B.

Council on the Kidney in Cardiovascular Disease Distinguished Achievement Award

Jeff M. Sands, MD, Juha P. Kokko Professor of Medicine and Physiology, Emory University, Atlanta, GA

Dr Sands will be recognized at 8:30 am on Wednesday, Sept. 10 in Grand Ballroom B.

The Harry Goldblatt New Investigator Award Sponsored by the Council for High Blood Pressure Research

The program recognizes a new independent investigator working in hypertension or cardiovascular research who has significantly contributed to our understanding of the causes of hypertension and related cardiovascular disease. The three finalists for 2014 will present their abstracts on Wednesday, Sept. 10 at 4:00 pm in Grand Ballroom B. The winner will be announced during the Annual Business Meeting/Awards Lunch on Thursday, Sept. 11 at 12:30 pm in Imperial.

4:00 pm Experimental Modest Weight Gain Increases 24-h Blood Pressure in Lean Healthy Subjects: Implications of Increased Visceral Fat Naima Covassin, Prachi Singh, Fatima H. Sert-Kuniyoshi, Abel Romero-Corral, Diane E Davison, Francisco Lopez-Jimenez, Michael D. Jensen, Virend K. Somers, Mayo Clinic, Rochester, MN

4:15 pm Dpp4 Inhibition Substantially Reverses Ang II-mediated Inflammation and Kidney Injury Independent of BP Reduction Ravi Nistala, Annayya Aroor, Alex Meuth, James Sowers, Adam Whaley-Connell, Shawn Bender, Susan Mckarns, Univ of Missouri-Columbia, Columbia, MO

4:30 pm Novel Role of Nlrp3 Inflammasome Activation beyond Canonical Inflammation: Coronary Endothelial Injury and Repair Yang Zhang, Min Xia, Yang Chen, Ashley L. Pitzer, Xiang Li, Krishna M. Boini, Pin-Lan Li, Virginia Commonwealth Univ, Richmond, VA

Australian High Blood Pressure Research Council Australia Young Investigator Award

Wednesday, Sept.10

4:45 pm The Effects of Positive Allosteric Modulation of Gabaa Receptors Upon Stress and Hypertension in Schlager Hypertensive Mice Emily Stevenson BBiomedSc (Hons), Baker IDI Heart and Diabetes Institute, Melbourne, Australia

British Hypertension Society Young Investigator Award

Wednesday, Sept.10

5:00 pm Chloe Park, PhD, University College London, London



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Abstract Awards

Annual High Blood Pressure Research Conference New Investigator Award Sponsored by the Council on Hypertension

Name Abstract/Presentation Number Day/TimeMasashi Mukoda 331 Tuesday, Sept. 9, 6:30 pm

Jiandong Zhang 2 Wednesday, Sept. 10, 8:45 am

Michelle Sullivan 23 Wednesday, Sept. 10, 11:30 am

Nan Cher Yeo 25 Wednesday, Sept. 10, 12:30 pm

Fei Wang 26 Wednesday, Sept. 10, 12:45 pm

Yan Hu 48 Thursday, Sept. 11, 8:30 am

Trevor Hardigan 64 Thursday, Sept. 11,12:00 pm

Jorge Giani 73 Thursday, Sept. 11, 3:45 pm

Annette de Kloet 81 Friday, Sept. 12, 9:15 am

Keisuke Shinohara 80 Friday, Sept. 12, 9:00 am

Council on Hypertension New Investigator Award Supported by the Council on Hypertension Trainee Advocacy Committee

Name Abstract/Presentation Number Day/TimeDenise Cornelius 27 Wednesday, Sept. 10, 1:00 pm

Jenny Sones 28 Wednesday, Sept. 10, 1:15 pm

Jing Wu 53 Thursday, Sept. 11, 9:45 am Maria Peleli 77 Thursday, Sept. 11, 4:45 pm

Muhammad Oneeb Rehman Mian 98 Friday, Sept. 12, 11:00 am

Kidney Council New Investigator Award Supported by the Council on Kidney in Cardiovascular Disease

Name Abstract/Presentation Number Day/TimeSathnur Pushpakumar 231 Tuesday, Sept. 9, 6:30 pm

Eric Judd 327 Tuesday, Sept. 9, 6:30 pm

Emily Henson 328 Tuesday, Sept. 9, 6:30 pm

Ebaa Alzayadneh 234 Tuesday, Sept. 9, 6:30 pm

Ajeeth Pingili 250 Tuesday, Sept. 9, 6:30 pm

Keisa Mathis 35 Wednesday, Sept. 10, 6:00 pm

Varunkumar Pandey 47 Thursday, Sept. 11, 9:45 am

Gabor Bodonyi-Kovacs 59 Thursday, Sept. 11, 12:15 pm

Brahmaraju Mopidevi 89 Friday, Sept. 12, 9:45 am

Ting Yang 86 Friday, Sept. 12, 9:00 am

New Investigator Travel Award for Japanese Fellows

Name Abstract/Presentation Number Day/Time Tomohiko Kisaka 329 Tuesday Sept. 9, 6:30 pm

Fusakazu Jo 83 Friday, Sept. 12, 9:45 am

Clinical Science Award

Name Abstract/Presentation Number Day/Time Francisco Rios 9 Wednesday, Sept. 10, 9:00 am


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General InformationRegistration

The conference registration desk can be found in the Yosemite Room of the Hilton SF Union Square Hotel. Pre-registered attendees can pick up their conference badge here. Please inquire here if you need a ticket for any of the ticketed events. The registration desk will be open beginning at 2:00 pm on Monday, Sept. 8 and will close at 11:00 am on Friday, Sept. 12.

Speaker Resource RoomThe Speaker Resource Room is in the Taylor Room. Speakers are asked to deliver their presentations on a USB drive to the Speaker Resource Room at least 12 hours before the beginning of the session in which they will speak. This will allow you time to prepare, rehearse and finalize your presentation before submitting it. Speakers may review and revise their presentations before submission. It is imperative that you review your presentation in the Speaker Resource Room if it contains video files or was created on a Macintosh computer. Staff will be available to assist with technical issues.

The Speaker Resource Room will be open during the following hours:

Monday, Sept. 8 2:00–6:00 pm

Tuesday, Sept. 9 7:00 am–6:00 pm

Wednesday, Sept. 10 7:00 am–6:00 pm

Thursday, Sept. 11 7:00 am–6:00 pm

Friday, Sept. 12 7:30–11:00 am

Abstract InformationAbstracts presented at the High Blood Pressure Research 2014 Scientific Sessions will be published in the Hypertension journal. It will be available at hyper.ahajournals.org. Abstracts presented at this conference are included in this program book for your reference as well.

Abstracts 1–101 will be presented as oral presentations throughout the conference.

Late-breaking abstracts start at presentation number 600 and above. They will be presented during Poster Session II and III.

Poster Session II and III will feature a 30 minute moderated poster session in the middle of each session. Five posters will be highlighted and attendees will be able to engage the presenters during this period.

Abstracts 200–585 and 600–670 will be presented as poster presentations as follows:

• Poster Session I, Tuesday, Sept. 9, 6:30–9:30 am, Abstracts 200–360

• Poster Session II, Wednesday, Sept. 10, 1:30–3:30 pm, Abstracts 400–499, 600–629, MP 01–MP 05

• Poster Session III, Thursday, Sept. 11, 2:00–3:30 pm, Abstracts 500–585, 630–670, MP 06–MP 10

All poster sessions will be held in the Grand Ballroom A.

Poster Session Date Presentation Time Set-up Time Tear-Down Time

Session I Tuesday, Sept. 9

6:30–9:30 pm 2:00–6:30 pm 9:30–10:00 pm

Session II Wednesday, Sept.10

1:30–3:00 pm 10:00 am–1:30 pm 3:00–3:30 pm

Session III Thursday, September 11

2:00–3:30 pm 10:00 am–2:00 pm 2:00–2:30 pm

ePostersNEW! ePosters and QR Code with Audio/Video

We are excited to offer ePosters for the first time at HBPR 2014! Poster presenters were asked to upload an ePoster and audio/video file. The QR codes allow attendees to view poster information through their smart phones and listen/view the author’s discussion of the study through a pre-recorded audio/video file.


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Policy InformationDisclaimer The High Blood Pressure Research 2014 Scientific Sessions is a scientific and educational conference for exchanging and discussing research results and scientific developments in the field of cardiovascular outcomes research. Accordingly, the American Heart Association cannot and does not offer any assurance or warranty of the accuracy, truthfulness or originality of the information presented at the conference.

Embargo GuidelinesAbstracts, lectures and presentations in HBPR 2014 are embargoed for release at the time of presentation. Information may not be released before the scheduled presentation time.

Photography/Recording PolicyUnauthorized recording of the AHA Scientific Sessions, scientific conferences and the ASA International Stroke Conference is prohibited, whether by video, still or digital photography, audio or any other recording or reproduction mechanism. This includes recording of presentations and supporting audio-visual materials, poster presentations and supporting poster materials.

The American Heart Association and America Stroke Association reserve the rights to all recordings or reproductions of presentations at AHA/ASA scientific conferences and meetings. Check the program for information about the availability of videotapes or audiotapes for purchase. Exceptions to this policy prohibition are:

1. Non-flash photography of the speaker and his/her presentation materials is permitted by attendees or AHA/ASA accredited reports upon the prior written consent of the AHA/ASA and of the speaker.

2. Audiotape recording for strictly personal and non-commercial use is permitted if not disruptive; and exhibitors may photograph their own booth for promotional purposes upon prior written consent of the AHA/ASA.

Conference PhotographyPlease be aware that during HBPR 2014 attendees, vendors and guests may be photographed and videotaped by AHA vendors in capturing the course of the event. Some of these photographs or videos may be displayed by the AHA in future publications or materials connected with the event. If you do not wish your image to be displayed by the AHA, please contact the AHA in writing at 7272 Greenville Avenue, Dallas, TX 75231, Attention: Manager, Scientific Conferences, HBPR 2014 Scientific Sessions, no later than Sept. 30, 2014.

No Smoking PolicyAHA policy prohibits smoking in conference meeting rooms and exhibits/registration areas. Thank you for your cooperation.

Seating/Badge RequirementSeating is on a first-come, first-served basis. According to fire code, a session must be closed if the room fills to capacity. You must wear your name badge at all times during the symposium. Nonregistered guests may not be permitted into the sessions or food and beverage events. Be sure to remove your badge when you leave the conference or your hotel room.

The American Heart Association reserves the right to revoke or deny attendance to any registered participant, speaker, exhibitor, news media reporter, or photographer of presentations or activities at AHA/ASA scientific conferences and meetings.


Program AgendaTUESDAY, SEPTEMBER 9

7:00 am

Registration OpensYosemite

8:00 am–4:30 pm

Review of Hypertension Symposium Open to all conference attendee. No additional cost. Plaza

Session I Session Chairs: Fred Luft, MD, Max-Delbrück Center, Berlin, Germany James Sowers, MD, University of Missouri, Kansas City, MO

8:00 Hypertension Perspectives

Highlights of the Recommendations from the Panel Members Appointed to the Eighth Joint National Committee (JNC8) Suzanne Oparil, MD, University of Alabama, Birmingham, AL

Hypertension: Its Impact on Global Health and Mortality Bernadette Thomas, MD, MS, Institute for Health Metrics and Evaluation, Seattle, WA

9:00 Brain

Brain Vascular Responses to Diabetes and Sepsis Feng Han, PhD, Zhejiang University, Hang Zhou, China

Is Oxidative or Endoplasmic Reticulum Stress the Key Switch for Hypertension in the Brain? Robin Davisson, PhD, Cornell University, Ithaca, NY

10:00 Gut

The Microbiome as a Novel Focus for Disease and Therapy Dominic Muller, PhD, Charite Hospital, Berlin, Germany

Intenstinal Na+/H+ Exchanges: A Novel Target for CVD and Hypertension Andrew G. Spencer, PhD, Stanford University, Stanford, CA

11:00 Aldosterone

Aldosterone Antagonists to Preserve Organ Function and Lower Blood Pressure Domenic Sica, MD, PhD, Virginia Commonwealth University, Richmond, VA

Diastolic Dysfunction: Role of Aldosterone in Cardiac Hypertrophy and Fibrosis Bertram Pitt, MD, University of Michigan, Ann Arbor, MI

12:00 Break

Session II Session Chairs: Allan Crowley, PhD, Medical College of Wisconsin, Milwaukee, WI Matthew Weir, MD, University of Maryland, Baltimore, MD

1:00 Diabetes

Hypoxia and Progression of Diabetic Renal Disease Frederick Palm, PhD, University of Uppsala, Uppsala, Sweden

Prospects for Rreventing Diabetic Nephropathy George Bakris, MD, University of Chicago, Chicago, IL

2:00 Genetics

Using Gene Manipulation to Understand Hypertension Thomas Coffman, MD, Duke University, Durham, NC

Progress in Understanding the Genetic Basis of Human Hypertension Anna Dominiczak, OBE, MD, Institute of CV and Molecular Science, Glasgow, Scotland

3:00 Salt

Pressor Natriuresis and Renal Mechanisms of Salt Sensitivity John Hall, PhD, University of Mississippi Medical Center, Jackson, MS

The Controversy Over Salt Intake, BP and CVD Theodore Kotchen, MD, Medical College of Wisconsin, Milwaukee, WI

4:00 General Discussion

5:30–6:30 pm Opening Session and Keynote Lecture Grand Ballroom B

5:30 Remarks by the AHA President Elliott Antman, MD, President American Heart Association, Brigham and Women’s Hospital, Associate Dean for Clinical/Translational Research, Harvard Medical School, Boston, MA

5:45 Keynote Address: Key Role of Hypertensive Microvascular Dysfunction in Stroke and Cognitive Impairment Costantino Iadecola, MD. Weill Cornell Medical College, New York, NY

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6:30–9:30 pm Poster Session I Trainee Onsite Poster Competition and Reception Grand Ballroom A

Posters 200–360 will be presented during this session. The session will also feature an onsite poster competition. All presenters who have not received a travel award are eligible for the competition. Onsite poster award winners will be announced during the awards luncheon.

This session features trainee poster presentations in the following categories:

Aldosterone, Its Receptors and Other Hormones 200Angiotensin Action and Signaling 201–202Blood Pressure Monitoring 203–206Brain Mechanisms 207–211Cardiac Hypertrophy and Dysfunction 212–217Cardiovascular-Renal Interactions 218–221Cerebrovascular Disease and Stroke 222–226Chronic Kidney Disease 227–231Diabetes 232–234Endothelial Function and Aging 235–236Epidemiology 237–243Gender Differences 244–250Genetics, Gene Therapy, Proteomics and Metabolomics 251–252Inflammation, Immunity and Cytokines 253–263Non-invasive Methods 264–265Novel Therapeutic Approaches, Clinical Studies and Trials 266–270Nutrition and Hypertension 271Obesity Insulin Resistance and Metabolic Syndrome 272–278Oxidative Stress 279–284Peripheral Neural Mechanisms 285Pregnancy and Preeclampsia 286Receptors and Signal Transduction 296–297Renal Hemodynamics and Renovascular Hypertension 298–301Renal Tubular Transport 302–304Renin-Angiotensin System 305–317Salt and Hypertension 318–329Secondary Resistant and Renovascular Hypertension 330Vascular Biology 331–340Vascular Remodeling and Dysfunction 341–353Vascular Stiffness 354–355

WEDNESDAY, SEPTEMBER 10

7:00–8:00 am

Continental BreakfastYosemite

7:00–8:00 am How-To Session I How to Create an Individual Development Plan Philip S. Clifford, PhD, University of Illinois Chicago, Chicago, Illinois Franciscan C

Session Chairs: Dylan Burger, PhD, Kidney Research Centre, Ottawa, Ontario, Canada Mariela Mendez, PhD, Henry Ford Hospital, Detroit, MI

8:00–8:30 am Oral Session I Presentation of the Lifetime Achievement Award and Distinguished Scientists Award Grand Ballroom B

2014 Irvine Page-Alva Bradley Lifetime Achievement Award Brian J. Morris, DSc, PhD, FAHA, Professor Emeritus, School of Medical Sciences and Bosch Institute, Sydney Medical School, The University of Sydney, Sydney, Australia

2014 Council on Hypertension Distinguished Achievement Award Jane F. Reckelhoff, PhD, Billy S. Guyton Distinguished Professor, Professor of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, MS

2014 Council on the Kidney in Cardiovascular Disease Distinguished Achievement Award Jeff M. Sands, MD, Juha P. Kokko Professor of Medicine and Physiology, Emory University, Atlanta, GA

8:30–10:00 am Oral I Concurrent A: Inflammation, Immunity and Cytokines Grand Ballroom B

Moderators: Meena Madhur,MD, PhD, Vanderbilt, Brentwood, TN Dominik N Muller, PhD. Max-Delbruck Center and Clinical Experimental Research Center, Berlin, Germany

8:30 Axl Expression by CD4+ T Lymphocytes 001 Promotes Salt-Dependent Hypertension Kristine M. Wadosky, Sri N. Batchu, Angie Hughson, Kathy Donlon, Craig N. Morrell, Deborah J. Fowell, Vyacheslav A. Korshunov, Univ of Rochester, Rochester, NY

8:45 Activation of AT1 receptors on Dendritic 002 Cells Restrains Angiotensin II-Dependent Hypertension Through a CCR7-dependent Mechanism Jiandong Zhang, Norah S. Karlovich, Robert Griffiths, Steven D. Crowley, Duke Univ, Durham, NC


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9:00 Cholinergic Expansion of an Inflammatory 003 Macrophage Population in the Pre-Hypertensive Spontaneously Hypertensive Rat Sailesh Harwani, Mark W. Chapleau, Fayyaz Sutterwala, Zuhair Ballas, David Meyerholz, Francois M. Abboud, Univ of Iowa, Iowa City, IA

9:15 Interleukin 17a Regulates Salt and Water 004 Retention Through Enhanced Sgk1 and Nhe3 Expression in the Renal Proximal Tubule Allison E. Norlander, Annet Kirabo, Juan Gnecco, Vanderbilt Univ, Nashville, TN; Nikhil Kamat, Univ of Southern California, Los Angeles, CA; Mohamed A. Saleh, Vanderbilt Univ, Nashville, TN; Alicia McDonough, Univ of Southern California, Los Angeles, CA; David G. Harrison, Meena S. Madhur, Vanderbilt Univ, Nashville, TN

9:30 Involvement of Decreases in Regulatory 005 T Cells and Splenic Sympathetic Nerve in the Development of Hypertension in Genetically Hypertensive Rats Masato Katsuki, Yoshitaka Hirooka, Takuya Kishi, Kenji Sunagawa, Kyushu Univ Graduate Sch of Medical Sciences, Fukuoka, Japan

9:45 Mutation of SH2B3, a GWAS Candidate 006 Gene for Hypertension, Attenuates Dahl SS Pathology Nathan P. Rudemiller, Hayley Lund, Aron Geurts, David L. Mattson, Medical Coll of Wisconsin, Milwaukee, WI

8:30–10:00 am Oral I Concurrent B: Aldosterone, Its Receptors and Other Hormones Plaza A

Moderators: Elise P. Gomez-Sanchez, PhD, University of Mississippi Medical Center, Jackson, MS TBD

8:30 Effects Of Finerenone - A Novel 007 Non-steroidal Mineralocorticoid Receptor Antagonist In A Model Of Pressure Overload-induced Cardiac Hypertrophy Jana Grune, Verena Benz, Sarah Brix, Zsofia Ban, Janek Salatzki, Beata Hoeft, Anna Foryst-Ludwig, Charité Berlin, Berlin, Germany; Robert Klopfleisch, Freie Univ Berlin, Berlin, Germany; Peter Kolkhof, Bayer Healthcare, Elberfeld, Germany; Ulrich Kintscher, Charité Berlin, Berlin, Germany

8:45 Novel Pathological Diagnosis Between 008 Aldosterone Producing Adenoma and Idiopathic Hyperaldosteronism Fumitoshi Satoh, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Yoshitsugu Iwakura, Kei Omata, Div of Nephrology, Endocrinology and Vascular Med, Tohoku Univ Hosp, Sendai, Japan; Kazumasa Seiji, Kei Takase, Dept of Diagnostic Radiology, Tohoku Univ Hosp, Sendai, Japan; Yasuhiro Nakamura, Dept of Pathology, Tohoku Univ Hosp, Sendai, Japan; Masao Doi, Dept of Systems Biology, Kyoto Univ, Kyoto,, Japan; Hitoshi Okamura, Dept of Systems Biology, Kyoto Univ, Kyoto, Japan; Celso Gomez- Sanchez, Div of Endocrinology, G.V. Montgomery VA Medical Ctr, and the Univ of Mississippi Medical Ctr, Jackson, MS; Hironobu Sasano, Dept of Pathology, Tohoku Univ Hosp, Sendai, Japan; Sadayoshi Ito, Div of Nephrology, Endocrinology and Vascular Med, Tohoku Univ Hosp, Sendai, Japan

9:00 CETP inhibitors Torcetrapib, Dalcetrapib, 009 and Anacetrapib induce adipocyte-derived Aldosterone production through Nox and STAT3 activation Francisco J. Rios, Univ of Glasgow, Glasgow, United Kingdom; Karla B. Neves, Univ of Sao Paulo, Ribeirao Preto, SP, Brazil; Aurelie Nguyen Dinh Cat, Sarah Even, Univ of Glasgow, Glasgow, United Kingdom; Roberto Palacios, Univ Rey Juan Carlos, Madrid, Spain; Carol Jenkins, Andy Carswell, Augusto C. Montezano, Rhian M. Touyz, Univ of Glasgow, Glasgow, United Kingdom

9:15 Adipocyte-derived Aldosterone and 010 Cortisol Are Nox1/4 Dependent: Implications in Obesity-associated Vascular Dysfunction Sarah E. Even, Francisco J. Rios, Aurélie Nguyen Dinh Cat, Univ of Glasgow, Glasgow, United Kingdom; Tayze T. Antunes, Marie Briet, Ying He, Glaucia E. Callera, Univ of Ottawa, Ottawa, ON, Canada; Karin Jandeleit-Dahm, Mark Cooper, Baker Inst, Melbourne, Australia; Cedric Szyndralewiez, Patrick Page, Genkyotex, Geneva, Switzerland; Augusto C. Montezano, Rhian M. Touyz, Univ of Glasgow, Glasgow, United Kingdom




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9:30 Identification and Electrophysiological 011 Characterization of a Novel Somatic Mutation (insT149KCNJ5) of the Potassium Channel Kir3.4 (KCNJ5) Gian Paolo Rossi, Maniselvan Kuppusamy, Brasilina Caroccia, Univ Hosp, Padua, Italy; Michael Bader, Max-Delbrück-Ctr for Molecular Med, Berlin, Germany; Livia Lenzini, Univ Hosp, Padua, Italy; Julia Stindl, Sascha Bandulik, Medical Cell Biology, Univ of Regensburg, Regensburg, Germany; Francesca Gioco, Univ Hosp, Padua, Italy; Veniamin Fishman, Max-Delbrück-Ctr for Molecular Med, Berlin, Germany; Giuseppe Zanotti, Dept of Biomedical Sciences, Univ of Padova, Padua, Italy; Celso Gomez-Sanchez, Univ of Mississippi Medical Ctr, Jackson, MS; Richard Warth, Medical Cell Biology, Univ of Regensburg, Regensburg, Germany

9:45 Mineralocorticoid Receptors Mediate 012 Western Diet-Induced Macrophage Polarization and Aortic Stiffness Guanghong Jia, Annayya R. Aroor, Vincent G. DeMarco, Zhe Sun, Brian P. Bostick, Gerald A. Meininger, Univ of Missouri, Columbia, MO; Iris Jaffe, Tuffs Univ Medical Sch, Boston, MA; James R. Sowers, Univ of Missouri, Columbia, MO

10:00–10:30 am Refreshments and Exhibits Yosemite

10:30 am–12:00 pm Oral Session II

10:30 am–12:00 pm Oral II Concurrent A: Obesity and Metabolic Syndrome Grand Ballroom B

Moderators: Lisa A. Cassis, PhD, University of Kentucky, Lexington, KY Ravi Nistala, MD, University of Missouri-Columbia, Columbia, MO

10:30 Chronic Intra-Renal Insulin Infusion 013 Increases Mean Arterial Pressure on a Background of Mild Angiotensin II Hypertension Michael W. Brands, Georgia Regents Univ, Augusta, GA; Alexander Staruschenko, Medical Coll of Wisconsin, Milwaukee, WI; Bonnie L. Blazer-Yost, Indiana Univ, Indianapolis, IN; Rabei Alaisami, Daniel Duggan, Georgia Regents Univ, Augusta, GA

10:45 Brain Endoplasmic Reticulum Stress 014 Mediates the Development of Non-Alcoholic Fatty Liver Disease Julie A. Horwath, Frederick N. Dong, Scott D. Butler, Cornell Univ, Ithaca, NY; Allyn L. Mark, Univ of Iowa, Iowa City, IA; Robin L. Davisson, Colin N. Young, Cornell Univ, Ithaca, NY

11:00 Regulation of Resting Metabolism by 015 the Angiotensin AT2 Receptor Nicole K. Littlejohn, Benjamin J. Weidemann, Nicole A. Pearson, Kathleen R. Markan, Matthew J. Potthoff, Curt D. Sigmund, Justin L. Grobe, Univ of Iowa, Iowa City, IA

11:15 Bbs1 Gene Deletion From the Leptin 016 Receptor Neurons Causes Obesity and Hypertension in Mice Deng Fu Guo, Donald A Morgan, Justin L. Grobe, Darryl Nishimura, Charles Searby, Val C. Sheffield, Kamal Rahmouni, the Univ of Iowa, Iowa, IA

11:30 Spironolactone Improves Insulin 017 Secretion In Metabolic Syndrome Subjects James M. Luther, Loretta M. Byrne, Chang Yu, Vanderbilt Univ Medical Ctr, Nashville, TN

11:45 Sympathetic Contribution to Obesity 018 Hypertension: Differential Hemodynamic Mechanisms between Prehypertension and Hypertension Luis E. Okamoto, Alfredo Gamboa, Cyndya Shibao, Amy C. Arnold, Jorge E. Celedonio, Andre Diedrich, Ginnie Farley, Sachin Y. Paranjape, Italo Biaggioni, Vanderbilt Univ, Nashville, TN

10:30 am–12:00 pm Oral II Concurrent B: Angiotensin Action and Signaling Plaza A

Moderators: Rhian M. Touyz, MD, PhD, FAHA, University of Glasgow, Glasgow, Scotland Christian Delles,MD, University of Glasgow, Glasgow, Scotland

10:30 Vascular Smooth Muscle ADAM17 019 Contributes to Angiotensin II-induced Abdominal Aortic Aneurysm Formation But Not Hypertension in Mice Toshiyuki Tsuji, Takehiko Takayanagi, Katherine Elliott, Takashi Obama, Kevin Crawford, Victor Rizzo, Satoru Eguchi, Temple Univ Sch of Med, Philadelphia, PA


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10:45 Angiotensin Ii-induced Hypertension 020 Has Significant Effects on Proliferation, Differentiation and Engraftment Efficacy of Hematopoietic Stem Cell Seungbum Kim, Christopher R. Cogle, Michael Zingler, Edward W. Scott, Mohan K. Raizada, Univ of Florida, Gainesville, FL

11:00 Haplotype-Dependent Differential 021 Regulation of the Human AT1R Gene is Exacerbated by Age: Effects on Tissue Inflammatory and Redox Milieu Anita Rana, Sudhir Jain, Nitin Puri, Brahmaraju Mopidevi, Meenakshi Kaw, Ashok Kumar, The Univ of Toledo, Toledo, OH

11:15 Evidence for AT2-receptor-MAS 022 Dimerisation from Fluorescence Resonance Energy Transfer (FRET) Imaging and Fluorescence Cross Correlation Spectroscopy (FCCS) Daniel C. Villela, Dept of Physiology and Biophysics, Biological Sciences Inst, Federal Univ of Minas Gerais, Belo Horizonte, Brazil; Anke Teichmann, Leibniz-Inst für Molekulare Pharmakologie (FMP), Berlin, Germany; Sebastian Kirsch, Maibritt Mardahl, Ctr for Cardiovascular Res, Charite – Medical Faculty, Berlin, Germany; Lisa M Münter, Dept. of Biochemistry, Free Univ, Berlin, Germany; Kristin Lucht, Ctr for Cardiovascular Res, Charite – Medical Faculty, Berlin, Germany; Natalia Alenina, Max Delbrück Ctr for Molecular Med, Berlin, Germany; Thomas Unger, CARIM – Maastricht Univ, Maastricht, Netherlands; Michael Bader, Max Delbrück Ctr for Molecular Med, Berlin, Germany; Raph Schülein, Leibniz-Inst für Molekulare Pharmakologie (FMP), Berlin, Germany; Robson A. Santos, Dept of Physiology and Biophysics, Biological Sciences Inst, Federal Univ of Minas Gerais, Belo Horizonte, Brazil; Ulrike M. Steckelings, Univ of Southern Denmark, Odense C, Denmark

11:30 Neuronal Overexpression of the Human 023 (Pro)renin Receptor Increases Sympathetic Tone that is Masked by Upregulation of Endothelial Nitric Oxide Synthase Michelle Sullivan, Wencheng Li, Colorado State Univ, Fort Collins, CO; Curt D. Sigmund, Univ of Iowa Carver Coll of Med, Iowa City, IA; Scott Earley, Univ of Nevada Sch of Med, Reno, NV; Yumei Feng, Colorado State Univ, Fort Collins, CO

11:45 20-HETE Activates the Transcription of 024 Endothelial Angiotensin Converting Enzyme (ACE) via NF-kB Translocation and Promoter Binding Victor Garcia, New York Medical Coll, Valhalla, NY; Laura Milhau, Faculté Pharmacie Montpellier, Montpellier, France; John R. Falck, Univ of Texas Southwestern Medical Ctr, Dallas, TX; Michal L. Schwartzman, New York Medical Coll, Valhalla, NY

12:00–12:30 pm Exhibits and Lunch on your own Yosemite

12:30–1:30 pm Oral Session III Top Trainee Oral Abstracts Grand Ballroom B

Moderators: Theodora Szasz, PhD, Georgia Regents University, Augusta, GA Aaron Trask, PhD, The Research Institute at Nationwide Children’s Hospital, Columbus, OH

12:30 Disruption of Shroom3 Contributes to 025 Impaired Glomerular Podocyte Function Nan Cher Yeo, Caitlin C. O’Meara, Kerry N. Veth, Medical Coll of Wisconsin, Milwaukee, WI; Ritu Tomar, Massachusetts General Hosp, Boston, MA; Michael J. Flister, Medical Coll of Wisconsin, Milwaukee, WI; Iain A Drummond, Harvard Medical Sch, Boston, Boston, MA; Jozef Lazar, Brian A. Link, Howard J. Jacob, Medical Coll of Wisconsin, Milwaukee, WI

12:45 Renal Medullary (Pro)Renin Receptor 028 Mediates Angiotensin II-Induced Hypertension via Enhancement of Local Renin Response and Renal Medullary α-ENaC Expression Fei Wang, Xiaohan Lu, The Inst of Hypertension, Zhongshan Sch of Med, Sun Yat-sen Univ, Guangzhou, China; Yumei Feng, Dept of Physiology, Colorado State Univ, Fort Collins, CO; Tianxin Yang, Dept of Internal Med, Univ of Utah, Salt Lake City, UT

1:00 T cell-Dependent B cell Activation Plays 027 a Role in Mediating Hypertension and Pathophysiology in Response to CD4+ T cells from Reduced Uterine Perfusion Pregnant Rats Denise C. Cornelius, Javier Castillo, Justin Porter, Nathan Campbell, Alexia Thomas, Lorena M. Amaral, Kedra Wallace, Janae Moseley, Babbette LaMarca, Univ of Mississippi Medical Ctr, Jackson, MS



1:15 BPH/5 Pre-eclamptic Mice Have 028 Increased Uterine Interleukin (IL)-15 and This is Associated with Decidual Natural Killer (dNK) Cell Loss at the Maternal-Fetal Interface Early In Pregnancy Jenny L. Sones, Heinrich E. Lob, Catherine E. Isroff, Jiunn Song, Emilie Williamson, Robin L. Davisson, Cornell Univ, Ithaca, NY

1:30–3:00 pm Poster Session II Grand Ballroom A

Moderated Posters Moderated posters on Brain Mechanisms will be featured at 2:00–2:30 pm. The following poster presenters will speak briefly, followed by a few minutes of question and answer.

Moderator: Richard Wainford, PhD, Boston University School of Medicine, Boston, MA

MP 01 Hypertension During Pregnancy is Associated with Cerebral Damage in an Animal Model of Severe Preeclampsia Kedra Wallace, Univ of Mississippi Medical Ctr, Jackson, MS; Sarah Tremble, Univ of Vermont, Burlington, VT; Malikarjuna R. Pabbidi, Rachael Morris, Shauna-Kay Spencer, Univ of Mississippi Medical Ctr, Jackson, MS; Marilyn Cipolla, Univ of Vermont, Burlington, VT

MP 02 Central Tumor Necrosis Factor-alpha Induces Sensitization of Angiotensin II-elicited Hypertension Baojian Xue, Fang Guo, Yang Yu, Terry G. Beltz, Robert B. Felder, Alan Kim Johnson, Univ of Iowa, Iowa City, IA

MP 03 Intracerebroventricular Administration of Autologous Bone Marrow-derived Cells Attenuate Inflammation and Increase in AT1 Receptor in the Brain of Angiotensin II Initiated Hypertensive Rats Masanobu Yamazato, Takuto Nakamura, Akio Ishida, Yoriko Yamazato, Yusuke Ohya, Univ of the Ryukyus, Okinawa, Japan

MP 04 In Vivo Bioluminescence Imaging Reveals a Pre-Hypertensive Surge of Nuclear-Factor-κ-B (NF-κB) Activity in the Subfornical Organ (SFO) During Obesity-Induced Hypertension Colin N. Young, Scott D. Butler, Robin L. Davisson, Cornell Univ, Ithaca, NY

MP 05 Mineralocorticoid and Angiotensin II Type 1 Receptors in the Subfornical Organ Mediate Angiotensin II Hypertension in Rats Hong-Wei Wang, Bing S. Huang, Aidong Chen, Monir Ahmad, Frans H. H. Leenen, Univ of Ottawa Heart Inst, Ottawa, ON, Canada

Poster Topics and Presentation Numbers Abstracts numbered 600 and above are late-breaking submissions.

Aldosterone, Its Receptors and Other Hormones 400 -404, 600Angiotensin Action and Signaling 405-406, 601Angiotensin, ACE Renin and Prorenin 407-408, 602Blood Pressure Monitoring 409-412, 603Brain Mechanisms 413-416, 604 - 605Cardiac Hypertrophy and Dysfunction 417-424, 606-609Cerebrovascular Disease and Stroke 417-424Endothelial Function and Aging 425-430, 610Epidemiology 431-439, 611Gender Differences 440-443, 612Inflammation, Immunity and Cytokines 444-460, 613 - 614Nutrition and Hypertension 461-464, 615Obesity Insulin Resistance and Metabolic Syndrome 465-473, 616-617Renin-Angiotensin System 474-484, 619-626Secondary Resistant and Renovascular Hypertension 485, 627

3:00–3:30 pm Oral Session IV Arthur C. Corcoran Memorial Lecture Demonstration of the Mechanism of Glomerular Hemodynamics and Strain Vessel Theory for Cardio-renal Association Sadayoshi Ito, MD, PhD, Tohoku University, Sendai, Japan Grand Ballroom B

3:30–4:00 pm Refreshments and Exhibits Yosemite

4:00–5:15 pm Oral Session V Goldblatt Award Finalists, Australian Council and British Society Young Investigator Awards Grand Ballroom B

Moderators: Jussara M. do Carmo, PhD, University of Mississippi Medical Center, Jackson, MS Richard Wainford, PhD, Boston University School of Medicine, Boston, MA

4:00 Experimental Modest Weight Gain 029 Increases 24-h Blood Pressure in Lean Healthy Subjects: Implications of Increased Visceral Fat Naima Covassin, Prachi Singh, Fatima H. Sert-Kuniyoshi, Abel Romero-Corral, Diane E. Davison, Francisco Lopez-Jimenez, Michael D. Jensen, Virend K. Somers, Mayo Clinic, Rochester, MN

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4:15 Dpp4 Inhibition Substantially Reverses 030 Ang II-mediated Inflammation and Kidney Injury Independent of BP Reduction Ravi Nistala, Annayya Aroor, Alex Meuth, James Sowers, Adam Whaley-Connell, Shawn Bender, Susan Mckarns, Univ of Missouri-Columbia, Columbia, MO

4:30 Novel Role of Nlrp3 Inflammasome 031 Activation beyond Canonical Inflammation: Coronary Endothelial Injury and Repair Yang Zhang, Min Xia, Yang Chen, Ashley L. Pitzer, Xiang Li, Krishna M. Boini, Pin-Lan Li, Virginia Commonwealth Univ, Richmond, VA

4:45 HBPR Council of Australia Young Investigator The Effects of Positive Allosteric Modulation of

Gabaa Receptors Upon Stress And Hypertension In Schlager Hypertensive Mice Emily Stevenson BBiomedSc (Hons), Baker IDI Heart and Diabetes Institute, Melbourne, Australia

5:00 British Hypertension Society Young Investigator Chloe Park, PhD, University College London, London

5:15–6:30 pm Oral Session VI

5:15–6:30 pm Oral VI Concurrent A: Neurogenic Mechanisms Grand Ballroom B

Moderators: Italo Biaggioni, MD, Vanderbilt University, Nashville, TN Feng Han, PhD, Zhejiang University, Hang Zhou, China

5:15 Carotid Chemoreceptor Activation Blunts 032 the Hypotensive Response Caused by the Electrical Stimulation of the Carotid Sinus in Conscious Rats Pedro L. Katayama, Jaci A. Castania, Rubens Fazan Jr, Helio C. Salgado Sr., Sch of Med of Ribeirão Preto, Ribeirão Preto, Brazil

5:30 Novel Neurohumoral Responses to Head 033 Upright Tilt Testing in Children with Chronic Nausea and Orthostatic Intolerance Ashley L. Wagoner, Wake Forest Univ Health Sciences, Winston-Salem, NC; Hossam A. Shaltout, Debra I. Diz, Hypertension and Vascular Res Ctr, Winston-Salem, NC; John E. Fortunato, Univ of Colorado Sch of Med, Denver, CO

5:45 Transient Receptor Potential Vanilloid-1 034 (TRPV1) Channels Mediate the Sympathoexcitatory and Pressor Responses to Central NaCl Stimulation Sean D. Stocker, Sarah S. Simmonds, Kirsteen N. Browning, Penn State Univ Coll of Med, Hershey, PA

6:00 Cholinergic Agonists Protect from the 035 Development of Hypertension during Chronic Inflammatory Disease Keisa W. Mathis, Univ of Mississippi Medical Ctr, Jackson, MS

6:15 Pomc Neurons, But Not Agrp Neurons, 036 are Required ror Leptin-induced Sympathetic Activation Balyssa B. Bell, Shannon M. Harlan, Donald A. Morgan, Kamal Rahmouni, Univ of Iowa, Iowa City, IA

5:15–6:30 pm Oral VI Concurrent B: Renin-Angiotensin System Plaza A

Moderators: Daniel Battle, MD, Northwestern University, Feinberg School of Medicine, Chicago, IL Jan Wysocki, MD, PhD, Northwestern University, Feinberg School of Medicine, Chicago, IL

5:15 Pancreatic-Angiotensin Type 1a Receptor 037 Deficiency Prevents Angiotensin II-Mediated Reductions In Glucose-Stimulated Insulin Secretion From Isolated Islets of Obese Mice Robin Shoemaker, Lisa Cassis, Univ of Kentucky, Lexington, KY

5:30 MicroRNA-181a Mimic Inhibits the 038 Renin-Angiotensin System and Attenuates Hypertension in a Neurogenic Model of Hypertension Kristy L. Jackson, BakerIDI Heart and Diabetes Inst, Melbourne, Australia; Francine Z. Marques, Federation Univ Australia, Ballarat, Australia; Thu-Phuc Nguyen-Huu, Emily R. Stevenson, BakerIDI Heart and Diabetes Inst, Melbourne, Australia; Fadi J. Charchar, Federation Univ Australia, Ballarat, Australia; Pamela J. Davern, Geoffrey A. Head, BakerIDI Heart and Diabetes Inst, Melbourne, Australia

5:45 Oral Delivery of Angiotensin Converting 039 Enzyme2 and Angiotensin-(1-7) Bioencapsulated in Plant Cells Attenuates Pulmonary Hypertension Vinayak Shenoy, Univ of Florida, Gainesville, FL; Kwang Chul Kwon, Univ of Pennsylvania, Philadelphia, PA; Anandharajan Rathinasabapathy, Univ of Florida, Gainesville, FL; Shina Lin, Guiying Jin, Univ of Pennsylvania, Philadelphia, PA; Chunjuan Song, Pollob Shil, Univ of Florida, Gainesville, FL; Anand Nair, Louisiana State Univ, Baton Rouge, LA; Yanfei Qi, Qiuhong Li, Univ of Florida, Gainesville, FL; Joseph Francis, Louisiana State Univ, Baton Rouge, LA; Michael Katovich, Univ of Florida, Gainesville, FL; Henry Daniell, Univ of Pennsylvania, Philadelphia, PA; Mohan Raizada, Univ of Florida, Gainesville, FL

6:00 Cells of the Renin Lineage in the 040 Peritoneal Cavity Brian Belyea, Theodore C. Mehalic III, R. Ariel Gomez, Maria Luisa S. Sequeira-Lopez, Univ of Virginia, Charlottesville, VA


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6:15 Distinct Populations of Cell Derived 041 Microvesicles in Angiotensin II-induced Hypertension Uta Erdbruegger, Christine Rudy, Joanne Lannigan, Joseph Gigliotti, Sylvia Chechova, Thu Le, Univ of Virginia Health System, Charlottesville, VA

7:00–11:00 pm Trainee Advocacy Mixer * OPEN TO ALL. The TAC welcomes all conference attendees to the entertainment portion of the mixer. Plaza B

THURSDAY, SEPTEMBER 11

7:00–8:00 am

Continental Breakfast Yosemite

7:00–8:00 am How-To Session II How to Build Support for Science: Lessons in Effective Communication Alice W. Ra’anan, American Physiological Society, Bethesda, Maryland Franciscan C

Session Chairs: Analia Loria, PhD, University of Kentucky, Lexington, KY Alta Schutte, PhD, North-West University, Potchefstroom, South Africa


8:00–8:30 AM Oral VII: Seldin Award Lecture Grand Ballroom B

Intrarenal Mechanisms Controlling Potassium and Blood Pressure Homeostasis Alicia A. McDonough, PhD, Professor, Cell and Neurobiology, Keck School of Medicine of USC, Los Angeles, Calif

8:30–10:00 am Oral VII Concurrent A: Renal Tubular Transport Grand Ballroom B

Moderators: Toshiro Fujita, MD, University of Tokyo, Tokyo, Japan Mariela Mendez, PhD, Henry Ford Hosp, Detroit, MI

8:30 Effects of Diuretics on Sglt2 042 Inhibitor-induced Changes in Urinary Sodium Excretion Rate In Obese Metabolic Syndrome Rats Akira Nishiyama, Yoshihide Fujisawa, Abu Sufiun, Kazi Rafiq, Daisuke Nakano, Hiroyuki Kobori, Asadur Rahman, Kagawa Univ Medical Sch, Kagawa, Japan

8:45 Acute K+ Intake Does Not Reduce Renal 043 Na-Cl Cotransporter Phosphorylation During Chronic AngII Hypertension Jiyang Han, Donna Lee, Luciana Veiras, Alicia A. McDonough, USC Keck Sch of Med, Los Angeles, CA

9:00 Ddah-1 And Adma Regulate Proximal 044 Tubular Fluid Reabsorption: Comparison of Pharmacological Blockade of Ddah-1 with Gene Knockdown Christopher S. Wilcox, Tracy Bell, Georgetown Univ Medical Ctr, Washington, DC; James A. Tomlinson, James Leiper, MRC Clinical Science Ctr, Imperial Coll, London, United Kingdom; William J. Welch, Georgetown Univ Medical Ctr, Washington, DC

9:15 Endogenous Flow-induced Superoxide 045 Stimulates Na/H Exchange Activity Via PKC in Thick Ascending Limbs Nancy J. Hong, Jeffrey L. Garvin, Case Western Reserve Univ, Cleveland, OH

9:30 High Fructose Intake Increases 046 Phosphorylation and Trafficking of the Na/K/2Cl Cotransporter (NKCC22) in Rat Thick Ascending Limbs Gustavo R. Ares, Mohammed Z. Haque, Pablo A. Ortiz, Henry ford Health System, Detroit, MI

9:45 20-SOLA, A Novel Water-soluble 20-HETE 047 Antagonist, Elicits Natriuresis and Abrogates Hypertension in Cyp4a14 Knockout Mice Varunkumar G. Pandey, Victor Garcia, Gregory Joseph, Frank Fan Zhang, Brian Shkolnik, Priyanka Mishra, New York Medical Coll, Valhalla, NY; Vijaya L. Manthati, John R. Falck, Univ of Texas Southwestern Medical Ctr, Dallas, TX; Jorge Capdevila, Vanderbilt Univ, Nashville, TN; Michal L. Schwartzman, New York Medical Coll, Valhalla, NY

8:30–10:00 am Oral VII Concurrent B: Vascular Biology Plaza A

Moderators: Satoru Eguchi, MD, PhD, FAHA, Temple University School of Medicine, Philadelphia, PA Vyacheslav Korshunov, PhD, Univeristy of Rochester, Rochester, NY

8:30 The Sphingosine-1-phosphate Receptor 048 S1P1 Regulates Kidney Vascular Development and Heart Development Yan Hu, Maria Luisa Sequeira Lopez, Univ of Virginia, Charlottesville, VA


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8:45 Role of Smooth Muscle BMAL1 in 049 Time-of-day Vasoconstriction Variation and Blood Pressure Circadian Rhythm Zhongwen Xie, Wen Su, Shu Liu, Guogang Zhao, Karyn Esser, Elizabeth A. Schroder, Mellani Lefta, Zhenheng Guo, Ming C. Gong, Univ of Kentucky, Lexington, KY

9:00 Endothelin-1 Overexpression in 050 Endothelial Cells Increases Blood Pressure in an Endothelin Type A Receptor-Dependent Manner Suellen C. Coelho, Yohann Rautureau, Asia Rehman, Lady Davis Inst for Medical Res, SMBD-Jewish General Hosp, McGill Univ, Montreal, QC, Canada; Stefan Offermanns, Dept of Pharmacology, Max-Planck-Inst for Heart and Lung Res and Medical Faculty, J.W. Goethe Univ Frankfurt, Montreal, QC, Canada; Pierre Paradis, Lady Davis Inst for Medical Res, SMBD-Jewish General Hosp, McGill Univ, Montreal, QC, Canada; Ernesto Schiffrin, Dept of Med, Lady Davis Inst for Medical Res SMBD-Jewish General Hosp, McGill Univ, Montreal, QC, Canada

9:15 The Myogenic Tone of Resistance Arteries 051 is Controlled by a Molecular Pathway Driven by Tgfβ Through Emilin1 and Converging on the Regulation of Trp Channels Daniela Carnevale, Sapienza Univ of Rome at IRCCS Neuromed, Pozzilli (IS), Italy; Manuel Casaburo, Massimiliano De Lucia, Fabio Pallante, IRCCS Neuromed, Pozzilli (IS), Italy; Giorgio Bressan, Univ of Padua, Pozzilli (IS), Italy; Giuseppe Lembo, Sapienza Univ of Rome at IRCCS Neuromed, Pozzilli (IS), Italy

9:30 Alpha1a-Adrenoceptor Genetic 052 Variant-Triggered Hyperproliferation in Cardiovascular Cells is Mediated by Novel Interacting Protein Spinophilin Ekaterina Babaeva, Irina Gradinaru, Univ of Washington, Seatlle, WA; Debra A. Schwinn, Univ of Iowa, Iowa City, IA; Anush Oganesian, Univ of Washington, Seatlle, WA

9:45 The Role of Adventitial Sca-1+ 53 Progenitor Cells in Angiotensin II-induced Aortic Stiffening Jing Wu, Kim Montaniel, Vanderbilt Univ, Nashville, TN; Virginia Hoglund, Xiurong Dong, Seattle Children’s Res Inst, Seattle, WA; Wei Chen, Vanderbilt Univ, Nashville, TN; Mark W. Majesky, Seattle Children’s Res Inst, Seattle, WA


10:30–11:00 am Oral Session VIII Harriet Dustan Award Lecture Grand Ballroom B

Protecting the Post-Stenotic Kidney Lilach O. Lerman, MD, PhD, Career Scientist/ Professor of Medicine and Physiology, Mayo Clinic, Rochester, Minnesota

11:00 am–12:30 pm Oral VIII Concurrent A: Epigenetics and Genetics Grand Ballroom B

Moderators: Bina Joe, MD, FAHA, University Toledo, Toledo, OH Mingyu Liang, MB, PhD, Medical College of Wisconsin, Milwaukee, WI

11:00 Mutations In Pde3a Explain Mendelian 054 Hypertension With Brachydactyly Philipp Maass, Atankan Aydin, Friedrich C. Luft, Hakan Toka, Irene Hollfinger, Yvette Wefeld-Neuenfeld, Eireen Bartels-Klein, Astrid Mühl, Enno Klussmann, Okan Toka, Sylvia Bähring, Experimental and Clinical Reseach Ctr, a joint cooperation between the Max-Delbrück Ctr for Molecular Med and the Charité Medical Faculty, Berlin, Germany

11:15 Locating Genetic Determinants of 055 Translational Significance Using the Rat Genome Ying Nie, Sivarajan Kumaraswamy, Xi Cheng, Harshal Waghulde, Blair Mel, Resmi Pillai, Bina Joe, Program in Physiological Genomics, Ctr for Hypertension and Personalized Med, Dept of Physiology and Pharmacology, Univ of Toledo Coll of Med and Life Sciences, Toledo, OH

11:30 Integrative Genomic Analysis Unravels 056 Novel Pathways and Key Regulatory Networks in Blood Pressure Yuqi Zhao, Xingyi Shi, UCLA, Los Angeles, CA; Ville-Petteri Mäkinen, South Australian Health and Medical Res Inst, Adelaide, Australia; Qingying Meng, Xia Yang, UCLA, Los Angeles, CA

11:45 High Salt (NaCl) Reduces the Activation 057 and Function Of Alternatively Activated (M2) Macrophages Via Epigenetic Modifications Katrina Binger, Matthias Gebhardt, Matthias Heinig, Carola Rintisch, Max-Delbruck Ctr for Molecular Med, Berlin, Germany; Agnes Schroeder, Friedrich-Alexander Univ of Erlangen-Nuremberg, Erlangen, Germany; Wolfgang Neuhofer, Univ of Munich, Munich, Germany; Karl Hilgers, Arndt Manzel, Christian Schwartz, Friedrich-Alexander Univ of Erlangen-Nuremberg, Erlangen, Germany; Markus Kleinewietfeld, Dresden Univ of




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Technology, Dresden, Germany; Ralf Linker, Friedrich-Alexander Univ of Erlangen-Nuremberg, Erlangen, Germany; Florian Lang, Univ of Tuebingen, Tuebingen, Germany; David Voehringer, Friedrich-Alexander Univ of Erlangen-Nuremberg, Erlangen, Germany; Norbert Huebner, Max-Delbruck Ctr for Molecular Med, Berlin, Germany; Ralf Dechend, HELIOS-Klinikum Berlin, Berlin, Germany; Jonathan Jantsch, Friedrich-Alexander Univ of Erlangen-Nuremberg, Erlangen, Germany; Jens Titze, Vanderbilt Univ, Nashville, TN; Dominik Muller, Max-Delbruck Ctr for Molecular Med, Berlin, Germany

12:00 Sirt3 Impairment and SOD2 058 Hyperacetylation Drive Vascular Oxidative Stress and Hypertension Rafal Nazarewicz, Anna Dikalova, Joshua P. Fessel, Hana Itani, William McMaster, David G. Harrison, Sergey Dikalov, Div of Clinical Pharmacology, Vanderbilt Univ Medical Ctr, Nashville, TN

12:15 Additive effect of the GSTM1(0) Null and 059 APOL1 High Risk Alleles in the African American Study of Kidney Disease (AASK) Tria Gabor Bodonyi-Kovacs, Jennie Z. Ma, Univ of Virginia, Charlottesville, VA; Michael S. Lipkowitz, Georgetown Univ Sch of Med, Washington, DC; Jeffrey B. Kopp, Natl Insts of Health, Natl Inst of Diabetes and Digestive and Kidney Diseases, Bethesda, MD; Cheryl A. Winkler, Ctr for Cancer Res, SAIC-Frederick, Natl Cancer Inst, Frederick, MD; Thu H. Le, Univ of Virginia, Charlottesville, VA

11:00 am–12:30 pm Oral VIII Concurrent B: Obesity and Diabetes Plaza A

Moderators: James Sowers, MD, University of Missouri, Kansas City, MO Iris Z. Jaffe, MD, PhD, Tufts Medical Center, Boston, MA

11:00 Adipose Derived Stem Cell (ADSC) 060 Therapy Prevents the Progression of Hypertension and Improves Cardiac Functions Yanfei Qi, Anandharajan Rathinasabapathy, Juan Zhang, Michael Zingler, Fong Wong, John W. Petersen, Michael J. Katovich, Mohan K. Raizada, Carl J. Pepine, Univ of Florida, Gainesville, FL

11:15 Prevention Of Oxidative Stress in the 061 Paraventricular Nucleus (PVN) Does Not Attenuate Hypertension During High Fat Diet (HFD), Despite Blunting Weight Gain Heinrich E. Lob, Jiunn Song, Scott D. Butler, Cornell Univ, Ithaca, NY; Allyn L Mark, Univ of Iowa, Iowa City, IA; Robin L. Davisson, Cornell Univ, Ithaca, NY

11:30 Up-regulation of Adenosine A2a Receptor 062 Contributes to Epoxyeicosatrienoic Acids-induced Improvement in Endothelial Function and Decreases in Renal Inflammation in Obese Mice Ahmed A. Elmarakby, Chelsey Pye, Babak Baban, Georgia Regents Univ, Augusta, GA

11:45 Phosphodiesterase 5 Inhibition Improves 063 Insulin Sensitivity and Disposition Index in Prediabetes without Altering Glucose-Stimulated Insulin Secretion Claudia E. Ramirez, Cyndya Shibao, Hui Nian, Chang Yu, James M. Luther, Nancy J. Brown, Vanderbilt Univ, Nashville, TN

12:00 Toll-like Receptor 2 Signaling Contributes 064 to Cerebrovascular Dysfunction and Decreased Cerebral Blood Flow in Type-1 and Type-2 Diabetes Trevor Hardigan, Nasrul Hoda, Mohammed Abdelsaid, Adviye Ergul, Georgia Regents Univ, Augusta, GA

12:15 Soluble Dipeptidyl Peptidase-4 Induces 065 Endothelial Dysfunction by the Release of Vasoconstrictor Prostanoids: Protective Effect of Dipeptidyl Peptidase Inhibitors Concepción Peiró, Univ Autonóma de Madrid, Madrid, Spain; Tania Romacho, Nina Wronkowitz, German Diabetes Ctr, Düsseldorf, Germany; Laura A. Villalobos, Univ Autónoma de Madrid, Madrid, Spain; Henrike Sell, Juergen Eckel, German Diabetes Ctr, Düsseldorf, Germany; Carlos F. Sánchez-Ferrer, Univ Autónoma de Madrid, Madrid, Spain

12:30–2:00 pm Annual Business Meeting and Awards Luncheon *Ticketed event. Imperial

2:00–3:30 pm Poster Session III Grand Ballroom A

Moderated Posters Moderated posters on Brain Mechanisms will be featured at 2:30-3:00 pm. The following poster presenters will speak briefly, followed by a few minutes of question and answer.

Moderator: Stephanie Watts, PhD, Michigan State University, East Lansing, MI

MP 06 The Protein Tyrosine Phosphatase Inhibitors Induce the Vasoconstriction Via Src/epidermal growth factor/rho-kinase Cascade Katsutoshi Yayama, Tomoya Sasahara, Hisaaki Ohba, Natsumi Ohkura, Asami Kobe, Hiroshi Okamoto, Kobe Gakuin Univ, Kobe, Japan


MP 07 Nicotine Promotes Vascular Inflammation and Endothelial Dysfunction In Obese Rats Ming-Sheng Zhou, Chang Liu, Liaoning Medical Univ, Jinzhou, China; Kiranmai Chadipiralla, Runxia Tian, Univ of Miami VA Medical Ctr, Miami, FL; Leopoldo Raij, Univ of Miami VA Medical Ctr, Miami, FL

MP 08 Perivascular Adipose Tissue Reduces Acetylcholine Relaxation in Femoral Artery from Obese Mice Amanda C. Sponton, Andressa S. Sousa, César B. Trifone, Maria A. Delbin, Univ of Campinas, Campinas, Brazil

MP 09 Vascular Rho-kinase Activation by Inflammatory Signaling Mediates Blood Pressure Increase in Overweight Cristiane Aoqui Aoqui, Stefan Chmielewski, Uwe Heemann, Marcus Baumann, Klinikum rechts der Isar, Technical Univ Munich, Munich, Germany

MP 10 Early Functional and Structural Alterations of Resistance Arteries in Mice Treated with an Inhibitor of the Vascular Endothelial Growth Factor Receptor Carmine Savoia, Emanuele Arrabito, Clinical and Molecular Med Dept, Sapienza Univ of Rome, Rome, Italy; Augusto C. Montezano, Inst of Cardiovascular and Medical Sciences, British Heart Fndn Glasgow Cardiovascular Res Ctr, Univ of Glasgow, Glasgow, United Kingdom; Carmine Nicoletti, DAHFMO-Unit of Histology and Med. Embr., Sapienza Univ of Rome, Rome, Italy; Heather Y. Small, Inst of Cardiovascular and Medical Sciences, British Heart Fndn Glasgow Cardiovascular Res Ctr, Univ of Glasgow, Glasgow, United Kingdom; Lidia Sada, Clinical and Molecular Med Dept, Sapienza Univ of Rome, Rome, Italy; Francisco Rios, Inst of Cardiovascular and Medical Sciences, British Heart Fndn Glasgow Cardiovascular Res Ctr, Univ of Glasgow, Glasgow, United Kingdom; Massimo Volpe, Clinical and Molecular Med Dept, Sapienza Univ of Rome, Rome, Italy; Rhian M. Touyz, Inst of Cardiovascular and Medical Sciences, British Heart Fndn Glasgow Cardiovascular Res Ctr, Univ of Glasgow, Glasgow, United Kingdom

Poster Topics and Presentation Numbers Abstracts numbered 600 and above are late-breaking submissions.

Cardiovascular-Renal Interactions 500-501, 630-632Novel Therapeutic Approaches, Clinical Studies and Trials 502-513, 633-638Receptors and Signal Transduction 514-518, 639Renal Hemodynamics and Renovascular Hypertension 519-525, 640Renal Nerves 526-527, 641-642Salt and Hypertension 528-535, 643-644Vascular Biology 526-527, 645-654Vascular Remodeling and Dysfunction 538-542 Vascular Stiffness 543-548, 655Chronic Kidney Disease 549-554, 656-657Diabetes 555-561, 658-660

Genetics, Gene Therapy, Proteomics and Metabolomics 562-570, 661-663Oxidative Stress 571-573, 664-665Pregnancy and Preeclampsia 574-581, 666-668

3:30–5:00 pm Oral Session IX

3:30–5:00 pm Oral IX Concurrent A: Oxidative Stress Grand Ballroom B

Moderators: Akira Nishiyama, MD, PhD, Kagawa University Medical School, Kagawa, Japan Matthew Zimmerman, PhD, University of Nebraska Medical Center, Omaha, NE

3:30 Cyclooxygenase-depended Signaling 066 Via Thromboxane Prostanoid Receptors Mediates Endothelin-i Induced Ros Generation in Mesenteric Resistance Vessels from Mice Infused With Angiotensin Ii Christopher S. Wilcox, Georgetown Univ Medical Ctr, Washington, DC; Cheng Wang, Third Hosp of Sun Yat-sen Univ, Guangzhou, China; Dan Wang, Georgetown Univ Medical Ctr, Washington, DC

3:45 Downregulation of Vascular Factor-erythroid 067 2-related Factor-2 and Associated Antioxidant Enzymes in Hypertension Rheure A. Lopes, Karla B. Neves, Augusto Montezano, Univ of Glasgow, Glasgow, United Kingdom; Rita Tostes, Univ of Sao Paulo, Ribeirao Preto, Brazil; Rhian Touyz, Univ of Glasgow, Glasgow, United Kingdom

4:00 Ghrelin Restores Nitric Oxide Availability 068 in the Forearm Microcirculation of Essential Hypertensive Patients Agostino Virdis, Emiliano Duranti, Umberto Dell’Agnello, Gianni Lorenzini, Stefano Taddei, Univ of Pisa, Pisa, Italy

4:15 Isoketals in Monocyte-Derived Dendritic 069 Dendritic Cells Activate T Cells and Promote Hypertension Roxana Loperena, Annet Kirabo, Sean S. Davies, L. J. Roberts, David G. Harrison, Vanderbilt Univ, Nashville, TN

4:30 Superoxide and Hydrogen Peroxide 070 Differentially Modulate Mouse Afferent Arteriolar Myogenic Responses Via Protein Kinase C And Protein Kinase G and Their Coupling to Membrane Potential Lingli Li, Georgetown Univ, Washington DC; Eny Yin Lai, Zhejiang Univ, Hangzhou, China; Christopher S. Wilcox, Georgetown Univ, Washington DC


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4:45 Cytokine-angiotensin II Interplay in 071 Cyclophilin D-mediated Vascular Oxidative Stress and Hypertension Rafal Nazarewicz, Anna Dikalova, Hana Itani, William McMaster, Alfiya Bikineyeva, David G. Harrison, Sergey Dikalov, Div of Clinical Pharmacology, Vanderbilt Univ Medical Ctr, Nashville, TN

3:30–5:00 pm Oral IX Concurrent B: Salt and Hypertension Plaza A

Moderators: Fred Luft, MD, Max-Delbrück Center, Berlin, Germany Jennifer Pollock, PhD, University of Alabama Birmingham, Birmingham, AL

3:30 Newly Developed Personal Device Can 072 Detect Changes and Variations of Urinary Na/K Ratio with Standardized Low- and High-salt Meals in Healthy Volunteers Junichi Yatabe, Midori Sasaki Yatabe, Kozue Takano, Ami Watanabe, Satsuki Kurosawa, Mizuho Yonemoto, Momoko Nochi, Yuri Ikeda, Fukushima Medical Univ, Fukushima, Japan; Toshiyuki Iwahori, Shiga Univ of Medical Science, Shiga, Japan; Toshikazu Shiga, Omron Healthcare Co., Ltd., Kyoto, Japan; Tsuyoshi Watanabe, Junko Kimura, Fukushima Medical Univ, Fukushima, Japan

3:45 The Absence of Renal Angiotensin- 073 Converting Enzyme Prevents Salt Sensitive Hypertension Jorge F. Giani, Tea Janjulia, Depts of Biomedical Sciences and Pathology, Cedars-Sinai Medical Ctr, Los Angeles, CA; Jiyang Han, Depts of Cell and Neurobiology, Keck Sch of Med. Univ of Southern California, Los Angeles, CA; Bernardo Rodriguez-Iturbe, Hosp Univrio de Maracaibo, Maracaibo, Venezuela, Bolivarian Republic of; Kenneth E. Bernstein, Depts of Biomedical Sciences and Pathology. Cedars-Sinai Medical Ctr, Los Angeles, CA; Alicia A. McDonough, Depts of Cell and Neurobiology, Keck Sch of Med, Univ of Southern California, Los Angeles, CA; Romer A. Gonzalez-Villalobos, Depts of Biomedical Sciences and Pathology, Cedars-Sinai Medical Ctr and Pfizer Inc, DSRD CoE, Groton, CT

4:00 Endothelial Caveolin-1 Mediates the 074 Effects of Dietary Sodium on Cardiovascular and Metabolic Function Fatthy Abidin, Amanda E. Garza, Elijah Trefts, Jose R. Romero, Gail K. Adler, Gordon H. Williams, Luminita H. Pojoga, Brigham and Women’s Hosp, Boston, MA

4:15 The Role of Immunological CD8+ Effector 075 Memory T Cells In Hypertension Hana A. Itani, Jing Wu, Liang Xiao, Feng Zhang, Danielle Michell, Wei Chen, David G. Harrison, Vanderbilt Univ, Nashville, TN

4:30 Urinary Exosomal Epithelial Sodium 076 Channel and Sodium-chloride Cotransporter Measurement in Humans Taopheeq Ayodele Mustapha, Victor Nwazue, Kevin Schey, Raj Satish, James Mathew Luther, Vanderbilt University, Nashville, TN

4:45 Renal Denervation Attenuates 077 Salt-Sensitive Hypertension and Oxidative Stress in Rats with Unilateral Hydronephrosis Maria Peleli, Karolinska Instt, Stockholm, Sweden; Ammar Al-Mashhadi, Uppsala Univ, Uppsala, Sweden; Ting Yang, Karolinska Instt, Stockholm, Sweden; Erik G. Persson, Uppsala Univ, Uppsala, Sweden; Mattias Carlstrom, Karolinska Instt, Stockholm, Sweden

5:00–5:15 pm Break and Exhibits Yosemite

5:15–6:00 pm The Excellence Award in Hypertension Research LecturesSupported by a grant from Novartis Pharmaceutical Corp. Grand Ballroom B

Life with Angiotensin Receptors Thomas M. Coffman, MD, Professor and Chief, Division of Nephrology, Duke University, Durham, NC

Mechanisms of Salt-Sensitive Hypertension Toshiro Fujita, MD, PhD, Professor at University of Tokyo, Tokyo, Japan

7:30–8:00 pm Reception for the Excellence Award in Hypertension Research Imperial Open to all conference attendees

8:00–10:00 pm Dinner for the Excellence Award in Hypertension Research Grand Ballroom B *Ticketed event. If you have not pre-registered please visit the conference registration desk for availability.

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8:00–8:30 am Oral X: The Lewis K. Dahl Memorial Lecture Grand Ballroom B

Dahl Rats and the ‘Inconvenient Truth’ about the Genetics of Hypertension Bina Joe, PhD, FAHA, Professor, University of Toledo, Toledo, Ohio

8:30–10:00 am Oral X Concurrent A: Brain and Renin-Angiotensin Grand Ballroom B

Moderators: Sean D. Stocker, PhD, FAHA, Penn State College of Medicine, Hershey, PA TBD

8:30 Angiotensin Converting Enzyme Type 2 078 Shedding in the Central Nervous System of Hypertensive Patients Huijing Xia, Frank Culicchia, Lisa Moreno-Walton, Louisiana State Univ Health Sciences Ctr, New Orleans, LA; Marko Poglitsch, Attoquant Diagnostics GmbH, Vienna, Austria; Eric Lazartigues, Louisiana State Univ Health Sciences Ctr, New Orleans, LA

8:45 (pro)renin Receptor Knockdown in the 079 Paraventricular Nucleus of Hypothalamus Attenuates the Development of Doca-salt Hypertension Wencheng Li, Yumei Feng, Colorado State Univ, Fort Collins, CO

9:00 Selective Knockout of the Intracellular 080 Isoform of Renin in the Brain Contributes to Metabolic and Cardiovascular Control Keisuke Shinohara, Matthew D. Folchert, Benjamin J. Weidemann, Xuebo Liu, Donald A. Morgan, Kamal Rahmouni, Justin L. Grobe, Curt D. Sigmund, Univ of Iowa Carver Coll of Med, Iowa City, IA

9:15 Reporter Mouse Strain Provides a Novel 081 Look at Angiotensin Type-2 Receptor Distribution in Central Nervous System Cardiovascular Control Centers Annette D. de Kloet, Lei Wang, Jacob A. Ludin, Helmut Hiller, Justin A. Smith, David J. Pioquinto, Deborah A. Scheuer, Univ of Florida, Gainesville, FL; Ulrike Steckelings, Univ of Southern Denmark, Odense, Denmark; Eric G. Krause, Colin Sumners, Univ of Florida, Gainesville, FL

9:30 Oral Minocycline Reduces Blood Pressure 082 and Restores Autonomic Balance in Chronic Ang II-Infusion Rat Model of Hypertension Monica M. Santisteban, Jasenka Zubcevic, Jessica Marulanda-Carvajal, Michael Zingler, Mohan K. Raizada, Univ of Florida, Gainesville, FL

9:45 Role of Endoplasmic Reticulum Stress in 083 the Subfornical Organ (SFO) in Fluid Balance and Metabolic Effects of Brain Renin-Angiotensin System (RAS) Activation Fusakazu Jo, Hiromi Jo, Aline M. Hilzendeger, Martin D. Cassell, D. Thomas Rutkowski, Univ of Iowa Carver Coll of Med, Iowa City, IA; Robin L. Davisson, Cornell Univ, Ithaca, NY; Justin L. Grobe, Curt D. Sigmund, Univ of Iowa Carver Coll of Med, Iowa City, IA

8:30–10:00 am Oral X Concurrent B: Kidney and Hypertension Plaza A

Moderators: Moshe Levi, MD, University of Colorado Health Science, Denver, CO Minolfa C. Prieto-Carrasquero, MD, PhD, Tulane University School of Medicine, New Orleans, LA

8:30 Activation Of Trpv1-expressing Renal 084 Sensory Nerves With N-oleoyldopamine Attenuates High Fat Diet-induced Impairment In Renal Function Shuang-Quan Yu, Donna H. Wang, Michigan State University, East Lansing, MI

8:45 The Role of Afferent and Efferent Renal 085 Nerves in T Lymphocyte Recruitment into the Kidneys and Development of Two Models of Salt-Dependent Hypertension Jason D. Foss, Jessica Fiege, Dusty Van Helden, Yoji Shimizu, John P. Collister, Tim Mayerhofer, Laurel Wood, John W. Osborn, Univ of Minnesota, Minneapolis, MN

9:00 Adenosine A3 Receptors Regulate 086 Oxidative Stress and Inflammatory Responses in a Model of Hypertension and Renal Disease Ting Yang, Micheal Hezel, Maria Peleli, Xingmei Zhang, Niccolo Terrando, Bertil Fredholm, Mattias Carlström, Karolinska Instt, Stockholm, Sweden

9:15 Intrarenal Ghrelin Receptor Inhibition 087 Attenuates Angiotensin II-Dependent Hypertension In Normal Rats Brandon A. Kemp, Nancy L. Howell, John J. Gildea, Shetal H. Padia, Univ of Virginia Health System, Charlottesville, VA

9:30 Angiotensin Converting Enzyme 2 (ACE2) 088 in the Kidney: Soluble ACE2 Restores Blood Pressure Regulation Susan Gurley, David Ortiz Melo, Natalie M. Ortiz, Jessica Prescott, Katherine Xu, Robert Griffiths, Duke Univ, Durham, NC; Kevin Burns, Univ of Ottawa, Ontario, ON, Canada




9:45 A Genetic Variant of Human Aldosterone 089 Synthase Gene Causes Salt-Dependent High Blood Pressure in Transgenic Mice Brahmaraju Mopidevi, Nitin Puri, Madhusudan Reddy Ponnala, Meenakshi Kaw, Narsimha Rao Keetha, Sudhir Jain, Anita Rana, Ashok Kumar, Univ of Toledo, Toledo, OH



10:30 am–12:30 pm Oral XI Concurrent A: Pregnancy and Preeclampsia Grand Ballroom B

Moderators: Joey Granger, PhD, University of Mississippi Medical Center, Jackson, MS Justin Grobe, PhD, University of Iowa, Iowa City, IA

10:30 Increased Uterine Artery Resistance Index 090 Results In Placental Hypoxia and Tnf-α in the Dahl Salt Sensitive Rat During Pregnancy Ellen E. Gillis, Michael R Garrett, Jennifer M. Sasser, Univ of Misssissippi Medical Ctr, Jackson, MS

10:45 Chronic Vasopressin Infusion: A Novel, 091 Clinically Significant, and Pregnancy- Specific Mouse Model of Preeclampsia Mark Santillan, Donna A. Santillan, Sabrina M, Scroggins, James Y Min, Jeremy A. Sangren, Nicole A. Pearson, Katherine Gibson-Corley, Justin L Grobe, Univ of Iowa, Carver Coll of Med, Iowa City, IA

11:00 Uterine Artery Dysfunction in ACE2 092 Deficient Mice is Associated with Placental Hypoxia and Reduced Umbilical Flow Liliya M. Yamaleyeva, Victor M. Pulgar, Wake Forest Sch of Med, Winston-Salem, NC; Sarah H. Lindsey, Tulane Univ, New Orleans, LA; Jasmina Varagic, Carolynne M. McGee, Larissa Yamane, K. Bridget Brosnihan, Wake Forest Sch of Med, Winston-Salem, NC

11:15 Progesterone Supplementation Improves 093 Blood Pressure and Uterine Artery Resistance in Response to Placental Ischemia During Pregnancy Lorena M. Amaral, Janae Moseley, Denise C. Cornelius, James N. Martin, Babbette LaMarca, Univ of Mississippi Medical Ctr, Jackson, MS

11:30 Cox2 Inhibition During Decidualization 094 Improves Fetal Growth Restriction in the BPH/5 Mouse Model Of Preeclampsia Jenny L. Sones, Scott D. Butler, Catherine E. Isroff, Cornell Univ, Ithaca, NY; Jeeyeon Cha, Sudhansu K. Dey, Cincinnati Children’s Res Fndn, Cincinnati, OH; Robin L. Davisson, Cornell Univ, Ithaca, NY

11:45 CD74 Deficient Mice are Resistant to 095 Toll-Like Receptor-Induced Preeclampsia Mohamad Hatahet, Olga Y. Gasheva, Valorie L. Chiasson, Piyali Chatterjee, Kelsey R. Bounds, Richard P. Tobin, M. Karen Newell-Rogers, Brett M. Mitchell, Texas A&M Health Science Ctr, Temple, TX

10:30 am–12:00 pm Oral XI Concurrent B: Vascular Remodeling Plaza A

Moderators: Curt D. Sigmund, University of Iowa Carver College of Medicine, Iowa City, IA Stephanie Watts, PhD, Michigan State University, East Lansing, MI

10:30 Secreted miR-27a in Extracellular Vesicles 096 from THP-1 Cells Cause Hypertension by Reduced Angiotensin-(1-7)-Mas Receptor Expression and Function in Artery Xue Zou, Jialiang Wang, Chunyu Zeng, Dept of Cardiology, Daping Hosp, The Third Military Medical Univ, Chongqing, China

10:45 EGF Receptor and ER Stress Mediate 097 End-organ Damage but Not Hypertension Induced By Angiotensin II In Mice Katherine J. Elliott, Toshiyuki Tsuji, Takashi Obama, Takehiko Takayanagi, Steven Forrester, Joon Park, Satoru Eguchi, Temple Univ Sch of Med, Philadelphia, PA

11:00 Foxp3+ T Regulatory Lymphocytes 098 Counteract Angiotensin Ii-induced Vascular Injury Muhammad Oneeb Rehman Mian, Tlili Barhoumi, Lady Davis Inst for Medical Res, McGill Univ, Montreal, QC, Canada; Marie Briet, Ctr Hospo-Univire d’Angers, Univ d’Angers, Angers, France; Adriana Cristina Ene, Asia Rehman, Pierre Paradis, Lady Davis Inst for Medical Res, McGill Univ, Montreal, QC, Canada; Ernesto L. Schiffrin, Lady Davis Inst for Medical Res and Dept of Med, Sir Mortimer B. Davis Jewish General Hosp, McGill Univ, Montreal, QC, Canada

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Poster Presentations 11:15 EGF Receptor Inhibitor Erlotinib 099

Prevented Abdominal Aortic Aneurysm But Not Hypertension Induced by Angiotensin II Plus Beta-aminopropionitrile Toshiyuki Tsuji, Takashi Obama, Yamato Fukuda, Katherine Elliott, Satoru Eguchi, Temple Univ Sch of Med, Philadelphia, PA

11:30 Interference with Smooth Muscle 100 Peroxisome Proliferator-Activated Receptor-gamma (PPARG) Exacerbates Hypertension and Vascular Dysfunction: Role of TIMP-4 Pimonrat Ketsawatsomkron, Deborah R. Davis, Justin L Grobe, Henry L. Keen, Curt D. Sigmund, Univ of Iowa Carver Coll of Med, Iowa City, IA

11:45 Chemerin, A Novel Adipokine, Regulates 101 Human Vascular Cell Function Through Redox-sensitive Processes Involving NADPH Oxidase 1/4 and Endothelial Nitric Oxide Sinthase Karla B. Neves, Rheure A. Lopes, Aurelie D. Nguyen, Univ of Glasgow, Glasgow, United Kingdom; Nubia S. Lobato, Univ of Goias, Jatai, Brazil; Ana Maria Oliveira, Univ of Sao Paulo, Ribeirao Preto, Brazil; Augusto C. Montezano, Univ of Glasgow, Glasgow, United Kingdom; Rita C. Tostes, Univ of Sao Paulo, Ribeirao Preto, Brazil; Rhian M. Touyz, Univ of Glasgow, Glasgow, United Kingdom

12:00 Adjourn

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ReSS: November 15–16CVN: November 18–19

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Hypertension Highlights at Scientific Sessions 2014

KEY DATES: Sept 3 Deadline to become an AHA/ASA Professional

Member to receive early registration rates

Sept 17 Deadline for early registration rates

Oct 1 Deadline to become an AHA/ASA Professional Member to receive member registration rates

Oct 15 Deadline for advance registration rates

• Innate and Adaptive Immunity in Hypertension Sunday, November 16, 2014, 5:30–6:45 pm

• Hypertension 2014 Monday, November 17, 2014, 9:00–10:15 am

• Contribution of Arterial Stiffness to the Development of Hypertension: From Bench to Bedside Tuesday, November 18, 2014, 7:30–8:45 am

• The Pressures of Aging Tuesday, November 18, 2014, 5:30–6:45 pm

• Joint AHA/American Society of Hypertension Session: Can We Identify Response Markers to Antihypertensive Drugs? Wednesday November 19, 9:00–10:15 am

DS-8477 HBPR14 FP Ad.indd 1 8/14/14 9:07 AM


Author IndexAasarød, K. .........................................553Abad, M. .............................................545Abassi, Z. ............................................574Abdelsaid, M. ......................................064Afshinnia, F. .........................................243Aggarwal, S. ........................................241Agrawal, Y. ..........................................241Aguero, J. ............................................419Aguirre-Amezquite, F. ..........................215Ahmad, M. ......................................MP 05Ahmad, S. ...........................................477Alenina, N. ...........................................022Allen, S. R. ..........................................580Alm, E. ................................................321Al-Saiegh, Y. ........................................521Alves, M. .....................................420, 553Alves-Filho, J. C. .................................336Alzamora, A. C. ...................................471Alzayadneh, E. M. .........................233, 234Amaral, L. M. ..............................027, 093, .............................................................295Ando, T. ...............................................431Antunes, J. ..........................................353Antunes, T. T. ...............................010, 277Aoqui, C. .....................................456, 547Aoqui, C. .........................................MP 09Ariel, I. .................................................574Armando, I. .........................252, 257, 296Armando, L. J. .....................................237Arnold, A. C. ........................................018Aroor, A. ..............................................030Aroor, A. R. ..........................................012Arrabito, E. ......................................MP 10Asghar, M. ...................................284, 309Asico, L. D. ..........................................252Asico, L. D. ..........................................296Asico, L. D. ..........................................525Ayer, T. ................................................433Baban, B. ............................................062Bader, M. .............................011, 022, 577Bækkerud, F. H. ...........................420, 553Bai, H.-Y. ..............225, 313, 349, 529,556Baker, P. ..............................................436Balamurugan, K. ..................................267Balogh, A. ...........................................321Baltatu, O. C. ......................................427Ban, Z. ........................................007, 213Banchs, J. E. .......................................203Bandulik, S. .........................................011Banegas, J. R. .....................................409Banek, C. T. .........................................288Bansal, V. ............................................501Baquero, G. .........................................203Barbosa, M. A. ....................................471Barceló-Radó, M. ................................506Barhoumi, T. ................................345, 346Barshack, I. .........................................551Baruscotti, I. ........................................541Batchu, S. N. .......................................001Batchu, S. N. .......................................566Batenburg, W. W. ................................507Batista, M. C. ......................................468Batlle, D. ..............................................407Baumann, M. ................... 456, 547,MP 09Becari, C. ............................................458Becker, B. K. .......................................210Beeram, M. R. .....................................580Beierschmitt, A. ............................219, 412

Béland-Bonenfant, S. ..........................311Bell, B. B. ............................................036Bell, T. .................................................044Belyea, B. ............................................040Belyea, B. C. .......................................312Belzer, V. ..............................................574Bender, S. ...........................................030Benvenuto, V. ......................................203Benz, V. .......................................007, 213Berk, B. C. ..........................................566Bernardes, N. ......................................472Bertagnolli, M. .....................................311Bessa, K. L. .........................................540Bhaggoe, U. M. ...................................507Biaggioni, I. ..........................................018Bihl, J. C. .............................................224Birkenfeld, A. L. ...................................469Bluijssen, H. ........................................456Boini, K. M. ..........................................031Bonaventura, K. ...................................264Bonifonte, A. .......................................433Bostick, B. P. .......................................012Bounds, K. R. ......................095, 459, 460Brandes, R. .........................................536Briet, M. ......................................010, 346Brito, J. O. ...........................................472Brix, S. ........................................007, 213Brognara, F. .........................................458Brooks, H. L. .......................................310Broome, H. J. ......................................535Brosnihan, K. .......................................577Brown, C. ............................................269Brown, N. J. ........................................270Browning, K. N. ...................................034Burchmore, R. J. .................................280Burke, R. M. ........................................566Burnett, R. ...................................515, 564Bursztyn, M. ........................................574Butler, S. D. .........................................287Cabral, P. D. ........................................304CAI, H. ................................................268Cai, J. ..................................................218Callera, G. E. ...............................010, 277Calquin, M. ..........................................308Campagnole-Santos, M. J. ..................471Campbell, N. .......................................027Campos, L. A. .....................................427Cao, P. Y. .............................................268Capdevila, J. .......................................047Carneiro, F. S. ......................................353Caroccia, B. ........................................011Carretero, O. .......................................445Carretero, O. A. ...................................447Carrillo-Sepulveda, M. .........................263Carswell, A. .........................................277Carswell, A. .........................................009Carvalho, H. F. .....................................540Cassell, M. D. ......................................083Cassis, L. ....................................037, 317Castania, J. A. .............................032, 458Castillo, J. ............................................027Cechova, S. .........................................568Celedonio, J. E. ...................................018Ceravolo, G. ........................................279Cha, S. ................................................239Chadipiralla, K. ................................MP 07Chan, R. ..............................................568Chandrasekharan, G. ..........................205

Chappell, M. C. ...........................233, 234Chatterjee, P. .......................................095Chechova, S. .......................................041Chen, A. ..........................................MP 05Chen, D. ..............................................424Chen, K. ..............................................281Chen, L. ......................................338, 436Chen, S. ..............................................224Chen, W. .............................................075Chen, Y. ..............................................224Chen, Y. ..............................................031Cheng, X. ............................................055Chiasson, V. L. .....................095, 459, 460Chisaka, T. ...........225, 313, 349, 529, 556Chmielewski, S. ...............456, 547, MP 09Chodavarapu, H. .................................314Chul Kwon, K. .....................................039Chung, O. ............................................264Cirera-Salinas, D. .................................406Clark, A. ..............................................433Clerici, S. P. .........................................540Cloutier, A. ...........................................311Co, M. A. M. ........................................580Coelho, S. C. .......................................050Coffman, T. M. .....................................424Coll de Tuero, G. ..................................506Collett, J. A. .........................................412Conti, F. F. ...........................................472Cook, A. K. ..........................................299Cooper, M. ..................................010, 277Cornelius, D. C. ...027, 093, 292, 294, 295Cornish, K. G. ......................................487Cox, T. A. ............................................329Crowley, S. D. ......................................424Cunha, F. Q. ........................................336Cunha, T. M. ........................................458Curato, C. ...........................................406Curry, W. .............................................203Dalboni, M. A. ......................................468Dalmasso, C. .......................................301Daniell, H. ............................................039Danser, A. H. J. ..................................507, ................................................................... 528Darby, M. M. ........................................292Darios, E. .............................................515Dartora, D. R. ......................................311Dascanio, J. ........................................412Da Silva, A. ..........................................245da Silva, A. A. ..............................209, 561da Silva, M. B. .....................................273Davel, A. P. ..........................................540Davies, S. S. ........................................069Davis, D. R. .........................................100Davisson, R. L. ....................083, 207, 287De Angelis, K. ..............................273, 472DeBlois, D. ..........................................311de Castro, U. G. M. .............................471Dechend, R. .......................290, 292, 295, .....................................321, 576, 577, 578de Kloet, A. D. .....................................081DE LA CRUZ, J. J. ...............................409DE LA SIERRA, A. ...............409, 506, 545Delbin, M. A. ................................... MP 08DeMarco, V. G. ....................................012Denny, J. C. .........................................270Dey, S. K. ............................................267Dias, D. P. M. .......................................512

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Author Index (continued)

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EX

Dias, D. S. ...........................................472Didier, D. ..............................................247Diedrich, A. ..........................................018Di Fulvio, M. .........................................314Dinamarco, M. .....................217, 259, 417Dinamarco, N. .....................217, 259, 417Dios, A. ...............................................311Diz, D. I. ......................................033, 513do Carmo, J. M. ..................209, 245. 561Domenig, O. ........................................479Donlon, K. ...........................................001Dorenkamp, M. ...................................264Douglas, L. ..........................................203Dubey, R. K. ........................................541Duerrschmid, C. ..................................215Dulak-Lis, M. G. ..................................283Edwards, I. ..........................................269Edwards, T. L. .....................................270Eguchi, S. ....................................097, 099Elased, K. M. .......................................314Elijovich, F. ...........................................266Elliott, K. ..............................................099Elliott, K. J. ..........................................097Elmarakby, A. A. ..................................062Endo, T. ...............................................431Engeli, S. .............................................469Entman, M. L. ......................................215Erdbruegger, U. ...................................041Ergul, A. ..............................................064Esser, K. ..............................................049Estes, A. M. .........................................341Even, S. ...............................................009Even, S. E. L. ...............................010, 277Falck, J. C. ..........................................338Falck, J. R. ..........................................047Fan, F. .........................................222, 223Fareed, J. ............................................501Farley, G. .............................................018Fassina, A. ...........................................401Faulkner, J. L. ..............................292, 295Fazan Jr, R. .................................032, 458Felder, R. A. .........................................257Feng, Y. ...............................................026Ferrario, C. M. .....................................477Ferreira, R. G. ......................................336Ferrucci, D. L. ......................................540Feurdean, M. .......................................226Fingerle, J. ...........................................541Fish, K. ................................................419Fishman, V. ..........................................011Fliegner, D. ..........................................213Flister, M. .............................................247Fodor, G. .............................................436Folchert, M. D. .....................................080Forrester, S. .........................................097Fortunato, J. E. ............................033, 513Foryst-Ludwig, A. .........................007, 213Fowell, D. J. ........................................001Fox, M. D. ...................................205, 240Fragin, J. .............................................203Francis, J. ............................................039Franqueiro, L. F. ...................................427Fraulob-Aquino, J. C. ..........................346Friesema, E. C. F. ................................507Fudim, M. ............................................266Fujiwara, K. .........................................566Fukuda, Y. ...........................................099Fullerton, L. .........................................269

Fulton, D. .............................................470Gallagher, P. ........................................577Gamboa, A. .........................................018Garcia, N. H. ...............................237, 302Garcia, V. .............................................047García-Ortiz, L. ....................................545Garrelds, I. M. ......................................507Garrett, M. R. ......................................227Garrido, J. M. ......................................506Garvin, J. L. .........................................304Gasheva, O. Y. ....................................095Geurts, A. M. ...............................222, 223Ghafoor, H. U. .....................................341Gigliotti, J. ...........................................041Gildea, J. .............................................257Gillespie, D. G. .............................541, 555Gillham, H. E. ......................................288Gioco, F. ......................................011, 401Glockner, J. .........................................330Gnecco, J. ...........................................004Goldberg, E. ........................................310Goleva, S. B. .......................................219Golic, M. .....................................290, 576, .............................................................578Gomez, R. ...................................040, 312Gómez-Marcos, M. .............................545Gomez-Sanchez, C. .....................011, 401Gomez-Sanchez, E. ............................401Gong, M. C. .......................................049Gonzalez, F. J. .....................................345Gonzalez-Vicente, A. ...........................304Gorostidi, M. ........................................409Gotlinger, K. H. ....................................338Gotou, H. ............................................474Govande, V. P. .....................................580Grabenauer, M. ....................................577Graham, D. ..........................................279Grande, J. P. ................................521, 523Greene, A. ...........................................247Griendling, K. .......................................279Grobe, J. .............................................415Grobe, J. L. .................016, 080, 083, 100Grobe, N. ............................................314Groom, K. L. ........................................266Grossman, E. ......................................551Grune, J. .............................................007Gu, X. ..................................................212Guan, Z. ..............................................522Guerra, R. ............................................471Guo, A. M. ...........................................338Guo, D. F. ....................................016, 415Guo, Y. ................................................296Guo, Z. ................................................049Guo, Z. ................................................227Gupta, V. .............................................241Gurley, S. B. ........................................424Gusky, T. .....................................420, 553Haase, N. ............................290, 576, 578Hajjar, R. J. ..........................................419Hall, J. E. .............................209, 245, 561Hallan, S. I. ..........................................553Hammoudi, N. .....................................419Han, F. .................................................257Han, J. ................................................043Han, Y. ................................................221Haque, S. K. ........................................407Harder, D. R. .......................................223Hardigan, T. .........................................064

Harding, P. ...................................212, 447Harlan, S. M. .......................................036Harmon, A. C. .............................294, 295Harrison, D. G. ....................004, 069, 075Hartono, S. ..................................521, 523Harvey, A. ............................................279Hasan, Z. I. ..........................................226Hasegawa, T. .......................................431Hatahet, M. .........................................095Haudek, S. B. ......................................215Haufe, S. .............................................469Haverkamp, W. ....................................264Havulinna, A. S. ...................................238Hay, M. ................................................441He, Y. ..................................010, 277, 279Heemann, U. ...........................547, MP 09Henrich, W. ..........................................578Heron, K. .............................................203Herrmann, S. .......................................330Herse, F. ......................290, 292, 576, 578Higaki, T. .............................................349Higashi, Y. ...........................................329Higashiyama, A. ..................................432Hiller, H. ...............................................081Hilzendeger, A. M. ...............................083Hirooka, Y. ...........................................005Hoda, N. ..............................................064Hoeft, B. ..............................................007Hong, N. J. ..........................................304Hoppensteadt, D. ................................501Horiuchi, M. .........225, 313, 349, 529, 556Hou, X. ................................................530Hougton, H. J. .....................................209Hu, Y. ..................................................048Huang, B. S. ....................................MP 05Huang, h. ............................................221Hughson, A. ........................................001Hünig, T. ..............................................290Iadecola, C. .........................................207Ibrahim, T. ...................................290, 295Idris-Khodja, N. ...................................345Ihm, S. .................................................216Ikeda, Y. ..............................................072Imran, T. F. ...........................................226Imthurn, B. ..........................................541Inscho, E. W. .......................................299Inscho, E. ............................................522Irigoyen, M. C. .............................273, 472Ishida, T. ..............................................329Ishii, E.-I. .............................................349ishikawa, k. ..........................................419Itani, H. A. ...........................................075Iwahori, T. ............................................072Iwanami, J. ..........225, 313, 349, 529, 556Jackson, E. K. .............................541, 555Jacob, H. ....................................222, 223Jaffe, I. ................................................012Jandeleit-Dahm, K. .......................010, 277Jenkins, C. ..................................009, 256Jenkins, C. J. ......................................283Jennings, B. L. ....................................341Jeuken, R. M. ......................................352Jia, G. ..................................................012Jia, Z. ..................................................227Jiang, X. ..............................................257Jin, G. .................................................039Jo, F. ...................................................083Jo, H. ..................................................083



Joe, B. ................................................055Johnson, A. K. .....................................441Johnson, A. C. ....................................227Johnson, S. M. ....................................288Jones, J. E. .................................257, 296Jones, R. O. ........................................580Jordan, J. ............................................469Jose, P. A. ...................252, 257, 296, 525Joseph, G. ..........................................047Joseph, T. ............................................267Jula, A. ................................................238Juncos, L. A. .......................................301Juncos, L. I. .........................................302Kamaladevi, A. ....................................267Kamat, N. ............................................004Kan-no, H. ...........................225, 313, 556Kanno, H. ............................................349Kappers, M. H. W. ...............................528Kario, K. ..............................................474Kashkari, N. .........................................314Katayama, P. L. ...................................032Katovich, M. ........................................039Katovich, M. J. ....................................060Katsuki, M. ..........................................005Keen, H. L. ..........................................100Kemmner, S. .......................................547Kershaw, E. E. .....................................213Ketsawatsomkron, P. ...................100, 331Kha’maisi, M. ......................................574Khan, N. S. ..........................................341Kihara, Y. .............................................329Kim, H. ................................................216Kim, S. ................................................226Kimura, J. ............................................072Kintscher, U. ................................007, 213Kirabo, A. ....................................004, 069Kirsch, S. .............................................022Kisaka, T. .............................................329Kishi, T. ................................................005Klopfleisch, R. .....................................007Knigin, D. .............................................574Knot, H. J. ...........................................412Knudsen, B. E. ............................521, 523Kobayashi, T. .......................................432Kobayashi, Y. .......................................265Kohan, D. E. ........................................308Kohara, K. ...........................................556Kokubo, Y. ...........................................432Kolkhof, P. ...........................................007Komadur Elayavilli, R. ..........................239Konkalmatt, P. .............................257, 525Konkalmatt, P. R. .................................252Korshunov, V. A. ..........................001, 566Kossovsky, T. .......................................574Koyama, M. .........................................431Krause, E. G. .......................................081Kuehl, T. J. ..........................................580Kukida, M. ...........................225, 313, 556Kukita, M. ............................................529Kukita, M. ............................................349Kumar, S. ............................................267Kumaraswamy, S. ................................055Kundu, S. ............................................267Kuppusamy, M. ...................................011Kurosawa, S. .......................................072Kwon, B. .............................................216Laffer, C. L. ..........................................266Lagarón, C. .........................................506

Lai, E. ..................................................070LaMarca, B. .........027, 093, 292, 294, 295LaMarca, B. .........................................290Langlo, K. A. R. ...................................553Lankhorst, S. .......................................528Lannigan, J. .........................................041LaPine, S. ............................................203Lazar, J. ...............................................247Le, T. ...................................................041Le, T. H. ...............................................568Lee, D. ................................................043Leenen, F. ....................................436, 530Leenen, F. H. ...................................MP 05Lefta, M. ..............................................049Leibowitz, A. ........................................551Leijten, F. P. J. ......................................507Leiper, J. ..............................................044Leisegang, M. ......................................536Lenzini, L. ............................................011Leonard, D. .........................................580Lerman, L. ...........................................330Lesko, P. ......................................420, 553Li, L. ....................................................070Li, P.-L. ................................................031Li, Q. ...................................................039Li, X. ....................................................031Lichtinghagen, R. ................................469Light, K. ...............................................269Lima, R. ...............................................245Lin, S. ..................................................039Liu, C. .............................................MP 07Liu, H. .................................................239LIU, M. ................................................268Liu, S. ..................................................049Liu, X. ..................................................080llesuy, S. ..............................................472Lobato, N. S. ...............................101, 276Loperena, R. ........................................069Lopes, A. .............................................458Lopes, R. A. M. ...........067, 101, 276, 353Lopez-Gutierrez, J. R. ..........................242Lotan, Y. ..............................................264Lu, X. ...........................................281, 026Lucht, K. .....................................022, 406Ludin, J. A. ..........................................081Luft, F. C. .............................................469Lukaszewski, M.-A. .............................311Madhur, M. S. ......................................004Mahon, B. ...........................................564Mäki, J. ...............................................238Mäkinen, V.-P. ......................................056Malfitano, C. ........................................472Malik, K. U. ..........................................341Manandhar, L. .....................................460Mancini, S. J. .......................................256Manthati, V. L. ......................................047Maranon, R. O. ............................245, 301Mardahl, M. .........................................022Mark, A. L. ...........................................207Marrocos, M. S. ...................................468Marshal, A. C. ......................................234Martin, J. N. .........................................093Martins Dias, D. P. ...............................458Mathis, K. W. .......................................035Matsusaka, T. ......................................308Matus, M. ............................................321Mayschak, T. .......................................269McDonough, A. ...................................004

McDonough, A. A. ...............................043Mckarns, S. .........................................030Medeiros, A. ................................420, 553Mehalic, T. C. .......................................040Meininger, G. .......................................557Meininger, G. A. ...................................012Mel, B. .................................................055Meng, Q. .............................................056Mestriner, F. L. .............................276, 336Meuth, A. ............................................030Mi, Z. ...................................................555Michell, D. ...........................................075Mintz, J. D. ..........................................470Mishra, P. K. ........................................487Mishra, P. .............................................047Mita, T. ................................................431Mitchell, B. M. .....................095, 459, 460Miyamoto, Y. .......................................432Moak, S. P. ..........................................209Mogi, M. ..............225, 313, 349, 529, 556Montezano, A. .............................067, 279Montezano, A. C. ...............009, 010, 101, .........................256, 277, 280, 283, MP 10Moreira, J. B. ...............................420, 553Moreno Jr., H. ......................217, 259, 417Morgan, D. A. ......016, 036, 080, 415, 512Morrell, C. N. .......................................001Moseley, J. ..........027, 093, 292, 294, 295Mukherjee, K. ......................................341Mukoda, M. .........................................331Müller, D. N. ..................290, 321,576, 578Mullick, A. ............................................564Munoz, R. T. ........................................240Münter, L. M. .......................................022Nagata, S. ...........................................477Nair, A. ................................................039Nakagawa, P. ..............................445, 447Nakagomi, A. .......................................265Nakai, M. .............................................432Nakao, Y. M. ........................................432Nakaoka, H. ........225, 313, 349, 529, 556Nandi, S. S. .........................................487Needham, K. W. ..................................288Ness, H. O. .................................420, 553Netterville, J. L. ....................................266Neves, K. B. ........009, 067, 101, 276, 353Newell-Rogers, M. K. ..........................095Nguyen, A. D. C. ..........................101, 283Nguyen Dinh Cat, A. .....009, 010, 256,277Nickolaus, M. ......................................203Nicolato, R. C. .....................................471Nicoletti, C. ......................................MP 10Nie, Y. ..................................................055Niimura, F. ...........................................308Niiranen, T. ..........................................238Nikolich-Zugich, J. ...............................310Nishimura, D. .......................................016Nishimura, K. .......................................432Nistala, R. ............................................030Nochi, M. .............................................072Norlander, A. E. ...................................004Nugent, K. ...........................................242Nunes, K. ............................................263Nuyt, A. ...............................................311Nyman, M. A. ......................................239Obama, T. ...................................097, 099Odunukan, O. W. .................................239Offermanns, S. ............................050, 345

AU

TH

OR

IND

EX



AU

TH

OR

IND

EX

Okada, S. ............................................265Okamoto, L. E. ....................................018Okamura, T. .........................................432Okino, N. .............................................474Olesen, S. ............................................321Oliva, K. ...............................................577Oliveira, A. ............................101, 276,545Olivon, V. .............................................353Olivon, V. C. .........................................336Olufade, R. ..........................................549Omar, B. A. ..........................................439Omar, M. .............................................439Onuma, Y. ...........................................431Orellana-Barrios, M. A. ........................242Osborn, J. L. ...............................219, 412Oshima, T. ...........................................329Ouerd, S. .............................................345Ozono, R. ............................................329Pabbidi, M. R. .............................222, 223Page, P. .......................................010, 277Palacios, R. .........................................009Pandey, V. G. .......................................047Paradis, P. ...................050, 311, 345, 346Paranjape, S. Y. ...................................018Park, J. ................................................097Pascual, A. ..........................................406Patel, U. ......................................207, 287Patil, C. N. ...........................................301Paz, M. ................................................506Pena, C. ..............................................242Peng, H. ..............................................445Pennathur, S. .......................................424Pepine, C. J. ........................................060Pereira Jr., V. L. ....................................427Perez, H. A. .........................................237Petersen, J. W. ....................................060Peterson, E. .................................212, 445Pillai, R. ...............................................055Pioquinto, D. J. ....................................081Pitzer, A. L. ..........................................031Poglitsch, M. .......................................479Pollow, D. P. ........................................310Porter, J. ..............................................027Przbyl, L. ....................................295, 290, .....................................................576, 578Pulgar, V. M. ........................................577Pye, C. ................................................062Qi, X. ...................................................401Qi, Y. ...........................................039, 060Qiu, S. .................................................470Queiroz, K. B. ......................................471Quelle, F. W. ........................................331Quinto, B. M. R. ..................................468Rahman, P. A. ......................................239Rahmouni, K. ......016, 036, 080, 415, 512Raij, L. .............................................MP 07Raizada, M. .................................039, 202Raizada, M. K. .....................................060Rakugi, H. ...........................................474Ramalho, L. .........................................353Ramkumar, N. .....................................308Rathinasabapathy, A. ..........................039, ................................................................... 060Rautureau, Y. .......................................050Reckelhoff, J. F. 245, 301Rehman, A. .........................................050Ren, H. ........................................218, 281

Rhaleb, N.-E. ...............................445, 447Rhoads, M. K. .............................219, 412Rios, F. ............................................MP 10Rios, F. J. .............................009, 010,277Roberts, L. ..........................................069Robertson, D. ......................................266Rodrigues, C. J. O. ..............................468Rodriguez, J. J. ...................................506Roellinger, D. .......................................239Roksnoer, L. C. W. ...............................507Rolfseng, T. .........................................420Rolim, N. .....................................420, 553Roman, M. H. ..............................459, 460Roman, R. J. ...............................222, 223Romero-Aleshire, J. .............................310Rosselli, M. ..........................................541Rossi, G. .....................................011, 401Rossitto, G. .........................................401Rossoni, L. V. ..............................352, 540Rudy, C. ......................................041, 568Ruginsk, S. ..........................................353Ruilope, L. M. ..............................409, 545Rutkowski, D. T. ..................................083Ryan, M. J. ..........................................535Saad, A. ..............................................330Sada, L. ...........................................MP 10Saez, M. ..............................................506Salatzki, J. ...................................007, 213Saleem, M. ..........................................309Saleh, M. A. .........................................004Salgado, H. C. .............................032, 458Salomaa, V. .........................................238Salt, I. P. ..............................................256Samareh- Jahani, F. .............................441Samra, M. ...........................................226Sanches, I. C. ......................................472Sanchez-Barrios, H. ............................242Sans Atxer, L. ......................................545Santisteban, M. ...................................202Santos, F. ............................................273Santos, R. A. S. ............................471, 022Santos-Silva, J. C. ...............................540Sarkar, N. ............................................267Sarkar, P. .............................................207Sarkar, S. .............................................267Sartori, M. ...........................................273Sasaki, N. ............................................329Savoia, C. ............................... 346, MP 10Scher, D. L. .........................................203Scheuer, D. A. .....................................081Schiffrin, E. ..........................................050Schiffrin, E. L. ......................311, 345, 346Schroder, E. A. ....................................049Schröder, K. ........................................536Schülein, R. .........................................022Schulz-Menger, J. ................................469Schwager, C. .......................................479Schwartzman, M. L. ....................047, 338Scicli, A. G. ..........................................338Scott, A. ..............................................280Searby, C. ...........................................016Segal, J. H. ..........................................243Segura, J. ....................................409, 545Sehnert, B. ..........................................406Seitz, B. M. ..........................................515Sequeira Lopez, M. .............................048Sequeira-Lopez, M.S. ..................040, 312Shah, A. ..............................................536

Shaltout, H. A. .............................033, 513Shan, B.-S. ..................225, 313, 529, 556Sheffield, V. C. .....................................016Shenoy, V. ............................................039Shi, X. ..................................................056Shibao, C. ...........................................018Shiga, T. ..............................................072Shil, P. .................................................039Shinohara, K. .......................................080Shkolnik, B. .........................................047Shoemaker, R. .............................037, 317Shoji, T. ...............................................265Shuey, M. M. .......................................270Sigmund, C. D. ............080, 083, 100, 331Silva, G. B. ..........................................302Silva, G. J. J. ...............................420, 553Silva, M. ......................................471, 353Simmonds, S. S. .................................034Singh, R. .............................................314Skarzinski, G. ......................................574Sleijfer, S. .............................................528Small, H. Y. ..............................340, MP 10Smith, A. .............................................209Smith, J. A. ..........................................081Smolock, E. M. ....................................566Sohns, C. ............................................264Somineni, H. K. ...................................314Sones, J. L. .........................................287Song, C. ......................................039, 202Sousa, A. S. ....................................MP 08Sowers, J. ...........................................030Sowers, J. R. .......................................012Sparks, M. A. ......................................424Spence, J. ...........................................237Sponton, A. C. S. ............................MP 08Stauss, H. M. ......................................512Steckelings, U. ....................................081Steckelings, U. M. .......................022, 406Stegbauer, J. .......................................424Stepp, D. .............................................470Stindl, J. ..............................................011Stocker, S. D. ......................................034Stodola, T. J. .......................................247Stuart, D. .............................................308Stump, M. ...........................................331Su, W. .................................................049Suárez, C. ...........................................545Sumners, C. ........................................081Sun, Z. ................................................012Sunagawa, K. ......................................005Sutherland, M. .....................................311Suzuki, J. ............................................313Syed, D. ..............................................501Szasz, T. ..............................................263Szyndralewiez, C. ........................010, 277Taffet, G. E. ..........................................215Takano, K. ...........................................072Takayanagi, T. ......................................097Takegami, M. .......................................432Tan, X. .................................................218Tarilonte, P. ..........................................506Teichmann, A. ......................................022Teixeira, A. A. .......................................468Tentler, A. ............................................226Textor, S. .............................................330Tezini, G. .............................................458Thelma, B. K. ......................................267Thirunavukkarasu, S. ...........................341



Thiruvarudsothy, S. ..............................226Thomas, A. ..........................................027Thomas, B. F. ......................................577Thomas, J. R. ..............................205, 240Thomas, T. ..........................................566Thompson, J. M. .................................515Tian, R. ............................................MP 07Tobin, R. P. ..........................................095Tobisawa, T. ........................................431Tofovic, S. P. ........................................555Togashi, N. ..........................................431Tomlinson, J. A. P. ...............................044Tostes, R. ....................................067, 353Tostes, R. C. ........................101, 276, 336Touyz, R. .....................................067, 279Touyz, R. M. ...............009, 010, 101, 256, .................................277, 280, 283, MP 10Trifone, C. B. ...................................MP 08Trindade, M. ........................................345Tsiropoulou, S. .....................................280Tsuchida, A. .........................................431Tsuji, T. ........................................097, 099Tsukuda, K. ..........225, 313, 349, 529,556Uddin, M. N. ........................................580Ul Haq, E. ............................................439Unger, T. ......................................022, 406Utz, W. ................................................469Valbuena-Diez, A. ................................287Valero-Esquitino, V. ..............................406Van Beusecum, J. ...............................299van den Meiracker, A. H. ......................528van Esch, J. H. M. ...............................507van Oyen, D. .......................................479van Veghel, R. .....................................507Varagic, J. ...................................477, 577Veiras, L. .............................................043Velarde-Miranda, C. .............................401Veledar, E. ...........................................433Vera, P. ................................................506Verlohren, S. ........................................578Victorio, J. A. .......................................540Vijapurkar, U. .......................................557Villar, V. A. ............................................296Villar, V. M. ...........................................525Villela, D. C. .........................................022VINYOLES, E. ......................................409Vivekanandan-Giri, A. ..........................424Volkov, A. ............................................551

Voll, R. .................................................406Volpe, M. .........................................MP 10VonCannon, J. L. .................................477Vongpatanasin, W. ...............................264Wadosky, K. M. ...................................001Waghulde, H. .......................................055Wagoner, A. L. .............................033, 513Wallace, K. ..................................027, 294Wang, C. .....................................066, 566Wang, D. .............................................066Wang, F. ..............................................026Wang, G. .............................................207Wang, H. ..............................210, 487,530Wang, H.-W. ................................... MP 05Wang, J. ......................................096, 224Wang, L. ..............................................081Wang, S. .............................................308Wang, X.-L. .................225, 313, 529, 556Wang, X. ......................................525, 284Wang, Y. ..............................................317Wang, Z. ..............................................221Warth, R. .............................................011Watanabe, A. .......................................072Watanabe, M. ......................................432Watanabe, T. ...............................072, 432Watkins, M. .........................................269Watts, S. W. ................................515, 564Webb, R. .............................................263Webb, R. C. ........................................299Weidemann, B. J. ................................080Weinman, E. J. ....................................296Weir, M. R. ...........................................557Welch, W. J. ........................................044Whaley-Connell, A. ..............................030White, A. .............................................256Wilck, N. ..............................................321Wilcox, C. S. ........................044, 066,070Wilson, B. A. ........................................234Wilson, P. ............................................433Wisløff, U. ....................................420, 553Wong, F. ..............................................060Wong, S. .............................................536Wongjarupong, A. ................................523Woong, R. ...........................................216Wu, J. ..................................................075Wysocki, J. ..........................................407Xia, M. .................................................031Xiao, L. ................................................075

Xiao, X. ................................................224Xie, Z. ..................................................049Xu, J. ....................................212, 445,447Xue, B. ................................................441Yabe-Nishimura, C. ..............................279Yamaguchi, M. .....................................474Yamaleyeva, L. M. ...............................577Yamashita, T. .......................................431Yang, J. ...............................................296Yang, T. ...............................................026Yang, X. ................................056, 420,553Yang, X.-P. ............................212, 445,447Yang, Y. ................................252, 257,525Yatabe, J. ............................................072Yatabe, M. S. .......................................072Ye, M. ..................................................407Yee, J. .................................................557Yetman, A. T. .......................................240Yonemoto, M. ......................................072Yoshida, H. ..........................................431Yu, F. ...................................................312YU, S. ..................................................268Zanotti, G. ...........................................011Zeng, C. ......................096, 218, 221, 281Zeng, J. ...............................................281Zettel, M. .............................................566Zhang, C. ............................................224Zhang, F. F. ...................................047,338Zhang, F. .............................................075Zhang, H. ............................................301Zhang, J. .....................................060, 474Zhang, S. ............................................299Zhang, X. Y. .........................................268Zhang, Y. .....................................031, 549Zhao, B. ..............................................224Zhao, D. ..............................................205Zhao, G. ..............................................049Zhao, X. ...............................................549Zhao, Y. ...............................................056Zheng, Y. .............................................268Zhou, L. ...............................................218Zhou, M.-S. .................................... MP 07Zhu, L. .................................................447Zingler, M. ............................................060Zou, X. ................................................096Zubcevic, J. .........................................202Zucker, I. H. .................................210, 487

AU

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OR

IND

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Tuesday, September 9 Wednesday, September 10 Thursday, September 11 Friday, September 12

7:00 am 7:00 am Registration Opens

7:00–8:00 am How-To Session I: How to Create an Individual Development PlanFranciscan C

7:00–8:00 am How-To Session II: How to Build Support for Science: Lessons in Effective CommunicationsFranciscan C

8:00 am 8:00 am–4:30 pm Review of HypertensionOpen to all conference attendees. No addtional cost. Plaza

8:00–10:00 am Oral Session I

8:00–8:30 am Presentation of Lifetime Achievement Award and Council Distinguished Achievement AwardsGrand Ballroom B

8:30–10:00 am Concurrent A: Inflammation, Immunity and Cytokines Grand Ballroom B Concurrent B: Aldosterone, Its Receptors and Other Hormones Plaza A


8:00–8:30 am Seldin Award LectureGrand Ballroom B

8:30–10:00 am Concurrent A: Renal Tubular TransportGrand Ballroom B Concurrent B: Vascular Biology Plaza A

8:00–10:00 am Oral Session X

8:00–8:30 am Dahl Award LectureGrand Ballroom B

8:30–10:00 am Concurrent A: Brain and Renin-Angiotensin Grand Ballroom B Concurrent B: Kidney and HypertensionPlaza A

10:00 am 10:00–10:30 amRefreshments and Exhibits Yosemite



10:30 am 10:30 am–12:00 pm Oral Session II

Concurrent A: Obesity and Metabolic Syndrome Grand Ballroom B Concurrent B: Angiotensin Action and SignalingPlaza A

10:30 am–12:30 pm Oral Session VIII

10:30–11:00 am Dustan Award LectureGrand Ballroom B

11:00 am–12:30 pm Concurrent A: Epigenetics and GeneticsGrand Ballroom B Concurrent B: Obesity and Diabetes Plaza A


Concurrent A: Pregnancy and PreeclampsiaGrand Ballroom B Concurrent B: Vascular RemoldelingPlaza A

NOON 12:00–12:30 pm Lunch Break

NOONAdjourn

12:30 pm 12:30–1:30 pm Oral Session IIITop Trainee Oral AbstractsGrand Ballroom B

12:30–2:00 pm Annual Business Meeting and Awards Luncheon*Ticketed Event Imperial

1:00 pm

1:30 pm 1:30–3:00 pmPoster Session IIGrand Ballroom A2:00 pm 2:00–3:30 pm

Poster Session IIIGrand Ballroom A

3:00 pm 3:00–3:30 pm Oral Session IV Arthur C. Corcoran Memorial Lecture Grand Ballroom B


3:30–5:00 pm Oral Session IXConcurrent A: Oxidative StressGrand Ballroom B Concurrent B: Salt and HypertensionPlaza A

4:00 pm 4:00–5:15 pm Oral Session V Harry Goldblatt FinalistsAustralian HBPR Council Young InvestigatorGrand Ballroom B


5:15 pm 4:45–6:00 pm Oral Session VI

Concurrent A: Neurogenic Mechanisms Grand Ballroom B Concurrent B: Renin-Angiotensin SystemPlaza A

5:15–6:00 pm The Excellence Award in Hypertension Research LecturesGrand Ballroom B

5:30 pm 5:30–6:30 pm Opening and Keynote LectureGrand Ballroom B

6:00 pm

6:30 pm 6:30–9:30 PM Poster Session I and Reception: Trainee Poster Session and Competition Grand Ballroom A

7:00 pm 7:00–11:00 pm Trainee Advocacy Mixer *Entertainment portion open to all. Plaza B

7:30 pm 7:30–8:00 pm Conference-wide ReceptionFranciscan Room

8:00–10:00 pm Excellence Award in Hypertension Research Dinner *Ticketed Event Grand Ballroom B

8:00 pm

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High Blood Pressure Research Scientific Sessions 2014

Final ProgramSeptember 9–12, 2014 | Hilton San Francisco Union Square | San Francisco, CA

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