nano tissue engineering greg

7/28/2019 Nano Tissue Engineering Greg

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Nature Nanotechnology, January 2011


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Part I: Understanding Tissue


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Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011.


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7/38Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011.


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Part II: Fabricating the ECM


13/38Barnes, C.P. et al. Nanofiber technology: Designing the next generation of tissue engineering scaffolds. Adv. Drug. Deliv. Rev. 2007
http://www.youtube.com/watch?v=E1zuQEYGMJ0


14/38Zhang, S. Fabrication of novel biomaterials through molecular self-assembly. Nature Biotechnol. 2003.


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21/38Freeman, I. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials. 2008.

bFGF bound to

scaffold

bFGF adsorbed to

scaffold

bFGF absent


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Freeman, I. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins. Biomaterials. 2008.

bFGF bound toscaffold

bFGF adsorbed toscaffold

bFGF absent


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Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011.Teixeira, AI. Epithelial contact guidance on well-defined micro- and nanostructured substrates. J. Cell. Sci. 2003.

Flat topography

Grooved topography


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Part III: Designing a Scaffold


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Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011.Kim, DH. Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. PNAS. 2010.


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Feng, ZQ. The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver

function. Biomaterials. 2009.


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Roohani-Esfahani, SI. The influence hydoxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coarted with

hydroxyapatite-PCL composites. Biomaterials. 2010.


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Part IV: Enhancing the Engineering Matrix


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Wang, S. F., Shen, L., Zhang, W. D. & Tong, Y. J. Preparation and mechanical properties of chitosan/carbon nanotubes composites. Biomacromolecules. 2005

Gui, X. et al. Soft, highly conductive nanotube sponges and composites with controlled compressibility.ACS Nano. 2010.


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Wu, S. L. et al. A biomimetic hierarchical scaffold: natural growth of nanotitanates on three-dimensional microporous Ti-based metals. Nano Lett. 2008


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Zhang, SF. Nanoparticulate systems for growth factor delivery. Pharm. 2009.


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Fan, D. Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires. Nature Nanotechnology. 2010.


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Souza, G. Three-dimensional tissue culture based on magnetic cell levitation. Nature Nanotechnology. 2010.


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Part V: Monitoring Tissue Development


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Tian, B. Three dimensional, flexible nanoscale field-effect transistors as localized bioprobes. Science. 2010.


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Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011.Heller, DA. Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes. Nature Nanotech. 2009.

Nature Nanotechnology, January 2011


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The End

nano tissue engineering greg

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