nanovehicles for targated delivery of drug to cancerous cell
TRANSCRIPT
Nanovehicles for drug delivery in Cancer treatment
By- Naveen Sundaria
ID- 44808
M.B.G.E
G.B.P.U.A.T
Index
• Cancer overview• Different paths of drug delivery• Life of a pill-passing different barriers• Chemotherapy vs control release• How drug identifies cancer cell
• Different mechanisms of bioerodible release systems
• References
Normal cell- undergoes regulated division, differentiation and apoptosis.
Cancer cell-• Lost the usual control.• Rapid proliferation.• Bypass Program Cell Death.• Result in tumor formation.
Tumor type-• Benign tumor(non cancerous)
Do not invade to tissues• Malignant tumor(cancerous)
Invade tissues
Metastasis
Cancer
Damaged DNA
RadiationChemicalsVirus
Malignant tumor
Carcinomas Sarcomas Lymphomas
Lining of tissues/organin epithelial cells90% cancer.
Connective tissues likeBones/muscles2% cancer
Blood forming cellCell of immune system8% cancer
Life of a pill-passing different barriers
Medication must be small so that it can pass throughstomach/intestinal lining
Absorbed drug
Life of a pill-passing different barriers
Medication may be destroyed by enzymesof liver
Drug may bind toprotein/fat moleculesreduced available drug
NO
NO
Design of nanocarriers
•Greater surface area/volume ratio•Greater bioavailability•Easy surface modification
•Small enough to avoid removal by phagocytes(<500 nm)•Large enough to avoid renal filtration by kidney(>5 nm)
Guide by external magnetic/electrical field
Different mechanisms of bioerodible release systems
1. Diffusion controlled(Reservoir system)
2. Chemically controlled(Pendant chain)
3. Solvent control(Osmosis/osmotic pump)
•Biodegradable and biocompatible polymers from natural source like polyethylene glycol(PEG), polycaprolactone(PCL), polycarbonate..etc•Natural polymers- cellulase, protein•Biomacromolecule•FDA approved drug doxorubicin and paclitaxe
2.Pendant chain
•Chemical control•Drug in prodrug form•Bond between drug and carrier Polymeric backbone arepH sensitive bond like Amide oxime carboxylic acid ester hydrazone bond
3.osmotic pump
•Solvent control•System driven by osmotic pressure•Whole system do not swell•Rigid membrane is permeable to water
Intravenous delivery of hydrophobic drugGuided by magnetic fields
Structural requirementsHydrophobic polymerHydrophilic polymerMagnetic polymerTargeting ligand linked polymer
FunctionLoad hydrophobic drugInteract with aqueous environmentGuided by external sourcesReceptor mediated endocytosis for Targeted delivery
1
Magnetic polymerHydrophilic polymer
Ligand linked polymer
Drug loaded hydrophobic polymer
Triblock copolymerStructure in aqueous environment
1 23
5
3.Locate cancer cells using Quantum Dot’s
• Semiconductor nanocrystal(8-10 nm)• Made up of cadmium selenide, zinc selenide• Invivo detection cancer cell
Cancer cell
References• Bosch, F. Xavier, et al. "Prevalence of human papillomavirus in
cervical cancer: a worldwide perspective." Journal of the National Cancer Institute 87.11 (1995): 796-802.
• Sun, Xiaoming, et al. "Nano-graphene oxide for cellular imaging and drug delivery." Nano research 1.3 (2008): 203-212.
• Washington, Neena, Clive Washington, and Clive Wilson. Physiological pharmaceutics: barriers to drug absorption. CRC Press, 2000.
• Liversidge, Gary G., et al. "Surface modified drug nanoparticles." U.S. Patent No. 5,145,684. 8 Sep. 1992.
• Uhrich, Kathryn E., et al. "Polymeric systems for controlled drug release." Chemical reviews 99.11 (1999): 3181-3198.
• Makhija, Sapna N., and Pradeep R. Vavia. "Controlled porosity osmotic pump-based controlled release systems of pseudoephedrine: I. Cellulose acetate as a semipermeable membrane." Journal of Controlled Release 89.1 (2003): 5-18.