natural selection can create linkage disequilibrium
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- Slide 1
- Natural Selection Can Create Linkage Disequilibrium
- Slide 2
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- Detecting Postive Selection by Linkage Disequilibrium Sabeti, et al. 2002
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- Admixture Can Create Linkage Disequilibrium
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- Recombination Reduces Linkage Disequilibrium
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- Chaos Paper
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- Bacteriophage 6 dsRNA
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- Mllers Ratchet dsRNA The fate of asexually reproducing organisms dsRNA Assume a single bacteriophage per bacterium = asexual reproduction dsRNA
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- Experimental Mllers Ratchet with 6 dsRNA 0.22 m filter 40X Pseudomonas phaseolicola
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- Paired Growth and Fitness of 6 Pseudomonas phaseolicola dsRNA marked parent marked parent wt parent Mller parent Pseudomonas phaseolicola Pseudomonas alcaligenes W t = R t /R 0 I.e., W 37A = (150:200)/(200:200) = 0.75
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- Fitness Results of 6
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- Experimental Sex with 6 0.22 m filter 40X Pseudomonas phaseolicola dsRNA
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- Fitness of Improvement of selfed and hybrids
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- Disequilibrium Disrupts HWE model
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- Mendelian Genetics of Quantitative Traits
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- Quantitative Results for Nicotiana longiflora
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- Diopsids - Stalk-eyed Flies (Cyrtodiopsis dalmanni) Wilkinson, Amitin & Johns Integr. Comp. Biol., 2005
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- QTL mapping: Mimulus phylogeny
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- QTL mapping: Mimulus hybrids
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- CharacteristicsM. CardinalisM. Lewisii Pollinator attraction Puple Yellow Lateral petal width
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- QTL mapping: predictions
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- Selection gradients
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- Skypilots
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- Heritability of flower size 1/2h 2 =0.5
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- Relative fitness
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- Selection gradient = slope Selection gradient = 0.13 S (selection differential) = selection gradient*variance S = 0.13*5.66 mm = 0.74 mm S = 0.74 mm/14.2 mm mean flower size = 0.05
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- Expected R = h 2 S = 1 x 0.05 = 0.05 Observed = 9% larger
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- Heritability of abdominal bristles in D. melanogaster Clayton, et al. 1957
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- Flies with >22 bristles bred to create generation 2 Mean bristle number G1 = 19.3 Mean bristle number of selected G1 = 22.7 Mean bristle number G2 = 20.1
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- G1 n = 115; mean bristle number = = 2221/115 = 19.3 G1 selected n = 22; mean bristles = 22.7 G2 n = 101; mean bristles = 20.1