Upload File

network integration and function prediction: putting it all together slides courtesy of curtis...

  • Home
  • Documents
  • Network integration and function prediction: Putting it all together Slides courtesy of Curtis Huttenhower 04-13-11 Harvard School of Public Health Department
Download Network integration and function prediction: Putting it all together Slides courtesy of Curtis Huttenhower 04-13-11 Harvard School of Public Health Department

If you can't read please download the document

Upload: darnell-everist

Post on 14-Dec-2015

216 views

Category:

Documents


0 download

Report

Tags:

TRANSCRIPT

  • Slide 1

Network integration and function prediction: Putting it all together Slides courtesy of Curtis Huttenhower 04-13-11 Harvard School of Public Health Department of Biostatistics Slide 2 A computational definition of functional genomics 2 Genomic data Prior knowledge Data Function Function Gene Gene Function Slide 3 A framework for functional genomics 3 High Similarity Low Similarity High Correlation Low Correlation G1 G2 + G4 G9 + G3 G6 - G7 G8 - G2 G5 ? 0.90.70.10.20.8 +---+ 0.50.050.10.6 High Correlation Low Correlation Frequency Coloc.Not coloc. Frequency SimilarDissim. Frequency P(G2-G5|Data) = 0.85 100Ms gene pairs 1Ks datasets + = Slide 4 MEFIT: A Framework for Functional Genomics 4 Golub 1999 Butte 2000 Whitfield 2002 Hansen 1998 Functional Relationship Biological Context Functional area Tissue Disease Slide 5 Functional network prediction and analysis 5 Global interaction network Metabolism networkSignaling networkGut community network Currently includes data from 30,000 human experimental results, 15,000 expression conditions + 15,000 diverse others, analyzed for 200 biological functions and 150 diseases HEFalMp Slide 6 HEFalMp: Predicting human gene function 6 HEFalMp Slide 7 HEFalMp: Predicting human genetic interactions 7 HEFalMp Slide 8 HEFalMp: Analyzing human genomic data 8 HEFalMp Slide 9 HEFalMp: Understanding human disease 9 HEFalMp


Courtesy of ...Courtesy of Courtesy of Created Date 20130722215009Z

Courtesy of by MI.pdfCourtesy of . Courtesy of . Courtesy of

Aamal e Qurani€¦ · Courtesy . Courtesy . Courtesy

Large scale functional data mining: What can we find in the data we have? Curtis Huttenhower 08-12-10 Harvard School of Public Health Department of Biostatistics

Wales By Gwendolyn Curtis By Gwendolyn Curtis 3MO 3MO

Computational Methodology for Microbial and Metagenomic Characterization using Large Scale Functional Genomic Data Integration Curtis Huttenhower 03-08-10

Computational metagenomics and the human microbiome Curtis Huttenhower 01-21-11 Harvard School of Public Health Department of Biostatistics

O"ICE. Cruikshank David Keene J H Cummings Jas,Peterborouyh Curtis Curtis Charles Curtis George Curtis Mark Datidgon Archibald -Lang Davidson Archibald

Name of National Lab - energy.gov Industry... · Courtesy GRC Courtesy NREL Courtesy CPike /ACEP Courtesy RAM Power Courtesy NREL Courtesy GRC Geothermal Technologies Office . Eric

Network integration and function prediction: Putting it all together Curtis Huttenhower 04-13-11 Harvard School of Public Health Department of Biostatistics

Curtis Biologia

Love Suicides at Sonezaki By Chikamatsu Monzaemon Courtesy of The Barbara Curtis Adachi Bunraku Collection, C.V. Starr East Asian library, Columbia University

courtesy of albrecht-durer org · 2019-10-31 · courtesy of albrecht-durer org . Title: Slide 1 Author: Rachel Curtis Created Date: 7/25/2016 11:36:40 AM

Package ‘curatedOvarianData’ - Bioconductor · jamin Haibe-Kains, Svitlana Tyekucheva, Jie Ding, Ina Jazic, Michael Birrer, Giovanni Parmi- giani, Curtis Huttenhower, Levi Waldron

CURTIS MACHINE TOOLS LTD - Douglas Curtis Group

Amplicon functional profiling with PICRUSt Curtis Huttenhower 08-15-14 Harvard School of Public Health Department of Biostatistics U. Oregon META Center

Internet Archive Nahi.pdf · Courtesy . Courtesy . Courtesy

Meta’omic functional profiling with ShortBRED Curtis Huttenhower 09-19-15 Harvard School of Public Health Department of Biostatistics U. Oregon

Courtesy of - Internet Archive...Courtesy of Courtesy of Created Date 20130717184246Z

Courtesy  · 2018. 8. 10. · Courtesy . Courtesy . Courtesy

Charting the function of microbes and microbial communities Curtis Huttenhower 11-17-11 Harvard School of Public Health Department of Biostatistics

Curriculum reform: material concerns Elizabeth Curtis Neil Curtis

Mitosis Curtis

The Human Microbiome in Health and Disease Curtis Huttenhower 10-21-11 Harvard School of Public Health Department of Biostatistics

Courtesy  · Courtesy . Courtesy . Courtesy

Walt Curtis courtesy of Marian Wood Kolisch from Portraits ... · Walt Curtis Revisited Walt’s seize-the-day persona dramatica appears in the film, as he did earlier in Penny Allen’s

Answering biological questions using large genomic data collections Curtis Huttenhower 10-05-09 Harvard School of Public Health Department of Biostatistics

Large scale genomic data mining Curtis Huttenhower 10-23-09 Harvard School of Public Health Department of Biostatistics

Supervised and unsupervised methods for large scale genomic data integration Curtis Huttenhower 03-25-10 Harvard School of Public Health Department of

Scalable data mining for functional genomics and metagenomics Curtis Huttenhower 01-06-1011 Harvard School of Public Health Department of Biostatistics

Soerlasting Memory - Of-dlgmedia1-...1997/07/03  · Tony B. Curtis Vencent B. Curtis Wayne A. Curtis Jeffry L. Curtis Derek L. Curtis David K. Curtis Jonathan K. Curtis Zeta Phi Beta

Edward curtis

Meta’omic functional profiling with HUMAnN Curtis Huttenhower 08-15-14 Harvard School of Public Health Department of Biostatistics U. Oregon META Center

GET WITH THE PROGRAMS! - Heritage Fund · Social Media Coordinator Curtis Hartwell, pictured above with some of ... GET WITH THE PROGRAMS! Photos courtesy April Knox Photography Top:

Curtis Huttenhower - Harvard UniversityPadmanabhan P, Trachtenberg A, Ankarklev J, Brancucci NM, Huttenhower C, Duraisingh MT, Ghiran I, Kuo WP, Filgueira L, Martinelli R, Marti M