new productsdownloads.hindawi.com/journals/jamc/1987/352943.pdf · 2019. 8. 1. ·...

Journal of Automatic Chemistry of Clinical Laboratory Automation, Vol. 9, No. 2 (April-June 1987), pp. 102-104

New productsPE 7700 for thermal analysis

Perkin-Elmer’s PE 7700 ProfessionalComputer for use with the 7 SeriesThermal Analysis System offersimproved performance over the PE7500 in terms of RAM memory andhard disk options. Other benefitsinclude dual floppy disk drive, fourR5-232C communications ports, anIEEE-488 communications port anda port for interfacing a streamingtape device for large scale hard diskback-up.

The new generation PSA hydride generator. Existing customers wishing to upgrade theirhydride generators should contact P S Analytical who can provide retrofit kits at extremelyattractive prices.

The PE 7700 uses a multitasking/multiuser operating system for directcontrol of multiple thermal analysermodules which, when combined withone of the several thermal analysissoftware libraries available, allowssimultaneous, independent operationofmultiple thermal analysers or dataanalysis tasks in real time.

Modified pump head enhancesperformance of PSA hydridegenerator

The P S Analytical hydride generatoris extensively used as a continuoussource of hydride generation in ICP,DCP, and atomic absorption spectro-scopy. Its inherent design featuresallow the user of each of these tech-niques to provide a stable base-linesignal with low noise characteristics.In addition, a gas-liquid separatorsystem provides rapid signal risetimes and minimal memory effects.In both of these areas, which arefundamental to obtaining excellentdetection levels and precision, thepumping action is critical.

Working with Watson Marlow (Fal-mouth, UK) and using the recentlyreleased 304D head arrangement, P SAnalytical are now able to offersignificant performance advantagesover the previous PSA 10.002. Themodified pump head is a retrofitaddition to existing models. Eachhead is simply linked to the driveshaft by a twist and snap-in mechan-ism, no screws are used to fix it to themotor. Correct tensioning in thepump, for the tubing in use, is

achieved accurately by adjustment oftwo sliding clamps in the pump body,Finally, tensioning is added usingpair of bayonet-type adjustments.These are released when the pump isnot in use, thereby releasing tensionin tube and giving prolonged tubelife.

Problems experienced with the origi-nal pump head: (1) difficulty inadjusting tension correctly; (2) needto dismantle pump head to releasetension; or (3) tube welding togetherand causing a blockage, have all beenovercome with this new develop-ment.

By avoiding tube deterioration andextending the life of the tube inaddition to overcoming the aggrava-tion of dismantling pump head thismodification will greatly enhance theattraction of the hydride generatorsystem. Interfaces for the completerange of ICP, DCP and atomicabsorption spectrometers are avail-able.

For further details or for OEM enquiriesplease contact P S Analytical Ltd, ArthurHouse, Cray Avenue, Orpington, KentBR5 3TR, UK. Tel.: 0689 31632.

For further information please contactPerkin-Elmer Ltd, Post Office Lane,Beaconsfield, Buckinghamshire HP91QA, UK. Tel.: 04946 6161.

Ruggedized industrial terminals

Originally designed for use in steelmanufacture, a range of rugged ter-minals is now available from Indus-trial Peripherals Ltd. The terminalsare suitable for use in a variety ofapplications from harsh shop-floorconditions to laboratories. Made inthe UK the 7 in, 9 in and 12 in CRTsare mounted into a metal chassiswhich is enclosed in a wrap-aroundsteel shroud. This gives excellentprotection against physical shock,vibration and impact, as well as dustand splashes.

A detachable sealed sheet keyboardin a metal case is supplied as stan-dard. Moving switch elements underthe overlay give a tactile responsewhich is more acceptable to opera-tors than a conventional membranekeyboard.

The internal RS232 interface boardgives VT52 compatibility. Corn-

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New products

prehensive control codes allowoptions such as cursor on/off, inversecharacters, double size charactersand cursor addressing to be selected.

Text mode gives 80 x 25, 64 x 16 or40 x 16 character formats. Thegraphics option includes line draw-ing and pre-programmed symbolswhich may be used to enhance textdisplays or for pure block graphics.

Interface standards conform toRS232c and include hardware hand-shake with CTS, DTR signals orsoftware handshake using the Xon,Xoff protocol. Baud rate and wordformat may be set using internalswitches.

A full catalogue of industrial computerperipherals is available fiom: IndustrialPeripherals Ltd, Hawarden IndustrialPark, Manor Lane, Deeside, Clwyd CH53PP, UK. Tel.: 0244 532718.

Screening pharmaceuticalsoptical purity

for

More than 50 racemic drugs havenow been separated using a newpatented HPLC chromatographysystem. Developed by LKB Pro-dukter of Bromma, Sweden in co-operation with Dr J6rgen Hermans-son, the patented EnantioPac cart-ridge chromatography columnsystem is specifically designed fordirect separation and quantitation ofoptical isomers.

Separations have been made in manydifferent structural families, andinclude the anti-arrhythmic drugdisopyramide antihistamines such aschlorpheniramine, the sedativeenhexymal and the local anaestheticbupivacaine. More than .40 separa-tions have been made using Enantio-Pac by the FDA.

In contrast to other methods, theEnantioPac chiral column allowsseparation and quantitation ofoptical isomers to be carried outwithout lengthy preparation of deri-vatives or use of expensive chemicaladditives. It provides a rapid eco-nomical screening process to testoptical purity in many differentracemic pharmaceuticals. This willhelp to meet the growing demand to

0.02

Buff, mM NHPONs.HPO, +O.IM NaCland 2-prpnoJ. pH

mgmmbr

"lkmp: :5"C

The EnantioPac cartridge chromatography system.

establish the optical purity of newdrugs before they can be generallyprescribed.

conventional chiral columns. Eachmolecule of 0tl-AGP provides onechiral interaction site.

Thalidomide

The cost and difficulty of synthesiz-ing a therapeutic enantiomer in theabsence of its partner have resultedin the commercial use of racemicdrugs which contains a mixture ofthetwo enantiomers. Normally only oneof these is therapeutically active. Thesecond enantiomer may behave as aninactive and harmless contaminant,but it may not. In the case of thesedative drug thalidomide, the non-therapeutic enantiomer triggeredabnormal foetal development inpregnant women by damaging grow-ing nerve-cells. The tragedy of thali-domide highlights the potentialdanger of racemic mixtures, anddemonstrates the need for an effectivescreen technique.

The EnantioPac system is able toseparate such a wide range ofracemic drugs because of the veryhigh number of chiral interactionsites available in the column. Thechiral stationary phase comprises amatrix of silica micro-particles(diethylaminoethyl silica, particlesize 10 [zm) upon which the humanplasma protein 0ta-acid glycoprotein(0t-AGP) has been immobilized.The chemistry of the coupling pro-cess allows 10 times as much 0q-AGPto be loaded than is possible in

When the column is in use, tempor-ary diastereomeric complexes formbetween the solute enantiomers andthe 0t-AGP stationary phase. Thesecomplexes form at rates determinedby their differing stereochemistry, sothat the passage ofone enantiomer isretarded relative to the other and theseparation is made.

Cartridge design

The .EnantioPac column comes incartridge form comprising a reusableholder and pre-packed stainless steelcartridge, measuring 4.0 mm internaldiameter x 100 mm long, which(after initial swaging of the steelferrules) can be fitted by hand. Thecolumn can withstand 100 bar pres-sure and a maximum temperature of45 C. It forms part of a completeHPLC set-up including gradient-pump system, auto-injector and vari-able wavelength monitor for quanti-tative detection.

Adaptability to varying mobile-phase compositions and other chro-matographic conditions such as tem-perature, pH, organic modifiers andinorganic salts, means that Enantio-Pac can successfully separateracemic drugs with widely differinghyrophobicity. The system alsoaccepts chiral and non-chiral deriva-

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New products

tives of racemates, increasing thenumber of compounds that can beseparated.

Further information from LKB ProdukterAB, Box 305, S-161 26 Bromma, Sweden.Tel.: 46 8 799 8000.

Clinical analysis

Beckman have recently added twonew instruments to their range ofclinical analysis equipment- listprices start at a little over 1300 andrise to around 13 000 for a fullyautomated version. The System 100is the lower priced instrument cover-ing virtually the entire spectrum ofclinical chemistries with awavelength range from 340 to 690 nmand reading absorbance values in0.001A increments for exceptionalaccuracy. The System 100 alsofeatures a built-in filter storage com-partment, and quick response opticswhich read standard cm cuvettes ormicro-cuvettes in less than s toprovide high throughput. The sealedmembrane keyboard is spill-resistantand easy to clean and an automaticone-key zero and blanking facilitysaves time. No manual calculationsfor final answers are necessary, andthere is a wide selection of optionalaccessories to extend the capabilitiesof the system.

The System 700, which will be es-pecially useful in a wide variety ofclinical laboratory situations, includ-ing large and small health servicelaboratories, private laboratories andveterinary practices.

The batch analyser accepts averagereagent volumes of 600 microlitresand produces up to 200 test resultsper hour. The system 700 provides 21pre-programmed Beckman chemis-tries which can be easily re-programmed (Beckman has over 50different reagents for this system)and in addition it features full alphacapability in naming tests and linear-ity check for kinetic chemistries. Anadvanced curve fitting programmefor Enzyme Immunoassay (EIA) andEMIT is included as standard.

Wavelengths range from 330 to 800nm with 8 mm bandwidth, using aholographic grating. An advanced

flow cell design helps eliminate bub-bles, and the cell heats or cools to25 C, 30C or 37 C (+0.1 C). Flowis controlled by a precision pumpwhich steps in 25 ]zl increments. Thesystem produces carry-over of lessthan 0.2% at 600 ]zl. The analyserhas an RS232 port for connection topersonal computers. Both the 100and 700 are fully supported by theextensive Beckman range ofreagents,standards and controls.

For further information contact BeckmanLtd, Progress Road, Sands IndustrialEstate, High Wycombe, Buckinghamshire,UK. Tel.: 0494 41181.

Laboratory Automation Con-troller

The Zymark Corporation exhibitedthe new expanded Zymate II Labor-atory Automation Controller at the1987 Pittsburgh Conference in Atlan-tic City. The Zymate II Controller,with its ability to control up to 25modules, and to monitor externalevents is used to program and oper-ate the Zymate Laboratory RoboticsSystem and collect data from otherlaboratory instruments, as well as tocommunicate with other computersin the laboratory. The EasyLab soft-ware running on the Zymate IIController can be used directly bylaboratory personnel to automateand control laboratory procedures.

The Zymate II Controller is wellsuited to control laboratory proce-dures and acquire data necessary forreliable operation and decision mak-ing in the laboratory. Iflarge quanti-ties of data are to be processedsimultaneously with experiment con-trol, the Zymate II Controller canport data to a laboratory computer.Two interfaces are available toremote computers permittingbidirectional transfer of data andeven program control between theZymate II Controller and the labcomputer.

Features highlighted by the manu-facturer are:

(1) String processing capacity, whichallows the Zymate II Controllerto receive inputs from theoptional laser or wand-type bar-

code readers and store, print, orpass this information on toanother computer.

(2) Automatic sample scheduling option,which will convert a user-writtenprocedure to process one samplethrough a laboratory routine intoa procedure which will auto-matically serialize the routineand schedule the sample flow forsimultaneous multiple sampleoperation.

(3) The concurrent EasyLab optionallows multiple EasyLab proce-dures to be running simul-taneously. For example, theController could be monitoringand controlling modules whichare performing an end-pointtitration while simultaneouslyweighing out the next sample tobe processed.

(4) On-line user input and promoting isprovided for partially automatedor user interactive laboratoryprocedures.

(5) Table printing is included andpermits data to be reported on areal-time basis as it is collectedor batched and reported at theend of a procedure.

(6) A remote control interfaceoption permits the Zymate II tobe controlled by a host computeror to simply exchange data withanother computer.

(5) ’Plug-in’ interfaces for analyticalinstruments have also been devel-oped for the Zymate II, allowinginstruments to be operated andautomatically controlled fromthe Zymate .II Controller.Instruments for which dedi-cated, preprogrammed inter-faces have been developedinclude: Hewlett-Packard gaschromatographs, liquid chro-matographs and UV/Vis spec-trophotometers; Mettlerbalances and titrators; Metrohmtitrators and Sartorius balances;Milton Roy and Beckman spec-trophotometers.

More information from Zymark Corpora-tion, Zymark Center, Hopkinton, Massa-chusetts O1748, USA. Tel.: 617 435 9501.

104

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