nirf weissleder et al., nature cancer rev 2002 2(1):11-8 wavelength [nm] absorption coefficient (cm...
TRANSCRIPT
![Page 1: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/1.jpg)
NIRF
Weissleder et al., Nature Cancer Rev 2002 2(1):11-8
Wavelength [nm]
Abs
orpt
ion
coef
ficie
nt (
cm-1)
![Page 2: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/2.jpg)
Proteasen sensitive KM
Weissleder et al., Nature Biotech; 1999;17:375-378
a
CY
PL
MPEG COATING
Enzym
Kein Signal Signal
![Page 3: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/3.jpg)
MMP-Probe
Bremer et al. Nat Med (2001) 7 (6) 743-8
![Page 4: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/4.jpg)
Enyzmatische Aktivierung
0
250
500
0 300 600 900 15001200
Zeit [min]
MMP-2 Probe
Kontroll-Probe
Flu
ore
szen
s [A
U]
![Page 5: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/5.jpg)
ZellexperimenteGenexpression: rt-PCR
BT20 HT1080 MW-Standard
- +
Bremer et al. Radiology 221 (2), 523-9 (2001)
![Page 6: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/6.jpg)
In-vivo Experimente
MMP-2 + MMP-2 -Lichtbild
NIRF-Bild
MMP-2 + MMP-2 -
Bremer et al. Radiology 221 (2), 523-9 (2001)
![Page 7: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/7.jpg)
Inhibition der Probenaktivierung
AG3340
0
50
100
150p
rob
e ac
t. [
%]
AG3340 [M]
Flu
ore
szen
san
stie
g [
%]
10-12 10-10 10-8 10-6 10-4
Bremer et al. Nat Med (2001) 7 (6) 743-8
![Page 8: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/8.jpg)
MMP-Hemmung
Kontrolle AG3340
Bremer et al. Nat Med (2001) 7 (6) 743-8
![Page 9: NIRF Weissleder et al., Nature Cancer Rev 2002 2(1):11-8 Wavelength [nm] Absorption coefficient (cm -1 )](https://reader035.vdocuments.net/reader035/viewer/2022070310/55204d8149795902118d480e/html5/thumbnails/9.jpg)
Fluorescence mediated Tomography
Ntziachristos et al; Nat Med 2002