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1 Steve Chaney PhD Dr. Chaney holds a B.S. in Chemistry from Duke University and a Ph.D. in Biochemistry from UCLA. He is Professor Emeritus in the Department of Biochemistry, Biophysics and the Department of Nutrition at the University of North Carolina, taught nutrition at the prestigious UNC-CH Medical School and headed an active cancer research program there for over 30 years. Dr. Chaney has published over 95 papers in peer reviewed scientific journals, plus 12 reviews and two chapters on nutrition for one of the leading biochemistry textbooks for medical students today. He’s also been named “Teacher of the Year” several times by the first year medical students and currently holds a Medical Alumni Distinguished Teaching Professorship. The following are notes from a presentation by Steve Chaney PhD Nutritional Support During Cancer Treatments. NUTRITIONAL SUPPORT FOR CANCER - MYTHS VS FACT Dealing with a Cancer Diagnosis the dreaded “C” word is a scary time for the patient as well as family members Too Many Myths and not enough facts about cancer treatments can cause undue stress and possibly hurt your overall recovery. Time to get informed! MYTH #1: VITAMINS FEED CANCER CELLS Withholding nutritional supplements is like destroying the village to save it. The only way to selectively starve cancer cells is to withhold glucose (carbs) and keep the body alkaline Normal healthy cells use carbohydrates, protein and fat for their energy. Cancer cells ONLY use glucose (carbohydrates) and require acidic conditions to metabolize the glucose.

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Page 1: NUTRITIONAL SUPPORT FOR CANCER - Legacy of Health - Home · Patients can succumb to infections from fungus, bacteria, yeast, etc. Or get internal bleeding or stroke from loss of platelets

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Steve Chaney PhD Dr. Chaney holds a B.S. in Chemistry from Duke University and a Ph.D. in Biochemistry from UCLA.

He is Professor Emeritus in the Department of Biochemistry, Biophysics and the Department of

Nutrition at the University of North Carolina, taught nutrition at the prestigious UNC-CH Medical

School and headed an active cancer research program there for over 30 years.

Dr. Chaney has published over 95 papers in peer reviewed scientific journals, plus 12 reviews and two

chapters on nutrition for one of the leading biochemistry textbooks for medical students today. He’s also

been named “Teacher of the Year” several times by the first year medical students and currently holds a

Medical Alumni Distinguished Teaching Professorship.

The following are notes from a presentation by Steve Chaney PhD Nutritional Support During

Cancer Treatments.

NUTRITIONAL SUPPORT FOR CANCER - MYTHS VS FACT

Dealing with a Cancer Diagnosis – the dreaded “C” word is a scary time for the patient as well as

family members

Too Many Myths and not enough facts about cancer treatments can cause undue stress and

possibly hurt your overall recovery.

Time to get informed!

MYTH #1: VITAMINS FEED CANCER CELLS

Withholding nutritional supplements is like destroying the village to save it.

The only way to selectively starve cancer cells is to withhold glucose (carbs) and keep the body

alkaline

Normal healthy cells use carbohydrates, protein and fat for their energy. Cancer cells ONLY use

glucose (carbohydrates) and require acidic conditions to metabolize the glucose.

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GOOD CANCER STRATEGY

Keep blood sugar low. Keep blood alkaline. Sugar, meat and dairy make blood acidic.

MYTH #2: VITAMINS INTERFERE WITH CHEMO DRUGS

No good clinical studies have ever shown that supplements interfere with chemotherapy.

To be cautious, stop taking antioxidant supplements 2 days before chemo until 2 days

after. (only antioxidants. Other supplements can continue)

Chemo drugs are designed to leave the body rapidly after they do their job.

A certain amount of time between chemo treatments is required for normal cells to recover

THE PURPOSE OF CHEMOTHERAPY IS TO KILL CANCER CELLS.

The effectiveness of chemotherapy is directly proportional to the number of treatments that can

be given to eradicate the cancer cells.

If the patient becomes too weak, if the white blood cells drop too low, treatment must stop.

So the goal is to keep the patient as strong as possible during treatment so the full round of

chemotherapy can be administered…

That is why it is essential to strengthen normal cells between chemo treatments.

MYTH #3: CHEMO ONLY AFFECTS CANCER CELLS

Traditional Side Effects of Chemotherapy

Chemotherapy non-selectively damages all rapidly growing cells in the body, Affecting…Hair,

Lining of Digestive Tract, and Bone Marrow causing skin lesions, Sores in the mouth

Digestive side effects are nausea, vomiting, and dehydration

Chemo causes neurological damage– “chemo brain”

Some drugs adversely affect the blood, damaging platelets, neutrophils, and lymphocytes

o All essential elements for the immune system

SUPPLEMENTS THAT PROVIDE NATURAL RELIEF AND ADDRESS DIGESTIVE ISSUES

Ginger (watch ginger ale for sugar)

o Zevia Soft Drinks (Harris Teeter) made with Stevia for sweeteners no sugar.

o * Stomach Soothing Complex – Ginger based

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Stay hydrated. Do Not use Gatorade or any commercial hydration drinks as they are loaded with

sugar.

o * Performance

Use a Probiotic

o *Optiflora to restore essential probiotics in the digestive track.

o Commercial Yogurts, Kiefers and probiotics are destroyed in the stomach due to acid

secretions

Important note that 70% the Immune System LIVES in the gut - what we eat also

may affect the body's immune response. Moreover, the normal bacteria in our

large intestine contribute to bloating and gas production when carbohydrates, such

as lactose and fructose, are not completely absorbed in the small intestine. 1

Eating whole foods instead of refined or processed foods is good for everyone. Processed foods

are convenient, but to make them taste better, manufacturers use chemical additives and high

fructose corn syrup, a sweetener that is often not absorbed well, resulting in bloating and

abdominal discomfort.

Digestive enzymes are needed to digest fats, proteins, carbohydrates, etc. if needed.

o * EZ - Gest

FACT: BIG CONCERN … BONE MARROW DAMAGE

o Bone marrow is the reservoir for undifferentiated stem cells for all blood cells–

o Platelets (for clotting), neutrophils & lymphocytes (white cells)

o Blood cells have a life span of a few weeks to a few months, so they need constant

replenishing.

o The conversion from stem cells to mature cells requires cell division and, therefore, is

potentially damaged by various chemotherapy drugs

o This is why blood counts often drop with chemotherapy drugs.

It is Critical to Provide Nutrients the Bone Marrow Needs to Replenish the White Blood Cells and the

Platelets: keep calories & protein intake up to healthy levels. NOT a time to diet

Feed healthy marrow cells with Vita C, Vita E, Zinc, B Complex, Carotenoids, and Vita

Lea * See Vitalizer

1

"Nutrition Consultations: Integrative Medicine and Digestive Center." Nutrition Consultations: Integrative Medicine and Digestive Center. Johns Hopkins, 15 Apr. 2014. Web.

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* Nutriferon – stimulates interferon production – which causes the bone marrow to make more

immune cells. (This is critical) **

WHAT ABOUT RED BLOOD CELLS

Red blood cells are less affected than white cells and platelets, but anemia can still be a problem.

B Complex –very important for red blood cell production

Iron Plus C — sometimes needed depending on age and overall health of patient

MYTH #4: CANCER CELLS ARE IGNORED BY THE IMMUNE SYSTEM IN CANCER

PATIENTS

The most life-threatening event is the weakening of the immune system from loss of white blood

cells

IMMUNE SYSTEM FAILURE

Patients can succumb to infections from fungus, bacteria, yeast, etc.

Or get internal bleeding or stroke from loss of platelets.

Immune system is critical to fight the cancer cells

DETOXIFICATION FACT: Chemotherapy drugs are poisons and need to be expelled ASAP

Chemo drugs are designed to attack their targets and then leave the body all within a few

days.

Detox the blood and liver

MYTH #5: ALL CANCER IS GENETIC

Only about 5% to 10% of all cancers are inherited – resulting directly from gene defects

(called mutations) inherited from a parent. 2

Our genes can alter our risk of cancer by changing the effects of our lifestyle choices. 3

2 "Nutrition Consultations: Integrative Medicine and Digestive Center." Nutrition Consultations: Integrative Medicine and Digestive Center. Johns Hopkins, 15 Apr. 2014. Web. 3 Yong, Ed. "Four Lifestyle Changes for Fourteen Years of Life." Cancer Research UK Science Blog Four Lifestyle Changes for Fourteen Years of Life Comments. Cancer Research UK, 1 Jan. 2008. Web. 15 June 2014.

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WHAT NORMAL CELLS NEED TO RECOVER BETWEEN CHEMOTHERAPY

TREATMENTS

Full Spectrum Nutrients needed by normal cells

o * Vitalizer

Repair damage of normal cells

o * Vivix and Protein:

It is essential to keep protein and calorie levels high – not the time to diet.

GOOD Fat is NOT BAD for you! “Good” fats—monounsaturated and polyunsaturated

fats—lower disease risk. Foods high in good fats include vegetable oils (such as olive,

canola, sunflower, soy, and corn), nuts, seeds, and fish. ****

Immune Nutrients and Supplements needed:

Nutriferon – causes production of interferon. Interferon stimulates production of more

immune cells

Vitalizer, - Complete Spectrum Bio Available

FlavoMax, - Flavonoids are powerful water-soluble plant nutrients that deliver potent

antioxidant protection to the blood and blood rich tissues, especially the liver and

intestines.*

Carotomax (PreVitamin A, controls cell growth)

Additional Nutrients

Echinacea purpurea to stimulate the body’s natural resistance

o Defend and Resist (1 week on 1 off)

SUGGESTIONS FOR RADIATION

Avoid antioxidants so as not to protect cancer cells from the radiation ( C, E, carotenoids, flavonoids,

Vivix, and Vitalizer, Cinch and Meal Shakes as they have antioxidants in them)

BUT take the supplements that are NOT antioxidants … Nutriferon, B Complex, Energizing Soy

Protein, Instant Soy Protein Mix, Optiflora , Zinc,

MYTH #7 - EICOSENOIDS: THE OMEGAS CAN CAUSE CANCER

What is an Eicosanoid: They are hormone-like substances that control cell growth. Good and Bad

Omega 3 fatty acids –produce “good” eicosanoids that inhibit cancer growth.

o Some experts think omega-3s may help protect against cancer. "Omega-3 fatty

acids are thought to reduce inflammation in the body. And a variety of cancers

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have been linked to chronic inflammation," says Sarah Rafat, RD, a senior

dietitian at MD Anderson Cancer Center.

o Good eicosanoids are made from good fats omega-3 fats in fish

o Omega-3 fatty acids are important nutrients that are involved in many bodily

processes. The body cannot make these fatty acids and must obtain them from

food sources or from supplements. Three fatty acids compose the omega-3 family:

alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid. Alpha-

linolenic acid (ALA) is found in English walnuts, in some types of beans, and in

canola, soybean, flaxseed/linseed, and olive oils. The other 2, eicosapentaenoic

acid (EPA) and docosahexaenoic acid (DHA), are found in fish, including fish oil

and supplements

Omega 6 fatty acids –produce “bad” eicosanoids that stimulate cancer growth.

o Bad Eicosenoids are made from bad fats omega-6 fats, saturated & trans fats –

these are found in fried foods, foods made with vegetable oils like safflower, corn

oil, sunflower oil etc, such as chips, crispy snacks, baked goods, processed foods,

some salad dressings, beef, pork and lamb fed corn to fatten them Reduce BAD

fats– increase good fats. 4

Omega 3 health the Body build back faster after Chemotherapy: 5

TO REVIEW – THE “TAKE HOME” LESSONS

There are no clinical studies showing whether or not supplementation interferes with chemotherapy.

Because of the uncertainty some caution is prudent while the chemo drugs are in the body, so we stop

antioxidant supplements 2 days before through 2 days after Chemo, as the drugs leave the body in

about 24-48 hours.

Then we resume them to help the normal cells recover between rounds of chemo so that more chemo

treatments can be given

Clinical studies do show supplements can improve quality of life on chemotherapy

To Review– during chemotherapy

Stop antioxidant supplements 2 days before through 2 days after chemo.

4 "Fats and Cholesterol." The Nutrition Source. Harvard School of Public Health, 4 Jan. 2014. Web. 15 June 2013. 5 Mayo Clinic, Staff. "Cancer - Simple Steps Can Improve Your Sense of Well-being and Your Quality of Life after Cancer

Treatment. Find out What You Can Do." Survivors: Care for Your Body after Treatment. Mayo Clinic, 11 Oct. 2011. Web. 15 June 2014.

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The only time B vitamins are not recommended is when taking methotrexate & related drugs.

Antioxidants should be avoided during radiation treatment

Antioxidants: Vita C, E, CarotoMax, FlavoMax, and Vitalizer, Cinch and Meal Shakes

(as they have antioxidants in them) and Vivix.

Non Antioxidants: Nutriferon, Optiflora, B Complex, Energizing Soy Protein shakes,

Instant Soy Protein Mix, and Zinc.

RECAP of Effective Products

Stomach aides during chemo:

EZ –GEST for and better nutrient absorption

STOMACH SOOTHING COMPLEX digestive relief

PERFORMANCE - Hydration without sugar

Immune and cell building: Nutriferon – causes production of interferon. Interferon stimulates production of

more immune cells

Vitalizer, - Complete Spectrum Bio Available

FLAVOMAX - Flavonoids are powerful water-soluble plant nutrients that deliver

potent antioxidant protection to the blood and blood rich tissues, especially the

liver and intestines.*

CAROTOMAX (Pre Vitamin A, controls cell growth)

OPTIFLORA – probiotics for digestion and assimilation - Immune support

ENERGIZING PROTEIN

ZINC

VITA C AND B

Thoughts from the Professor

Chemotherapy is “the best of times and the worst of times”

At its best, it offers miraculous cures

At its worst, it exerts a terrible toll on the normal cells in our body

A prudent approach to supporting our normal cells while minimizing the interference with

chemotherapy offers the possibility of:

Minimizing side effects & improving quality of life

Maximizing the number of chemotherapy treatments that can be given

Check with your Oncologist for specific interactions of your treatment plan. Show them the

research that backs up the claims on this document.

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Dr. Chaney has chosen to partner with the Shaklee Corporation because of his belief if the efficacy and

purity of their products.

REFERENCES

"Nutrition Consultations: Integrative Medicine and Digestive Center." Nutrition Consultations:

Integrative Medicine and Digestive Center. Johns Hopkins, 15 Apr. 2014. Web.

"Heredity and Cancer." Heredity and Cancer. American Cancer Society, 28 Mar. 2013.

Yong, Ed. "Four Lifestyle Changes for Fourteen Years of Life." Cancer Research UK Science Blog

Four Lifestyle Changes for Fourteen Years of Life Comments. Cancer Research UK, 1 Jan. 2008. Web.

15 June 2014.

"Fats and Cholesterol." The Nutrition Source. Harvard School of Public Health, 4 Jan. 2014. Web. 15

June 2014.

Mayo Clinic, Staff. "Cancer - Simple Steps Can Improve Your Sense of Well-being and Your Quality of

Life after Cancer Treatment. Find out What You Can Do." Survivors: Care for Your Body after

Treatment. Mayo Clinic, 11 Oct. 2011. Web. 15 June 2014.

Spliier, GA, TS Pattison, CD Jensen, and LG Wong. "Result Filters." National Center for Biotechnology

Information. U.S. National Library of Medicine, 1985. Web. 15 June 2014.

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REFERENCE FOR SHAKLEE SUPPLEMENTS:

Shaklee products are Gluten free. No artificial flavors, sweeteners, colors, or

preservatives added.

VITA C

Vitamin C is a critical component of your body’s antioxidant defense network that protects cells and

enhances immune function. It also helps maintain the health of eyes, teeth, and gums as well as bones,

muscles, and blood vessels. Vitamin C is not manufactured or stored in the body and must be

continually replenished through diet. The clinically proven delivery system used in all-natural Sustained

Release Vita-C has been shown to maintain vitamin C levels over 12 hours

VITA E

Helps Promote Heart and Immune System Health Vita-E provides a powerhouse of substances shown in

studies to help maintain a healthy heart and immune system. Vita-E contains only natural vitamin E with

mixed tocopherols. This delivers more effective antioxidant protection than synthetic vitamin E.

Selenium complements the activity of vitamin E.

CAROTOMAX

With SIX key carotenoids CarotoMax delivers all six of the most important carotenoids— potent, fat-

soluble antioxidants that promote the long-term health of the eyes, prostate, cervix, heart, lungs,

immune system, and overall wellness. Carotenoids help protect cells against the onslaught of harmful

free radicals. For complete antioxidant protection, take CarotoMax and FlavoMax®.*

REFERENCES:

Bialy TL, Rothe MJ, Grant-Kels JM. Dietary factors in the prevention and treatment of

nonmelanoma skin cancer and melanoma. Dermatologic Surgery 2002; 28:1143–1152.

Catapano AL. Antioxidant effect of flavonoids. Angiology 1997; 48:39–44.

Eastwood MA. Interaction of dietary anti-oxidants in vivo: how fruit and vegetables prevent

disease? QJM 1999; 92:527–530.

Gerster H. Anticarcinogenic effect of common carotenoids. International Journal for Vitamin and

Nutrition Research 1993; 63:93–121.

Giugliano D. Dietary anti-oxidants for cardiovascular prevention. Nutr. Metab. Cardiovasc. Dis.

2000; 10:38–44.

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Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for

antioxidant treatment. Drugs and Aging 2001; 18:685–716.

Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, Griel AE,

Etherton TD. Bioactive compounds in foods: their role in the prevention of cardiovascular

disease and cancer. American Journal of Medicine 2002; 113 Suppl 9B:71S–88S.

Mares-Perlman JA, Millen AE, Ficek TL, Hankinson SE. The body of evidence to support a

protective role for lutein and zeaxanthin in delaying chronic disease: overview. Journal of

Nutrition 2002; 132:518S–524S.

Mojzisova G, Kuchta M. Dietary flavonoids and risk of coronary heart disease. Physiological

Research 2001; 50:529–535.

Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. Journal of the

American Dietetic Association 1996; 96:1027–1039

FLAVOMAX

With All Six Key Flavonoids FlavoMax supplies all six of the most important classes of flavonoids—

powerful, water-soluble plant nutrients that deliver potent antioxidant protection to the blood and

blood-rich tissues, especially the liver and intestines. Flavonoids defend the body against the destructive

actions of free radicals, promoting overall cell health and providing support for protection against

cellular damage.* For the best, most complete antioxidant protection, take FlavoMax and

CarotoMax®.*

REFERENCES:

Bialy TL, Rothe MJ, Grant-Kels JM. Dietary factors in the prevention and treatment of

nonmelanoma skin cancer and melanoma. Dermatologic Surgery 2002; 28:1143–1152.

Catapano AL. Antioxidant effect of flavonoids. Angiology 1997; 48:39–44.

Eastwood MA. Interaction of dietary anti-oxidants in vivo: how fruit and vegetables prevent

disease? QJM 1999; 92:527–530.

Gerster H. Anticarcinogenic effect of common carotenoids. International Journal for Vitamin and

Nutrition Research 1993; 63:93–121.

Giugliano D. Dietary anti-oxidants for cardiovascular prevention. Nutr. Metab. Cardiovasc. Dis.

2000; 10:38–44.

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Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for

antioxidant treatment. Drugs and Aging 2001; 18:685–716.

Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, Griel AE,

Etherton TD. Bioactive compounds in foods: their role in the prevention of cardiovascular

disease and cancer. American Journal of Medicine 2002; 113 Suppl 9B:71S–88S.

Mares-Perlman JA, Millen AE, Ficek TL, Hankinson SE. The body of evidence to support a

protective role for lutein and zeaxanthin in delaying chronic disease: overview. Journal

of Nutrition 2002; 132:518S–524S.

Mojzisova G, Kuchta M. Dietary flavonoids and risk of coronary heart disease. Physiological

Research 2001; 50:529–535.

Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. Journal of the

American Dietetic Association 1996; 96:1027–1039.

VITALIZER

A comprehensive and advanced multinutrient supplement using S.M.A.R.T. patent-pending delivery

system designed to significantly improve absorption of key nutrients, ensuring that key nutrients get to

the right place at the right time.

The nutrients in Vitalizer™ are based on the results of 12 clinical studies and a first of its kind

Landmark Study. In this groundbreaking study, published in Nutrition Journal, long-term Shaklee users

had markedly better overall health than non-supplement users, based on the most important heart-health

biomarkers recognized by the American Heart Association.

Supplement Facts

Serving Size: 1 Vita-Strip™

Selenium (as trace mineral protein hydrolysate) 70 mcg 100%

Copper (as copper gluconate) 1 mg 50%

Manganese (as manganese gluconate) 2 mg 100%

Chromium (as trace mineral protein hydrolysate) 120 mcg 100%

Molybdenum (as trace mineral protein hydrolysate) 75 mcg 100%

Sodium 10 mg <1%

Total Omega-3 fatty acids 500 mg † (from ultra-pure marine lipid concentrate)

Our full spectrum includes:

EPA (eicosapentaenoic acid) 280 mg 215%

DHA (docosahexaenoic acid) 180 mg 138%

And five other naturally found fatty acids, including:

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docosapentaenoic, stearidonic, eicosatetraenoic,

heneicosapentaenoic, and alpha-linolenic acids. 40 mg †

Bifidobacterium longum (probiotic) 250 million CFU †

Lactobacillus acidophilus (probiotic) 250 million CFU †

Lycopene (from tomato extract) 2.5 mg †

Lutein (as lutein ester from marigold flower extract) 5 mg †

Zeaxanthin (as zeaxanthin ester from marigold flower extract) 200 mcg †

Mixed tocopherols (Gamma-, beta-, and delta-tocopherols) 35 mg †

Cranberry extract (Vaccinium macrocarpon) (fruit) 50 mg †

Nickel (as trace mineral protein hydrolysate) 15 mcg †

Tin (as trace mineral protein hydrolysate) 10 mcg †

Vanadium (as trace mineral protein hydrolysate) 20 mcg †

Boron (as trace mineral protein hydrolysate) 1 mg †

Silicon (as silicon dioxide) 2 mg †

**Percent Daily Values (DV) are based on a 2,000 calorie diet. †Daily Value not established.

Calories 20

Calories from Fat 10

Total Fat 1 g 2%**

Total Carbohydrate 2 g 1%**

Protein <1 g 1%**

Vitamin A (75% as beta-carotene from 6,250 IU 125%

Blakeslea trispora and Dunaliella salina and 25% as vitamin A acetate)

Vitamin C (as calcium ascorbate and ascorbic acid) 500 mg 833%

Vitamin D3 (as cholecalciferol) 1,000 IU 250%

Vitamin E 200 IU 667% (as d-alpha-tocopherol concentrate, d-alpha-tocopheryl

succinate, mixed tocopherols, and mixed tocotrienols)

Vitamin K (as phytonadione) 80 mcg 100%

Thiamin (as thiamine mononitrate) 9 mg 600%

Riboflavin 10.2 mg 600%

Niacin (as niacinamide) 120 mg 600%

Vitamin B6 (as pyridoxine hydrochloride) 12 mg 600%

Folate (as folic acid) 400 mcg 100%

Vitamin B12 (as cyanocobalamin) 36 mcg 600%

Biotin (as d-biotin) 300 mcg 100%

Pantothenic Acid (as d-calcium pantothenate) 60 mg 600%

Calcium (as dicalcium phosphate and calcium ascorbate) 500 mg 50%

Iron (as ferrous fumarate) 18 mg 100%

Phosphorus (as dicalcium phosphate) 350 mg 35%

Iodine (as potassium iodide and sea kelp) 150 mcg 100%

Magnesium (as magnesium oxide) 200

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REFERENCES IN SHAKLEE LANDMARK STUDY

1. US Depart of Health and Human Services: The Surgeon General's report on nutrition and health.

Public Health Service, Washington, DC; 1988.

2. National Research Council Food and Nutrition Board Committee on Diet and Health: Diet and health:

Implications for reducing chronic disease risk. National Academy Press. Washington, DC;

1989.

3. Ervin RB, Wright JD, Reed-Gillette D: Prevalence of leading types of dietary supplements used in the

Third National Health and Nutrition Examination Survey, 1988–94. In Advanced data from vital health

statistics; no 349 Hyattsville, Maryland: National Center for Health Statistics; 2004.

4. Radimer K, Bindewald B, Hughes J, Ervin B, Swanson C, Picciano MF: Dietary supplement use by

US adults: Data from theNational Health and Nutrition Examination Survey, 1999–2000. Am J

Epidemiol 2004, 160:339-349.

5. Huang H-Y, Caballero B, Chang S, Alberg AJ, Semba RD, Schneyer CR, Wilson RF, Cheng T-Y,

Vassy J, Prokopowicz G, Barnes GJ, Bass EB: The efficacy and safety of multivitamin and mineral

supplement use to prevent cancer and chronic disease in adults: a systematic review for a National

Institutes of Health State of- the-Science Conference. Ann Int Med 2006, 145:1-14.

6. National Health and Nutrition Examination Survey, 2001– 2002

[http://www.cdc.gov/nchs/about/major/nhanes/nhanes01-

02.htm]

7. National Health and Nutrition Examination Survey, 2001- laboratory methods

[http://www.cdc.gov/nchs/about/major/ nhanes/lab_methods01_02.htm]

8. National Center for Health Statistics: Plan and operation of the third National Health and Nutrition

Examination Survey, 1988–94. Vital Health Stat 1(32); DHHS publication (PHS) 94-1308 1994

[http://www.cdc.gov/nchs/about/major/nhanes/ NHANESIII_Reference_Manuals.htm]. Hyattsville,

MD: National Center for Health Statistics

9. Gunter EW, Lewis BL, Koncikowski SM: Laboratory methods used for the third National Health and

Nutrition Examination Survey (NHANES III), 1988–1994. 1996 [http://

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www.cdc.gov/nchs/about/major/nhanes/ NHANESIII_Reference_Manuals.htm]. Hyattsville, MD:

Centers for Disease Control and Prevention

10. Araki A, Sko Y: Determination of free and total homocysteine in human plasma by HPLC with

fluorescence detection. J Chromatograph 1987, 422:43-53.

11. Bachorik PS, Kwiterovich PO: The measurement of plasma cholesterol, low density lipoprotein- and

high density lipoprotein- cholesterol. In Techniques in diagnostic human biochemical genetics: A

laboratory manual Edited by: Hommes FA. New York: Wiley-Liss, Inc; 1991:425-439.

12. Bucolo G, David HL: Quantitative determination of serum triglycerides by the use of enzymes. Clin

Chem 1973, 19:476-482.

13. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson

BJ, Oparil S, Wright JT Jr, Roccella EJ: The Seventh report of the Joint National Committee on

Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA

2003, 289:2560-2572.

14. Life Sciences Research Office: Assessment of the folate nutritional status of the U.S. population

based on data collected in the second National Health and Nutrition Survey, 1976– 1980. In Prepared

for the Center for Food Safety and Nutrition, Food and Drug Administration Rockville, MD: Federation

of American Societies for Experimental Biology; 1984.

15. Pfeiffer CM, Caudill SP, Gunter SP, Osterloh J, Sampson EJ: Biochemical indicators of B vitamin

status in the US population after folic acid fortification: results from the National Health and Nutrition

Examination Survey 1999–2000. Am J Clin Nutr 2005, 82:442-450.

16. Villareal D, Civitelli R, Chines A, Avioli L: Subclinical vitamin D deficiency in postmenopausal

women with low vertebral bone mass. J Clin Endocrinol Metab 1991, 72:628-634.

17. Holick M: Vitamin D and bone health. J Nutr 1996, 126:1159S-1164S.

18. Dawson-Hughes B: Calcium and vitamin D nutritional needs of elderly women. J Nutr 1996,

126:1165S-1167S.

19. Hathcock JN, Shao A, Vieth R, Heaney R: Risk assessment for vitamin D. Am J Clin Nutr 2007,

85:6-18.

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20. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jong R, Lindemans J, de

Groot LC, Hofman A, Witteman JC, van Leeuwen JP, Breteler MM, Lips P, Pols HA, Uitterlinden AG:

Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004, 350:2033-2041.

21. American Heart Association: C-reactive protein concentrations

[http://www.americanheart.org/presenter.jhtml?identi fier=3007984.]

22. American Heart Association: Lipid concentrations [http://

www.americanheart.org/presenter.jhtml?identifier=183]

23. Food and Nutrition Board Institute of Medicine: Dietary reference intakes for vitamin C, vitamin E,

selenium, and carotenoids. National Academy Press, Washington DC; 2000.

24. Gey KF: Vitamins E plus C and interacting conutrients required for optimal health. A critical and

constructive review of epidemiology and supplementation data regarding cardiovascular disease and

cancer. Biofactors 1998, 7:113-174.

25. AREDS Research Group: The Age-Related Eye Disease Study (AREDS): a randomized, placebo-

controlled, clinical trial of high-dose supplementation with Vitamins C and E, beta carotene, and zinc for

age-related macular degeneration and vision loss. AREDS Report No. 8. Arch Ophthalmol 2001,

119:1417-1436.

26. Libby P: Inflammation in atherosclerosis. Nature 2002, 420:868-874.

27. Block G, Jensen C, Dietrich M, Norkus EP, Hudes M, Packer L: Plasma C-reactive protein

concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Coll Nutr

2004, 23:141-147.

28. Wannamethee SG, Lowe GDO, Rumley A, Bruckdorfer KR, Whincup PH: Associations of vitamin

C status, fruit and vegetable intakes, and markers of inflammation and hemostasis. Am J Clin Nutr 2006,

83:567-74.

29. Chan DC, Watts GF, Nguyen MN, Barrett PHR: Factorial study of the effect of n-3 fatty acid

supplementation and atorvastatin on the kinetics of HDL apolipoproteins A-I and A-II in men with

abdominal obesity. Am J Clin Nutr 2006, 84:37-43.

30. Reiffel JA, McDonald A: Antiarrhythmic effects of omega-3 fatty acids. Am J Cardiol 2006, 98:50i-

60i.

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31. Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, Franzosi MG, Geraci E,

Levantesi G, Maggioni AP, Mantini L, Marfisi Publish with BioMed Central and every scientist can

read your work free of charge "BioMed Central will be the most significant development for

disseminating the results of biomedical research in our lifetime."

32. Idler EL, Benyamini Y: Self-rated health and mortality: a review of twenty-seven community

studies. J Health Soc Behav 1997, 38:21-37.

33. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM: Dietary approaches to prevent

and treat hypertension: a scientific statement from the American Heart Association.

Hypertension 2006, 47:296-308.

34. Forman JP, Rimm EB, Stampfer MJ, Curhan GC: Folate intake and the risk of incident hypertension

among US women. JAMA 2005, 293:320-329.

35. Ness AR, Chee D, Elliott P: Vitamin C and blood pressure: an overview. J Hum Hyperten 1997,

11:343-350.

36. van Dijk RA, Rauwerda JA, Steyn M, Twisk JW, Stehouwer CD: Long-term homocysteine-lowering

treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with

improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year,

randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol 2001, 21:2072-2079.

37. Mangoni AA, Sherwood RA, Swift CG, Jackson SH: Folic acid enhances endothelial function and

reduces blood pressure in smokers: a randomized controlled trial. J Intern Med 2002, 252:497-503.

38. Ceriello A, Motz E: Is oxidative stress the pathogenic mechanism underlying insulin resistance,

diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc

Biol 2004, 24:816-823.

39. Bjelakovic G, Nikolava D, Lotte L, Simonetti RG, Gluud C: Mortality in randomized trials of

antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.

JAMA 2007, 297:842-857.

40. Miller ER III, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E: Meta-analysis:

high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005,

142:37-46

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VIVIX contains both resveratrol and a proprietary phytonutrient blend. This phytonutrient blend

harnesses the powerful antioxidant properties of rare muscadine grapes and has been shown to be 10X

more powerful than resveratrol alone in slowing a key mechanism of cellular aging.*

1. Cell Defense

In a clinical study, Vivix key ingredients were shown to blunt the biological stress response, which, over

time, can lead to cellular aging.*†

2. Cell Energy

In a laboratory study, Vivix key ingredients were shown to increase energy production at the cellular

level, which is known to decline as we age.*

3. Cell Repair

In laboratory studies, Vivix key ingredients were shown to protect and repair DNA, which is assaulted

millions of times every day.* These assaults can damage the cell’s DNA, creating a “typo” that may

compromise cell function and longevity.

4. Cell Performance

In laboratory studies, Vivix key ingredients activated a genetic regulator that helps improve cellular

performance and slows the formation of damaging AGE proteins, which can accumulate and result in

cell damage.*

† Study name: A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory

Response to a High-Fat, High-Carbohydrate Meal. Date published: February 2, 2011.

NUTRIFERON

NATURAL INTERFERON*

Immunity Supplement Created by the Discoverer of Natural Interferon. Patented, power-packed

phytonutrient blend naturally invigorates your immune system.* NutriFeron contains a clinically

tested natural interferon booster† to provide immune support at the cellular level.* Gluten free.

Human Clinical Studies

1. Ushiroyama T, Yoshida S, Tadaki K, Ikeda A, Ueki M. Clinical efficacy of EH0202, a Kampo

formula, on the health of middle-aged women. Am J Chin Med. 2004; 32(5):755-770.

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2. Ushiroyama T, Yoshida S, Tadaki K, Ikeda A, Ueki M. A pilot study of a Kampo formula,

EH0202, with intriguing results for menopausal symptoms. J Altern Complement Med. 2004

Apr; 10(2):397-399.

3. Kaji K, Yoshida S, Nagata N, Yamashita T, Mizukoshi E, Honda M, Kojima Y, Kaneko S. An

open-label study of administration of EH0202, a health-food additive, to patients with chronic

hepatitis C. J Gastroenterol. 2004 Sep; 39 (9):873-878.

4. Kubo M, Hashimoto Y, Yoshida S. The effect of health food containing EH0202 on physical

and mental symptoms accompanying menstruation in women with premenstrual syndrome

(PMS). Clin Pharm Ther. 2004; 14(2):129-142

OPTIFLORA

Optiflora is a unique, two-product system that:

Provides dietary support for the normal, healthy balance of intestinal microflora

Promotes colon health by supporting the growth of healthy microflora naturally found in the

colon.*

Delivers guaranteed live probiotics Bifidobacterium longum and Lactobacillus acidophilus,

along with the prebiotics FOS and inulin and provides gammatocopherol, a nutrient associated

with colon health.*

Optiflora Prebiotic Complex

Provides a welcome environment for the friendly, beneficial bacteria that live and work

in the colon.

Pleasant tasting powder provides nutrients—including FOS and inulin—that selectively

feed friendly bacteria, encouraging their growth and multiplication.*

Optiflora Probiotic Complex

A unique capsule transports live beneficial bacteria safely through the acidic conditions

of the stomach

Optiflora’s triple encapsulation protects the helpful bacteria so they can be delivered live

to the intestines

B COMPLEX

There are eight essential B vitamins, and they work best when they work together. Unfortunately, the

typical Western diet doesn’t provide enough whole grains, leafy green vegetables, and fish needed to

provide 100% of the Daily Value. Shaklee B-Complex provides all the B vitamins you may not be

getting in your diet. The eight B vitamins, including biotin, work to:

• Help power your brain, heart, lungs, and other essential organs*

• Help metabolize energy from carbohydrates, fat, and protein

• Aid in the synthesis of DNA and new cells

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Patented Bioactivated Delivery System™

Dietary folate, a critical B vitamin, isn’t easily absorbed. Shaklee’s patented folic acid coating

makes the nutrient more accessible to promote absorption.

* Ubbink JB, Vermaak WJH, van der Merwe A, Becker PJ. Vitamin B12, vitamin B6 and folate

nutritional status in men with hyperhomocysteinemia. American Journal of Clinical Nutrition. 1993;

57:47-53.

Riggs KM, Spiro A, Ticker K, Rush D. Relations of vitamin B12, vitamin B6, folate and homocysteine

to cognitive performance in the Normative Aging Study. American Journal of Clinical Nutrition. 1996;

63:306-314.

ENERGIZING SOY

Non GMO

The highest quality plant-based protein available, Energizing Soy Protein is a biologically complete

protein source that's:

Naturally low in fat

Cholesterol free

Replete with all essential amino acids.

As part of a healthy diet:*

Helps build muscle, skin, and hormones

Supports the immune system

Retains normal cholesterol levels

Promotes heart and prostate health.

Contains soy isoflavones, which can help minimize hot flashes and promote breast health.

ZINC

It’s present in all cells in the body. As part of enzyme reactions, zinc is involved in such diverse

biochemical activities as protein digestion, amino acid metabolism, energy production, bone

metabolism, vitamin A utilization, and insulin production. Zinc is necessary for growth and

development, and to maintain normal immune function. It is also important for the synthesis of protein

and the genetic material DNA

EZ-GEST

• Supports complete digestion of fat, protein, and carbohydrates*

• Contains enzymes like those found in Lactaid® and Beano®***

• Alleviates discomfort such as gas and bloating*

• Helps digest “problem foods” including dairy and gas-producing vegetables such as

beans and broccoli, proteins, starchy carbohydrates, and fats*

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• Now in a vegetarian capsule

DEFEND & RESIST COMPLEX

Scientific studies suggest that along with a healthy diet and getting enough rest, consuming certain

herbal ingredients can help you be prepared for the moment when you first feel the need to bolster your

immune system.* Defend & Resist Complex can help your body respond to seasonal challenges by

giving your immune system what it needs to stay strong,* with a unique formula based on standardized

extracts of herbs.

■ Stimulates the body’s natural resistance* — Echinacea purpurea is the most studied herb

species. Echinacea contains plant components (herb and root) rich in cichoric acid, and

alkylamides with immunoactive properties.*

■ Maintains a healthy immune response* — Black Elderberryis a rich source of

polyphenols and anthocyanadins, powerful phytonutrients that help maintain the

immune system.*

■ Enhances immune support* — Larch Tree enhances Echinacea’s benefits with

immunoactive arabinogalactans extracted from the heartwood of the Larch Tree.*

■ Provides Zinc — Daily intake of Zincis important for proper immune function.*

REFERENCES

1 Barrett B,Volmann M, Calabrese C. Evidence-based clinical review — Echinacea for upper

respiratory infection.

The Journal of Family Practice. 1999; 48:628–35.

2 Zakay-Rones Z,Varsano N, Zlotnick M et al. Inhibition of Several Strains of Influenza Virus In

Vitro and Reduction

of Symptoms by an Elderberry Extract (Sambucus nigra L.) During an Outbreak of Influenza B

Panama.

Journal of Alternative and Complementary Medicine. 1995; 1:361-9.

STOMACH SOOTHING COMPLEX* is a powerful herbal blend that for centuries has calmed upset

stomachs, including discomfort caused by motion sickness. It makes the "not quite right" stomach calm

again.*

¹ Mowrey DB, Clayson DE. Motion sickness, ginger, and psychophysics. Lancet. 1982; 1:55-57.

PERFORMANCE:

Shaklee Performance® is clinically proven to hydrate better than water. Plus, Performance has more

electrolytes and provides more energy than the leading hydration drink. Our proprietary OPTI-LYTE™

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electrolyte blend plus our unique mix of carbohydrates delivers instant and sustained energy and

supports optimal hydration.

Clinically Proven

Minimizes fluid loss for enhanced hydration

Maintains blood-glucose levels to sustain intense energy output and to increase stamina

Increases endurance for better athletic performance

No artificial flavors, sweeteners or added preservatives.

1. Sports Nutrition Virtual Conference Sponsored by Euro monitor January 2011.

2. The Effects of Sodium: Carbohydrate (Na: Carb) Ratios in Rehydration Beverages (RB) on

Plasma (PG), osmolality (Po), Volume (PV), and Subject Tolerance (ST). FASEB J 1990;4:A381

(abstr).

3. Carbohydrate-Protein Complex Increases the Rate of muscle

Glycogen Storage after Exercise. Zawadzki, Yaspelkis, Ivy. J Appl Physiol 1992;72:1854-9.

4. Sports Nutrition Virtual Conference Sponsored by Euro monitor January 2011.

5. Exercise and fluid Replacement. Medicine & Science in Sports & Exercise, february 2007;

Volume 39, Issue 2. pp. 377-390.

6. Nutrition and Athletic Performance. Medicine & Science in Sports & Exercise, march 2009;

Volume 41, Issue 3. pp. 709-731.