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Learning Objectives: Immunology

Lecture 1: Introduction to the Immune system (9/18/12)

1. Describe the types of leukocytes in the blood (cells of immune system)?2. What is the distribution of lymphoid tissue in body and how does it function (tissues of

the immune response)?

3. Compare and contrast innate to specific/adaptive immunity.4. How do different types of lymphocytes mediate humoral and cellular immunity5. What are the differences between nave, effector and memory T and B cells?

Lecture 2/3: Innate Immunity (9/18/12)

1. To explain how the innate immune system recognize microbes2. To know the components of the innate immunity3. To explain how different components of innate immunity function to combat different

kinds of microbes

4. To know some examples of as to how microbes evade the innate immune system5. To know the differences between innate and adaptive immune responses6. To know some examples of cytokines of innate immunity7. To know the role of the innate immunity in stimulating adaptive immune responses

Lecture 4: Antigen Presentation to Lymphocytes (9/20/12)

1. Describe MHC Class I and Class II molecules2. How are foreign peptides loaded into the clefts of these molecules? W3. Why is cross-presentation important?4. What is the meaning of MHC restriction? of codominant expression? 5. Describe the consequences of MHC polymorphism.

Lecture 5: Antigens Receptors of B and T Cells: Commonalities (9/21/12)

1.

Compare and contrast the structure of an IgG and a TCR molecule and describe a Faband a Fc fragment.

2. Describe the immunoglobulin fold.3. What is the significance of hypervariable regions?4. Define the mechanism of VJ and VDJ joining?5. How are antibody and TCR diversities generated?

Lecture 6: Antigens Receptors of B and T Cells: Differences (9/24/12)

1. Why is somatic hypermutation important in B- not T-cell diversity?2. What is the role of the thymus in lymphocyte maturation?3. Describe the steps in B- and T-cell development.4.

What is allelic exclusion? What is its significance?

Lecture 7: Humoral Immune Reponses I (9/25/12)

1. Describe the structures and characteristics of IgM, IgD, IgG, IgA, and IgE.2. How are antibodies transported across epithelial barriers?3. What is the mechanism of isotype switching? (Genetics of isotype switching)4. How can antibodies be secreted or act as membrane-bound receptors?

Lecture 8: Humoral Immune Reponses II (9/27/12)

1. Define B cell maturation distinguish antigen-dependent v. -independent steps.

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2. Describe the life cycle of a B cell.3. How can monoclonal antibodies, both mouse and human, be made and used. Describe

ELISA assays and Western blots, agglutination and precipitation reactions, fluorescent-

activated cell sorting (FACS) and immunohistochemistry.

Lecture 9: T-Cell Mediated Immune Responses (9/28/12)

1. Definition of immune response2. Innate and adaptive immune response3. Main lymphocyte subsets

a. Th1b. Th2c. Th17d. Regulatory T cells

4. Cytokine and biological activities of Th1 and Th2 Subsets5. Process of:

a. Infectionb. Induction of immune responsec. Eradication of microorganismd. Generation of memorye. Immunoregulation

Lecture 10: Humoral Immune Reponses III (10/1/12)

1. Describe B cell activation with and without T cells2. What are the consequences of T helper cells interacting with activated B cells?3. Where do T-cells and B-cells interact?4. How is the humoral response down regulated?

Lecture 11: Effector Mechanisms of Humoral Responses (10/2/12)

1.

What are the effector functions of antibodies in:a. Serumb. Involving the cellular immune response

2. Describe 3 pathways of complement activationa. Classicalb. Alternativec. Terminal

3. What are the biological consequences of complement activation?4. How is complement cascade regulated?5. Describe diseases associated with complement deficiencies

Lecture 12: Immunology of Allergic Disease and Asthma (10/4/12)1. Hygiene Hypothesis2. Allergic asthma etiology and prevalence3. Cells that are participate in allergic disease and asthma, their role, and what they

produce

a. B-cellsb. T-cellsc. Eosinophilsd. Mast cells

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Lecture 13: Immunological Memory (10/4/12)

1. Compare and contrast a primary and a memory immune response2. What is the medical significance of a memory response3. What are the differences between effector memory and central memory T-cells?4. Where are the plasma cells and memory B cells generated?5. What families of molecules are essential for memory cell function?

Lecture 14: Vaccines