PRESS RELEASE O.D.A.white Kiss goodbye to melanin A skin brightening ingredient with a new mechanism of action from the heart of the melanocyte Sedermalaunchesanewingredient :O.D.A.whitetotreatskinpigmentationdisorderssuchas freckles, melasma, hyperpigmentation and general dark colourof the ethnic skin. Theenzymetyrosinaseisagoodtargetforthisinterferenceasitseemstobethelimitingfactorof therateofmelanogenesis.Manyskinlighteningingredients(orclaimedassuch)areessentially conceivedasaninhibitorofthistyrosinase.O.D.A.whiteappearedasagoodcandidatefor effectingmelaninsynthesisdecreaseviaanother,evenfurtherupstream,mechanism.Sederma showedthatO.D.A.whitedoesnotmediatemelaninsynthesisreductionbyadirectinhibitionof tyrosinasebutcaninhibitthewholemelaninsynthesispathwayfromthemelanocytenucleusby targeting the tyrosinase genevia the PPAR complex. Invitrostudiesshowed,thatinthepresenceofO.D.A.white,mRNAtyrosinaseandtyrosinase quantities decrease by 50%, producing a decrease of the pigmentation by 44%. Aclinicalstudywascarriedoutonatotalof21Chinesepanellists,withtwicedailyrandom applicationsof1%O.D.A.whiteagainstarbutinontheforearmfor8weeksfollowedbya4-week regression period. It has shown spectacular skin brightening effects. Themelaninsynthesisbeginstodecreaseafterapplication,reaches-22%after8weeksforthe majority(76%)ofthepanelandleadstoanincreaseoftheskinclarityupto28%.Thiseffectis reversible. For more information contact: Sederma SAS 29 rue du Chemin Vert 78612 Le Perray-en-Yvelines cedex France Tel: ++ 33 1 34 84 10 10 sederma@sederma.fr Week 0 Week 8: right arm treated by 1%O.D.A.white