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3/18/2014 1 Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA OfficeBased Laryngology Sunil Verma, M.D. University Voice and Swallowing Center Department of OtolaryngologyHead and Neck Surgery University of California, Irvine Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA Disclosures None Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA Learning Objectives Describe the evolution of officebased laryngology Recognize disease processes that can be treated in the office. Identify methods and tools used to anesthetize the laryngo pharynx.

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3/18/2014

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Office‐Based Laryngology

Sunil Verma, M.D.University Voice and Swallowing Center

Department of Otolaryngology‐Head and Neck SurgeryUniversity of California, Irvine

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Disclosures

• None

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Learning Objectives

• Describe the evolution of office‐based laryngology

• Recognize disease processes that can be treated in the office.

• Identify methods and tools used to anesthetize the laryngo pharynx.

3/18/2014

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Office‐based Laryngology ‐From Cough to Cancer

Sunil Verma, M.D. University Voice and Swallowing CenterDepartment of Otolaryngology‐Head and Neck Surgery

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Laryngology

• Originated in the office

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

3/18/2014

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Jacob Solis‐Cohen, 1870

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

3/18/2014

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Kirstein, 1897

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Chevalier Jackson , 1915

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Laryngology developments

• Operating microscope

• Instrumentation

• Lasers

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Office‐based procedures

• Vocal fold injection

• Tracheobronchoscopy

• Panendoscopy for cancer

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Technological improvements

• Distal Chip Endoscopy

• Esophagoscopy

• Fiber‐guided lasers

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Combination of these events

• Moving away from the operating room to the office

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Why?

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Risk of anesthesia increases with age

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Direct Laryngoscopy

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Cost of Health Care

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Improved efficiency

• Operating room• Procedure time:  1 hour

• Turnover time: 30 minutes to 1 hour

• Office• Procedure time: 15 – 30 minutes

• Turnover time: 5‐10 minutes

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

3/18/2014

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

So…

• Improved safety

• Improved morbidity for patient

• Improved cost savings

• Improved efficiency

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Office‐based Laryngology

• Laryngoscopy and biopsy

• Bronchoscopy

• Esophagoscopy

• Vocal fold injection

• Laser surgery

The ‘other’ operating room

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Procedures

• Scheduled as 30‐45 minute procedures

• Street clothes

• No IV line

• No sedation

• No monitoring

• Patients drive themselves to and from office

• Return to work the same day

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Conflict

• Physician wants access to protected place:– Pharynx– Larynx– Trachea– Esophagus

• But…protective reflexes are in place:– Gag– Laryngospasm– Cough

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Beware

Pain and anxiety co-influence each other

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

What do we need to do?

• Advanced preparation

• Communication

• Adequate anesthesia

• Communication

• Patient positioning

• Communication

• Proper tools

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Advanced Preparation

• Information sheets given at prior visit

• Same RN or MA if possible

• Consistency of set‐up

• Not for everyone – Medical provider andpatient

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

“The Patient Experience”

• Reduce the unknown

– Introductions

– Environment

• Orientation

• Room lighting

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Reduce the unknown

Chronological expectations

Chronological expectations

• First…

• Then…

– Sensation expectations

• “This is what’s going to happen and this is how it may make you feel”

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Need a balance of anesthesia

NOT ENOUGH TOO MUCH

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

“Too much of a good thing”

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Topical 4% Lidocaine

• Cheap, safe and effective

• Works almost immediately

• 3 Goals – Suppress gag

– Suppress laryngospasm 

– Suppress cough

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Endoscopy case study

• 38 year old female c/o shortness of breath 

• Mild hoarseness

• Otherwise healthy

• Wheezes with exercise

• Treated for asthma but still symptomatic

• No medical or surgical history

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Physical examination

• Examination is essentially normal

• Inspiratory noisy breathing

• Mirror examination of larynx is normal

• What next?

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Flexible Laryngoscopy

• Likely next step

• May, or may not, give us what we need

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Bronchoscopy

• Typically performed by pulmonolgists

• Can be performed by otolaryngologists

• Tremendous amount of information

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Nebulized Lidocaine

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Nebulizer

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Procedure

• Introduce endoscope

• Suspend above larynx

• Laryngeal gargle– Necessary 0‐5% of the time

• Pass endoscope through larynx

Procedure

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Bronchoscopy

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Office tracheobronchoscopy

• Determine the length of stenosis• Assess the characteristics of stenosis

– Severity (Grade)– Distance from the vocal folds– Quality 

• Web‐like vs. thick• Localized versus circumferential• Scar vs. cartilage

– Levels• Single versus multilevel• Relationship to tracheotomy tube

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Other ways of imaging: CT

• Need has decreased with office endoscopy

• Best for cartilaginous vs. membranous stenosis

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Vocal fold injection

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Indications for vocal fold injection

• Augmentation

• Paralysis

• Paresis

• Presbylarynx

• Medication delivery

• Steroid

• Botulinum toxin

• Cidofovir

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Case study

• 54 year old male with 3 months voice change

• Voice sounds “different”

• Runs out of breath  and feels “winded”

• Coughs on liquids

• No PMHx

• No Tob/EtOH/PSHx/Intubations

• CN II‐XII intact

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Laryngoscopy and stroboscopy

• INSERT VIDEO HERE

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Work‐up

• Repeat cranial nerve examination

• Cranial nerve X, XI, and XII

• Image path of recurrent laryngeal nerve

• CT or MRI from skull base to aortic arch

• Modified barium swallow study if suspicious

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

How do you manage this?

• Observation

• Voice therapy and swallowing therapy

• Vocal fold injection laryngoplasty

• Thyroplasty

• Recurrent laryngeal nerve reinnervation

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Vocal fold injection laryngoplasty

• Augmentation material

• First described in 1911

• Multiple materials have been tried

• Paraffin

• Collagen

• Teflon

• Gelfoam

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Injection laryngoplasty

• Medialize the vocal fold

• Lateral vocal fold injection

• Add bulk to the vocal fold

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Injection location

Teflon injection

Courey, MS. Injection Laryngoplasty. Otolaryngol Clin N Am 37 (2004) 121-138

Size matters

• Courey, MS.  Injection Laryngoplasty.  Otolaryngol Clin N Am 37 (2004) 121‐138.

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Timing of injection• As early as possible

• Studies are showing that early injection may lead to  better outcomes

• Exception – immediately after extubation

Prendes BL, et al.  Long‐term effects of injection laryngoplasty with a temporary agent on voice quality and vocal fold position.  Laryngoscope. 2012 Oct;122(10):2227‐33Friedman AD, et. al.   Early versus late injection medialization for unilateral vocal cord paralysis.  Laryngoscope. 2010 Oct;120(10):2042‐6

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Office or O.R.?

• Initial reports of injections in the office

• Then more commonly performed in the OR

• Now many surgeons perform in the office

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Office                     Operating room

• Patient awake

• No risk of general anesthesia

• Quick

• Titrate volume

• No ETT in the way

• Cost

• Better control

• No gag reflex to supress

• Supplies bought by OR

• Can inject fat

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Vocal Fold Injection

• Many different techniques

• Slight overcorrection

• 0.6 – 1 cc volume of injectate

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Which agent?

• No good answer

• Calcium hydroxyapatite

• Carboxymethylcellulose

• Micronized dermis

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Transoral injection

• Rigid transoral endoscope

• Halogen (not strobe) light

• One person technique

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Atomizer sprays

• Three sprays

• Each spray 1‐2 seconds each

• Spray # 1: Oral Cavity

• Spray # 2: Tonsillar Pillars

• Spray # 3: Posterior Pharyngeal Wall

Base of tongue

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Oral cavity sprays

• Hand patient tissue before you start

• Warn patient of foul taste

• Give time to swallow between sprays

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Reassure patient beforehand

• “Coughing, tearing, and gagging is normal”

• Lidocaine may make you feel as if:

• You can’t breathe

• You can’t swallow

3/18/2014

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Oral anesthesia

• 4% lidocaine via atomizer to oral cavity

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Patient positioning

• Sniffing position

• Holding tongue with  4x4 gauze

• Staring at object

• Eye level of surgeon to patient’s mouth

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Positioning

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Abraham cannula

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

“Batman”

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Laryngeal Gargle

• Three separate 1 cc aliquots of lidocaine

• Abraham cannula

• Sustained /e/

• “Inhale when you run out of breath”

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Final aliquot

• INSERT LARYNGEAL GARGLE VIDEO

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Injection laryngoplasty

• VOCAL FOLD INJECTION VIDEO

Paralysis: Where to inject?

University Voice and Swallowing Center               epartment of Otolaryngology‐Head and Neck Surgery

B

D

C

A

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Depth for augmentation

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Two‐person technique

• Flexible laryngoscope ‐ transnasal

• Injection performed transcutaneously

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Two‐person technique

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

From above

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Thyrohyoid injection

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

From below

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Pointers (learned from pitfalls)

• Adequately anesthetize nose

• Use 1% lidocaine for skin anesthesia

• Insert needle into airway and spray lidocaine

• Channeled endoscope – perform laryngeal gargle

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Tips for assistant

• Holding the endoscope is tiring!

• Conserve your energy

• Stabilize elbows against body

• Get out of the way

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Another approach

• http://www.youtube.com/watch?v=5E2DiYsGhi8

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Hoarseness case study

• 21 year old male recently intubated for 5 days

• Bilateral throat discomfort three months later

• Hurts to speak

• Speaks “softly” 

• No breathing or swallowing problems

• Refractory to voice rest

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Delivery of steroids

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

After steroids

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Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA

Summary

• Office based laryngology has many applications

• Keys

– Adequate Anesthesia

– Proper equipment

– Communication

– Patient Selection

Fourth Annual ENT for the PA-C | April 24-27, 2014 | Pittsburgh, PA