one-pot sequence for the decarboxylation of α-amino acids

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2003 Amino acids Amino acids U 0400 One-Pot Sequence for the Decarboxylation of α-Amino Acids. — Treatment of α-amino acids with NBS under buffered conditions at pH 5 results in decarboxylation and formation of intermediate nitriles which are directly reduced to the corresponding amines in a one-pot manner using NaBH4/NiCl2 as the reductant. — (LAVAL, G.; GOLDING*, B. T.; Synlett 2003, 4, 542-546; Sch. Nat. Sci., Univ. Newcastle, Newcastle upon Tyne NE1 7RU, UK; Eng.) — Mais 29- 153

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Page 1: One-Pot Sequence for the Decarboxylation of α-Amino Acids

2003 Amino acids

Amino acidsU 0400 One-Pot Sequence for the Decarboxylation of α-Amino Acids. — Treatment of

α-amino acids with NBS under buffered conditions at pH 5 results in decarboxylation and formation of intermediate nitriles which are directly reduced to the corresponding amines in a one-pot manner using NaBH4/NiCl2 as the reductant. — (LAVAL, G.; GOLDING*, B. T.; Synlett 2003, 4, 542-546; Sch. Nat. Sci., Univ. Newcastle, Newcastle upon Tyne NE1 7RU, UK; Eng.) — Mais

29- 153

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