op estero mycli

www.mycli.com

The Italian Brand for the skin

1. Quality

2. Pharmaceutical approuch andexperience

3. Italian brand power: Luxuryfeeling and Technology for highstanding products

4. Effort and Support

Esthetic Line the products foraging treatment that really workwithout side effects

Dermatologic Line dermatologicproductsfor skin diseases and sensitive skins

Cleanser

OP LIQUID SOAP

Fluid soap without irritating and allergenic detergents; it isspecifically formulated for intolerant and stressed skin especiallyafter dermatological and surgical treatments. It cleans gently theskin, maintaining the epidermal surface lipids and reducingirritation thanks to Jojoba Oil and Vitamin E.Completely hypo-allergenic and physiological pH.

Indications: It is indicated for sensitive and intolerant skin,suffering cleansing with common soap or detergents. You shoulduse the product in case of several skin diseases and afterdermatological or surgical practice such us chemical peelings orother medical practice.Apply a small amount of fluid soap on skin and massage. Rinse itup with abundant water.

Size: 250 ml

Cleanser

OP LIQUID SOAPFeatures: absolutely free from allergenic substances;

Physiological pH;

Advantages: you can use it for any kind of skinproblem, after surgery and also like make up remover toavoid irritation;

Benefits: daily skin cleaning for any kind of skin;

Target: Pediatrists, General Prac., Aesthetic Doctors,Dermatologists, Plastic Surgeons, Beauticians;

Main Competitor: Eucerin fluid Price: $15.00Size: 200 ml

Cleanser

OP LIQUID SOAPGraphs describing the improvement of the skin feeling after 4 weeks application twice perday of OP liquid sensible skin soap after laser therapy. University of Pavia – Italy

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Cleanser

OP GENTLE BODY CLEANSER

OP Gentle Body Cleanser is the latest answer from Mac Pharma researchin order to clean the sensitive and intollerant skins.Sensible skin is very sensitive to the external aggressions both for the lackof barrier skin lipids and for hypersensitivity to the normal externalstimulations. OP gentle Body Cleanser cleans sweetly even the moresensible skin without sensitization favouring the replenish of importantfatty acids capable to restore the integrity and function of skin barrier.

Indications: Physiological cleaning of sensible and reactive skin in courseof irritative and allergic dermatitis such DAC, DIC Atopic dermatitis and incase of aesthetic and dermatologic treatments. OP Gentle Body Clenaseris indicated for all the skin type and also for children both for the faceand for the body

Size: 500 ml

Cleanser


Characteristics: absolutely free from allergenicsubstances;

Physiological pH;

Advantages: can be applied on any kind of“untreatable” skin;

Benefits: effective cleanser, daily usage for any kind ofskin;

Target: Pediatrists, General Prac., Aesthetics Doctors,Dermatologists, Plastic Surgeons, Beauticians.

Main Competitor: Aveeno Emulave Sensitive fluidPrice: $20.00 Size: 400 ml

Cleanser


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Graphs describing the improvement of the skin feeling after 4 weeks application twice perday of OP liquid sensible skin soap after laser therapy. University of Pavia – Italy

Moisturizer and lenitive

OP LENITIVE CREAM

The product contains several molecules suitable to modulate the most importantsigns of skin irritation and inflammation after dermatological and surgicalpractices or photo-induced skin burning.It works normalizing excessive vasodilatation, inhibiting inflammatory skin signsand induce an anaesthetic effect against skin pain and burning.Very high absorbing vehicle and hypo-allergenic.

Indications: This cream contains molecules suitable to reduce inflammation,itching, burning in case of several skin conditions such excessive sun exposition,dermatological or surgical skin practices such chemical peeling, laser therapy,dermo-abrasion. Polidocanol induces a mild skin anaesthesia, glycyrrhetic acidreduces inflammation signs and Rutin restores dermis vascular systemphysiology.Apply two or more time a day with a small massage.

Size: 50 ml

Moisturizer

OP LENITIVE CREAM

Features: Effective mix of polidocanol and liqoriceextract;

Advantages: Daily action to restore and protect the skinfrom any kind of irritations and pollution withmoisturizing effect;

Benefits: protect sensitive skin, restore wellness afterdermatologic treatments, reduce discomfort of atopicand allergic skin;

Target: Dermatologists, Plastic Surgeons, Pediatrists,General Prac., Aesthetics Doctors, Beauticians;

Main Competitor: Lichtena, Giuliani PharmaSize 50ml Price 25,00 Euro

Moisturizer

OP LENITIVE CREAM

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Graphs describing the improvement of the skin feeling after 4 weeks application twice perday of OP lenitive cream skin after laser therapy. University of Pavia – Italy

Prevention Anti Aging

OP REBUILDING SERUM AGE

This is a new anti-age serum with a liposome based vehicle composed of themost effective anti-age molecules available. This lipidic serum allows toreplace effectively the lost skin lipids, to induce the restoration of themetabolic processes of the skin, to enhance the antioxidant activity within theskin cells.Particularly indicated for the treatment of eye contour skin marks, finewrinkles, atrophy and poor skin hydration and elasticity.

Indications: OP REBUILDING SERUM is indicated for a daily care of skinface, to prevent aging signs, to enhance skin tone and pigmentationuniformity.

Size: 75 ml


OP REBUILDING SERUM AGEFeatures: anti-age serum for face and neck with silky texture;

Advantages: it’s capable to induce a strong filling and smoothingaction;

Benefits: It’s easy to absorbe and ensures an immediate liftingeffect. Thanks to Trylagen-KGF active principle it boost up collagensynthesis, uniformes skin pigmentation and inibits enzymaticdestruction.

Target: Pharmacists, customers.

Main Competitor: EC 30 - 5 senses system- 30 ml € 130,00


OP REBUILDING SERUM AGEGraphs of the results after 4 weeks application twice per day of OP rebuilding serum age.University of Pavia – Italy

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Treatment Body

OP HYDRA SVELT

A new brand based on synergy of active ingredients such asPanthenol, Hyaluronic Acid, Shea Butter, Olive leaf flavonoidsand PCA working closely with the skin to moisturize, rebuild andrestore the naturally protective hydro-lipidic film. The highconcentration of Jaluronic Acid ensures a constant moisturizinglevel over a long period of time, whilst Shea Butter and Oliveleaf flavonoids help to induce a deep sensation of comfort andsuppleness.

Directions: Apply all over the body making sure the skin isthoroughly cleaned and massage until fully absorbed.

Size: 250 ml

Treatment Body

OP HYDRA SVELT

Features: The high concentration of Jaluronic Acid ensures a constantmoisturizing level over a long period of time, whilst Shea Butter and Olive Oilhelp induce a deep sensation of comfort and suppleness.

Advantages: Easily absorbed, OP Hydra Svelt is ideal after bath or showerto smooth the skin stressed by sun, wind and pollutants or simply naturally dry;

Benefits:If used regularly, improve the firmness, hydration and elasticity ofyour skin.


Main Competitor: HYDRA – FLASH Spécial Corps Formule Intensive - Sisley –200 ml. – 98.00 Euro

Treatment Body

OP HYDRA SVELTGraphs of the results of the skin after 4 weeks application twice per day of OP hydrasvelt. University of Pavia – Italy

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OP LIGHTENING CREAM

Extra Care

The formulation contains innovative active compounds capable to inhibit themelanic pigments biosynthesis and mainly to induce the production of clearestpigments able to camouflage with the normal colour of the skin.It furthermore contains Liquorice extract which shows reduction of melanicpigmentation and anti-bruise and sun burns preventing actions;

Indications: This formulation is particularly indicated to treat melanic skinspots thanks to its unique and innovative way of action capable to reducemelanin skin synthesis and anyway to produce clearer melanins;

Apply this formulation twice a day with light massage.

Size: 50 ml

Extra Care

Characteristics: emulsion with association of Acethylcistein,Sodium ascorbyl phosphate and Glabridin from Liquoricecapable to reduce melanic spots, melasma and eumelanicsynthesis;

Advantages: effective cosmetic treatment in case of melasma,sun induced skin spots and chemical peeling;

Benefits: it reduces production of eumelanins, bleaches skinspots physiologically and maintains uniform skin pigmentation;

Target: Dermatologists, Plastic Surgeons, Pediatrists, GeneralPrac., Aesthetics Doctors, Beauticians.

Main Competitor: NeoStrata Bionic Skin Lightening Cream. size30 ml

OP LIGHTENING CREAM

Extra Care

Graphs of the results after 6 weeks application twice per day of OP Lightening cream.University of Pavia – Italy

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OP LIGHTENING CREAM

Extra Care

OP SOFT PEEL

New formulation for a soft daily exfoliation and skin surfacerenewal. It contains mandelic acid, an a-hydroxyacid with goodcheratoplastic activity and safe skin behaviour. In combinationwith allantoin, resveratrol and mild glucosidic surfactants it actsas exfoliating and normalizing skin tissue even in case ofexcessive sensibility and irritation. It has been formulated for thepreparation and maintenance of the professional chemicalpeeling and to improve skin surface appearance andhomogenise skin pigmentation.

Indications: This formulation is particularly indicated for thepreparation and maintenance of chemical peeling. It can beapplied as detergent and to uniform skin surface andpigmentation.

Size: 100 ml;

Extra Care

OP SOFT PEELFeatures: Film former and riepetilizing agent and sweettensioactive agent for a mild face cleansing;

Advantages: it improves capillaries resistance andneutralize free oxigen radicals; help to uniformcutaneous colour and to inhibit excessive melanic activity;

Benefits: It mantains peeling effect for a long time andsafety;

Target: Pharmacists, customers

Main Competitor: Perfectionist Peel2-Step Enzyme Activating Treatment 50 ml - EstéeLauder - € 94,00

Extra Care

OP SOFT PEEL

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Graphs of the results after 4 weeks application twice per day of OP soft peeling.University of Pavia – Italy

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Sun Booster

OP BRONZ SVELT

This product, born from nanoemulsion technology, is capable to inducea deep absorption of active ingredients (kinetic analisys withDiclofenac sodium salt).The active molecule is a liphophilic Tyrosine capable to stimulatephysiologic melanins synthesis;Viscous gelified form with more than 65% of eudermal lipids.The nano-structurated lipogel is completely vegetable based (Patent).Paraben and IMU free.Structure similar to the healthy horny layer (protein-lipids domains).

Indications:Skin pigmentation modulator: without UV exposure, poor uniform skincolour, localized acromie;Tan sublimating: Natural or artificial UV exposure (UV-A and UV-B),lenitive after-sun and melanic pigmentation mantainance

Size: 200 ml

Sun Booster

OP BRONZ SVELT

Features: Nano-structured lipogel completely vegetableable to increase sun tanning physiologically;

Advantages: increasing sun tanning uniformity and lasting;

Benefits: More rapid and safe sun tanning;

Target: Pharmacists, customers

Competitors: Attiva-Bronz – ROUGJ – 125 ml - € 18,00

Sun Booster

OP BRONZ SVELT

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Graphs results after 4 weeks application twice per day of OP bronz svelt. University ofPavia – Italy

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Nutraceutical

OP BIOREPAIR PLUS

Contains:Glutathion, an antioxidant enzyme to maintain cells healthy;Glucosamine, the main brick of glucosaminoglycans such as Hyaluronic acid,Lipoic Acid, an enzyme cofactor effective to prevent skin aging and reduce wrinkles depth;B Vitamins, to improve cell metabolism;Ascorbic Acid, to boost up collagen maturation and epithelia restoaration;Betacaroten, to prevent sun damage and sustain skin trophism;

Directions: One sachet a day possibly far from meals, simply dissolved in the mouth or glass ofwater.

Biorepair plus is a nutritional supplement indicated to prevent skinaging and the most frequent phenomena such as wrinklesformation, atrophy, melanic spots and sagging. It contains the mostpowerful ingredients to sustain skin metabolism, improve skinfirmness and reduce oxidative damage. Thanks to its oro-solubleform with good taste and flavour it results nice to take.

Nutraceutical

OP BIOREPAIR PLUS

Features: thanks to the synergy of these substances, OPBIOREPAIR PLUS is ideal as an anti-oxidant and trophicnutritional support for the skin tissues during beauty medical andsurgery treatments;

Advantages: an effective nutritional answer to skin agingproblems, for successful and safe exposure to the sun and toreduce cell aging according to the most recent biochemistry-research breakthroughs;

Benefits: In this powder formulation, soluble in the mouth, itoffers high bio-availability of active ingredients (under-the-tongue absorption) and has a pleasant taste.


Main Competitor: Inneov Re-Age Fermete (20 days) – 28.00 €- each day: 1,40 €

Nutraceutical

OP BIOREPAIR PLUS

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Graphs of the results after 4 weeks of OP Biorepair plus’ use University of Pavia – Italy

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Biomedical

OP EMOLLIENT FOAM (14% Zinc Oxide)

Thanks to the Panthenol this new brand foam can improve epithelia restorationin case of invasive skin treatment and bruise conditions.The formulation is based, also, on high concentration (14%) micronized oxidezinc and Vit. E in an innovative vehicle capable to transfer the microgranules ofactive oxide zincum, deeply in the epidermal layer. The greatly enhancedcontact surface developed by micronization of oxide zinc allows to treat wideskin areas with relatively small mousse amount.

Indications: This light and soft foam contains micronized zinc oxide andVitamine E and it is specifically formulated to treat sensitive, irritate andbruised skin specially in paediatrics.Its quick and complete penetration allows to induce an effective epitheliarestoration.Apply several times a day with a mild massage on the skin involved.

Size: 30 ml

Biomedical

Features: highest concentration of micronized zinc oxide;

Advantages: fast action for all Skin irritations without whiteeffect;

Benefits: rapid relief after any skin injury;

Target: Pediatrists, General Prac., Aesthetics Doctors,Dermatologists, Plastic Surgeons, Beauticians.

Main Competitor: Obagi Derm Healthy Skin Protection 9%Micronized Zinc Oxide SPF 35 3 oz Price: $32.00


BiomedicalCosmetic Efficacy

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Graphs of the results after 1 week application twice per day of OP foam after lasertherapy. University of Pavia – Italy


Biomedical

OP HAND AND FEET CREAM 20% UREA

Op Hands and feet cream is a new A/O dermatologic formulationspecifically formulated for all the skin conditions characterizes by severedryness and scaling. This formulation is based on lanolin alcool 5% andUrea 20% that in synergy with an W/O vehicle is capable to restore skinlipids and physiologic skin moisture. By mean of an-effective emollientproprieties Op Hands and Feet cream improves all the signs of altered skinbarrier in case of several dermatologic conditions such as xerosys, itching,atopic dermatitis, psoriasis and severe scaling. This formulation isparticularly and especially indicated for the treatment of hand-feetsyndrome which can occur in case of oncological therapy such as 5FU.

Indications: sever scaling and dry skin conditions.

Size: 50 ml

Biomedical

OP HAND AND FEET CREAM 20% UREA

Characteristics: A/O emulsion with high percentage of Urea and lanolinalcohol. It creates a barrier on the skin and improves skin dryness andelasticity in case of severe skin impairments, hands-feet syndrome, xerosys.

Advantages: very fast skin signs improving (dryness, scaling) and long lastingprotection

Benefits: reduce discomfort and hands-feets impairment in case ofdermatosys induced by chemotherapic drugs. Very effective also in course ofexfoliative skin diseases such as psoryasis, ichthyosis, atopic dermatitis

Target: Dermatologists, Oncologist, General Prac..

Main Competitor: no products competitors with 20% of Urea

Biomedical

OP HAND AND FEET CREAM 20% UREAGraphs of the results after 5 weeks application twice per day of OP Hand and feet cream.University of Pavia – Italy

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OP SAFETY GEL

This innovative nano-structured formulation is realized with a patented nano-emulsifier and contains natural oils, emollients and lenitive terpens. Thisformulation is a nano-gel with up to 70% of oils and inside its water corecontains an effective concentration of hyaluronidase, an enzyme capable tosoften deep dermal tissue and solve the most common aesthetic side effectsconcerned with sclerotherapy (extravasayion, inflammation) and with dermalfiller implantation (hyaluronic acid accumulation, inflammation and oedema).Thanks to its specificity on hyaluronic acid breakage and to the high absorptionnano-sized structured vehicle, SAFETY GEL could be considered the elective topictreatment for all the main aesthetic treatments side effects. It is completely safe,not allergenic, and adapt for all skin type.

Indications: The product is indicated for sclerotherapy side effects, oedemaafter hylauronic acid implants, skin inflammation;

Size: 20 ml

Biomedical

OP SAFETY GELCharacteristics: New nanostructured lipogel containing high purificationhyaluronidase (350 UI). It acts promoting high absorption of enzyme intothe skin and favouring reabsorption of oedemas, dermal hyaluronic acidaccumulation and to improve signs and symptoms of irritations aftersclerotherapy extravasation.

Advantages: innovative and high performing nanogel; deep absorptionof hyaluronidase into dermo-epidermal tissue; preservants free; high skintollerability;

Benefits: dermatologic formulation to treat most frequent side effects indermatologic practice.

Target: Plastic Surgeons and Aesthetics Doctors.

Main Competitor: no products competitors

Biomedical

OP SAFETY GEL

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Graphs of the results after 4 weeks application twice per day of Safety gel. University ofPavia – Italy

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Biomedical

OP C-KADERMSilicon based lipogel specifically formulated to prevent and managehypertrofic scars and Keloids. It acts as film forming onto the skinsurface, reducing scar extension, hydrating scar tissue, reducing scarredness and discomfort. Musqueta oil improves skin tissue normalization,reduces inflammation and favours skin epithelia restoration.

Indications: cosmetic manage of hypertrophyc scars incase of surgical treatment, aesthetic treatment and small dermatologicsurgery;

Size: 20 ml

Biomedical

OP C-KADERM

Features: New lipogel containing high purification silicon polymersacting as film-folmer. Elective formulation to manage hyperthrophicscars and keloids. Thanks to Rosa Mosqueta Oil it acts as a skinepithelia restoring and moisturizer.

Advantages: innovative and high performing silicon based lipogel;high hydrating properties, emollient, scar tissue emollient anddepigmenting;

Benefits: dermatologic formulation to treat most frequentabnormalities of scarring.

Target: Plastic Surgeons and Aesthetics Doctors

Main Competitor: Dermatix gel 15 g - Valeant - € 40,00

Biomedical

OP C-KADERMStudy of the citotoxicity and evaluation on wound healing of C-kaderm - EVIC HISPANIA -February 2004 - Barcelona

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IngredientsOP LIQUID SOAP 250 ML - INCIAqua, Cocamidopropylbetaine, Coco Glucoside, PEG-18 Glyceril Oleate/Cocoate, Glycol Distearate, Buxus Chinensis, Hydrolyzed WheatProtein, Sodium Chloride, Citric Acid, Disodium Edta, Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Sodium Dehydroacetate.

OP GENTLE BODY CLEANSER - INCIAqua, Coco Glucoside, Cocamidopropyl Betaine PEG-18 Glyceryl Oleate/Cocoate, Glycol Distearate, Simmondsia Chinensis Oil, SodiumChloride, Hydrolyzed Wheat Protein, Citric Acid, Disodium EDTA, Sodium Benzoate, Sodium Dehydroacetate, Parfum.

OP LENITIVE CREAM - INCIAqua, Octyl Palmitate, C12-20 Acid PEG-8 Ester, Glycerin, Cetearyl Alcohol, Glyceryl Stearate, Ruscus Aculeatus, Glycyrrhetinic Acid, Laureth-9,Allantoin, Tocopheryl Acetate, Bisabolol, Lecithin, Tocopherol, Ascorbyl Palmitate, Citric Acid, Dimethicone, Phenoxyethanol, Methylparaben,Ethylparaben, Propylparaben, Disodium Edta, Sodium Dehydroacetate.

OP HYDRA SVELT - INCIAqua, C12-15 Alkyl Benzoate, Glycerin, Caprylic/Capric Triglyceride, Hexamethyldisiloxane, Triticum Vulgare Germ Oil, Butyrospermum ParkiiButter, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Panthenol, Phenoxyethanol, Olive OilPeg-8 Esters, Polysorbate 20, Arginine, Cetearyl Glucoside, Bisabolol, Anthemis Nobilis, Sodium Pca, Urea, Xanthan Gum, Lactose, Glucose,Sucrose, Sorbitol, Ascorbyl Palmitate, Hydrolyzed Collagen, Choleth-15, Glyceryl Oleate, Sodium Hyaluronate, Glycine, Ceteth-15, Oleth-40,Fructose, Lactic Acid, Bht, Bha, Hexylene Glycol, Methoxydiglycol, MagnesiumChloride, Potassium Chloride, Imidazolidinyl Urea, Sodium Hydroxide, Disodium Edta, Citric Acid, Geraniol, Linalool.

OP LIGHTENING CREAM - INCIAqua, Octyl Palmitate, Glyceryl Stearate, Sodium Ascorbyl Phospate, Steareth-2, Tocopheryl Acetate, Glycerin, Steareth-21, Acetylcisteine,Glycyrrhizza Glabra, Cetearyl Alcohol, Lecithin, Tocopherol, Ascorbyl Palmitate, Citric Acid, Dimethicone, Sodium Hydroxymethylglicinate,Disodium Edta, Sodium Dethydroacetate, Lactic Acid.

Ingredients

OP SOFT PEEL - INCIAqua, Mandelic Acid, Propylene glycol, PEG-40 Hydrogenated Castor Oil, Phytic Acid, Hydroxyethylcellulose, Coco glucoside, SodiumHydroxide, Retinyl Palmitate, Polygonium Cuspidatum Extract, Allantoin, Bisabolol, Chamomilla Recutita Extract, Lactic Acid, Sodium PCA,Lecithin, Tocopherol, Ascorbyl palmitate, Citric acid.

OP BRONZ SVELT - INCIPotassium Lauroyl Oat Amino Acids, Palm Glycerydes, Capryloyl Glycine, Ethylexyl Isononanoate, Dicapryl Ether, Capryloyl Tyrosine,Potassium Sorbate, Sodium Benzoate, Parfum.

OP BIOREPAIR plus - INCIFruttosio, Aromi, Vitamina C, Maltodestrine da Mais, Acidificante: Acido Citrico, Glucosamina solfato 2KCl, Antiagglomerante: biossido disilicio, Acido -lipoico, Niacina, Taurina, Vitamina E acetato 50%, Glutatione, Licopene al 6% (da estratto secco di Pomodoro-Licopersicumlesculentum frutto), succo di melone concentrato (Cucumis melo frutto), Acido folico, Vitamina B12

IngredientsOP EMOLLIENT FOAM – INCIAqua, Zinc Oxid, PEG-8 Caprylic/Capric Glycerides, Isobutane, Glycerin, Propane, Polysorbate 80, Panthenol, Butane, Tocopheryl Acetate,Benzyl Alcohol, Disodium Lauriminodipropionate Tocopheryl Phosphates, Hydrogenated Lecithin, Potassium Sorbate.

OP HAND/FEET CREAM - INCIPetrolatum, Aqua, Urea, Lanolin Alcohol, Sorbitan Isostearate, Polyglyceryl-3 Ricinoleate, Sodium laccate, Lactic Acid, Magnesium Sulfate,Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben.

OP SAFETY GEL - INCIAqua, Ethylexyl Isononanoate, Palm Glycerides, Dicaprylyl Ether, Capriloyl Glycine, Potassium Lauroyl Wheat Amino Acids, bisabobol, Lecithin,hyaluronidase, Potassium Sorbate, Sodium Benzoate, Disodium EDTA.

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OP PLURIATTIVO 3STAMINAL AGEREVOLUTION

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•Innovative features•Indications

•Marketing strategies

MY CLIDirezione scientifica-R&S

Andrea Fratter

OP PLURIATTIVO 3 STAMINAL AGE REVOLUTION

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• Liquid cristals technology;

• Centella asiatica staminale cells;

• Innovative association between Nicotinamideand Glucosamine for the structuralrestoration of dermal layer and bleaching ofmelanic spots;


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LIQUID CRISTALS

• Technology capable to promote high stability to the formulations,high skin feeling and boost up penetration of active compounds;

• Liquid cristals overcome the concept of classic emulsion in which awater phase and an oily one are mixed together;

• Liquid cristals are “small islands” in which water and oil mixtogether thanks to particular emulsifiers: as like in a cream boxthere are milions of microscopic droplets of active principles;


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CENTELLA ASIATICA(vegetal stem cells)

• Glucosides extracted from this plant show a vigorous action in the inhibiting ofjaluronidase, enzyme involved in jaluronic acid destruction;

• Association with Glucosamine is particularly inteersting because represents thebrick of jaluronic acid and promote its biosynthesys; it is possible to reducephysiologic jaluronic acid degradation and so inducing an “endo-filler” effect;

• Centella asiatica is widely employed in dermatology as epithelia restorationagent, scar promoting and blood vessels protector;

• An innovative biotechnological technique is capable to isolate Centella asiaticastem cells highly enriched in active molecules. This technique allows to maintainplant phyto-complex with an high active principles content (up to 50% ofglucosides on the plant weight) (Patent, IRB);


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• Main brick of GAG (jaluronic acid, condroitinsulphate);

• An adequate introduction of Glucosamine (at less 100mg/die) permits a correct turn-over of dermal matrix(water embedded in dermal matrix);

• Glucosamine promotes sinovial liquid rigeneration(cartilages protection);

• Particularly indicated the assumption for at least onemonth before a dermal filler injection or chemical peelingto improve esthetic result;

• It works as melanic bleaching in sinergy withnicotinamide;

GLUCOSAMINE


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• Glucosamine: an ingredient with skin and other benefits.

• Bissett DL.

• Procter & Gamble Co., Miami Valley Laboratories, Cincinnati, OH 45252, [email protected]

• Both glucosamine and its derivative N-acetyl glucosamine are amino-monosaccharides thatserve key biochemical functions on their own and as substrate precursors for the biosynthesisof polymers such as glycosaminoglycans (e.g., hyaluronic acid) and for the production ofproteoglycans. Glucosamine has an excellent safety profile and has been shown to providebenefits in several clinical disorders. Glucosamine compounds have been reported to haveseveral beneficial effects on the skin or skin cells. Because of its stimulation of hyaluronic acidsynthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, anddecrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melaninproduction and is useful in treatment of disorders of hyperpigmentation. Mechanistically,glucosamine also has both anti-inflammatory and chondroprotective effects. Clinical trials haveshown benefit in using oral glucosamine supplementation to improve symptoms and slow theprogression of osteoarthritis in humans. Glucosamine has also been used to prevent andtreat osteoarthritis in animals. Based on other observations, glucosamine has been suggestedfor additional clinical uses, including treatment of inflammatory bowel disease, migraineheadaches, and viral infections. The current clinical uses for topical and oral glucosaminecompounds and the mechanistic rationale for these uses are reviewed here.

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Br J Dermatol. 2010 Feb 1;162(2):435-41. Epub 2009 Aug 28.Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination oftopical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlledtrial.Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL.Harvard Medical School, Boston, MA 02114, USA. [email protected]: Topical niacinamide and N-acetyl glucosamine (NAG) each individually inhibit epidermalpigmentation in cell culture. In small clinical studies, niacinamide-containing and NAG-containing formulationsreduced the appearance of hyperpigmentation. OBJECTIVES: To assess the effect of a combination ofniacinamide and NAG in a topical moisturizing formulation on irregular facial pigmentation, including specificdetection of changes in colour features associated with melanin. METHODS: This was a 10-week, double-blind,vehicle-controlled, full-face, parallel-group clinical study conducted in women aged 40-60 years. After a 2-week washout period, subjects used a daily regimen of either a morning sun protection factor (SPF) 15sunscreen moisturizing lotion and evening moisturizing cream each containing 4% niacinamide + 2% NAG (testformulation; n = 101) or the SPF 15 lotion and cream vehicles (vehicle control; n = 101). Product-inducedchanges in apparent pigmentation were assessed by capturing digital photographic images of the womenafter 0, 4, 6 and 8 weeks of product use and evaluating the images by algorithm-based computer imageanalysis for coloured spot area fraction, by expert visual grading, and by chromophore-specific imageanalysis based on noncontact SIAscopy for melanin spot area fraction and melanin chromophore evenness.RESULTS: By all four measures, the niacinamide + NAG formulation regimen was significantly (P < 0.05) moreeffective than the vehicle control formulation regimen in reducing the detectable area of facial spots and theappearance of pigmentation. CONCLUSIONS: A formulation containing the combination of niacinamide +NAG reduced the appearance of irregular pigmentation including hypermelaninization, providing an effectbeyond that achieved with SPF 15 sunscreen.

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• Treatment of atrophic, aplastic and oxidized skin; highly photo-damaged skin(pigmentations, poor hydration, wrinkles);

• Neck and decolletè (main districts of application);

• Rich and nourishing formulation, very nice sensoriality and good misturizingproperties;

• This formulation is to be considered effectively a filler boosting formulationcapable to enhance dermal filler duration and reduce its degradation (veryimportant to associate BIOREPAIR PLUS);


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• Protocol for face and neck aging;

• Association with CELAZOME;

• Association with ULTRA ANTIOXIDANT FORMULA (face)

• Association with BIOREPAIR PLUS;


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1

OP PLURIATTIVO 3 CORPOBODY CREAM

Antiage revolution for body careMY Cli, Scientific Affairs and Formulation

ManagerAndrea Fratter

Pharm. D, PhD Cosmetic Sciences

2

The product

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• Liquid crystals technology;

• Silky and vanishing sensoriality;

• Very fast absorption (body lotion with high “spreadingvalue” lipids):

Average “spreading value”: 1500 mm2/10 min;

• Association of ElastocellTM (Inci: Lysine Carboxymethyl

Cysteinate) and Reboescin-salTM (Patent pending),active blend of pure trans-Resveratrol, Escin, SalicylycAcid, Retinol and Centella Asiatica Stem Cells ;

Innovative features

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Innovative features

Liquid cristals

• Technology capable to ensure high stability ofthe emulsions, very good sensoriality feelingand improve active compounds skinpenetration;

• Liquid cristals are “small islands” in which waterand oil create a unique continous phase thanksto peculiar emulsifying agents: in a cream boxthere are bilions of microscopic emulsiondroplets entrapping active compounds;

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• Synthetic molecule produced starting fromL-Cysteine (Inci: Lysine CarboxymethylCysteinate) capable to induce a completerenovation of epidermal layer andimprove skin elasticity up to 30% after 3weeks of application);

• Patented molecule capable to improveskin distensibility, surface smoothness andrejuvenate epidermis;

• Very useful and effective to improve skinquality of the body in course of aging,cellulitis and poor elasticity;

ELASTOCELLTM (5% w/w)

Innovative features

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RESVERATROL (1% w/w)• Phytoextrogen extracted from Vitis Vinifera seeds and

skin and from Poligonum Cuspidatum roots;

• One of the most investigated natural substances;

• Scientifically and clinically clarified its phytoextrogenic,cardiovascular protective and onco-preventive activities;

• Highly effective to improve structure and health ofmature skin (menopausa) and in the management ofsevere aging skin conditions, especially if photo-damaged;

• Very good skin penetration at the contrary of thesistemic absorption;

Innovative features

Arch Biochem Biophys. 2011 Apr 15;508(2):164-70. Epub 2011 Jan 4.The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges.Ndiaye M, Philippe C, Mukhtar H, Ahmad N.SourceDepartment of Dermatology, University of Wisconsin, Madison, WI 53706, USA.AbstractResveratrol, a phytoalexin antioxidant found in red grapes, has been shown to have bothchemopreventive and therapeutic effects against many diseases and disorders, including thoseof the skin. Studies have shown protective effects of resveratrol against ultraviolet radiation-mediated oxidative stress and cutaneous damages including skin cancer. Because many of theskin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears tohave promise and prospects against a wide range of cutaneous disorders including skin agingand skin cancers. However, there are a few roadblocks in the way of this promising agentregarding its translation from the bench to the bedside. This review discusses the promise andprospects of resveratrol in the management of skin disorders and the associated challenges.

Arch Dermatol Res. 2010 Mar;302(2):71-83. Epub 2009 Nov 7.Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repairmechanisms.Nichols JA, Katiyar SK.SourceDepartment of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard,Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA.AbstractEpidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiationin various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disordersare caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc.The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit,reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety ofpolyphenols or phytochemicals, most of which are dietary supplements, have been reported topossess substantial skin photoprotective effects. This review article summarizes thephotoprotective effects of some selected polyphenols, such as green tea polyphenols, grapeseed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation,oxidative stress and DNA damage, etc., with a focus on mechanisms underlying thephotoprotective effects of these polyphenols. The laboratory studies conducted in animalmodels suggest that these polyphenols have the ability to protect the skin from the adverseeffects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols mayfavorably supplement sunscreens protection, and may be useful for skin diseases associatedwith solar UV radiation-induced inflammation, oxidative stress and DNA damage.

J Drugs Dermatol. 2010 Dec;9(12):1523-6.Dose-dependent antioxidant function of resveratrol demonstrated via modulation of reactive oxygenspecies in normal human skin fibroblasts in vitro.Jagdeo J, Adams L, Lev-Tov H, Sieminska J, Michl J, Brody N.SourceDepartment of Dermatology, SUNY Downstate, Brooklyn, NY 11203, USA. [email protected] study of free radicals is particularly relevant in the context of human skin carcinogenesis and photoagingbecause of their ability to induce DNA mutations and damaging lipid peroxidation byproducts. Therefore, itis important to identify and evaluate agents with the ability to modulate intracellular free radicals.Significant interest exists in evaluating the chemotherapeutic and anti-oxidant properties of resveratrol(trans-3,4',5-trihydroxystilbene). Resveratrol is a phytoalexin, a naturally occurring compound derived fromthe skin of grapes and other plants. Resveratrol was selected for evaluation because of demonstratedchemopreventive and chemotherapeutic properties in a murine skin cancer model and other human cancermodels through a variety of mechanisms. However, the intracellular anti-oxidant properties of resveratrolon free radicals in human skin cells in vitro is not well characterized. The purpose of this research is toinvestigate the ability of resveratrol to modulate the hydrogen peroxide-induced upregulation of reactiveoxygen species (ROS) free radicals in normal human skin fibroblast cells in vitro. Hydrogen peroxide is a wellknown generator of free radicals that occurs during endogenous and UV-induced oxidation processes in thehuman skin and was used to upregulate ROS in normal human skin fibroblast cells. Using a flow cytometry-based assay, the results demonstrate highly significant (P<0.001) dose-dependent reduction of intracellularhydrogen peroxide-upregulated ROS by resveratrol at 0.01%, 0.001% and 0.0001% concentrations in humanskin fibroblasts in vitro.

Biofactors. 2010 Sep;36(5):342-9.Effect of resveratrol on endothelial cell function: Molecular mechanisms.Schmitt CA, Heiss EH, Dirsch VM.SourceWolfson Institute for Biomedical Research, University College London, United Kingdom.AbstractThe polyphenolic natural product resveratrol (RV), best known for its occurrence in grape skinand red wine, is considered a candidate drug for prevention and treatment of cardiovasculardiseases. This review aims to summarize the molecular effects of RV on endothelial cells,which line the inner walls of blood vessels and play a key role in the development of thosediseases. We describe how RV enhances endothelial nitric oxide production, improvesendothelial redox balance and inhibits endothelial activation in response to pro-inflammatoryand metabolic insults. Furthermore, we summarize effects of RV on endothelial senescence,apoptosis, endothelin-1 release, and endothelial progenitor cell function. As many of RV'sactions seem to be mediated by SIRT₁, different mechanistic possibilities how RV may lead toSIRT₁ activation are discussed.

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ESCIN (0,6% w/w)• Steroidic Saponine extracted from Horse chestnut seeds

and cortex;

• Very effective molecule in the protection and trophismof veno-linfatic vessels, to reduce and absorb oedema,soft tissue congestion and imbibition and to preventconnective fibrosis (cellulitis);

• In form of hydrogel at percentage of 1 and 2% isconsidered drug (REPARIL GEL);

• Very effective and quick to reduce dermal and adiposesoft tissue infiltration in course of cellulitis;

• The most effective molecule in the topical treatment ofcellulitis;

Innovative features

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RETINIL PALMITATE (0,6% w/w)

• Esterified Retinol with palmitic acid (simmetry with AscorbylPalmitate);

• One of the tree biological active form of Vitamina A(Retinol, Retinaldheyde, Retinoic acid);

• It is converted in the skin to Retinoic acid acting as dermalrenoving agent (boosting up of hyaluronic acid, collagen,amorphous substance synthesys);

• Very high percentage (0,6% w/w) equivalent to Retinoicacid at 0,05% w/w (Retin-A); usually it is employed at nomore than 0,2% w/w;

• Very good skin penetration and rapid onset of esthetic anddermo-plastic effect;

Innovative features

Br J Dermatol. 2008 Mar;158(3):472-7. Epub 2007 Dec 6.Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product.Watson RE, Long SP, Bowden JJ, Bastrilles JY, Barton SP, Griffiths CE.SourceDermatological Sciences Research Group, The University of Manchester, Manchester M13 9PT, [email protected]:Photoaged skin is characterized by coarse and fine wrinkles. The mechanism of wrinkle formation appears to involvechanges to components of the dermal extracellular matrix. Topical treatment with all-trans retinoic acid (RA) can repairphotoaged dermal matrix; this is regarded as the 'gold standard' against which repair agents are judged. To date, little isknown regarding the ability of over-the-counter 'antiageing' products to repair photoaged skin.OBJECTIVES:We used a modified occluded patch test to ascertain whether topical applications of cosmetic 'antiageing' products are ableto repair photoaged human skin.METHODS:Commercially available test products [basic moisturizer, 'antiageing' cream containing different active complex levels (6%active: lipopentapeptide, white lupin peptides, antioxidants, retinyl palmitate; 2% active: lipopentapeptide, white lupinpeptides, antioxidants)] were applied under occlusion for 12 days prior to biopsy and histological assessment in photoagedvolunteers (n=9). RA was used as a positive control.RESULTS:In agreement with previous studies, the patch-test study revealed that RA produced significant fibrillin-1 deposition in thepapillary dermis (P<0.01) but had little effect on procollagen I or matrix metalloproteinase-1 expression. The 6% total activecomplex formulation, however, increased the deposition of fibrillin-1 and procollagen I (P<0.01, P<0.05, respectively).CONCLUSIONS:This study indicates that in an in vivo 12-day patch test an over-the-counter cosmetic product can induce changes inphotoaged dermal extracellular matrix, which are indicative of repair.

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CENTELLA ASIATICA (0,5% w/w)(Vegetal stem cells)

• Glucosydes extracted from this plant show a vigorous action ofinhibition of the enzymes involved in the degradation of hyaluronicacid (hyaluronidase);

• It is possible to induce a lower hyaluronic acid degradation sopromoting an “endo-filler effect”;

• Centella asiatica is widely employed in dermatology as epitheliumrestoration agent, scarring promoting agent and phlebotonic(Madecassoside, Roche Posai);

• This innovative biotechnological technique is capable to select andreproduce meristem vegetal cells of Centella asiatica;

• This technology allows to maintain phytocomplex of the plant soimproving its properties and promoting the production of an highpercentage of active molecules (up to 50% in weight, Patentedtechnology by IRB);

Innovative features

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SALICYLYC ACID (0,5% w/w)

• b-hydroxyacid with keratolytic and dermo-purifying activity;

• It works reducing horny layer cells cohesionand promoting their physiological detachment;

• Works as skin penetration/absorptionenhancer;

• Favours skin surface uniformity;

Innovative features

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Indications

• The most effective body lotion in the Italian market for the concentration andactivity of the active molecules introduced;

• Treatment of body skin aging, aplastic skin and severe dermal structure lost, elasticityand firmness;

• Very effective for the mature skin during and after menopausa;

• Very good sensoriality features, very quick absorption; it can be applied few minutesbefore dress (not greasy, not sticky);

• It is advisable to apply the product at least one time per day (the best is 2applications per day for the first week), after shower or bath to improvepenetration;

op estero mycli

Health & Medicine

surgical skin

intolerant skin

reactive skin

skin pain

skin conditions

moresensible skin

skin type

kind of skin target