opening remarks: what do we mean by “tissue...
TRANSCRIPT
What Do We Mean by ?“Tissue Chip”?
On behalf of Martin Stephens, Ph.D. Center for Alternatives to Animal Testing, Johns Hopkins University
Ivan Rusyn, M.D., Ph.D. University of North Carolina at Chapel Hill
• 2D cell cultures • 2D cell cultures with modified substrates • Microphysiological systems and 3D models • Organ-on-a-chip • Lab-on-a-chip • Human-on-a-chip
Timothy.ruban en.wikipedia.org
Conceptual Schematic of a Human-on-a-Chip
“An organ-on-a-chip is a multi-channel 3D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems [that has] permitted the study of human physiology in an organ-specific context […]. One day, they will perhaps abolish the need for animals in drug development and toxin testing”
http://en.wikipedia.org/wiki/Organ-on-a-chip
“Tissue Chips” Brought to you by:
Micro-engineering
Material science
Nanotechnology
Stem-cell technology
Systems biology
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10
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1,000
10,000
100,000
Human Studies Animal Studies
Studies in vitro and in alternative species Predictions using inherent chemical properties
Integrated Science
Assessments
Integrated Risk Information
System
Provisional Peer-Reviewed
Toxicity Value
High-Throughput Risk Assessment
Num
ber o
f che
mic
als
SYSTEMS BIOLOGY DATA
Human Health Assessor’s “Tool Box”: Decision contexts and data availability
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Continuity with Previous Committee Workshops
Continuity with Previous Guidance from the National Research Council
http://www.niehs.nih.gov/news/newsletter/2013/3/science-crowdsourcing/
Continuity with the Concept of the Adverse Outcome Pathway
“Tissue/Organ-Chip”
Aims of this Meeting • State of science
• Near-, mid-, long-term horizons
• Realistic appraisal of the challenges
• Toxicological & risk assessment applications [Others: efficacy, bioterrorism countermeasures]
• Role in the toxicology “toolbox”
• Strengthening awareness among the
stakeholders
AGENDA
Session 1: Potential of the tissue chip
Session 2:
Tissue chips: State-of-development
Session 3: Scientific considerations for use of
tissue chips in environmental health research
Session 4:
Use of tissue chip technologies for environmental health decisions:
Regulatory considerations