pablo vitiligo proposal
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Pablo Andrés González
Relationship Between Vitiligo and the Stress Produced Hormone Corticotropin
Dr. Edwin Vázquez Ph.DJuly 12,2011University of Puerto Rico CayeyBiol-3009
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About the diseaseVitiligo is a pigmentation disorder in which
melanocytes in the skin are destroyed (a result of apoptosis).
As a result white patches appear on the skin.
The hair that grows on areas affected by vitiligo sometimes turns white.
It affects 1% of the worldwide population regardless of sex, age, and race.
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ClassificationVitiligo focalis- only one or more maculae in
one areaVitiligo segmentalis- one or more maculae
in a quasidermatomal patternVitiligo acrofacialis- distal extremity and
faceVitiligo vulgaris- scattered macules over the
entire bodyVitiligo universalis- Almost all body
depigmentation
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MelanocytesMelanocytes are special skin cells located
in the bottom layer of the epidermis that are responsible for the production of melanin.
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ACTHACTH is a hormone that stimulates the
adreal cortex and its produced as a response to corticotropin- releasing hormones.
Corticotropin is released with stress.
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PathogenesisThere are four hypothesis to why these
melanocytes are affected:Autoimmune hypothesisNeural hypothesisSelf-destruction hypothesisCombination of 1, 2, and 3
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Certain modifications in the immune system result in the destruction of the melanocytes.
The presence of a certain neurochemical mediator that is cytotoxic to pigment cells.
Precursors of melanogenesis are toxyc to melanocytes.
All of these factors are involved in the destruction of the melanocytes.
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Other types of disordersPsoriasis bulgarisAlopecia areataSeborrhea
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HypothesisIf I submit subjects, such as mice, to a
stressful environment they will produce Adrenocorticotropic (ACTH or corticotropin) hormone and destroy they melanocytes. By analyzing this substance I can create something to counter that effect or to regenerate the damaged melanocytes.
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ObjectiveTo determine why the body produces
adrenocorticotropic hormone during periods of extreme emotional stress that affect the melanocytes in the skin.
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MethodologySurvey different types of people that have
or are prone to the disease.Make a culture of normal (people with
medical history of vitiligo) and affected melanocytes. Then expose them to ACTH.
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StepsMake different groups of 5 people,
depending on their age. - One group 1-12 years - Another group 15-20 years - A group of 23-55 years - One last group of 60-73 years
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Ask them If they have any medical history of Vitiligo.
Question them about the first time they notice an outbreak of the disorder.
Where did the white patches start.Did they feel any different.What did they do to manage their
condition.
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Expected ResultsThe production of ACTH causes the
destruction of melanocytes if the person has a medical history of Vitiligo. The melanocytes of the people affected with vitiligo will start to undergo apoptosis.
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ReferencesYaghoobi R..Vitiligo: a review of the
published work. PubMed.gov. May 38 201. http://www.ncbi.nlm.nih.gov/pubmed/21667529
Wu Cs. Narrow-band UVB irradiation stimulates the migration and functional development of vitiligo-IgG antibodies-treated pigment cells. PubMed.gov. May 4, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21545543
Kadri Asif M. Causes of Vitiligo. 2008. http://www.vitiligoguide.com/vitiligo-videos/causes-of-vitiligo-video/
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Inoue K. Stress augmented ultraviolet-irradiation-induced pigmentation. PubMed.gov. Kuly 12, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12839577
Costin Gertrude. Human skin pigmentation: melanocytes modulate skin color in response to stress. The FASEB Journal. January 22, 2007. http://www.fasebj.org/content/21/4/976.short
Lerner Aron, A Mouse Model for Vitiligo http://hamiltongen677s10.weebly.com/uploads/3/6/1/9/3619132/a_mouse_model_for_vitiligo.pdf
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Njoo et.al. Vitiligo: A review. University of Amsterdam. 1997-1998