pato fisiologi kuliah 4 temperature
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DR. Dr. Tenri Esa, Msi, SpPK
Departemen Patologi Klinik
UNHAS
Temperature, Energy
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The aim o thermoregulation is to maintainthe actual !ore temperature o the "o#y atthe set level o a"out $% & '
the set le(el is raise# in e(er, an# thethermoregulatory me!hanisms are thusresponsi"le or maintaining the raise#
temperature
Fever
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)e(er is parti!ularly !ommon *ith ine!tions in the !ourse o the acute-phase reaction
Exogenous pyrogens are !onstituents o pathogens, among *hi!h the lipopoly+
sa!!hari#e !omplees -en#otoins o gram+negati(e "a!teria or pyrogens, are
opsoni/e# "y !omplementan#phago!yto/e# 0 ma!rophages 0 sel ku1er
fever
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'ytokines -23 4, 5, 6, an# 44, intereron 7an# 8 , TN) 7, an# ma!rophage+in9ammatory protein M2P 4 release#
En#egenous pyrogen
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Norepinephrine that has "een release#there !auses the ormation o P:E; an#thus e(er.
release o a#iuretin -ADH< =4 re!eptore1e!t,
>+melano!yte+stimulating hormone ->+MSH, an# the !orti!otropin+releasing hormone
!orti!oli"erin -'RH, endogenousantipyretics
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The value of fever pro"a"ly lies in its!ountera!ting ine!tion.
The raise# temperature inhi"its therepli!ation o some pathogens, !ells#amage# "y (iruses are #estroye#
Antipyreti!s shoul# in general only "e use#i the e(er lea#s to febrile convulsions,or rises so high -? $@'
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Bn se(ere physi!al e1ort -in!rease# heatpro#u!tion an#0or in a hot en(ironment-#e!rease# net heat loss
Thermoregulatory me!hanisms o theorganism are o(ertaske#
Co#y,s !ore temperature Set le(el
Hyperthermia, HeatInjuries
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Potentially lethal result o heterogeneousgeneti! #ee!ts o sar!oplasmi! 'a;transport, in *hi!h the 'a;+releasing!hannel -ryano#ine re!eptor is a1e!te#.
Some inhalation anestheti!s -halothane,in9urane, iso9urane an# #epolari/ing
mus!le relaants -suamethonium !hlori#e!ause the su##en an# e!essi(e release o'a; rom the sar!oplasmi! reti!ulum
Malignant Hyperthermia
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The result is a!i#osis, hyperkalemia,ta!hy!ar#ia, arrhythmia, an# rapi#ly risinghyperthermia
2 re!ogni/e# in time, malignanthyperthermia
!an "e su!!essully treate# "y #is!ontinuing
the anestheti!s an#0or mus!le relaants, as*ell as !ooling the "o#y.
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Malignant Hyperthermia
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