pechakacha presentation apri lrums

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Functional role of enzyme AMPK April Irums

GRANT PROPOSAL

What is AMPK?

AMP-activated protein Kinase

More On AMPK

What Does AMPK Really DO?

AMPK aids in efficient fatty acid oxidation. (FAT LOSS!)

Heart & Liver

protein synthesis insulin resistance

How Can We Benefit From AMPK?

Activated with exercise

Facilitates stronger heart muscles

How Can We Benefit From AMPK?

Cardiac Hypertrophy

Diabetes

Faulty hormone signalling

What Do We Already Know?

We Also know That.

Mitochondria

HypothesisIncreased AMPK levels in the body will increase mitochondrial density in type 1 muscle fibres and myocytes

How Are We Going To Test This?

Examine SamplesAMPK Levels within SamplesProlonged Exercise

Control Group

NO exercise!Sedimentary Lifestyle

Experimental Group

Use of Biopsy equipment30 days to exerciseIncrease Heart RateMeasure AMPK LevelsRat Food

How Will We Do This?

Muscle and Heart Biopsy

Procedure

SUPER TINY SCAR!

Main Goal

Figuring out the functional role of AMPK in the body!

What We Expect To See

Heart Patients

Problems With Weight

Significance