personal perspective on the science, ethics and commercialization of xenotransplantation
TRANSCRIPT
A Personal Perspective on the Science, Ethics, and Commercialization of
XenotransplantationMartine Rothblatt
United Therapeutics Corp
IXA, Baltimore, September 2017
2013 20162014 2015
5 G
6 G
7 G
8+ G
Research,Select,Engineer,Confirm Expression,Test Ex Vivo,Test In Vivo, Repeat to Improve,Go 2 Steps Forward,For Inevitable 1 Step Back
9/24/2017 6
9/24/2017 779/24/2017
Cardiac Grafts Expressing TBM Survive for Long Period (> 1 Year)
0 2 0 0 4 0 0 6 0 0 8 0 0 1 0 0 0
0
5 0
1 0 0
D a y s a fte r X e n o tra n s p la n ta t io n
Pe
rc
en
t s
urv
iv
al G a lK o .C D 4 6 (n = 3 )
G a lK o .C D 4 6 .T B M (n = 5 )
p v a lu e = -0 .0 0 4 2
Paradigm for Kidney Clinical Xenotransplantation Trials
9/24/2017 10
Like
lyX
en
ogr
aft
Pat
ien
ts10exp6
10exp3
% Safe Xeno Tolerance
10% 50% 100%
10exp4