PERSONALIZED MEDICINE

What is Personalized Medicine?

• Information-based healthcare

– Person-by-person: high content, resolution & fidelity

– Ushered in by the sequencing of human genomes

– Enhanced by new biological knowledge

– “Right drug, right patient, right dose, right time”

– But NOT limited to management of therapy

Overall Goals

• Improve outcomes– Disease care – Health care

• Reduce costs

How?

• Disease care– Target medicines precisely (“pharmacogenomics”)– Administer medicines safely (“toxicogenomics”)

• Health care– Predict disease susceptibility

• Prevent disease

– Detect early onset of disease• Preempt disease progression

How?

• Because Health-care trumps Disease-care– Create a healthier population– Shift more responsibility for care to the individual – Reduce overall “healthcare” costs?

personalized MEDICINEHEALTH

“pH”

What are potential disadvantages?

• Greater costs of diagnostics/biomarkers

• Smaller patient markets for therapeutics

• Need to track individual health information

• Necessity for accelerated HIT

• Diagnoses without treatments

• Re-education of healthcare professionals

• Distraction from other $ saving opportunities

As the train is leaving the station…

Does California Government have a role

In the ”Personalized Health Rush”?

If so, what?

What priorities?

How to createa recommended plan?

What priorities?

• Economics & reimbursement– Short-term vs. long-term perspective– Micro-economics vs. macro-economics

• Regulation & Policy development– Privacy & Non-discrimination– Redundancies & confusions – Unintended consequences

• Health Information Technology – Encouraging innovation – Educating & training – Integration and implementation

Task Force Leaders

• Macroeconomics: Richard Levy

• Regulation: William D. Young– Kathy Hibbs

• HIT: Ramesh Rao

Next Step?

• Complete the Funding

-Steven E. Brenner