polypoid endometriosis of the cervix · 2019. 6. 25. · on speculum examination, the cervical os...

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Polypoid Endometriosis of the Cervix Alsulami Somayah 1* , Albasri S 2 and Alghanmi N 1 1 Department of Pathology, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia 2 Department of Urogynecology, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia * Corresponding author: Alsulami Somayah, Department of Pathology, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia, E-mail: [email protected] Received date: September 24, 2017; Accepted date: May 09, 2018; Published date: May 14, 2018 Copyright: © 2018 Somayah A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Background: Polypoid endometriosis of the cervix is an uncommon variant of endometriosis that could be mistaken for a neoplasm on clinical, intraoperative, and gross examination. It may be asymptomatic or may present with a diverse range of persistent symptoms and even life-threatening haemorrhage. We report a 47 y old woman with polypoid endometriosis in the cervix who was referred to us because of uncertain diagnosis. Case report: A 47 y old woman presented to the gynaecological clinic with metrorrhagia, dysmenorrhea, and irregular menstrual cycles, associated with fatigue and loss of appetite and weight. She had received blood transfusion for anaemia secondary to vaginal bleeding, but otherwise had no significant medical history. Speculum examination revealed a large ulcerated polyp arising from the cervix. The differential diagnoses were cervical polyp vs. neoplasm. Polypectomy was performed. Histopathological examination confirmed polypoid cervical endometriosis. Discussion: Most patients with polypoid endometriosis of the cervix present with menorrhagia. Polypoid endometriosis can mimic cervical neoplasia clinically, radiologically, and intraoperatively. The cervix uteri are an uncommon site for endometriosis. However, the number of reports is increasing, and this differential must be kept in mind when assessing a patient with cervical polyp. Conclusion: Polypoid endometriosis should be considered in the differential diagnosis during evaluation of polypoid lesions of the cervix. Keywords: Endometroisis; Cervical polyp; Cervical neoplasm; Dysmenorrhea; Metrorrhagia Introduction Polypoid endometriosis of the cervix is a rare form of endometriosis that may be mistaken for a malignancy on clinical and radiological examination. We report a 47 y old woman with polypoid endometriosis of the cervix who was referred to gynaecology clinic because of suspicion of malignancy. is report demonstrates the need to keep this differential in mind when assessing a cervical polyp. Case Report A 47 y old woman, gravida 0 para 5, with no significant medical or surgical history presented to the gynaecology clinic with symptoms of metrorrhagia, dysmenorrhea, and irregular menstrual cycles. For the past 1 y, she had been having her periods 3 times every month. She had also experienced fatigue, loss of appetite, and weight loss of ~3 kg. She had received 2 units of blood 3 months back for treatment of anaemia secondary to vaginal bleeding. Physical examination was unremarkable. Her vital signs were stable, and cardiorespiratory examination was normal. Her hemoglobin level was 6.7 g/dL (normal range 12-15 g/dL). e Mean Corpuscular Volume (MCV) and the Mean Corpuscular Haemoglobin (MCH) levels were low (57.1 fL and 15.5 pg, respectively, normal range 80-94 fL and 32-36 pg). ere was no leucocytosis. yroid function tests were normal. Ultrasonography revealed a markedly enlarged and bulky retroverted uterus, measuring 10 × 5.6 × 6 cm, with endometrial thickness of around 0.84 cm. A 3.3 × 3.3-cm hyper-echoic structure, consistent with fibroid, was noted in the middle of the anterior wall of the uterus. e ovaries were not visualized. Minimal free fluid was present in the pouch of Douglas. Multiple nabothian cysts were noted in the cervix, the largest measuring 1.3 cm in diameter. On speculum examination, the cervical os was closed, and the vagina appeared normal. A large polyp, with an area of ulceration, was seen arising from the cervix. With these presenting symptoms and clinical findings, the main differential diagnoses were cervical polyp and cervical neoplasm. Polypectomy was performed and the specimen was sent for histopathological examination. Pathological Examination Gross appearance e polyp was 3.5 × 4 × 3 cm in size, with focally ulcerated and haemorrhagic outer surface. e cut surface is solid, with cystic spaces containing dark brown fluid and focal papillary areas. Microscopic appearance Sections showed endometrial cells underneath ectocervical mucosa (Figure 1). e cystic spaces were lined by endometrial cells. e sub- J o u r n a l o f M e d i c a l & S u r g i c a l P a t h o l o g y ISSN: 2472-4971 Journal of Medical & Surgical Pathology Somayah et al., J Med Surg Pathol 2018, 3:2 DOI: 10.4172/2472-4971.1000153 Case Report Open Access J Med Surg Pathol, an open access journal ISSN:2472-4971 Volume 3 • Issue 2 • 1000153 RETRACTED

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Page 1: Polypoid Endometriosis of the Cervix · 2019. 6. 25. · On speculum examination, the cervical os was closed, and the vagina appeared normal. A large polyp, with an area of ulceration,

Polypoid Endometriosis of the CervixAlsulami Somayah1*, Albasri S2 and Alghanmi N1

1Department of Pathology, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia2Department of Urogynecology, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia*Corresponding author: Alsulami Somayah, Department of Pathology, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia, E-mail: [email protected]

Received date: September 24, 2017; Accepted date: May 09, 2018; Published date: May 14, 2018

Copyright: © 2018 Somayah A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Polypoid endometriosis of the cervix is an uncommon variant of endometriosis that could bemistaken for a neoplasm on clinical, intraoperative, and gross examination. It may be asymptomatic or may presentwith a diverse range of persistent symptoms and even life-threatening haemorrhage. We report a 47 y old womanwith polypoid endometriosis in the cervix who was referred to us because of uncertain diagnosis.

Case report: A 47 y old woman presented to the gynaecological clinic with metrorrhagia, dysmenorrhea, andirregular menstrual cycles, associated with fatigue and loss of appetite and weight. She had received bloodtransfusion for anaemia secondary to vaginal bleeding, but otherwise had no significant medical history. Speculumexamination revealed a large ulcerated polyp arising from the cervix. The differential diagnoses were cervical polypvs. neoplasm. Polypectomy was performed. Histopathological examination confirmed polypoid cervicalendometriosis.

Discussion: Most patients with polypoid endometriosis of the cervix present with menorrhagia. Polypoidendometriosis can mimic cervical neoplasia clinically, radiologically, and intraoperatively. The cervix uteri are anuncommon site for endometriosis. However, the number of reports is increasing, and this differential must be kept inmind when assessing a patient with cervical polyp.

Conclusion: Polypoid endometriosis should be considered in the differential diagnosis during evaluation ofpolypoid lesions of the cervix.

Keywords: Endometroisis; Cervical polyp; Cervical neoplasm;Dysmenorrhea; Metrorrhagia

IntroductionPolypoid endometriosis of the cervix is a rare form of endometriosis

that may be mistaken for a malignancy on clinical and radiologicalexamination. We report a 47 y old woman with polypoidendometriosis of the cervix who was referred to gynaecology clinicbecause of suspicion of malignancy. This report demonstrates the needto keep this differential in mind when assessing a cervical polyp.

Case ReportA 47 y old woman, gravida 0 para 5, with no significant medical or

surgical history presented to the gynaecology clinic with symptoms ofmetrorrhagia, dysmenorrhea, and irregular menstrual cycles. For thepast 1 y, she had been having her periods 3 times every month. She hadalso experienced fatigue, loss of appetite, and weight loss of ~3 kg. Shehad received 2 units of blood 3 months back for treatment of anaemiasecondary to vaginal bleeding.

Physical examination was unremarkable. Her vital signs were stable,and cardiorespiratory examination was normal. Her hemoglobin levelwas 6.7 g/dL (normal range 12-15 g/dL). The Mean CorpuscularVolume (MCV) and the Mean Corpuscular Haemoglobin (MCH)levels were low (57.1 fL and 15.5 pg, respectively, normal range 80-94fL and 32-36 pg). There was no leucocytosis. Thyroid function tests

were normal. Ultrasonography revealed a markedly enlarged and bulkyretroverted uterus, measuring 10 × 5.6 × 6 cm, with endometrialthickness of around 0.84 cm. A 3.3 × 3.3-cm hyper-echoic structure,consistent with fibroid, was noted in the middle of the anterior wall ofthe uterus. The ovaries were not visualized. Minimal free fluid waspresent in the pouch of Douglas. Multiple nabothian cysts were notedin the cervix, the largest measuring 1.3 cm in diameter.

On speculum examination, the cervical os was closed, and thevagina appeared normal. A large polyp, with an area of ulceration, wasseen arising from the cervix. With these presenting symptoms andclinical findings, the main differential diagnoses were cervical polypand cervical neoplasm. Polypectomy was performed and the specimenwas sent for histopathological examination.

Pathological Examination

Gross appearanceThe polyp was 3.5 × 4 × 3 cm in size, with focally ulcerated and

haemorrhagic outer surface. The cut surface is solid, with cystic spacescontaining dark brown fluid and focal papillary areas.

Microscopic appearanceSections showed endometrial cells underneath ectocervical mucosa

(Figure 1). The cystic spaces were lined by endometrial cells. The sub-

Jour

nal o

f Med

ical & Surgical Pathology

ISSN: 2472-4971

Journal of Medical & SurgicalPathology Somayah et al., J Med Surg Pathol 2018, 3:2

DOI: 10.4172/2472-4971.1000153

Case Report Open Access

J Med Surg Pathol, an open access journalISSN:2472-4971

Volume 3 • Issue 2 • 1000153

RETRACTED