Nutrition and cancer II 59

modification was necessary in all HNCP and six still usedenergy drinks or tube feeding (19%).Conclusion: Also at the long term HNCP treated by chemoradiation are at risk for malnutrition and weight loss.Food intake is far from normal, a high degree of foodmodifications and nutritional supplements is necessaryand nutritional intake is far beneath the recommendedDutch food based dietary guidelines. Nutritional adviceby dieticians should focus on malnutrition risk/ weightloss and food quality: normal food consistency and therequired amount of food groups.

Disclosure of Interest: None Declared

PP092-SUN Outstanding abstractFISH OIL SUPPLEMENT ALTERS MARKERS OFINFLAMMATORY AND NUTRITIONAL STATUS INCOLORECTAL CANCER PATIENTSJ.A. Pastore-Silva1, E.B.S.M. Trindade1, M.E.S. Fabre2,S. Gevaerd2, V.M. Menegotto3, T.S. Frode4, Z.S. Buss4.1Nutrition, Federal University of de Santa Catarina,2Nutrition, 3Oncology, CEPON, 4Pharmacology, FederalUniversity of de Santa Catarina, Florianopolis, Brazil

Rationale: Inflammation is a common feature in cancer.The presence and magnitude of the chronic systemicinflammatory responses may produce progressive nutri-tional decline. This study aims to investigate whetherthere arechanges in inflammation markers and/or innutritional status of patients with colorectal-cancerundergoing chemotherapy who were supplemented withfish oil.Methods: The clinical trial was conducted with anequally randomized, 23 patients parallel-group. Thesupplemented group (SG) consumed 2 grams of fish oilduring nine weeks. Nutritional and inflammatory markersstatus were available both in a baseline (M0), and afternine weeks of chemotherapy (M9) in the SG and inthe non supplemented group (NSG). Statistical analysiswas conducted in the STATA 11.0 software. Fisher’sexact-test was used with categorical variables, T-testfor parametric variables, and Mann-Whitney for nonparametric variables. C-RP/Albumin was compared withthe score risk.Results: SG and NSG presented the same baseline char-acteristics (p > 0.05). Body mass index and body weight,nutritional status indicators, suffered modifications onlyin the group NSG when comparing M0 and M9, p = 0.03and p = 0.01 respectively, while in SG these indicatorsdid not varied. Patients supplemented with fish oil (SG)showed a clinically relevant decrease in the C-reactiveprotein/albumin relation (p = 0.005).Conclusion: Low doses of fish oil supplement canpositively modulate the nutrition status and theC-RP/Albumin relation.

Disclosure of Interest: None Declared

PP093-SUNEVOLUTION OF INFLAMMATORY MARKERS IN PATIENTSWITH ADVANCED HEAD AND NECK CARCINOMA WITHPROPHYLACTIC PERCUTANEOUS GASTROSTOMYM.J. Tapia1, M. Gonzalo1, G. Olveira1,2, M. Laínez3,R. Perez4, J. Contreras4, F. Soriguer1,2. 1Endocrinologyand Nutrition, Hospital Universitario Carlos Haya,2CIBERDEM, CIBER de Diabetes y EnfermedadesMetabolicas (Instituto de Salud Carlos III), Malaga,3Endocrinology and Nutrition, Hospital Juan RamonJimenez, Huelva, 4Radiation Oncology, HospitalUniversitario Carlos Haya, Malaga, Spain

Rationale: To assess the response of inflammatorymarkers of nutritional intervention by prophylactic gas-trostomy (study group) in patients with stage III or IVhead and neck carcinoma (HNC) treated with concurrentradiochemotherapy or altered fractionation radiotherapy,compared with conventional treatment group (controlgroup).Methods: Prospective study of nutritional intervention inpatients with advanced HNC prior to radiotherapy treat-ment. We compared the prophylactic use of radiologicalgastrostomy (PRG) versus conventional nutrition therapy(CNT). We evaluated inflammatory cytokines: interleukin6, C-reactive protein, TNF alpha and its soluble markers(1 and 2), before, during and after treatment.Results: Thirty-eight patients with advanced HNC wererandomized to either prophylactic gastrostomy (n = 19) orconventional nutritional therapy (n = 19).In the PRG group: mean age was 59±8 years, 50% male,10% Stage III and 90% stage IV. The percentage weightloss at 8 weeks after start of treatment was lower in PRGgroup ( 3%) compared with CNT group ( 5.8%) (p 0.07).Inflammatory cytokines were not changed significantlyin the PRG group, but in the control group (CNT)citokines increased significantly (p < 0.05). There were nodifferences in either group compared to the levels of TNFand its soluble receptors.Conclusion: Nutritional intervention with prophylacticgastrostomy in patients with advanced head and neckcancer reduces the inflammatory response to radiother-apy and reduces weight loss compared to conventionalnutritional therapy, which allow them to remain betternutritional status.

Disclosure of Interest: None Declared

PP094-SUNA SUPPORTIVE NURSING CARE CLINIC FOR PATIENTSWITH HEAD AND NECK CANCER EFFECTS ONNUTRITIONAL STATUS, NUTRITIONAL TREATMENT ANDADMISSIONS TO HOSPITALM. Larsson1, K. Bjuresater1. 1Department of Nursing,Karlstad University, Karlstad, Sweden

Rationale: Severe and sustained nutritional problems arevery common among patients with head and neck cancer(HNC). A supportive nursing care clinic (SNCC) with focuson symptom control, nutritional care, and psychosocialand emotional support was established as a complementto regular care (RC) and the patients attended the clinicregularly before and during the medical treatment and

60 Poster presentations

during one year after completion of treatment. Theobjective was to investigate the impact of the SNCC onnutritional status, nutritional treatment, and admissionsto hospital due to nutritional problems for HNC patientstreated with radiotherapy.Methods: A comparative design was used. 20 consecutivepatients treated at the SNCC were followed prospectivelyand 50 patient records from the same hospital were usedas a historical control. Data were collected each weekduring radiotherapy and after one, three, six and twelvemonths using a study specific questionnaire coveringeating problems, weight, nutritional interventions, andreasons for admission to hospital. Descriptive and non-parametric statistics were used.Results: Eating problems were common in both groupsbut the SNCC group had significantly less weight loss afterthree weeks of radiotherapy (p = 0.000), after completedradiotherapy (p = 0.000), and after 12 months (p = 0.000).All patients in the SNCC group received dietary supple-ments and were more often treated with enteral nutritionthan the RC group (70% and 42% respectively) in whichfew were prescribed dietary supplements. Admissions tohospital due to nutritional problems were 20% in the SNCCgroup and 48% in the RC group.Conclusion: A SNCC can make appropriate early nu-tritional interventions possible and thereby optimizenutritional status in patients with HNC. SNCC seemsto be cost effective as admissions to hospital due tomalnutrition was lowered in this study.

Disclosure of Interest: None Declared

Nutrition and chronic diseases IPP095-SUNVISCOSITIES OF THICKENED DRINKS AND READY-TO-USEFOOD PRODUCTS TARGETED FOR DYSPHAGIA PATIENTSA. Oudhuis1, K. Vallons1. 1Functional Ingredients, TNOHealthy Living, Zeist, Netherlands

Rationale: International standardization to categorizethe consistencies of thickened foods within dysphagia islacking. This may lead to confusion and in some casesprescription of a product with the wrong consistencyto a patient. In this study the viscosities of a rangeof commercially available thickeners and ready-to-useproducts were measured to map out the current situation.Methods: Artificial tap water thickened with a rangeof commercially available thickeners and a range ofcommercially available ready-to-use food products wereanalysed.Thickened drinks: 20 ml of water and amount of powderaccording to manufacturer’s instructions was added toa RVA cup. The sample was mixed at high speed for1 min, and after that viscosity was measured for 20 min at150 rpm (which approaches 50 s 1). Viscosity after 11 minwas selected for analysis.Ready-to-use products: a sample was gently transferredto a RVA cup and viscosity was measured for 20 min at150 rpm (which approaches 50 s 1). Viscosity after 11 minwas selected for analysis.

Results: Average viscosities for thickened water were:238 (syrup), 920 (custard), and 3060 (pudding). Strongestdeviation was found for ThickenUp Clear having a viscos-ity of 310 (custard) and 480 (pudding). Average viscositiesfor the ready-to-use products were: 329 (syrup), 874(custard), and 2268 (pudding). Strongest deviation wasfound for Fresubin Thickened Stage-2 having a viscosityof 307 (custard).Conclusion: In some cases viscosities of thickened drinksand/or ready-to-use products strongly deviated from theviscosity of other products in the same category. Thereis a strong need for standardization within the field ofdysphagia to support proper judging of the consistency ofthickened drinks and ready-to-use foods.

Disclosure of Interest: None Declared

PP096-SUNNUTRITIONAL INTERVENTION WITH HYPOCALORIC DIETFOR CHILDREN AND ADOLESCENTS WITH PRADER WILLISYNDROMEV.P. Lima1, M.L.G. Mesquita1, A.C.A. Colucci1,M.C.T.V. Teixeira1. 1Center for Health and BiologicalSciences, Mackenzie Presbyterian University, Sao Paulo,Brazil

Rationale: The Prader Willi Syndrome (PWS) is a neu-robehavioral disorder resulting from the loss of imprintedgene expression within chromosome 15q11-q13. The mainsymptom is hyperphagia and its associated comorbidities.The objective of this study was to implement and assessthe efficiency of a specific nutritional program withhypocaloric diet for children and adolescents with PraderWilli Syndrome.Methods: Five individuals with PWS (mean age = 13 yearsold; mean Intelligent Quotient = 58.2/intellectual dis-ability) and their respective mothers participated inthe study. The instruments for data collection were:(a) nutritional anamnesis, (b) assessment of anthropo-medical measures of weight, height, abdominal cir-cumference and body mass index BMI, (c) ChildBehavior Checklist (CBCL/6 18). The training and follow-up nutritional program with hypocaloric diet took 10sessions and lasted 8 months. The strategies used were:workshops, prescriptions, lists of food substitution andrecipes, informative tables about calories, prizes (tokensas positive reinforcers).Results: The main results found in the Friedman testindicate that there was a statistically significant differ-ence for the BMI and height. The mean of these valuesdecreased between the first and the last assessment. Itwas observed a loss of 200 g to 6.300 g in the body weight.Correlation tests to verify the association betweenanthropo-medical measures and behavioral problems didnot result in statistically significant coefficients.Conclusion: Although not all anthropo-medical measurespresented statistically significant differences, the de-crease of weight and BMI reinforces the effectivenessof the program. This kind of low cost initiative can beimplemented even in Brazilian public health services.

Disclosure of Interest: None Declared