prescribing practices
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Prescribing Practices. Andrew M. Peterson, PharmD, PhD Dean, Mayes College of Healthcare Business and Policy University of the Sciences. Presentation Format . Case-based approach Topics Medication Compliance Medication Errors Underlying theme - PowerPoint PPT PresentationTRANSCRIPT
Andrew M. Peterson, PharmD, PhDDean, Mayes College of Healthcare
Business and PolicyUniversity of the Sciences
Prescribing Practices
Presentation Format
• Case-based approach• Topics
– Medication Compliance– Medication Errors– Underlying theme
• Identify trends in laws and regulations that can impact your prescribing practice
• Describe emerging technologies and how they are influencing the medication use process
Medication Compliance Objectives• Differentiate among the concepts of
medication adherence, compliance and persistence
• Identify four predictors of medication compliance
• Articulate three reasons for medication non-compliance specific to the elderly
• Given a specific case, identify at least two strategies to improve medication compliance
Medication Compliance• Non- compliance to medical therapy is a major threat
to public health in the United States• Non- compliance to prescribed medication costs
nearly 125,000 lives per year. • 10% of hospital and 23% of nursing home admissions
are linked to compliance.• $300 billion annually• 1/3 of all prescriptions NOT picked up
– Non- compliance to pharmacotherapy is estimated to be 50% overall• wide ranges reported in the literature for different
disease states (30-70%)Sources: Noncompliance with Medication Regimens. An Economic Tragedy. Emerging Issues in Pharmaceutical Cost Containing. Washington, DC.
National Pharmaceutical Council. 1992;1-16.; Luscher TF. Vetter W. Adherence to medication. Journal of Human Hypertension. 4 Suppl 1:43-6, 1990 Feb; McGhan WF, Peterson AM. Pharmacoeconomic impact of patient noncompliance. IMPACT – US Pharmacist. October 2001.
Case Description
Definitions• Compliance
– the extent to which patients are obedient and follow the instructions of a health care professional1
• Adherence– the extent to which a person’s behavior – taking
medication, following a diet, and/or executing lifestyle changes corresponds with agreed upon recommendations from a health care provider2
• Persistence– how long a patient remains on therapy,
introducing length of treatment as a factor
Sources: 1. Meichenbaum D, Turk DC. Facilitating Treatment Adherence: A Practitioner’s Guidebook. Boston: Plenum Press; 1987: 20, 52, 26-29; 2. World Health Organization. Adherence to long term therapies: evidence for action. 2003. www.who.int/chronic_conditions/adherencereport/en. Viewed Nov 2003.
Measuring Compliance• Objective Measures
– Direct• Blood levels
– Indirect• Pill Counts
– Manual, Electronic• Pharmacy Refill Data• Health Outcomes
• Subjective Measures– Patient self reports– Practitioner reports
Variables Potentially Related to Compliance• Patient variables
– Patient characteristics– Diagnosis/symptoms/severity– Knowledge/Health Beliefs
• Treatment variables– Treatment complexity – Dosing – Adverse effects
• Relationship variables– Inadequate communication/poor rapport– Method of teaching/environment– Follow-up/assessment
Adapted from: Meichenbaum D, Turk DC. Facilitating Treatment Adherence: A Practitioner’s Guidebook. Boston: Plenum Press; 1987: 20, 52, 26-29.
Patient Characteristics• Age1
– Elderly – average compliance is 45%– Adolescents – 40-60%– Pediatrics patients (parent as caregiver) – 34-82%
• Sex2,3
– Kidney transplant patients, Dunn et al found that men were significantly more noncompliant than women.
– In contrast, Schweizer et al found no significant differences in compliance due to gender in more than 600 transplant recipients
Race
Intelligence
EducationSources: 1. Meichenbaum D, Turk DC. Facilitating Treatment Adherence: A Practitioner’s Guidebook. Boston: Plenum Press; 1987: 20, 52, 26-29. 2. Dunn J, Golden D, Van Buren CT, Lewis RM, Lawen J, Kahan BD Causes of graft loss beyond two years in the cyclosporine era. Transplantation. 1990;49:349-353. 3. Schweizer RT, Rovelli M, Palmeri D, Vossler E, Hull D, Bartus S. Noncompliance in organ transplant recipients. Transplantation. 1990;49;374-377.
Compliance Rates by DiagnosisCondition Reported Rates of non-
compliance
Arthritis 55-71%Asthma 20%Diabetes 40-50%Epilepsy 30-50%Hypertension 40%Schizophrenia 41%
Source: Noncompliance with Medication Regimens. An Economic Tragedy. Emerging Issues in Pharmaceutical Cost Containing. Washington, DC. National Pharmaceutical Council. 1992;1-16.
Health Beliefs and Compliance
• 77% of patients compliant when curing a disease
• 63% of patients compliant when preventing a disease
• Over extended periods of time, compliance rates dropped dramatically to approximately 50% for either prevention or cure
Sackett DL, Snow JC. The magnitude of compliance and noncompliance. In: Haynes NRB, Taylor DW, Sackett DL, eds. Compliance in Healthcare. Baltimore: Johns Hopkins University Press; 1979:11-22.
Predictors of Compliance
• Questions to ask your patient– Do you ever forget to take your medicine?– Are you careless at times about taking your
medicine?– When you feel better do you sometimes stop
taking your medicine?– Sometimes if you feel worse when you take the
medicine, do you stop taking it?• Moriskey et al:
– 75% with high scores had BP under control at year 2 (p<0.01)
– α=0.61Morisky DE. Green LW. Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Medical Care. 1986:24:67-74.
Compliance Predictability by Variable Variables Utility as a
Predictor Explanation
• Patient demographics (age, sex, race, socio-economic status)
Weak
Literature lacks consensusUsefulness depends on therapeutic area and patient population
• Patient/provider relationship
• Regimen characteristics
• Patient health services use
ModerateGeneral consensus in literatureEffect may vary by therapeutic area and population
• Time since initiation• Medication compliance
historyStrong Always the strongest predictors
and easy to measure
Adapted from Benner J. ISPOR 2007
Factors Affecting Elderly Compliance
• Cognitive Ability• Prospective Memory Changes• Functional Literacy
Cognitive Impairment Predicts Noncompliance• STUDY
– 220 Japanese community dwelling elders– MMSE scores estimated impairment– Pill counts as compliance– Logistic regression to determine predictors of non-
compliance• Variables: Age, sex, eyesight, hearing, number of drugs,
frequency, packaging, medication calendar, drug knowledge and cognitive ability
• RESULTS– Average age: 75.7 years– 27% MMSE ≤23 (impaired)– 34.6% noncompliant– Odds Ratio
• Cognitive Impairment – 2.94 (1.32-6.58)
Okuno et al, 2001 – Eur J Clin Pharmacol
Prospective Memory Changes Affect Compliance• Cognitive performance declines with age
– Korten et al, 1997 – Psych Med• Decline not seen in language, visio-spatial ability or
abstract reasoning– Small et al, 1999 – Neurology
• Difficulty with prospective memory increases with additional tasks
– Martin, 2001 – Int J Behavioral Development• Poor memory performance amplified when
executive function required– D’Yewalle, 2001 – Am J Psychology
• Difficulty still exists even when task was habitual– Einstein, 2001 – Psychol Science
Basic Question…
“Did I take it today or do I think I took it because I have been for the past x years?”
Compensation for Memory Changes
Omitting/Repeating Doses
• Unintentionally omitting or repeating a dose
• Small interruptions to routines– phone call, doorbell
• Larger interruptions to routines– Shopping, dining out
• Intentionally omitting doses
Compensation for Memory Changes
Boron JB, et al. Medication adherence strategies in older adults. Proceedings of human factors and ergonomics society – 50th annual meeting; 2006.
• Association• Location• Mental Planning• Pain• Physical Reminder• Pill Box• Visibility
Functional Literacy
• Physical Challenges• Eyesight changes• Manual dexterity
• Cognitive Challenges• Dose selection• Understanding directions• Drug / disease knowledge
• System Challenges• Readability of pharmacy labels• Dosage form (inhaler, injectable)
Medication Management Skills
Medication Management Skills
• DRUGS (Drug Regimen Unassisted Grading Scale)– Identify medication – Open container– Remove appropriate dosage– Demonstrate appropriate timing
• Correlated to medication compliance
Identifying the Medication
Opening the Med and Removing Appropriate Dosage
Education Level
<6 7-8 >9
59% 67% 84% ‡
6% 50% 78% *
0% 5% 14% *
* p<.0001, ‡ p<.05;
Comprehension of Warning Labels Increase with Literacy Level
Data: Davis TC. LSU Health Science Center, Shreveport, LO.
Davis, T. C. et. al. Ann Intern Med 2006;145:887-894
Demonstrating Appropriate Timing
Medication Management Skills
• DRUGS (Drug Regimen Unassisted Grading Scale)– Identify medication – Open container– Remove appropriate dosage– Demonstrate appropriate timing
• Correlated to medication compliance
Case Description
Medication Errors Objectives
• Define the nature and significance of medication errors
• Describe two types of medication errors and opportunities to improve systems and prevent errors
• Given a specific case, identify at least two strategies to prevent a medication error from occurring
Case Description
Definitions
Error - The failure of a planned action to be completed as intended or the use of a wrong plan to achieve the aim
Adverse Event - An injury caused by medical management rather than the underlying condition
Preventable Adverse Event - An adverse event attributable to an error
VHA Medication Safety Report: 2004
Statistics On Medication Errors
• 44,000 to 98,000 Americans die from medical errors each year
• 7,000 die from medication errors alone
• 20 to 28% of adverse drug events are preventable
• Cost per error is $2,013 to $4,700 per admission
Preventing Medication Errors
• Consumer Actions to Enhance Medication Safety
• Issues for Discussion with Patients by Providers
• e-prescribing by 2010• Drug naming, labeling and
packaging• Oversight and regulation
Medication Error• Bates: “Any error occurring in the medication use
process.” • NCCMERP “Any preventable event that may
cause or lead to inappropriate medication use or patient harm, while the medication is in the control of the health care professional, patient, or consumer.”– related to professional practice systems including:
• Prescribing/order communication• Product labeling, packaging and nomenclature• Compounding/dispensing/distribution• Administration/education/monitoring and use
High Alert Medications• High alert drugs are drugs that bear a
heightened risk of causing significant patient harm when they are used in error. (ISMP.org; accessed Nov 6, 2009)
• ISMP suggestions to reduce risk:– improving access to information about these drugs– limiting access to high-alert medications– using auxiliary labels and automated alerts; – standardizing the ordering, storage, preparation,
and administration– employing redundancies such as automated or
independent double checks when necessary.
High Alert Medications• Anticoagulants (warfarin, heparin & LMWH)
– Current TJC National Patient Safety Goal• Chemotherapy• Pediatric medications• Parenteral narcotics (opiates)• Insulin• Magnesium sulfate• Potassium chloride injection concentrate• Neuromuscular blockers• Vasoactive substances
Medication Safety:Opportunities for Improvement• Selection and procurement• Storage• Prescribing• Dispensing• Administration / Counseling• Monitoring
System vs Knowledge vs Competent?
Look-Alike/Sound Alike:Error Prevention• Education: Information from the
literature• Tall Man Lettering:
– NovoLOG and NovoLIN – oxyCODONE and OxyCONTIN– ceFAZolin and cefTRIAXONE– FLUoxetine and DULOXetine.
• Tall Man lettering on medication labels, shelving labels, medication records, etc.
Drug Administration Technology
• Automated medication cabinets– Pyxis, OmniCell– Interfaced with pharmacy profiles
• Pharmacy generated MARs• Smart pumps
– Drug library with standard concentrations– Defines soft and hard administration limits
• Bedside barcode administration system
Medication Reconciliation• Avoid errors such as omission, duplication,
dosing errors or drug interactions• Each transition of care• Five steps
– Develop list of previous meds– List of newly prescribed meds– Compare the lists– Respond to differences– New list to care-givers and patient
Ideal Medication Error Prevention Program
• Addresses all components of the medication use process
• Uses an interdisciplinary approach to resolving problems
• Involves all levels of employees, practitioners and administration
• Identifies and addresses underlying causes• Supports system improvements, reduces risk, and
improves patient outcomes
Case Description
Key Issues to Remember
• People will make mistakes• Mistakes are opportunities to learn
where the process is broken• Effective change requires all
stakeholders’ participation
Conclusion