Principales presentaciones de AstraZeneca/MedImmune en el congreso de ESMO 2017 Autor principal Título del abstract Detalles de la presentación

Cáncer de pulmón

Paz-Ares L PACIFIC: A double-blind, placebo-controlled Phase III study of durvalumab after chemoradiation therapy (CRT) in patients with Stage III, locally advanced, unresectable NSCLC

Oral

Lung Cancer

Saturday 9th September, 16:30-18:10

Presentation Time: 16:30-16:45

Location: Madrid Auditorium

Abstract #LBA1

Ramalingam S Osimertinib vs SoC EGFR-TKI as first-line treatment in patients with EGFRm advanced NSCLC (FLAURA)

Oral

Lung Cancer

Saturday 9th September, 16:30-18:10

Presentation Time: 17:30-17:45

Location: Madrid Auditorium

Abstract #LBA2

Zhou C Detection of EGFR T790M in Asia-Pacific patients (pts) with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC): circulating tumour (ct) DNA analysis across 3 platforms

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #1331P

Zhou C Osimertinib in Asia-Pacific patients (pts) with EGFR T790M-positive advanced NSCLC: updated Phase II study results including progression-free survival (PFS)

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #135P

Zhou C CNS response to osimertinib in Asian-Pacific patients (pts) with T790M-positive advanced NSCLC: data from an open-label Phase II trial (AURA17)

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #1353P

Mitsudomi T Overall survival (OS) in patients (pts) with EGFR T790M-positive advanced non-small cell lung cancer (NSCLC) treated with osimertinib: results from two Phase II studies

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #1348P

Pinotti G EGFR T790M detection in TKI-naïve NSCLCs carrying sensitive EGFR mutations

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #1335P

Postel-Vinay S A randomized double-blind Phase II trial evaluating maintenance PARP inhibitor Olaparib versus placebo in patients with platinum-sensitive advanced non-small cell lung cancer: PIPSeN trial

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #1381TiP

Kim Y C Phase II Trial of AZD9291 in Second Line Treatment after Acquired Resistance with T790M Mutation Detected From Circulating

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Tumores femeninos

Martinez Bueno A Disruptive mutations in TP53 associate with survival benefit in a PARPi trial in Ovarian Cancer

Oral

Ovarian Cancer

Saturday 9th September, 09:15-10:45

Presentation Time: 09:15

Location: Cartagena Auditorium

Abstract #LBA42

Tumor DNA (LiquidLung-O-Cohort 2)

Abstract #1360P

Calabuig-Farinas S Clinical value of cfDNA and CTCs in EGFR mutations detected in advanced NSCLC

Poster

Lung Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #1638P

Leduc C Ultrasensitive detection of EGFR T790M mutation by droplet digital PCR (ddPCR) in TKI naïve non-small cell lung cancer (NSCLC) harboring EGFR mutation: results of the nationwide program Biomarkers France of the French Cooperative Thoracic Intergroup (IFCT)

Poster Discussion

Lung Cancer

Saturday 9th September, 9:00-10:45

Presentation Time: 10:16

Location: Pamplona Auditorium

Abstract #85PD

Wu Y-L A Phase 3 study of first-line durvalumab vs platinum-based chemotherapy in patients with advanced NSCLC and high PD-L1 expression: PEARL

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #1378TiP

Zhang X Prediction of survival with durvalumab in locally advanced or metastatic NSCLC using early tumor assessments

Poster

Lung Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #1312P

Ruiz-Borrego M Phase III evaluating the addition of fulvestrant (F) to Anastrozol (A) as adjuvant therapy in postmenopausal women with hormone receptor positive HER2 negative (HR+/HER2-) early breast cancer (EBC): results from the GEICAM/2006-10 study

Oral

Breast Cancer

Friday 8th September, 14:00-15:30

Presentation Time: 14:24-14:36

Location: Pamplona Auditorium

Abstract #148O

Delaloge, S. OlympiAD: Further efficacy outcomes in patients with HER2-negative metastatic breast cancer and a germline BRCA mutation receiving olaparib monotherapy vs standard single-agent chemotherapy treatment of physician’s choice

Poster Discussion

Breast Cancer

Sunday 10th September, 09:15-10:45

Presentation Time: 09:45

Location: Sevilla Auditorium

Abstract #243PD

Wang J FRIEND: A randomized pilot study to compare the efficacy and tolerability of fulvestrant 500mg with exemestane as first line endocrine therapy for post-m ER positive HER2 negative ABC patients relapse after adjuvant non-steroidal aromatase inhibitors (NSAI)

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #311TiP

Kawaguchi H Factors associated with prolonged time to treatment failure with fulvestrant 500 mg in patients with postmenopausal estrogen receptor-positive advanced/metastatic breast cancer (JBCRG-C06; Safari): A subgroup analysis

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #302P

Kaufman P Abemaciclib plus fulvestrant in patients (pts) with HR+/HER2- endocrine therapy naïve (EN) advanced breast

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

cancer - an exploratory analysis of MONARCH 2

Location: Hall 8

Abstract #235P

Zimmer A A Phase I PK/PD study of durvalumab (D) in combination with olaparib (O) and cediranib (C) in recurrent women’s cancers

Poster

Ovarian Cancer, Cervical, Breast, Endometrial

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #390P

Westin S Phase I Expansion of olaparib (PARP inhibitor) and AZD5363 (AKT inhibitor) in recurrent ovarian, endometrial and triple negative breast cancer

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #391P

Turner N BEECH: A randomised Phase 2 study assessing the efficacy of AKT inhibitor AZD5363 combined with paclitaxel in patients with ER+ve advanced or metastatic breast cancer, and in a PIK3CA mutant sub-population

Poster Discussion

Breast Cancer

Sunday 10th September, 09:15-10:45

Presentation Time: 09:55

Location: Sevilla Auditorium

Abstract #241PD

Lui JF A pilot study to evaluate the feasibility, usability, and perceived satisfaction with eCO (eCediranib-Olaparib), a mobile application for side effect monitoring and reporting, in women with recurrent ovarian cancer

Poster

Ovarian Cancer

Sunday 10th September, 13:15-14:15

Location: Hall 8

Abstract #1560P

Nicum S OCTOVA: A randomised Phase II trial of olaparib, chemotherapy, or olaparib and cediranib in patients with BRCA-mutated platinum-resistant ovarian cancer

Poster

Ovarian Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #989TiP

Taylor J N-DUR: Matched Pair Pharmacodynamics Study of Neoadjuvant Durvalumab in Combination with Chemotherapy in Frontline Ovarian Cancer

Poster

Ovarian Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #992TiP

Penson R Efficacy of olaparib maintenance therapy in patients (pts) with platinum-sensitive relapsed ovarian cancer (PSROC) by lines of prior chemotherapy: Phase III SOLO2 trial (ENGOT Ov-21)

Poster Discussion

Ovarian Cancer

Saturday 9th September, 09:15-10:45

Presentation Time: 09:15

Location: Cartagena Auditorium

Abstract #932PD

Dalvi T BREAKOUT: a cross-sectional, prospective, observational study of germline BRCA mutation (gBRCAm) prevalence and real-world outcomes among patients (pts) with HER2-negative (HER2-ve) metastatic breast cancer (mBC)

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #316TiP

Shimomura A Gene alteration in triple negative breast cancer patients in a phase I/II study of combination therapy with eribulin and olaparib

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #282P

Aogi K Efficacy and safety of olaparib combined with eribulin in patients with advanced or metastatic triple negative breast cancer (TNBC) previously treated with anthracyclines and taxanes: the final analysis of a Japanese Phase I/II trial

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #251P

Robson ME OlympiAD: Health-related quality of life (HRQoL) in

Poster

patients with HER2-negative metastatic breast cancer (mBC) and a germline BRCA mutation (gBRCAm) receiving olaparib monotherapy vs standard single-agent chemotherapy treatment of physician’s choice (TPC)

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #290P

O’Connor M Generation of a novel preclinical PK/PD model provides insights into PARP inhibitor clinical monotherapy activity

Poster

Women’s Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #393P

Tutt A OlympiA: a randomized Phase III trial of olaparib as adjuvant therapy in patients with high-risk HER2-negative breast cancer (BC) and a germline BRCA1/2 mutation (gBRCAm)

Poster

Breast Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #216TiP

Sugiyama T Japan CHARLOTTE: Characterizing the cross-sectional approach to ovarian cancer: Genetic testing of BRCA

Poster

Ovarian Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #984TiP

Oza A Evaluation of tumour responses and olaparib efficacy in platinum-sensitive relapsed ovarian cancer (PSROC) patients (pts) with or without measurable disease in the SOLO2 trial (ENGOT Ov-21)

Poster

Ovarian Cancer

Saturday 9th September, 13:15-14:15

Location: Hall 8

Abstract #965P

Callens C BRCA1&2 tumoral and germline status for ovarian cancer patients in first line setting within the PAOLA-01 trial

Poster Discussion

Ovarian Cancer

Saturday 9th September, 09:15-10:45

Location: Cartagena Auditorium

Abstract #935PD

Moore K A Multicentre Phase II Study of AZD1775 plus Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Poster

Ovarian Cancer

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #990TiP

Pjuade-Lauraine E OReO/ENGOT Ov-38: A Phase IIIb trial of olaparib maintenance retreatment in patients with epithelial ovarian cancer

Poster

Ovarian Cancer

Saturday 9th September; 13:15-14:15

Location: Hall 8

Abstract #987TiP

Cáncer de cabeza y cuello

Cohen EE Phase Ib/II Study (SCORES) Assessing Safety, Tolerability, and Preliminary Anti-tumor Activity of Durvalumab Plus AZD9150 or AZD5069 in Patients With Advanced Solid Malignancies and Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Oral

Head and Neck Cancer

Monday 11th September, 11:00-12:30

Presentation Time: 11:15-11:30

Location: Madrid Auditorium

Abstract #1135O

Zandberg DP Durvalumab for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): preliminary results from a single-arm, Phase II study

Oral

Head and Neck Cancer

Monday 11th September, 15:00-16:20

Presentation Time: 15:39-15:51

Location: Granada Auditorium

Abstract #1042O

Stokes M Relationship between PD-L1 expression and survival in head and neck

Poster Discussion

Head and Neck Cancer

squamous cell carcinoma (HNSCC) patients (pts)

Saturday 9th September, 14:45-16:15

Presentation Time: 15:07

Location: Alicante Auditorium

Abstract #1049PD

Pai S Retrospective cohort study of PD-L1 expression in recurrent and/or metastatic squamous cell carcinoma of the head and neck (SUPREME-HN)

Poster Discussion

Head and Neck Cancer

Saturday 9th September, 14:45-16:15

Presentation Time: 15:07

Location: Alicante Auditorium

Abstract #1048PD

Even C MEDINDUCTION: Phase I trial evaluating the safety of durvalumab in combination with Docetaxel, Cisplatin and 5-FU (DCF) in induction for locally advanced squamous cell carcinoma of the head and neck (SCCHN)

Poster

Head and Neck Cancer

Sunday 10th September, 13:15-14:15

Location: Hall 8

Abstract #1109TiP

Otros tipos de cáncer

Choueiri T Savolitinib versus sunitinib in patients with MET-driven, unresectable and locally advanced or metastatic papillary renal cell carcinoma: SAVOIR, a randomised, Phase III trial

Poster

Urothelial Carcinoma (UC)

Sunday 10th September, 13:15-14:15

Location: Hall 8

Abstract #924TiP

Zheng Y Modeling of Tumor Kinetics and Overall Survival to Identify Predictive Factors for Efficacy of Durvalumab in Patients with Urothelial Carcinoma (UC)

Poster

Urothelial Carcinoma (UC)

Sunday 10th September, 13:15-14:15

Location: Hall 8

Abstract #869P

Gonzalez-Cao M A Phase II exploratory study of durvalumab (MEDI4736) in HIV-1

Poster

HIV

patients with advanced solid tumors

Sunday 10th September, 13:15-14:15

Location: Hall 8

Abstract #1208TiP

Wiester T Comparison of continuous measures across diagnostic PD-L1 assays using image analysis

Poster

Biomarker Testing

Monday 11th September, 13:15-14:15

Location: Hall 8

Abstract #103P

Chen R Efficacy and safety in first-line combined androgen blockade in advanced prostate cancer; a systematic review and meta-analysis

Poster

Prostate Cancer

Sunday 10th September, 13:15-14:15

Location: Hall 8

Abstract #805P

infografia ESMOPresentaciones AstraZeneca ESMO 2017