problems of the central nervous system epilepsy, spina bifida, cerebral palsy 2009
TRANSCRIPT
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Problems of the Central Nervous System
EPILEPSY, SPINA BIFIDA, CEREBRAL PALSY
2009
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SEIZURE DEFINED
• Episodes of abnormal sudden, excessive, uncontrolled electrical discharge of neurons within the brain
• May result in alteration in consciousness, motor or sensory ability and/or behavior
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EPILEPSY
• Chronic disorder• Characterized by recurrent unprovoked
seizure activityCAUSE OF EPILEPSY • abnormal electrical neuronal activity• Imbalance of neurotransmitters: Gamma
aminobutyric acid (GABA)
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CAUSE OF SEIZURES• Inherited• Cause is unknown (idiopathic)Can follow:• Birth trauma• Asphyxia during birth• Head injuries• Infectious disease• Toxicity (carbon monoxide and lead poisoning)• Fever• Drug/alcohol intoxication• Brain tumors
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INTERNATIONAL CLASSIFICATION OF SEIZURES
• Classified by the part of the brain involved– PARTIAL SEIZURES beginning in one part of one cerebral
hemisphere• Complex partial seizures• Simple partial seizures
– GENERALIZED SEIZURES involving both cerebral hemispheres
– UNCLASSIFIED SEIZURES:• Unclassified• Idiopathic
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PARTIAL SEIZURES
• Simple partial seizures • Complex partial seizures
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PARTIAL SEIZURES
• SIMPLE PARTIAL SEIZURES:– Unilateral movement of extremity– Unusual sensations– Autonomic or psychic symptoms (heart rate,
flushing, epigastric discomfort)– May experience unusual or unpleasant sights,
sounds, odors, tastes (aura) occurring before seizure
– No loss of consciousness
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COMPLEX PARTIAL
– Automatism: Person remains motionless or moves automatically, but inappropriately for time and place (eg: lip smacking, patting, picking at clothes)
– May experience excessive emotions of fear, anger, elation, or irritability
– No memory of episode, loss of consciousness, black out 1-3 min
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GENERALIZED SEIZURES (previously GRAND MAL)
• TONIC-CLONIC SEIZURE– Lasts 2-5 min– Starts with tonic movements: stiffening or rigidity of the
muscles of arms and legs– Loss of consciousness– Clonic movements follow: rhythmic jerking of all
extremities– May bite tongue, incontinent of urine/feces– Followed by an hour of fatigue, confusion, lethargy
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GENERALIZED SEIZURES CONTINUED
• Tonic seizures: – Abrupt increase in muscle tone– Loss of consciousness– Loss of autonomic signs for 30 sec to several minutes
• Clonic seizure: – Lasts several minutes– Muscle contraction and relaxation
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GENERALIZED SEIZURES CONTINUED
• Absence seizure– Common in children– Runs in families– Brief (seconds) loss of consciousness– Blank starring, returning to normal– May occur frequently throughout day
• Myoclonic seizure:– Brief jerking/stiffening extremities– Singly or in groups– Lasts few seconds
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GENERALIZED SEIZURES CONTINUED
• Atonic(akinetic)seizure– Sudden loss of muscle tone for a few seconds,
may fall– Followed by POSTICTAL(after seizure) confusion
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POST-ICTAL STATE
• POST-ICTAL STATE: after seizure Pt is confused and hard to arouse, may sleep for hours
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ASSESSMENT AND DIAGNOSTIC TESTS
• History• Identify causes• MRI• EEG• SPECT (single photon emission computed
tomography) – helps identify zone giving rise to seizures, can then be removed surgically
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TREATMENT
• Remove or treat cause• Surgically remove/excise the part of the brain
that is causing the problem as long as it doesn’t produce neurologic deficits– Pt is alert
• Generator may be implanted under the clavicle: helps control the seizure
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MEDICATIONS: antiepileptics (AED’s)
• Unknown why they work• Control seizures, do not cure• Starts with one med, dosage gradually increased looking for
SE, may add another drug• Therapeutic blood levels: Blood levels checked, absorption
varies among patients• Dosage changed with illness, weight changes, stress• Sudden withdrawal avoided• Lots of drug/drug interactions and drug/food interactions
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SIDE EFFECTS OF DRUGS
• Allergic reaction (skin)• Acute toxicity (seen initially)• Chronic toxicity (seen later in therapy)• REACTIONS seen in an organ• Common SE of Dilantin: gingival hyperplasia
(swollen and tender gums)
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ASSESSMENT DURING SEIZURE
• Assess for preseizure behavior, aura, loss of consciousness
• Assess seizure activity• Record the time the activity began• Assess for fecal or urinary incontinence• Assess for post seizure behavior (memory loss,
loss of consciousness, lethargy)
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RECORD SEIZURE ACTIVITY
• Include onset time• Include focus of seizure (part of body involved)• Identify duration of seizure (time)• Identify change in respirations• Define progression of movement through body• Identify changes in neurological status• Describe post-ictal activity (duration, status,
behavior)
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IMPLEMENTATION
• Gently lower the standing or sitting patient to the floor (supine)
• Turn the head to the side, hyperextend neck and pull jaw slightly forward
• Maintain patent airway• Have oxygen and suction available whenever a
patient indicates they have a history of seizures!!!• PLACE NOTHING IN THE MOUTH!
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IMPLEMENTATION CONTINUED
• Do not restrain the patient• Remove dangerous objects the might injure
the patient• Loosen tight or restrictive clothing• Record seizure activity
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TEACHING• Wear Medic Alert• Avoid stimulant drugs (caffeine) may cause a seizure
to break through the anticonvulsant medication• Avoid alcohol – can cause overdose of medications• Teach family/patient triggers to seizures:
hypoglycemia, fatigue, exhaustion, hormonal changes, illness, stress, alcohol, caffeine, constipation, hyperventilation, excessive activity
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TEACHING CONTINUED
• High fiber diet/high fluid diet to prevent constipation caused by anticonvulsant meds
• Adequate rest, stress reduction, good diet• Anticonvulsant meds cause gingival hyperplasia:
need good dental care• Provide name of local Epilepsy Foundation• Assist in dealing with feelings
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RESTRICTIONS until seizure free for 3 months to 1 year
• No driving motor vehicles• No operating heavy machinery• No working in potentially dangerous situations• No swimming, no water sports• Possibly no tub bathing• LENGTH OF RESTRICTION DEPENDS UPON
STATE REGULATIONS
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MEDICATIONSDilantin (phenytoin)Therapeutic drug level 5-20 ug/dl• Cannot be withdrawn suddenly• Watch for toxicity (nystagmus, ataxia, dysarthria,
encephalopathy)• Do not combine with warfarin (Coumadin)
SIDE EFFECTS: • Lethargy, abnormal movements, Gingival hyperplasia, mental
confusion, cognitive changes
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MEDICATIONS FOR STATUS EPILEPTICUS
Fosphenytoin (Cerebyx)Diazepam (Valium); give slowly, drug of choice
for status epilepticus, have ventilatory support available
Lorazepam (Ativan)
Given IV during status epilepticus
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MEDICATIONS
• Ethosuximide (Zarontin): N & V, gastric distress, gradually withdraw
• Carbamazepine (Tegretol): expensive, watch effects on heart and lungs
• Valproate (Depakene): effects liver, causes tremors, alopecia
• Galbapentin (Neurotonin): dizziness, somnolence, wgt gain
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MEDICATIONS
Clonazepam (Klonopin): drowsiness, palpitationsFelbamate (Felbatol): cognitive impairmentsLamotrigine (Lamictal): tremorLevetiracetam (Keppra): somnolenceOxacarbazepine (Trileptal): tremor, loss of
coordination
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MEDICATIONS
• Phenobarbitol (Luminal): sedation• Primidone (mysoline): lethargy, impotence• Tiagabine (Gabitril): dizziness, buckling knees• Topiramate (Topamax): fatigue, anorexia, depression• Zonisamide (Zonegran): somnolence, agitation
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STATUS EPILEPTICUS
• Series of generalized seizures tht occur without full recovery of consciousness between attacks
• Also includes continuous electrical seizures lasting at least 30 minutes even without impairment of consciousness
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RISKS OF STATUS EPILEPTICUS
• Respiratory arrest at height of each seizure leading to hypoxia which can lead to brainb damage
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FACTORS THAT TRIGGER STATUS EPILEPTICUS
• Withdrawal of seizure meds• Fever• Concurrent infection
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STATUS EPILEPTICUS
MEDICAL EMERGENCY• cerbyx, Ativan, Valium IV• Oxygen & Airway device/intubation inserted
between seizures• Suction• Hydration IV using glucose for hypoglycemia
(high metabolic demand during seizure)
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TREATMENT FOR STATUS EPILEPTICUS CONTINUED
• May have to anesthetize with short acting barbiturate to stop seizure
• Serum levels of anti- seizure meds• Cardiac/respiratory depression may be
lifethreatening• Cerebral edema can occur
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CEREBRAL PALSY
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CEREBRAL PALSY
• DEFINED AS:• A neurologic problem• Characterized by impaired movement and
posture• It involves a lack of motor control of voluntary
muscles• Comes from a lesion in the brain that occurred
prenatally, at birth or postnatally
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CAUSE OF CP
• PRIMARY CAUSE: ANOXIA• SECONDARY CAUSE: INFECTION
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CLINICAL MANIFESTATIONS
• Delayed gross motor development: universal symptom
• Abnormal motor performance• Alterations muscle tone: rigidity, stiffness• Abnormal postures: scissoring• Reflex abnormalities: persistance of primitive
infantile reflexes
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ASSOCIATED DISABILITIES
• May have mental retardation• Common to have seizures• Attention deficit/hyperactivity• Sensory impairment
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CLASSIFICATION
• Spastic: increased muscle tone• Dyskinetic (athetoid): abnormal writhing
movements, drooling, dysarthria, • Ataxic: difficulty with balance• Mixed: athetoid and spastic
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DIAGNOSIS
• Know growth and development• Observe in newborn nursery• Early recognition important
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TREATMENT
• TEAM APPROACHGoals:• Establish locomotion, communication, self-
help• To gain optimum function• To correct associated defects• To provide educational opportunities
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MOBILIZING DEVICES
• Braces• Ambulation devices• Scooter boards• Wheeled go carts• Strollers• w/c
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SURGERY
• Orthopedic• TAL (tendon achilles lengthening)• release of tight wrist and hip muscles
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NURSING CARE
1. FEEDING: • Avoid semi-reclining• Place in flexed position • Gentle upward stroking of the neck2. DIET: high calorie diet3. MAINTAIN SKIN INTEGRITY4. PROMOTE SELF-CONCEPT
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NURSING CARE CONTINUED
5. PROMOTE KNOWLEDGE 6. USE THE PARENTS AS BEST RESOURCE7. PROVIDE REST8. PREVENT/TREAT RESPIRATORY INFECTIONS9. DENTAL PROBLEMS10. PROVIDE PARENTAL SUPPORT
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SPINA BIFIDA
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SPINA BIFIDA
DEFINED: incomplete fusion of one or more vertebral laminae and defective development of the spinal cord
ETIOLOGY: • Environmental• Genetic• Vitamin deficiency
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CATEGORIES
• MENINGOMYELOCELE OR MYELOMENINGOCELE
• MENINGOCELE• SPINA BIFIDA OCCULTA
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MENINGOMYELOCELE (MMC)
• Most common• Involves the spinal cord• Have soft rounded protrusion• Sac containing meninges, portions of spinal
cord and nerve roots and CSF• Sac protrudes through defective vertebra• MASS DOES NOT TRANSILLUMINATE
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MMC CONTINUED
• DEGREE OF NEUROLOGIC DYSFUNCTION• Flaccid lower extremities• Partial paralysis• Bowel and bladder incontinence• Deformities
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MENINGOCELE
• Does not involve spinal cord• Sac like cyst contains meninges with CSF, no
neural tissue• MASS CAN BE TRANSILLUMINATED• LACK OF PARALYSIS
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SPINA BIFIDA OCCULTA
• Common, usually asymptomatic• No external protrusion• Failure of spinous processes to join in the L5
to S1 area• Skin depression, dimple, birthmark, hair,
lipoma• May have bowel/bladder sphincter control
prblems
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MANAGEMENT
Multidisciplinary approach:• Neurosurgeon• Orthopedic surgeon• GU• Psychologist• Educators• Social workers• Pediatric nurse clinician
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NURSING MANAGEMENT AT BIRTH
• Place under overhead warmer• On abdomen• Keep sac moist
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SAC CARE
PREVENT RUPTURE, DRYING AND INFECTION OF SAC
• Antibiotics IV• Prone• Skin care• Soaks on sac (NSS, bacitracin, silver nitrate)
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COMPLICATIONS
• MENINGITIS• NEUROLOGIC INVOLVEMENT• HEAT AND FLUID LOSS• LEAKAGE OF SPINAL FLUID• DEFORMITIES
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SURGICAL REPAIR
• Neurosurgeon and plastic surgeon• Excision of protrusion
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POST-OP NURSING CARE
• Incubator/overhead warmer• Oxygen• Prone/some require head lowered• Plastic apron• NPO to clear fluids to full fluids• Daily head circumferences• Observe for hydrocephalus/meningitis/urinary
retention
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CARE OF SITE AT HOME
• Wash the incision with peroxide and rinse with water to remove crusts
• Observe for drainage and call MD• Keep diaper below site • After healed, tub baths
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LONG TERM PROBLEMS
ORTHOPEDIC ABNORMALITIES• Hip dislocations, club foot, scoliosis,
contractures in hips, knees, anklesNURSING CARE:• PROM, turning, check for reddened areas, pad
seats, cribs, soft toys, check toes, check braces
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GENITOURINARY ABNORMALITIES
• Renal failure• UTI• Urinary retention• Urinary refluxTREATMENT: clean intermittent catherization
programEXPERIMENTAL: artificial sphincters, bladder
pacemaker
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NURSING CARE BLADDER
• Change diapers q 2 hrs• Wash bottom with antibacterial soap• No rubber pants• A&D and Desitin• Drugs which cause urinary retention
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BOWEL MANAGEMENT
• Bowel control depends upon innervation• Regular toilet habits• Prevention of constipation and impaction• Diet high in fiber and high fluids• BOWEL PROGRAM: 2-3 yrs of age• Rectalaid enemas, cathartic (senekot)
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DEVELOPMENTAL CONSIDERATIONS
• Toddler: can bear down by coughing or blowing up balloons, bowel routine ritual
• Preschooler: asks why? Answer the truth• “It’s because of the opening on your back when you
were born. You can’t go to the bathroom like other people.”
• School age and Adolescent: do independently, concern – privacy, peer rejection
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SEXUALITY
• Males: erection and ejaculation possible, most sterile from retrograde ejaculation
• Females: fertility well documented. 4-5% risk of having a MMC child. SEX ED IMPORTANT.
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PSYCOSOCIAL:
Multifaceted:• Body image• Sexuality• Urinary problems• Bowel problems