protein and amino acid supplements...kinds of protein. apart from proteinbiosynthesis, amino acid...

© IIPRD, 2016

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Landscape Study -Protein and Amino Acid Nutraceutical

© IIPRD, 2016 2

Introduction

Introduction

• Protein is one powerful nutrient. It is part of every living cell, and plays a majorrole in our body — from building our body tissues to making importanthormones. An adequate protein intake in the diet is important across the lifecycle, especially as we age.

• Amino acids (AA) are the building blocks of protein. There are 22 different aminoacids required by the body. These amino acids join together to make all differentkinds of protein. Apart from protein biosynthesis, amino acid also act as precursorfor many other biomolecules. Nine amino acids which are considered essentialamino acids are not made by the body and therefore obtained from food. Theother amino acids are synthesized by the body and thus are considerednonessential amino acids.

• The proteins in our bodies are constantly broken down and replaced. The bodydoes not store amino acids like it stores carbohydrates and fats, so a daily supplyof amino acids is required to make new proteins. The protein in the foods we eatis digested into amino acids that can be used to replace the proteins in ourbodies.

© IIPRD, 2016 3

Introduction

• Most official nutrition organizations recommend a fairly modest protein intake. The DRI (Dietary Reference Intake) is 0.8 grams of protein per kilogram of body weight, or 0.36 grams per pound.

• The protein requirement is based on several parameter(s) for e.g., whole-bodyprotein mass, muscle mass, physical function, immune function, or metabolicfunction. Additionally, the protein requirement depends on quality—that is AAcomposition and digestibility—and physical activity level.

• It is more important than ever to be able to describe appropriately the proteinand amino acids supplied by food/diets. The match between dietary supply andhuman protein and amino acid needs is imperative to support the health andwell-being of human populations.

• Most people get enough protein. But in certain cases requirement ofprotein/amino acid is much higher compared to normal individual. Proteinsupplements are used to provide protein that may otherwise not be consumed insufficient quantities.

© IIPRD, 2016 4

Introduction

• Protein supplements are available in form of powder, tablet, jelly, drink,beverages etc. Protein powder dominates protein products and growing rapidly.These supplements are used to address problems associated with heart health,diabetes, weight management, digestion, ageing etc.

• Global protein and amino acids market is estimated to grow CAGR of more than6% by 2020.1

• Major factors driving growth of protein nutraceutical includes: increased healthawareness, omnipresent fitness and health maintenance trend, focus on leadingactive lifestyles and increased participation in sports and fitness activities asmeasured by higher enrollment in gyms and sports clubs. Further, protein is oneof the most marketing claim for the sale of product.

• In 2014, North America accounted for the largest share in the protein ingredients,owing to the high consumption of protein-based products. The global market inthe Asia-Pacific region is emerging with substantial opportunities.2

© IIPRD, 2016 5

http://www.technavio.com/report/global-food-protein-ingredients-markethttp://www.marketsandmarkets.com/Market-Reports/protein-ingredients-market-114688236.html

Introduction

The top health benefit of protein from consumer point of view is summarized in the table below.1

© IIPRD, 2016 6

Health Benefit % Consumer

General Health 84

To keep Active and Agile 81

Muscle maintenance 73

Muscle recovery 71

Kids to grow 68

Strong bones 67

Sports performance 64

Weight management 58

Supress hunger 44

http://www.slideshare.net/fonterra/follow-up-presentation-consumer-insights

© IIPRD, 2016 7

Bibliographic Analysis

Geographical Origin of Innovation

© IIPRD, 2016 8

Analysis of priority country indicates that maximum number of innovations originated from China (58 patent families) followed by USA (57 Patent Families). Economical growth in Chinaattributes for the Chinese firms filing more patent in protein and amino acid based nutraceutical sector.

58 57

96 4 3 2 2

6

0

10

20

30

40

50

60

70

China USA Europe France WIPO Italy Belgium Japan Other

No.

of P

aten

t Fam

ilies

Priority Country

IPC Class Distribution (1/3)

© IIPRD, 2016 9

Analysis of IPC Class indicates that 85 Patent families have IPC Class A23L (Foods, foodstuffs, or non-alcoholic beverages), followed by 51 Patent Families having A61K (Preparations for medical, dental, or toilet purposes).


© IIPRD, 2016 10

51

24

18

9 84 4 4 3 2 2 2 1

0

10

20

30

40

50

60

A23L33/00

A23L1/00

A23L7/00

A23L2/00

A23L19/00

A23L29/00

A23L17/00

A23L13/00

A23L25/00

A23L11/00

A23L5/00

A23L3/00

A23L15/00

No.

of P

aten

t Fam

ilies

IPC Class

40 0 0 3

4 5 3 2

1119

31

3

0

10

20

30

40


© IIPRD, 2016 11

31

20

15

9 84 4 4 3

10

5

10

15

20

25

30

35

A61K31/00

A61K38/00

A61K36/00

A61K35/00

A61K9/00

A61K8/00

A61K45/00

A61K33/00

A61K47/00

A61K39/00

No.

of P

aten

t Fam

ilies

IPC Class

31 1 1

3 35

3

7 8

14

20

0

5

10

15

Priority Year based Filing Trend

© IIPRD, 2016 12

60

23 22 21

53

42

119

56

41

97

62

40

4

0

20

40

60

80

100

120

140

< 2005 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

No.

of P

aten

ts

Year

• 2010 was the priority year for maximum number of applications (119) followed by 2013(97).

Note: For this graph, all family members were taken into consideration.

© IIPRD, 2016 13

Taxonomy

Taxonomy

© IIPRD, 2016 14

Taxonomy and Definitions

Privileged and Confidential

Landscape Study - Protein/Amino Acid Nutraceutical

Proposed Taxonomy and Definitions

ProteinPlant Based ProteinSoyThis category indicates that nutraceutical composition contains soy protein.

PeaThis category indicates that nutraceutical composition contains pea protein.

RiceThis category indicates that nutraceutical composition contains rice protein.

WheatThis category indicates that nutraceutical composition contains wheat protein.

GenericThis category indicates that nutraceutical composition contains plant based protein, without specifying further details.

OthersThis category indicates that nutraceutical composition contains other plant derived protein.

Milk Based ProteinWhey This category indicates that nutraceutical composition contains whey protein.

CaseinThis category indicates that nutraceutical composition contains casein protein.

GenericThis category indicates that nutraceutical composition contains milk based protein, without specifying further details.

OthersThis category indicates that nutraceutical composition contains other type of milk protein.

Animal based ProteinEggThis category indicates that nutraceutical composition contains egg protein.

GelatineThis category indicates that nutraceutical composition contains gelatine protein.

CollagenThis category indicates that nutraceutical composition contains collagen protein.

GenericThis category indicates that nutraceutical composition contains animal derived protein, without specifying further details.

OthersThis category indicates that nutraceutical composition contains other type of animal based protein.

Microbial ProteinThis category indicates that nutraceutical composition contains protein derived from microorganism.

Generic ProteinThis category indicates that nutraceutical composition contains protein, without specifying further details.

Amino AcidEssentialBCAA(Branched Chain Amino Acids)LeucineThis category indicates that nutraceutical composition contains leucine.

IsoleucineThis category indicates that nutraceutical composition contains isoleucine.

ValineThis category indicates that nutraceutical composition contains valine.

MethionineThis category indicates that nutraceutical composition contains methionine.

LysineThis category indicates that nutraceutical composition contains lysine.

PhenylalanineThis category indicates that nutraceutical composition contains phenylalanine.

OtherThis category indicates that nutraceutical composition contains other essential amino acid.

Non- EssentialArginineThis category indicates that nutraceutical composition contains arginine.

Glutamine/ Glutamic acidThis category indicates that nutraceutical composition contains glutamine/glutamic acid.

CysteineThis category indicates that nutraceutical composition contains cysteine.

OthersThis category indicates that nutraceutical composition contains other non-essential amino acids.

Target PopulationSportsThis category indicates that nutraceutical composition for athletic person.

InfantThis category indicates nutraceutical composition for baby/infant.

WomenThis category indicates nutraceutical composition for women.

PatientThis category indicates nutraceutical composition for patient.

Older PersonThis category indicates nutraceutical composition for older person.

AdultsThis category indicates nutraceutical composition for adults.

GenericThis category indicates target population of nutraceutical composition is not specified.

OthersThis category indicates nutraceutical composition for other than above categories.

ApplicationBody Mass ManagementThis category indicates nutraceutical composition for body mass management.

Weight ManagementThis category indicates nutraceutical composition for body weight management.

Anti-agingThis category indicates nutraceutical composition for anti-ageing.

Bone HealthThis category indicates nutraceutical composition for bone health.

CancerThis category indicates nutraceutical composition for cancer treatment/management.

Cardiac HealthThis category indicates nutraceutical composition for cardiac health.

DiabetesThis category indicates nutraceutical composition for prevention or treatment of diabetes.

Mental HealthThis category indicates nutraceutical composition for mental health.

Immunity EnhancementThis category indicates nutraceutical composition for body immunity enhancement.

Improving SleepThis category indicates nutraceutical composition for sleep impovement.

Overall HealthThis category indicates nutraceutical composition for promotion of overall health.

OthersThis category indicates nutraceutical composition for application other than above categories.

Product FormSolid Dosage FormPowder/GranulesThis category indicates that nutraceutical composition is in the form of powder/granules.

Bar/ Biscuit/ CookiesThis category indicates that nutraceutical composition is in the form of bar/biscuit/cookies.

CapsulesThis category indicates that nutraceutical composition is in the form of capsules.

TabletsThis category indicates that nutraceutical composition is in the form of tablets.

Generic SolidsThis category indicates that nutraceutical composition is in the solid form without specifying details of solid form.

Liquid Dosage FormBeveragesThis category indicates that nutraceutical composition is in the form of beverages.

Suspensions/EmulsionsThis category indicates that nutraceutical composition is in the form of suspensions/emulsions.

Generic Liquids/ SolutionsThis category indicates that nutraceutical composition is in the liquid form without specifying details of liquid form.

Confectionary/ Food ProductsThis category indicates that nutraceutical composition is in the form of confectionary/ food Products.

SemisolidThis category indicates that nutraceutical composition is in the form of semisolid products.

GenericThis category indicates that detail about physical form of nutraceutical composition is not specified.

OtherThis category indicates that physical form of nutraceutical composition is other than above.

© IIPRD, 2016 15

Technical Data Analysis

Product Form - Distribution

© IIPRD, 2016 16

81

22

16

11

6

30

27

8

11

5

32

10

0 20 40 60 80 100

Powder/Granules

Tablets

Capsules

Bar/ Biscuit/ Cookies

Generic

Generic Liquids/ Solutions

Beverages

Suspensions/Emulsions

Confectionary/ Food Products

Semisolid

Generic

OtherSo

lid D

osag

e Fo

rmLi

quid

Dos

age

Form

No. of Patent Families

Prod

uct F

orm

Analysis of product forms indicates that maximum number of patents/publishedapplications included protein and amino acid based nutraceutical compositions in the formof powders/granules (81), followed by liquids/solutions (30) and beverages (27).

Note: The data is mutually inclusive and hence the overall count maybe higher than the individual patent families.

Product Form – Filing Trend

© IIPRD, 2016 17

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016Powder/Granules 1 2 0 0 1 2 6 5 6 11 45 2Tablets 0 1 0 0 0 1 2 2 1 3 12 0Beverages 0 1 0 1 2 2 2 2 2 2 13 0

0

5

10

15

20

25

30

35

40

45

50N

o. o

f Pat

ent F

amili

es

Application Year

Analysis of filing trend of product forms indicates that maximum number ofpatents/published applications containing powder/ granule, tablet and beverages basednutraceutical compositions were filed in the year 2015 (~45, ~12, ~13 respectively),followed by a dip in 2016 which maybe due to applications not published so far.


Protein Ingredient - Distribution

© IIPRD, 2016 18

37

1210 9

1

2927

14 15

10

18

11

62

14

7 7

0

5

10

15

20

25

30

35

40 S

oy

Ric

e

Whe

at

Pea

gen

eric

Oth

ers

Whe

y

Case

in

gene

ric

Oth

ers

Colla

gen

Egg

Gel

atin

gene

ric

othe

r

Mic

robi

al P

rote

in

Gen

eric

Pro

tein

Plant Based Protein Milk Based Protein Animal based Protein

No.

of P

aten

t Fam

ilies

Protein

Analysis of protein ingredients indicates that maximum number of patents/publishedapplications included soy based nutraceutical compositions (37), closely followed byWhey (27) and Collagen (18).


Protein Ingredient – Filing Trend

© IIPRD, 2016 19

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016Soy 1 0 0 0 1 0 3 4 2 5 20 1Whey 1 0 0 0 0 1 1 2 2 1 19 0Collagen 0 0 0 0 0 0 0 0 1 2 15 0

0

5

10

15

20

25

No.

of P

aten

t Fam

ilies

Application Year

Analysis of filing trend of protein ingredients indicates that maximum numberpatents/published applications containing soy, whey and collagen based nutraceuticalComposition were filed in the year 2015 (~20, ~19, ~15 respectively), followed by a dip in2016 which maybe due to applications not published so far.


Amino Acid - Distribution

© IIPRD, 2016 20

14

7

8

11

6

7

13

16

9

10

11

0 2 4 6 8 10 12 14 16 18

Other

Phenylalanine

Lysine

Methionine

Isoleucine

Valine

Leucine

Other

Cysteine

Glutamine/Glutamic Acid

ArginineBr

anch

cha

in

Esse

ntia

lN

on- E

ssen

tial


Amin

o Ac

id

Analysis of amino acids indicates that maximum number of patents/publishedapplications included Leucine based nutraceutical compositions (13), closely followed byArginine (11) and Methionine (11).


Target Population - Distribution

© IIPRD, 2016 21

0

10

20

30

40

50

60

70

80

90

Patient Infant OlderPerson

Adult Women Sports Generic Others

2623

118 7 6

85

3

No.

of P

aten

t Fam

ilies

Target

Analysis of target population indicates that maximum number of patents/publishedapplications included protein and amino acid based nutraceutical compositions directedtowards the treatment of specific patients (26), followed by infant formulas (23).


Target Population – Filing Trend

© IIPRD, 2016 22

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016Infant 1 1 0 0 0 1 1 1 1 5 11 1Patient 0 0 0 0 2 0 1 4 2 4 12 0

0

2

4

6

8

10

12

14

No.

of P

aten

t Fam

ilies

Application Year

Analysis of filing trend of target population indicates that maximum numberpatents/published applications containing infant and patient based nutraceuticalcompositions were filed in the year 2015 (~11, ~12 respectively), followed by a dip in 2016which maybe due to applications not published so far.


Application - Distribution

© IIPRD, 2016 23

Analysis of applications (end-uses) indicates that maximum number of protein and aminoacid based nutraceutical composition containing patents/published applications weredirected towards the overall health benefit (58), followed by weight management (23) andimmunity enhancement (20).


Application – Filing Trend

© IIPRD, 2016 24

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016Overall Health 1 1 0 1 1 1 2 3 5 7 33 3Weight management 0 0 0 0 1 2 0 0 1 6 12 0Immunity Enhancement 0 1 0 0 1 0 0 0 0 2 16 0

0

5

10

15

20

25

30

35N

o. o

f Pat

ent F

amili

es

Application Year

Analysis of filing trend of applications (end-uses) indicates that maximum number ofpatents/published applications containing protein and amino acid nutraceuticalcomposition directed towards the overall health benefit, weight management andimmunity enhancement containing were filed in the year 2015 (~33, ~12, ~16 respectively),followed by a dip in 2016 which maybe due to applications not published so far.


© IIPRD, 2016 25

Competitor Analysis

Top Assignees (1/2)

© IIPRD, 2016 26

3

3

5

5

11

18

0 2 4 6 8 10 12 14 16 18 20

South China University of Technology

LKK Health Products Group

Qidong Wanying Electrical Factory

Qidong Xinyang Electronics Co. Ltd.

Nestle S.A.

Abbott Laboratories


Assi

gnee

s

Abbott Lab and Nestle were found to be top assignees with highest number of innovations (individual patent families), significant patent filing in the technology domain. Abbott leads the pack with highest number of filing (18 patent families), followed by Nestle (11 Patent Families).

Top Assignees (2/2)

© IIPRD, 2016 27

10

10

11

11

12

13

14

18

29

33

110

151

0 50 100 150 200

Groupe Danone

Puretein Bioscience Llc

Institut National De La Recherche Agronomique (Inra)

Raisio Nutrition Ltd

Murray Goulburn Co-Operative Co Limited

Laboratoires Expanscience

Ls2 Llc

Cargill Inc

Natural Alternatives International Inc.

Northern Innovations Holding Corp.

Abbott Laboratories

Nestle S.A.

No. of Patents

Assi

gnee

Abbott Lab and Nestle were found to be top assignees having 151 and 110 patent publication filed worldwide. Interestingly, Nestle has less number of innovations compared to Abbott but has sought much wider protection for the innovations.

Note: For this graph, all family members were taken into consideration.

Assignee Filing Trend

© IIPRD, 2016 28

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016Abbott 1 0 0 0 0 0 4 1 1 0 11 0Nestle 0 0 0 0 1 1 0 2 2 1 4 0

0

2

4

6

8

10

12

No.

of P

aten

t Fam

ilies

Application Year

In 2015, Abbott Lab and Nestle has maximum no. of patent applications, 11 and 4 patent families respectively.

Assignee Vs Protein

© IIPRD, 2016 29

NestleAbbott

0

5

10

15

Soy Pea Rice Wheat Whey Casein Egg Gelatin Collagen MicrobialProtein

PlantMilk

Animal

21 1 2

5

21

9

6 6

2

54

1 23

Assi

gnee

No.

of P

aten

t Fam

ilies

Protein

• Abbott Lab has primary focus on the soy based protein (9 patent families) composition. In many of Abbott’s products (Similac and RCF), soya protein is main protein source.

• Nestle has primarily focus on Whey based protein (5 patent families) compared to Soy (2 patent families). Nestle’s product (Good Start) have whey based protein.

Assignee Vs Product Form

© IIPRD, 2016 30

Nestle

Abbott0

5

10

15

Pow

der

Tabl

ets

Bar

Caps

ules

Beve

rage

s

Susp

ensi

ons/

Emul

sion

s

Conf

ectio

nary

Sem

isol

id

SolidLiquid

9

1 1

2 1 2 1

12

42 3

21 2

1

Assi

gneeNo.

of P

aten

t Fam

ilies

Product Form

Both Abbott (12 patent families) and Nestle (9 patent Families) have primary focus on the powder as product form. Advantages of powder is : (a) Powder is stable and does not enter into reaction in solid state, (b) manufacturing of powder is economic, (C) less incompatibility as compared to liquid dosage form and (D) protein nutraceutical required in larger amount (in grams), conventional dosage of a supplement based requirement of can easily dispensed.

Assignee Vs Target

© IIPRD, 2016 31

Nestle

Abbott0

5

10

15

Infant Sports Patient women Old Person Adults

15

4

2

10

2 3

Assi

gnee

No.

of P

aten

t Fam

ilies

Target

Abbott Lab has primary focus on infants (10 Patent families). Whereas, Nestle has maximum patents targeting patients (5 patent families).

Assignee Vs Application

© IIPRD, 2016 32

Nestle

Abbott

0

5

10

15

42

12 1

10

3 31

Assi

gnee

No.

of P

aten

t Fam

ilies

Application

• Abbott Lab (10 Patent families) and Nestle (4 patent families) have primary focus on overall health.

Market Data (1/2)

© IIPRD, 2016 37

• Dietary supplements are products that arespecifically intended help meet recommendeddietary requirements and supplement regular diet.The dietary supplement is multi-billion dollarbusiness. Market share for different ingredient ispresented in the figure left. Protein and amino acidaccounted for more than 55% revenue.1

• Global protein and amino acids market is estimatedto grow CAGR of more than 6% by 2020 2 andprojected revenue by 2022 is USD 40.8 billion. 1% breakdown of revenue for dietary ingredient

Protein Market Share by Region

For 2014, region wise market share of proteinIngredients presented in image. The North Americanregion accounted for the largest share, owing to thehigh consumption of protein-based products. Theglobal market in the Asia-Pacific region is emergingwith substantial opportunities.3

http://www.strategyr.com/MarketResearch/Protein_Ingredients_Market_Trends.asphttp://www.technavio.com/report/global-food-protein-ingredients-markethttp://www.strategyr.com/MarketResearch/Protein_Ingredients_Market_Trends.asphttp://www.marketsandmarkets.com/Market-Reports/protein-ingredients-market-114688236.html

Market Data (2/2)

© IIPRD, 2016 38

• Protein ingredients are essentially protein extracts from different sources such as plant(soy, pea), animal (egg, collagen), milk (whey, casein), microorganism (spirulina) so on.The demand for particular type of protein is dependent end user.

• Protein Ingredients market size in terms of volume1 and revenue2 is presented in thefollowing graphs. There is a paradigm shift in the protein market. plant proteiningredients will dominate the protein ingredients market and is expected to grow at aCAGR of more than 7% by 2020.3

0

500

1000

1500

2000

2500

3000

3500

4000

2014 2015 2016 2017 2018 2019 2020Animal 2536 2705 2818 2953 3156 3382 3607Plant 1815 1916 2029 2119 2198 2311 2480

Kilo

Ton

s

Global protein type by volume

0,0

10,0

20,0

30,0

40,0

2015 2020

22,729,8

6,4

9,2

Billi

on U

SD

Plant Animal

Global protein type by Revenue

http://www.grandviewresearch.com/industry-analysis/protein-ingredients-markethttp://www.marketsandmarkets.com/PressReleases/protein-ingredients.asphttp://www.technavio.com/report/global-food-protein-ingredients-market

Mergers and Acquisitions

© IIPRD, 2016 39

Acquirer Acquiree Highlight Year Source

Nestle Pfizer Nutrition

To strengthen position in global infant nutrition market nestle acquired Pfizer

Nutrition.

2012 http://www.nestle.com/media/pressreleases/allpressreleases/pfizer-nutrition-closing

Archer Daniels Midland (ADM)

Harvest Innovations

Archer Daniels Midland (ADM) Enhances Plant Protein, Gluten-Free Ingredient Portfolio with Purchase of

Harvest Innovations, an industry leader in minimally processed, expeller-

pressed soy proteins, oils and gluten-free ingredients.

2016 http://www.adm.com/news/_layouts/PressReleaseDetail.aspx?ID=706

BalchemCorporati

on

Albion International,

Inc.

Strategic expansion of human health and wellness solutions portfolio

Balchem Corporation acquired Albion International.

2016 http://www.balchem.com/balchem-corporation-acquires-albion-international-inc-1

http://www.nestle.com/media/pressreleases/allpressreleases/pfizer-nutrition-closinghttp://www.adm.com/news/_layouts/PressReleaseDetail.aspx?ID=706http://www.balchem.com/balchem-corporation-acquires-albion-international-inc-1

protein and amino acid supplements...kinds of protein. apart from proteinbiosynthesis, amino acid...

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