proteins and molecular chaperones
TRANSCRIPT
PROTEINS AND MOLECULAR CHAPERONES
Ana María Cano Valencia3rd Semester
Molecular BiologyMarch 09-2015
FOLDING
INTRODUCTION
The proteins are macromolecules that execute almost all the activities of the cells and the
responsibles that all of this occur in the normal way
The protein structure can be primary, secondary, tertiary or quaternary
The molecular chaperones are a diverse group of families of proteins that are requires for the correct folding, transport and degradation of
others proteins in vivo. Are formed for amino acid monomers
Are formed for amino acid monomers
1. “Natural ‘molecular chaperone’ inhibits
Alzheimer’s”Nature Structural & Molecular BiologyTuesday, 17 February 2015
They used tests on mice to show that a human brichos domain can disrupts the catalytic chain reaction associated with
the aggregation of theamyloid-β peptide (Aβ42)
The onset of Alzheimer´s could be delayed with a molecular
chaperone which can inhibits the chain reaction that damages the
brain. The researchers are led by Dr. Samuel Cohen from the
university of cambridge
The researchers are led by Dr. Samuel Cohen from the
university of cambridge
“Natural ‘molecular chaperone’ inhibits
Alzheimer’s”
Which typically appear years before symptoms
such a memory loss
Which typically appear years before symptoms
such a memory loss
This process leads to the dementia.
This process leads to the dementia.
“Natural ‘molecular chaperone’ inhibits
Alzheimer’s”
The mices had been give injections of amyloid proteins in the brain to mimic
the biology of Alzheimer´s
This reduce the level of electrical activity called
“gamma waves” in the brain
When these was injected with Brichos and amyloid
proteins, their gamma wave activity was normal
The findings prove that Alzheimer's devastating impact on memory and personality can be interrupte, however would be difficult to
convert the molecula in a drug.
“A good tactic now is to search for other molecules that have this same highly targeted effect and to see
if these can be used as the starting point for developing a future therapy,” said Cohen.
“Natural ‘molecular chaperone’ inhibits
Alzheimer’s”
The molecular chaperones can help to maintein protein homeostasis by a selectivy
suppressing steps within the complex reaction pathways responsible for thetoxic effects of protein misfolding and
aggregation.
Is difficult that Brichos can be
converted into a drug because it
would be absorbed before work in the
brain
Is difficult that Brichos can be
converted into a drug because it
would be absorbed before work in the
brain
PERSONAL OPINION
I think this topic is very interesting and their applications in the medicine are very extensive , this can be a future solution of a very big amount of diseases, these notices can gift hope for the people
who suffer these type of disease, which every day affect more persons.
Is necessary make more researches of molecular chaperones in the search of find new alternatives for cure many types of diseases.
“The Horrific Dangers Of Protein Powder Consumption“
The protein shakes and smoothies are very popular, these are associated with a
healthy lifestyleAre accesible for all
the rates of age
In the market can be found many types and flavors like chocolate,
vainilla and cand be mixed with a big number options.
Recent studies demonstrate that these protein shakes can have serious health consequences
INQUISITRMarch 1, 2015
“The Horrific Dangers Of Protein Powder Consumption”
The typical protein powder contains 20 to 50 grams of
protein per serving.
Their consumption can
carry to a decrease of the kidney function and a calcium
loss.
Their consumption can
carry to a decrease of the kidney function and a calcium
loss.
In a study reported in 2013
Was found that a increase of amount of protein
caused a increase in urine calcium loss
The researchers use diferents
concentrations of protein (47, 95 and
142 grams per day).
“The Horrific Dangers Of Protein Powder Consumption”
Are the body´s filtration system
A excess of protein increases the kidneys
workload.
Big concentrations Large period time
Can increase the acid load on the kidneys and increase the
risk of kidney stone formation
“The Horrific Dangers Of Protein Powder Consumption”
Many of protein shakes contein heavy metals
Was teste a muscle milk chocolate powder and this
have four heavy metals
Lead levels of 13.5µg
exceed the USP limite of 10µg per day
Cadmium leves was
5.6µg and the USP limit is
5µg per day.
Arsenic and mercury
levels are into USP
limits
The body only can break down 5 to 9 grams of
protein per hour, the excess is
converted to fat or excreted
The body only can break down 5 to 9 grams of
protein per hour, the excess is
converted to fat or excreted
“So it’s a ridiculous waste to be recommending so much more
than you really need.” Kathleen Laquale
PERSONAL OPINION
I think it´s very important know the risk of consumption of these type of products that is consumed in a big amount in the world.
This product is selling with the idea that are healthy, but a little part of population know the real health consequences of their consume, this products lead a big deterioration in the kidneys and these organs are
very important for the life and for a good quality of this.
I think is necessary make more studies of this topic and show this to all the people, for make a responsibility consumption of this products.
MEDICAL UTILITY OF PROTEINS AND MOLECULAR
CHAPERONES
Molecular chaperones are involved in the pathogenesis
of a extensive number of pathologies, like Parkinson, alzheimer and Huntington so these proteins could be
an important pharmacological target
MEDICAL UTILITY OF PROTEINS AND MOLECULAR
CHAPERONES
Proteins in our body are used for diagnosis of diseases, these can be measured in
serum as CRP for mesure the risk of a CV event or in urine
like the albumin, according to their levels may indicate a
specific pathology or a type of pathologies
MEDICAL UTILITY OF PROTEINS AND MOLECULAR
CHAPERONES
Knowing the structure of protein hormones can lead
to modification of their amino acid sequences to
improve their pharmacological effects, as in the case of biosynthetic
insulin
MEDICAL UTILITY OF PROTEINS AND MOLECULAR
CHAPERONESCurrently are developing a lot of technological advancements in relation with proteins, such is the case of antifreeze proteins that can be used
to preserve organs and tissues for transplantation
REFERENCES
• Cohen S I A, et al. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nature Structural & Molecular Biology, Tuesday, 17 February 2015. Retrieved March 8, 2015 from http://www.onmedica.com/NewsArticle.aspx?id=1f1e86ca-197b-4815-ac4f-5b326d845d68
• INQUISTIR. (2015). The Horrific Dangers Of Protein Powder Consumption. March 1, 2015. Retrieved March 8, 2015 from http://www.inquisitr.com/1885022/the-horrific-dangers-of-protein-powder-consumption/#oK8fzcScv2kwDzPX.99
• Martínez Sánchez, Lina María; Vargas Grisales, Natalia; Toro Montoya, Andrés Eduardo; Pamplona Sierra, Ana Paulina; Queveda Orrego, Esteban. “Biología molecular”. 7. ed. Medellín, Colombia. Editorial Universidad Pontificia Bolivariana, 2014. pp: 112-120
• Images from www.google.com