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is obtained from theroots of rhubarb(Rheum rhaponticum).

We used an in silicoscreening to evaluate

and select rhaponticin,a molecule present inrhubarb that ats as anatural agonist ofPPARy.

aquaxtremTM

Keratinocytes, during thedifferentiation process, areresponsible for the production ofelements of these structures, such as:

aquaxtremTM

Stimulates barrier function and skinhydration from the inside

Boosts keratinocyte differentiation

By activating PPARy, receptor thatcontrols gene expression of differentcells, aquaxtremTM:

Lipids of cutaneous barrier

Involucrin

Filaggrin

Natural moisturizing factor (NMF)

Cutaneous barrier

The skin has mechanisms andstructures designed to maintainthe hydration:

Activates the own mechanisms of the skin for a long-lasting moisturization

aquaxtremTM

Hydration is key

As years go by, keratinocyte movementslows down and skin becomes dry, weak

and aged.

works from the inside, stimulating

hydration mechanisms of the skin,

through the activation of PPARy

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D29S4vsD29S

aquaxtremTMreduces water loss (TEWL)repairing the barrier function.

TEWL evaluation

25

20

15

10

5

0

PERCENTAGE

aquaxtremTMimproves natural mechanismsinvolved in the barrier function and provides adeep and long-lasting hydration.

Hydration evaluation

CERFTOTALLIPIDS

PERCENTAGE OF LIPIDS VS. CONTROL

400

300

200

100

0PERCENTAGE

Improvement of skin barrier

* RH 5 (rhaponticin 5 ppm); RH 25 (rhaponticin 25 ppm)

Stratum corneum resistance and cohesion

Improvement of barrier functionRecovery of skin hydration

Effects of rhaponticin on human epidermalkeratinocytes were analysed to prove itscapacity of modulating filaggrinand involucrinproduction, key elements for stratum corneum.

The more fluorescence intensity, the morefilaggrin and involucrin levels:

In vivo study protocol

In vitro efficacy

MOISTURIZING

In vivo efficacyIncrease of stratum corneum cohesion

CHOLES-TEROL

FREE FATTYACIDS

CHOLES-TERYL

ESTERS

Rhaponticin (RH 5) increases production ofbarrier lipids, thus protects the body andavoids skin dehydration.

Barrier recoveryAccumulated hydrationCohesion

Start treatment

D0 Barrier (TEWL)HydrationCohesion

D1

End treatmentD28

D29

D31 Long-lasting hydration

+9.6%+11.6%

D29 D31

PLACEBOaquaxtremTM

-14.13%

-7.13%

* D29S (after stripping); D29S4 (4h after stripping)

-15 -10 -5 0

D29vs

D0

INVOLUCRIN

RH25RH5NIACINAMIDECONTROL

INTENSITY600

500

400

300

200

100

0

+37% +32%+62%

RH25RH5NIACINAMIDECONTROL

FILAGGRIN

350300250200150100500

+36%+20%

+59%

INTENSITY

25 women between 40-57 years old, with dry skin. Placebo and

aquaxtremTM

(1.5%) on arms and legs, twice daily for 28 days.

PERCENTAGE OF aquaxtremTMVS. PLACEBO

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Transparent liquidBrown - dark brown color

Mango - ECOG

Bismuth Oxychloride, Mica, Iron Oxides (CI77491)

F

Polysorbate 20Parfum (Fragrance)Glycerin, Leuconostoc/Radish Root FermentFiltrate, Lonicera Japonica (Honeysuckle)Flower Extract, Lonicera Caprifolium(Honeysuckle) Extract, Populus TremuloidesBark Extract, Gluconolactone

E

D Aqua (Water), Sodium Hydroxide

C

B

Polymethyl Methacrylate, Sodium Acrylate/Sodium Acryloyl Dimethyl Taurate Copolymer,Isohexadecane

Alcohol Denat.aquaxtremTM

Aqua (Water)Acrylates/C10-30 Alkyl Acrylate Crosspolymer

A

INCI / PCPC

1.00

0.03

0.500.151.75

1.20

2.00

10.001.50

81.270.60

% (w/w)

RECOMMENDED DOSE

SOLUBILITY

APPEARANCE

ACTIVE MOLECULES

0.5 - 1.5 %

Soluble in aqueous solutions

Rhaponticin

Stimulates the skin naturalmechanisms of hydration throughthe activation of PPARy

PROPERTIES

Activates the own mechanisms of the skin for a long-lasting moisturization

aquaxtremTMMOISTURIZING

In vivo efficacyEvaluation of skin dryness and stratum corneum cohesion (microscope images)

D0 D29

cosmetic applications

aquaxtremTMnormalizes stratum corneumdesquamation, stimulating differentiation

of keratinocytes and natural hydrationmechanisms.

Technical specifications Formulation

Facial and body care (shower gel, body milk, hand cream) Specific treatments for dry, very damaged or mature skin Hair care (shampoos, lotions, conditioners, masks) Make-up Sun care products

aquaxtremTM75680 Perfect Moisture Gel

V01-2013