CURRICULUM VITAE

Majid Shahbazi PhDMedical Cellular & Molecular Research CenterTalghani Children University hospitalBolv. Janbazan, Zip cod- 4916668197Gorgan, Iran

Shahbazim@Goums.ac.ir shahbazimajid@yahoo.co.uk Majidshahbazi@hotmail.com

Positions:

Since 2004 I have been working in Gorgan University of Medical Sciences as an assistant professor & Director of Medical Cellular & Molecular Research Center.

2001-2003 Post-doctoral position on the Wellcome trust for cell matrix center on gene expression of Cycline-Dependent Kinase Inhibitors (CDKIs) on chondrocytes in Dr Gillian Wallis and Dr Ray Boot-Handford labs, which is funded by National Institute of Health (NIH) Arthrit Research Council (ARC)

Training:

1998-2001: PhD in the field of immunology and genetics, under supervision of professor Ian V HutchinsonThe Subject was: GROWTH FACTOR GENES Polymorphisms. (EGF, IGF-I, PDGF, bFGFand VEGF) in control and diseases.

1997-1998: MSc in Immunology & immmunogetics.1987-1990: MSc in medical parasitology from school of Public Health University of medical sciences the subject was study of cross reactivity between hydatic cyst and Actinomycetes. 1983-1987: BSc from school of Public Health University of medical sciences.

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Publication

1. Majid Shahbazi, Reza Abdolmohammadi, Hamid Ebadib, Touraj Farazmandfar. Novezl functional polymorphism in IGF-1 gene associated with multiple sclerosis: A new insight to MS. Multiple Sclerosis and Related Disorders. 13 (2017) 33–37

2. Reza Abdolmohammadi, Saleh Shahbazi Azar, Ayyoob Khosravi, Majid Shahbazi. CCR5 polymorphism as a protective factor for hepatocellular carcinoma in hepatitis B virus-infected Iranian patients. Asian Pac J Cancer Prev. Accepted 2016

3. Ehsan Alaee, Behnaz Bazrafshan, seyed Ali Reza Azaminejad, Mahnaz Fooladi Nejad, Majid Shahbazi. The association between prolonged jaundice and UGT1A1 gene polymorphism (G71R) in Gilbert’s syndrome. Journal of Clinical and Diagnostic Research (JCDR). Accepted 2016

4. Fatemeh T Shamsabadi, Mohammad Reza Akbari Eidgahi, Parvaneh, Mehrbod, Nasibeh Daneshvar, Zeenathul Nazariah Allaudin, Ahad Yamchi, Majid Shahbaz. Survivin, a Promising Gene for Targeted Cancer Treatment. Asian Pac J Cancer Prev. 17 (8), 3709-3717

5. Nadia Ghasemian, Majid Shahbazi. Interferon Gamma Gene Polymorphism (+874 T > A) and Chronic Hepatitis B in the Population of Gorgan, North-Eastern Iran. doi: 10.5812/jjm.33639. Jundishapur Journal of Microbiology. 2016 August; 9(8):e33639

6. Saleh Shahbazi Azar, Maryam Mansoori, Marzieh Attar, Majid Shahbazi. Tumor Necrosis Factor Alpha -308 G/A Single Nucleotide Polymorphism and Susceptibility to Hepatocellular Carcinoma via Hepatitis B Infection. Asian pacific journal of cancer prevention. Asian Pac J Cancer Prev, 17 (7), 3381-3384

7. Majid Shahbazi , Javad Sadeghi allah abadi, Danial Roshandel, Maryam Koochaki, Hosein Amiri, Rahim Kohansal, Seied Mohammad Baghbanian, Mahdi Zamani. Combination of IL-10 gene promoter polymorphisms with HLA-DRB1*15 allele are associated with multiple sclerosis. The Indian Journal of Medical Research.accepted 14/Jul/16

8. Marzieh Attar, Saleh Shahbazi Azar, Majid Shahbazi. Interlukin-6 -174 promoter polymorphism intensifies susceptibility to hepatitis B virus as a risk factor for hepatocellular carcinoma in an Iranian population. Asian Pac J Cancer Prev, 17 (5), 2395-2399

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عباسیان، .9 مهدی پورهاشم، شهبازی زینب . مجید یامچی احد کلسی ، هورمون هترولوگ بیانباکتری در : . E.coliتونین . پذیرش گرگان پزشکی علوم دانشگاه علمی 24/12/94مجله

گلشن، .10 شهبازی فرناز .مجید حیدری کامران کلنی ، کننده تحریک فاکتور تنظیمی اثراز حاصل های رویان گزینی النه موفقیت و گزاری تخمک تعداد بر گرانولوسیت

نژاد سوری موش در : .NMRIآمیزش . پذیرش گرگان پزشکی علوم دانشگاه علمی مجله27/4/95

11. Maryam Mansoori, Masoud Golalipour, Shahriar Alizadeh, Ataollah Jahangirerad, Seyed Reza Khandozi, Habibollah Fakharai and Majid Shahbazi. Genetic variation in the ABCB1 gene may lead to mRNA level change: Application to gastric cancer cases. Asian pacific journal of cancer prevention. 2015;16(18):8467-71.

تهذیبی، .12 عباس آقاجانی، حسین شهبازی محمد صورت. مجید به پاراتیروئید پروتئین بیان و کلونینگ . زمستان گرگان، پزشکی علوم دانشگاه علمی مجله اشرشیاکلی باکتری در دوره 94محلول ،17،

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13. Ayyoob Khosravi, Bita Javan, Mohammad Amin Tabatabaiefar, Hamid Ebadi, Davood Fathi, Majid Shahbazi. Association of Interleukin-1 gene cluster polymorphisms and haplotypes with multiple sclerosis in an Iranian population. Journal of Neuroimmunology. 2015 Nov 15;288:114-9

14. Masoumeh Ghasemi, Elham Kashani, Azadeh Fayyaz, Marzieh Attar, Majid Shahbazi. Interleukin-1 alpha variation is associated with the risk of developing preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology . 193 (2015) 75–78

15. Hamidreza Iranpoor, Eskandar Omidinia, Venus Vatankhah, Vahid Gharanjik ,Majid Shahbazi. Expression of Recombinant Human Insulin-like Growth Factor Type 1 (rhIGF-1) in Escherichia coli. Avicenna Journal of Medical Biotechnology. Vol. 7, No. 3, July-September 2015

16. Touraj Farazmandfar, Mohammad Reza Haghshenas, Majid Shahbazi. Inhibition of HIV-1 by a Lentiviral Vector with a Novel Tat-Inducible AU2c Expression System and a Specific Tropism to the Target Cells. Human gene therapy, volume 26 number 00. doi: 10.1089/hum.2015.031

17. Mahakizadeh Simin; Jahanshahi Mehrdad; Haidari Kamran, Shahbazi Majid. Dopamine Receptors Gene Expression in Male Rat Hippocampus after Administration of MDMA (Ecstasy). Int. J. Morphol. 33(1):301-308, 2015.

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18. Arash Tahmasebifar, Yaghoub Yazdani, Pooria Gill, Majid Shahbazi. Nanoscopic Study of Gold Nanorods Used for Efficient Delivery of Sirna in Cancer NanoTherapy. American Journal of Advanced Drug Delivery. 2014

19. Alireza Haghighi, Davood Fathi, Majid Shahbazi, Mohammad-Mahdy Motahari, Bethany Friedman. Identification of a c.601 C>G mutation in the CCM1 gene in a kindred with multiple skin, spinal and cerebral cavernous malformations. Journal of the Neurological Sciences (2013)

20. Kollaee A, Ghaffarpor M, Pourmahmoudian H, Shahbazi M, Zamani M: Investigation of CD24 and Its Expression in Iranian Relapsing-Remitting Multiple Sclerosis. Int J Neurosci. 2011 Dec;121(12):684-90

21. M. Zamani, M. Mehri, A. Kollaee, P. Yenki, M. Ghaffarpor, M.H. Harirchian M.   Shahbazi :  Pharmacogenetic Study on the Effect of Rivastigmine on PS2 and APOE Genes in Iranian Alzheimer. Dement Geriatr Cogn Disord Extra 2011; 1:180–189.

22. Shahbazi M , Roshandel D, Omidineya E, Rashidbaghan A: Interaction of HLA-DRB1*1501 allele and TNF-alpha -308 G/A single nucleotide polymorphism in the susceptibility to multiple sclerosis. Clin Immunol. 2011; 139(3):277-81.

23. Shahbazi M , Ebadi H, Fathi D, Roshandel D, Mohamadhosseni M, Tahmasebi A, Shahbazi S, Zamani M, Rashidbaghan A. HLA-DRB1*1501 intensifies the impact of IL-6 promoter polymorphism on the susceptibility to multiple sclerosis in an Iranian population. Mult Scler. 2010; 16(10):1173-7.

24. Shahbazi M , Roshandel D, Ebadi H, Fathi D, Zamani M, Boghaee M, Mohammadhoseeeni M, Rshaidbaghan A, Bakhshandeh A, Shahbazi S.High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis. Clin Immunol. 2010 ;137(1):134-8

25. Shahbazi M , Ebadi H, Fathi D, Roshandel D, Mahamadhoseeni M, Rashidbaghan A, Mahammadi N, Mahammadi MR, Zamani M. CCR5-delta 32 allele is associated with the risk of developing multiple sclerosis in the Iranian population. Cell Mol Neurobiol. 2009; 29(8):1205-9.

26. Shahbazi M , Pravica V, Nasreen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osborne JE, Lear JT, Smith AG, Hutchinson IV.Association between functional polymorphism in EGF gene and malignant melanoma. Lancet. 2002; 359(9304): 397-401.

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27. Shahbazi M, Fryer AA, Pravica V, Brogan IJ, Ramsay HM, Hutchinson IV, Harden PN.Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol. 2002; 13(1): 260-4.

Presentation

1. Marzieh Attar, Maryam Mansoori, Majid Shahbazi. Evaluation of IL6 gene polymorphism (position: -174) in Gastric cancers patients and healthy controls. The Second International Gastrointestinal Cancer Congress. 14 - 16 October 2015, Olympic Hotel, Tehran, Iran

2. Azam Bakhshandeh, Majid Shahbazi. Reviewing effect of paraoxonase gene on coronary artery disease.2nd international and 14th Iranian Genetic Congress. 21-23 may 2016, Shahid Beheshti University, Tehran, Iran

3. Ehsan Alaee, Behnaz Bazrafshan, seyed Ali Reza Azaminejad, Mahnaz Fooladi Nejad, Majid Shahbazi. Evaluation of polymorphism UDGT1 (G71R) in the neonates with prlonged icter. Third National Congress on Cellular and Molecular News in Non-Contagious Diseases. 13-15 May 2015, Babol University of Medical Science. Babol. Iran

4. Parham Nejati, Reza Salehi Manzari, Mahdi Raeatnavaz, Majid Shahbazi. Evaluation of TNF-alpha gene promoter polymorphism (position -308) in patients with Coronary Artery Disease and healthy people. First international and 13th Iranian Genetic Congress.May 24-26, 2014. Tehran, Iran

5. Masoomeh Mohammad Zadeh, Majid Shahbazi,Kamran Haidari. The Effects of estradiol and ECG combination on ZP3 Gene in mouse oocyte.Word Congress of Reproductive Biology. Sep 2-4, 2014. Scotland

6. Alireza Azizi, Majid Shahbazi, Kamran Haidari. The Effects of Mesenchymal Stem Cell-Conditioned Medium on the fertilization rate, embryo development and OCT-4 gene expression og 8-cell NMRI mice embryos.Word Congress of Reproductive Biology. Sep 2-4, 2014. Scotland

7. Samaneh Naeimipour, Marzieh Attar,Azam Bakhshandeh,Majid Shahbazi. Investigation of frequency of interleukin-13 polymorphism (position +110) in multiple sclerosis patients and

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control group. 10th International Iranian Ms congress. 2013, Isfahan, Iran

8. Azam Bakhshandeh, Marzieh attar, Samaneh naeimipour, Behnaz Bazrafshan, Parastoo kush, Majid shahbazi. Evaluation of HLA-DQ gene polymorphism (DQ-A1 position: 0102) in MS patients and healthy population. 10th International Iranian Ms congress. 2013, Isfahan, Iran

9. Behnaz Bazrafshan, Parastoo Kusha, Azam Bakhshandeh, Marzieh Attar, Samaneh Naeimipour, Majid shahbazi. Evaluation of HLA-DQ gene polymorphism (DQ-B1 position: 0602) in MS patients and healthy population. 10th International Iranian Ms congress. 2013, Isfahan, Iran

10. Samaneh Naeimipour, Reza Salehi Manzari, Aref Salehi, Seied Ali Sharifian, Marzieh Attar1, Majid shahbazi. Investigation of InterLukin-13 ( +110( polymorphism in patients with Coronary Artery Disease and healthy people. 2nd international Preventive Cardiology congress. 16-18 oct 2013. Shiraz, Iran

11. Behnaz Bazrafshan, Reza Salehi Manzari, Samaneh Naeimi Pour, Seied Ali Sharifian, Aref Salehi, Majid Shahbazi. Study of Functional Insulin-Like Growth Factor 1 gene polymorphism in position -383 in people with Coronary Artery Disease (CAD) and healthy control. 2nd international Preventive Cardiology congress. 16-18 oct 2013. Shiraz, Iran

12. Marzieh Attar, Reza Salehi Manzari, Seied Ali Sharifian, , Samaneh Naeimipour, Majid shahbazi. Evaluation of mthfr gene polymorphism (position C677T) in people with Coronary Artery Disease and healthy controls. 2nd international Preventive Cardiology congress. 16-18 oct 2013. Shiraz, Iran

13. Marzieh Attar, Majid Shahbazi. Association of IL6-174 promoter polymorphism with hepatitis B infection in an Iranian population. 3nd Iranian genetic in medicine Congress. 15-16 may 2013. Tehran, Iran.

14. S.ziyaie, Z.siyamarzgoie, M.baghbaniyan, M.shahbazi. Evaluation of genotyping in GM-CSF (position - 1916) in multiple sclerosis patients & healthy controls Iranian population. 3nd Iranian genetic in medicine Congress. 15-16 may 2013. Tehran, Iran

15. Reza Salehi Manzari, Aref Salehi, Hossein Ali Sharifian, Samaneh Naeimipour, Marzieh Attar, Majid Shahbazi . Study of Functional Vascular Endothelial Growth Factor gene polymorphism in position -2578 in people with CoronaryArtery Disease (CAD) and healthy control. 3nd Iranian genetic in medicine Congress. 15-16 may 2013. Tehran, Iran

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16. Shahbazi M., Koochaki M., Sadeqi J., Fathi D. The susceptibility of multiple sclerosis is influenced by IL-10 promoter polymorphisms and their combination with HLA-DRB1*15 alleles, among Iranian population. The 9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012

17. Ziaee S., Siamarzgoie Z., Baghbanian M., Shahbazi M. Evaluation of genotyping in GM-CSF in positions of GM-CSF (-1916) in multiple sclerosis patients & healthy controls Iranian population. The 9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012

18. Safari R , Sadeqi J, Koochaki M , Ebadi H ,Shahbazi M. Genetic variation of Nerve Growth Factor )NGF( gene in MS patients and healthy Turkmen and non-Turkmen samples . The 9th

international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012

19. Saleh Shahbazi, Davood Fathi, Majid Shahbazi. High frequency of the IL-2 −330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis. The 9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012

20. Shahbazi M , Roshandel D , omidnyiab E , Rshaidbaghan A ,bakhshandeh A, Attar M. Interaction of HLA-DRB1*1501 allele and TNF-alpha−308 G/A single nucleotide polymorphism in the susceptibility to multiple sclerosis. The 9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012

21. Khosravi Ayyoob, Bita Javan, Mehrnaz Izadpanah, Majid Shahbazi. Association of IL-1β gene polymorphisms with multiple sclerosis in Iranian population. The 9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012

22. Abdolmohammadi R, Ebadi H, Bakhshande A, Shahbazi M. Novel functional IGF-1 promoter polymorphism (-383C>T) Association with the susceptibility to multiple sclerosis. The 9th international MS congress of Iran. Tehran, Iran, 1-2 Nov 2012

23. Ghasemi M. Shahbazi M. Evaluation of IL-1alpha gene polymorphism (position -889) in pre-eclampsia and healthy pregnancy. 12th Iranian Genetic congress, 21-23 May 2012. shahid beheshti university, Tehran, Iran (Persian)

24. Ghasemian N. Shahbazi M. Frequency determination of IFN_gamma gene polymorphisms in HBs-Ag positive individuals and healthy controls. 12th Iranian Genetic congress, 21-23 May 2012. shahid beheshti university, Tehran, Iran (Persian)

25. Javan B., Shahbazi M. polymorphisms of interleukin-1 Beta Genes in Patients with Chronic Hepatitis B in Iran. 4th international Tehran Hepatitis Congress. Nov. 2011

26. Abdolmohammadi R. et al. Association of IGF-1 promoter polymorphism (-383C>T) with

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the susceptibility to multiple sclerosis.2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June 2011

27. Mansoori M. et al. Association of TNF-α promoter polymorphism (-308G>A) with the outcome of hepatitis B virus infection. 2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June 2011

28. Bita Javan, et al. Polymorphism of interleukin-1 receptor antagonist gene in patients with Chronic hepatitis B in Iran. 2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June 2011

29. Tahmasebifar A. et al. HLA-DRB1*1501 intensifies the impact of IL-6 promoter polymorphism on the susceptibility to multiple sclerosis in an Iranian population. 2nd

Genetic in Medicine congress, Tehran, Iran, 20-21 June 2011

30. Shahbaziazar S., et al. High frequency of the IL-2 −330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis. 2nd Genetic in Medicine congress, Tehran, Iran, 20-21 June 2011

31. Bita Javan, Mohammad Reza Kalani, Ayyoob Khosravi, Maryam Mansoori, Reza Abdolmohammadi, Majid shahbazi: Polymorphisms association of interleukin-1 alpha genes in patients with chronic hepatitis B. The first international student congress on cell and molecular medicine. Shiraz, Iran(17-19 february 2011)

32. Abdolmohammadi Reza, Ayyoob khosravi, Maryam Mansoori, Bita Javan, Saleh Shahbazi, Majid Shahbazi. Association between CCR5 polymorphisms and susceptibility to HBV infection. The first international student congress on cell and molecular medicine. Shiraz, Iran(17-19 february 2011)

33. Javad Sadeghi allah abadi, Majid Shahbazi. Il-10 promotor polymorphism and their combination with HLA-DRB allels are associated with multiple sclerosis in Iranian population. 12th student’s international conferences on biomedical interdisciplinary research. Sep 2011. Isfahan. Iran

34. M. Shahbazi, H. Ebadi, M. Rahmat, M. Mohammad Hosseyni and N. Mohammadi: Role of interleukin 4 in Iranian multiple sclerosis patients. (13th international of Immunology 2007)

35. M. Shahbazi, H. Ebadi, N. Mahammadi, D. Fathei, and M. Mahammadi: Association of CCR5delta32 gene Deletion with multiple sclerosis in Iranian patients. (13th international of Immunology 2007)

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36. M. Shahbazi, H. Ebadi, D. Fathei, M. Mohammad Hosseyni and J. Lotfi: An assessment of the association between IL-6 gene polymorphisms and Iranian patients with multiple sclerosis . (13th international of Immunology 2007)

37. M. Shahbazi, H. Ebadi, a. Rashidbaghan, D. Fathei and, J. Lotfi : Genetic association studies of tumour necrosis factor alpha-308 alleles in Iranian multiple sclerosis. (13th international of Immunology 2007)

38. M. Shahbazi, H. Ebadi, D. Fathei, D. Roshandel, M. Mohammad Hosseyni and N. Mohammadi :

IL-10 promoter polymorphisms in Iranian patients with multiple sclerosis. (13th international of Immunology 2007)

39. M. Shahbazi, M. Rahmat, A. Borghei, A. Bakhshandeh and J. Lotfi: Role of Heat shock protein (HSP) 70-1 gene polymorphism in Iranian multiple sclerosis patients. (13th international of Immunology 2007)

40. HM Ramsay, AA Fryer. PN Harden, M Shahbazi, V Pravica, IV Hutchinson: Platelet derived growth factor gene polymorphisms are associated with non- Melanoma skin cancer risk in renal transplant recipients. 6th annual scientific meeting of the international dermato-epidermiology association. the Eden –IDEA congress the Netherlands 2001

41. M Shahbazi, V pravica, AA Fryer, HM Ramsay, IV Hutchinson and PN Harden: Insulin like growth factor polymorphisms are associated with renal acute rejection risk. The British renal association Annual meeting, Nottingham, UK, 2001

42. Majid Shahbazi, Anthony A Fryer, Vera Pravica, Helen M Ramsay, Paul N Harden and Ian V Hutchinson: Functional Polymorphisms in VEGF are associated with increased risk of acute rejection in renal transplant recipients. The 7the Basic sciences symposium of the transplantation society August 2001 Switzerland, it will be published on transplant Immunology on spring 2002.

43. M.Shahbazi, H.Fakhoury, A. A. Fryer, V. Pravica, R. C. Strange, P. E.Hutchinson, J.E. Osborne, J. T. Lear, A. G. Smith and I.V. Hutchinson: Functional Polymorphism in the human EGF gene malignant melanoma; 7th Annual Congress of British Society for Immunology, Harrogate, UK; Immunology. Vol 101, Supplement 1 December 2000.

44. M. Shahbazi, A. A. Fryer, V. Pravica, H. M. Ramsay, P. N. Harden and I.V.Hutchinson: Functional Polymorphisms in the human VEGF gene associated with renal acute rejection; 7th Annual Congress of British Society for Immunology, Harrogate, UK; Immunology. Vol 101, Supplement 1 December 2000.

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45. M. Shahbazi, V. Pravica. M.R. Awad, I. Brogan, I. V. Hutchinson: Functional polymorphisms in the growth factors (EGF, PDGF-BB, VEGF); The third joint international meeting of the ICS and the ISICR Amsterdam the Netherlands; European cytokine Network Vol 11, Special issue, November 2000.

46. Majid Shahbazi, Vera Pravica, Anthony A Fryer, Helen M Ramsay, Ian V Hutchinson and Paul N Harden: Vascular endothelial growth factor gene Polymorphisms are associated with acute rejection risk; The American society of nephrology 33rd Annual meeting 11-16 October 2000 Toronto, Canada.

47. M Shahbazi, H. Fakhoury, V. Pravica, and I. V. Hutchinson:  A novel Polymorphism in the 5' UTR of the human epidermal growth factor (EGF) gene associated with EGF production in vitro. (Presentation BSI 1999).

Awards and Prizes:

Distinguished lecturer by Iranian Ministry of Health & Medical Education (1994).

Ongoing Research:

1- Gene profiling Multiple sclerosis (MS) patients and Turkmen and non-Turkmen healthy individuals. 2- Cloning and expression of human interleukin (IL-11) and analyses of it bioactivity in in vitro3- Studying the changes in apoptosis induction of Adriamycin by IL-11 and changes in expression of genes and proteins of p53, Bcl-2 and Caspase 3 in K562 and T47D human cancer cell lines.4- Cloning and expression of human interleukin 2 gene in E.coli for production recombinant protein.

Further I have found and submitted following novel gene polymorphisms in the gene bank:

DEFINITION Homo sapiens insulin-like growth factor gene, promoter region.ACCESSION AF417592VERSION AF417592.1 GI:16033735KEYWORDS .SOURCE human. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.REFERENCE 1 (bases 1 to 282) AUTHORS Shahbazi,M. and Hutchinson,I.V. TITLE Human insulin-like growth factor (IGF-I) gene, promoter region

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JOURNAL UnpublishedREFERENCE 2 (bases 1 to 282) AUTHORS Shahbazi,M. and Hutchinson,I.V. TITLE Direct Submission JOURNAL Submitted (10-SEP-2001) 3.239 CID, Immunology Research Group, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, Lancashire M13 9PT, UKFEATURES Location/Qualifiers source 1..282 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="12" /map="12q23" /cell_type="peripheral blood mononuclear cells" /tissue_type="blood" promoter <1..>282 /note="insulin-like growth factor; IGF-I" variation 96 /note="polymorphism" /replace="t"BASE COUNT 70 a 73 c 54 g 85 tORIGIN 1 ctcatcgcag gagaaaaagt atgagacagt gccctaaagg gaccaatcca 51 atgctgcctg cccctccata ggttctagga aatgagatca cacccctcac 101 ttggcaactg ggacaagggg tcacccgagt gctgtcttcc aatctacttt 151 accccagtca cttcagggtt aaaattgtag agtttgctgg agagggtctt 201 atcgtccttt ctttcttttt ttgttttaaa taatgcattt gctctagaat 251 ctaaaattgc tctcccatcc cccatattcc tt

DEFINITION Homo sapiens insulin-like growth factor gene, promoter region.ACCESSION AF417591VERSION AF417591.1 GI:16033733KEYWORDS .SOURCE human. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.REFERENCE 1 (bases 1 to 307) AUTHORS Shahbazi,M. and Hutchinson,I.V. TITLE Human insulin-like growth factor (IGF-I) gene, promoter region JOURNAL UnpublishedREFERENCE 2 (bases 1 to 307) AUTHORS Shahbazi,M. and Hutchinson,I.V. TITLE Direct Submission

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JOURNAL Submitted (10-SEP-2001) 3.239 CID, Immunology Research Group, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, Lancashire M13 9PT, UKFEATURES Location/Qualifiers source 1..307 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="12" /map="12q23" /cell_type="peripheral blood mononuclear cells" /tissue_type="blood" promoter <1..>307 /note="insulin-like growth factor; IGF-I" variation 271 /note="polymorphism" /replace="c"

BASE COUNT 110 a 66 c 54 g 77 tORIGIN 1 aatgttgctg aacatagtgc accattgaca caacataatt ccagatttct 51 aactttgatt tctgaaaggt aaacattgct acaatgtatt aaccacacag 101 aagactcaaa caaacccaac ccccttccaa acaaagcagg tttgtttgtt 151 ttttgttagg gcacccactt ctacaaacaa atttctggcc ccaggataac 201 acaaagagcc agagtaggat ttcaagcaga actgtgtttt cagttgatgt 251 gtcagtcccc tgagagccat gtggaaaaaa aaaaaaagaa aaaattcaag 301 gtccagg

DEFINITION Homo sapiens platelet-derived growth factor A chain (PDGFA) gene, exon 1 and partial sequence.ACCESSION AF417590VERSION AF417590.1 GI:16033732KEYWORDS .SOURCE human. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.REFERENCE 1 (bases 1 to 392) AUTHORS Shahbazi,M. and Hutchinson,I.V. TITLE Human platelet-derived growth factor A-chain (PDGF) gene, 5' end region JOURNAL UnpublishedREFERENCE 2 (bases 1 to 392) AUTHORS Shahbazi,M. and Hutchinson,I.V.

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TITLE Direct Submission JOURNAL Submitted (10-SEP-2001) 3.239 CID, Immunology Research Group, School of Biological Sciences, University of Manchester, Oxford Road, Manchester, Lancashire M13 9PT, UKFEATURES Location/Qualifiers source 1..392 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="7" /map="7p22-p21" /cell_type="peripheral blood mononuclear cells" /tissue_type="blood" 5'UTR <1..>392 /gene="PDGFA" mRNA <1..>392 /gene="PDGFA" /product="platelet-derived growth factor A chain" gene <1..>392 /gene="PDGFA" exon <1..>392 /gene="PDGFA" /number=1 variation 327 /gene="PDGFA" /note="polymorphism" /replace="c"

BASE COUNT 29 a 142 c 182 g 39 tORIGIN 1 ctactcctcc tcctcctctc ccggcggcgg ctgcggcgga ggcgccgact 51 cggccttgcg cccgccctca ggcccgcgcg ggcggcgcag cgaggccccg 101 ggcggcgggt ggtggctgcc aggcggctcg gccgcgggcg ctgcccggcc 151 ccggcgagcg gagggcggag cgcggcgccg gagccgaggg cgcgccgcgg 201 agggggtgct gggccgcgct gtgcccggcc gggcggcggc tgcaagagga 251 ggccggaggc gagcgcgggg ccggcggtgg gcgcgcaggg cggctcgcag 301 ctcgcagccg gggccgggcc aggcgttcag gcaggtgatc ggtgtggcgg 351 cggcggcggc ggcggcccca gactccctcc ggagttcttc tt

DEFINITION Homo sapiens basic fibroblast growth factor gene, partial sequence.ACCESSION AF239155VERSION AF239155.1 GI:8308033KEYWORDS .SOURCE human. ORGANISM Homo sapiens

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Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.REFERENCE 1 (bases 1 to 250) AUTHORS Shahbazi,M. and Hutchinson,I.V. TITLE Direct Submission JOURNAL Submitted (24-FEB-2000) Cell, Development & Immunology, School of Biological Sciences, Univesity of Manchester, 3.239 Stopford Bldg., Oxford Road, Manchester M13 9Pt, UKFEATURES Location/Qualifiers source 1..250 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="4" /map="4q25-q27" /cell_type="mononculear" /tissue_type="blood" promoter <1..11 mRNA 12..>250 /product="basic fibroblast growth factor" 5'UTR 12..>250 exon 12..>250 /number=1 variation 91 /replace="c" variation 233 /replace="t"

BASE COUNT 43 a 71 c 107 g 29 tORIGIN 1 aactcagagg ccggccccag aaaacccgag cgagtagggg gcggcgcgca 51 ggagggagga gaactggggg cgcgggaggc tggtgggtgt cgggggtgga 101 gatgtagaag atgtgacgcc gcggcccggc gggtgccaga ttagcggacg 151 gctgcccgcg gttgcaacgg gatcccgggc gctgcagctt gggaggcggc 201 tctccccagg cggcgtccgc ggagacaccc atctgtgaac cccaggtccc

DEFINITION Homo sapiens egf gene promoter and 5'UTR.ACCESSION AJ131611VERSION AJ131611.1 GI:7378722KEYWORDS egf gene; epidermal growth factor.SOURCE human. ORGANISM Homo sapiens

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Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.REFERENCE 1 (bases 1 to 242) AUTHORS Shahbazi,M., Fakhoury,H., Pravica,V. and Hutchinson,I.V. TITLE A novel polymorphism in the human epidermal growth factor EGF) 5'untranslated region JOURNAL UnpublishedREFERENCE 2 (bases 1 to 242) AUTHORS Fakhoury,H. TITLE Direct Submission JOURNAL Submitted (22-DEC-1998) Fakhoury H., Immunology Research Group, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UNITED KINGDOMFEATURES Location/Qualifiers source 1..242 /organism="Homo sapiens" /db_xref="taxon:9606" promoter <1..78 /gene="egf" /standard_name="epidermal growth factor" gene 1..242 /gene="egf" 5'UTR 79..242 /gene="egf" /standard_name="epidermal growth factor" variation 139

/gene="egf" /replace="g"

BASE COUNT 64 a 54 c 52 g 72 tORIGIN 1 tgtcactaaa ggaaaggagg tggagcctga agagctttaa aaagcaaagc 51 tgagtcattc cacttttcaa aaagagaaac tgttgggaga ggaatcgtat 101 ctccatattt cttctttcag ccccaatcca agggttgtag ctggaacttt 151 ccatcagttc ttcctttctt tttcctctct aagcctttgc cttgctctgt 201 cacagtgaag tcagccagag cagggctgtt aaactctgtg aa

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