Purinsynthese

O

OHHO

C

O O OP P

OOOOP O

5-Phosphoribosyl-1-pyrophosphat(PRPP)

GlutamatGlutamin

COO--OOC CH2 CH2 C

H

+NH3O

OHHO

CP ONH2

O OP

OO

OP

OO

O

5-Phosphoribosyl-1-amin

W. Storch D. Doenecke

Glutamat

O

OHHO

CP O NH2

COO-

H

CH +NH3

Phosphoribosylamin

Glycin

NH

+NH3

C

O

CH2

O OHP

OO

C

O

H THF

THF

C

O

H NH

Glutamin

C

O

CH2

NH

COO--OOC CH2 CH2 C

H

+NH3

N

NH2

N

C

CH

HC

N

NH2

N

C

C

HC

C

O

O

O OHP

OO

NH

N

NH

C

CH2

C

O

H

C

CH

H

C

O

O

HO

N

HN

N

C

CH

HC

C

O

O

O

OHHO

CP O

O OHP

OO

Bicarbonat

CH3N

C

CH2

C

H

OHO

OO

+

AspartatN

NH2

N

C

C

HC

C

O

CHN

C

CH2

C

H

OHO

OO

C

C

CH

C

H

OHO

OO

N

NH2

N

C

C

HC

C

O

NH2

Fumarat

O OHP

OO

THF

N

N

N

C

C

HC

C

O

NH

CH

H2O

Inosinat (IMP)

COTHF

H

N

N

N

C

C

HC

C

O

NH2

H CO

H

Adenylat (AMP)

C

C

CH

C

H

OHO

OO

N

N

N

C

C

HC

C

N

CH

N

N

N

C

C

HC

C

O

NH

CH

O

OHHO

CP O

CH3N

C

CH2

C

H

OHO

OO

+

Aspartat

Fumarat

Inosinat (IMP)

CHN

C

CH2

C

H

OHO

OOH

NH2

OP

OO

O

NH2

NADH+H+

N

N

N

C

C

HC

C

O

NH

CH

O

OHHO

CP O

Inosinat (IMP)

N

HN

N

C

C

HC

C

O

NH

C

O

Glutamin

COO--OOC CH2 CH2 C

H

+NH3

Glutamat

N

N

C

C

HC

C

O

HN N

C

H

Guanylat (GMP)