radioisotopes · radioisotopes 1 1 12614-01_ch01-rev3.qxd 10/25/11 10:56 am page 1 not for...
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C H A P T E R
Radioisotopes1
1
12614-01_CH01-rev3.qxd 10/25/11 10:56 AM Page 1
Not for
Dist
ributi
on
2 NUCLEAR PHARMACY QUICK REFERENCE
TAB
LE 1
-1R
adio
ph
arm
aceu
tica
ls U
sed
in N
ucl
ear
Med
icin
e
Che
mic
al F
orm
and
Ty
pica
l Dos
age
Rad
ionu
clid
eD
osag
e Fo
rmU
se(A
dult
a )R
oute
b
Car
bon
C 1
1
Car
bon
C 1
1
Car
bon
C 1
1
Car
bon
C 1
1
Car
bon
C 1
1
Car
bon
C 1
4
Chr
omiu
m C
r 51
Cob
alt C
o 57
Fluo
rine
F 1
8
Fluo
rine
F 1
8
Fluo
rine
F 1
8
Gal
lium
Ga
67
Indi
um In
111
Indi
um In
111
Car
bon
mon
oxid
e
Flum
azen
il in
ject
ion
Met
hion
ine
inje
ctio
n
Rac
lopr
ide
inje
ctio
n
Sodi
um a
ceta
te in
ject
ion
Ure
a
Sodi
um c
hrom
ate
inje
ctio
n
Cya
noco
bala
min
cap
sule
s
Flud
eoxy
gluc
ose
inje
ctio
n
Fluo
rodo
pa in
ject
ion
Sodi
um fl
uori
de in
ject
ion
Gal
lium
citr
ate
inje
ctio
n
Cap
rom
ab p
ende
tide
inje
ctio
n
Indi
um c
hlor
ide
ster
ileso
lutio
n
Car
diac
: Blo
od v
olum
e m
easu
rem
ent
Bra
in: B
enzo
diaz
epin
e re
cept
or im
agin
g
Neo
plas
tic d
isea
se e
valu
atio
n in
bra
in
Bra
in: D
opam
ine
D2
rece
ptor
imag
ing
Car
diac
: Mar
ker
of o
xida
tive
met
abol
ism
Dia
gnos
is o
f Hel
icob
acte
r py
lori
infe
ctio
n
Labe
ling
red
bloo
d ce
lls (R
BC
s) fo
r m
ea-
suri
ng R
BC
vol
ume,
sur
viva
l, an
d sp
leni
cse
ques
trat
ion
Dia
gnos
is o
f per
nici
ous
anem
ia a
ndde
fect
s of
inte
stin
al a
bsor
ptio
n
Glu
cose
util
izat
ion
in b
rain
, car
diac
, and
ne
opla
stic
dis
ease
Dop
amin
e ne
uron
al d
ecar
boxy
lase
act
ivity
in b
rain
Bon
e im
agin
g
Hod
gkin
’s d
isea
se, l
ymph
oma
Acu
te in
flam
mat
ory
lesi
ons
Met
asta
tic im
agin
g in
pat
ient
s w
ith b
iops
y-pr
oven
pro
stat
e ca
ncer
Rad
iola
belin
g va
riou
s 11
1 In
radi
opha
r-m
aceu
tical
s
60–1
00 m
Ci
20–3
0 m
Ci
10–2
0 m
Ci
10–1
5 m
Ci
12–4
0 m
Ci
1 µC
i
10–8
0 µC
i
0.5
µCi
10–1
5 m
Ci
4–6
mC
i
10 m
Ci
8–10
mC
i5
mC
i
5 m
Ci
Var
ious
Inha
latio
n
IV IV IV IV PO IV PO IV IV IV IV IV IV
12614-01_CH01-rev3.qxd 10/25/11 10:56 AM Page 2
Not for
Dist
ributi
on
3RADIOISOTOPES
Indi
um In
111
Indi
um In
111
Indi
um In
111
Indi
um In
111
Iodi
ne I
123
Iodi
ne I
123
Iodi
ne I
123
Iodi
ne I
125
Iodi
ne I
125
Iodi
ne I
131
Iodi
ne I
131
Iodi
ne I
131
Indi
um o
xine
ste
rile
solu
tion
Pent
etat
e in
ject
ion
Pent
etre
otid
e in
ject
ion
Ibri
tum
omab
tiux
etan
inje
ctio
n
Ioflu
pane
Inje
ctio
n
Sodi
um io
dide
cap
sule
san
d so
lutio
n
Iobe
ngua
ne in
ject
ion
Alb
umin
inje
ctio
n
Ioth
alam
ate
sodi
um
inje
ctio
n
Alb
umin
inje
ctio
n
Iobe
ngua
ne in
ject
ion
Sodi
um io
dide
cap
sule
san
d so
lutio
n
Labe
ling
auto
logo
us le
ukoc
ytes
Cis
tern
ogra
phy
Neu
roen
docr
ine
tum
ors
Bio
dist
ribu
tion
imag
ing
prio
r to
ther
apeu
ticdo
sing
with
90Y
Zev
alin
(Bio
gen
Idec
) in
the
trea
tmen
t of n
on-H
odgk
in’s
lym
phom
a
Stri
atal
dop
amin
e tr
ansp
orte
r vi
sual
izat
ion
(ass
ist i
n th
e ev
alua
tion
of a
dult
patie
nts
with
sus
pect
ed P
arki
nson
ian
synd
rom
e) (P
S)
Thyr
oid
glan
d im
agin
gTh
yroi
d m
etas
tase
s (to
tal b
ody)
Pheo
chro
moc
ytom
a, c
arci
noid
tum
ors,
non
-se
cret
ing
para
gang
liom
as, n
euro
blas
tom
a
Plas
ma
volu
me
dete
rmin
atio
n
Glo
mer
ular
filt
ratio
n ra
te (
GFR
) de
term
inat
ion
Bloo
d vo
lum
e/pl
asm
a vo
lum
e de
term
inat
ion
Pheo
chro
moc
ytom
a, c
arci
noid
tum
ors,
non
-se
cret
ing
para
gang
liom
as, n
euro
blas
tom
a
Thyr
oid
func
tion
Thyr
oid
imag
ing
(nec
k)Th
yroi
d im
agin
g (s
ubst
erna
l)Th
yroi
d m
etas
tase
s (to
tal b
ody)
Hyp
erth
yroi
dism
Car
cino
ma
500
µCi
500
µCi
3 m
Ci (
plan
ar)
6 m
Ci (
SPEC
Tc )
5 m
Ci
3–5
mC
i
400–
600
µCi
2 m
Ci
0.14
mC
i/kg
(chi
ld)
10 m
Ci (
adul
t)
5–10
µC
i
30 µ
Ci
5–50
µC
i
0.5
mC
i/1.7
m2
5–10
µC
i50
–100
µC
i10
0 µC
i2
mC
i5–
33 m
Ci
150–
200
mC
i
IV Intr
athe
cal
IV IV IV PO PO IV IV IV IV IV PO
(con
tinue
d)
12614-01_CH01-rev3.qxd 10/25/11 10:56 AM Page 3
Not for
Dist
ributi
on
4 NUCLEAR PHARMACY QUICK REFERENCE
TAB
LE 1
-1R
adio
ph
arm
aceu
tica
ls U
sed
in N
ucl
ear
Med
icin
e (C
on
tin
ued
)
Che
mic
al F
orm
and
Ty
pica
l Dos
age
Rad
ionu
clid
eD
osag
e Fo
rmU
se(A
dult
a )R
oute
b
Iodi
ne I
131
Iodi
ne I
131
Nitr
ogen
N 1
3
Oxy
gen
O 1
5
Phos
phor
us P
32
Phos
phor
us P
32
Rub
idiu
m R
b 82
Sam
ariu
m S
m 1
53
Stro
ntiu
m S
r 89
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Iodo
hipp
urat
e so
dium
inje
ctio
n
Tosi
tum
omab
Am
mon
ia in
ject
ion
Wat
er in
ject
ion
Chr
omic
pho
spha
te
susp
ensi
on
Sodi
um p
hosp
hate
inje
ctio
n
Rubi
dium
chl
orid
e in
ject
ion
Lexi
dron
am in
ject
ion
Stro
ntiu
m c
hlor
ide
inje
ctio
n
Alb
umin
inje
ctio
n
Alb
umin
agg
rega
ted
inje
ctio
n
Rec
over
able
ren
al fu
nctio
n
Trea
tmen
t of r
efra
ctor
y lo
w-g
rade
non
-H
odgk
in’s
lym
phom
a
Myo
card
ial p
erfu
sion
stu
dies
Car
diac
per
fusi
on
Peri
tone
al a
nd p
leur
al e
ffusi
ons
Poly
cyth
emia
Myo
card
ial p
erfu
sion
stu
dies
Bon
e pa
in p
allia
tion
in c
onfir
med
oste
obla
stic
met
asta
tic b
one
lesi
ons
Bon
e pa
in p
allia
tion
in c
onfir
med
oste
obla
stic
met
asta
tic b
one
lesi
ons
Hea
rt b
lood
poo
l im
agin
g
Perf
usio
n lu
ng im
agin
g
200
µCi (
2 ki
dney
s)75
µC
i (1
kidn
ey)
Patie
nt-s
peci
fic d
osin
g;no
t >75
cG
y w
hole
body
10–2
0 m
Ci
30–1
00 m
Ci
10–2
0 m
Ci
1–8
mC
i
30–6
0 m
Ci
1.0
mC
i/kg
4 m
Ci
20 m
Ci
3 m
Ci
IV IV IV IV Intr
aper
i-to
neal
or
intr
aple
ural
(Not
for
IV
use
)
IV IV IV IV IV IV
12614-01_CH01-rev3.qxd 10/25/11 10:56 AM Page 4
Not for
Dist
ributi
on
5RADIOISOTOPES
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Arc
itum
omab
Bic
isat
e in
ject
ion
Dis
ofen
in in
ject
ion
Exam
etaz
ime
inje
ctio
n
Glu
cept
ate
inje
ctio
n
Meb
rofe
nin
inje
ctio
n
Med
rona
te in
ject
ion
Mer
tiatid
e in
ject
ion
Oxi
dron
ate
inje
ctio
n
Pent
etat
e in
ject
ion
Pyro
phos
phat
e in
ject
ion
Red
blo
od c
ells
inje
ctio
n
Sest
amib
i inj
ectio
n
Recu
rren
t or m
etas
tatic
col
orec
tal c
arci
nom
a
Adj
unct
to
CT/
MR
Idin
pat
ient
s w
ith
conf
irm
ed s
trok
e
Hep
atob
iliar
y im
agin
g
With
or
with
out m
ethy
lene
blu
e fo
rre
gion
al c
ereb
ral p
erfu
sion
in s
trok
e
With
out m
ethy
lene
blu
e fo
r le
ukoc
yte
labe
ling
Bra
in im
agin
gR
enal
per
fusi
on im
agin
g
Hep
atob
iliar
y im
agin
g
Bon
e im
agin
g
Kid
ney
imag
ing
Ren
ogra
m—
rena
l tra
nspl
ant
Ren
ogra
m—
capt
opri
l
Bon
e im
agin
g
GFR
(qua
ntita
tive)
Ren
ogra
m (d
iure
tic)
Ren
al p
erfu
sion
imag
ing
Infa
rct-
avid
sca
n
GI b
leed
(int
erm
itten
t)
Myo
card
ial p
erfu
sion
and
func
tion,
para
thyr
oid
imag
ing
20 m
Ci
20 m
Ci
5 m
Ci
20 m
Ci
10 m
Ci
20 m
Ci
10 m
Ci
5 m
Ci
20–3
0 m
Ci
5 m
Ci
1–3
mC
i1–
3 m
Ci
20–3
0 m
Ci
3 m
Ci
3 m
Ci
10 m
Ci
15 m
Ci
15 m
Ci
8–40
mC
i
IV IV IV IV IV IV IV IV IV IV IV IV IV IV IV IV IV IV IV
(con
tinue
d)
12614-01_CH01-rev3.qxd 10/25/11 10:56 AM Page 5
Not for
Dist
ributi
on
6 NUCLEAR PHARMACY QUICK REFERENCE
TAB
LE 1
-1R
adio
ph
arm
aceu
tica
ls U
sed
in N
ucl
ear
Med
icin
e (C
on
tin
ued
)
Che
mic
al F
orm
and
Ty
pica
l Dos
age
Rad
ionu
clid
eD
osag
e Fo
rmU
se(A
dult
a )R
oute
b
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Tech
netiu
m T
c 99
m
Thal
lium
Tl 2
01
Xen
on X
e 13
3
Yttr
ium
Y 9
0
aEx
cept
whe
re o
ther
wis
e no
ted.
bIV
=in
trav
enou
s; P
O =
oral
.cSP
ECT
=si
ngle
-pho
ton
emis
sion
com
pute
d to
mog
raph
y.dC
T =
com
pute
d to
mog
raph
y; M
RI =
mag
netic
res
onan
ce im
agin
g.
Sodi
um p
erte
chne
tate
inje
ctio
n
Succ
imer
inje
ctio
n
Sulfu
r co
lloid
inje
ctio
n
Tetro
fosm
in in
ject
ion
Thal
lous
chl
orid
e in
ject
ion
Xen
on
Ibri
tum
omab
tiux
etan
Bra
in im
agin
gTh
yroi
d im
agin
gR
adio
nucl
ide
vent
ricu
logr
amR
adio
nucl
ide
cyst
ogra
phy
Dac
ryoc
ysto
grap
hyM
ecke
l’s d
iver
ticul
um
Rena
l sca
n—di
ffere
ntia
l ren
al fu
nctio
nR
enal
sca
n—co
rtic
al a
nato
my
Live
r–sp
leen
sca
nLy
mph
osci
ntig
raph
y (b
reas
t)Ly
mph
osci
ntig
raph
y (m
elan
oma)
Gas
tric
em
ptyi
ng (s
cram
bled
egg
)G
I ble
ed (a
cute
)Lu
ng a
spir
atio
nG
astr
oeso
phag
eal r
eflu
x
Myo
card
ial p
erfu
sion
and
func
tion
Myo
card
ial p
erfu
sion
imag
ing
Para
thyr
oid
imag
ing
Lung
ven
tilat
ion
imag
ing
Trea
tmen
t of r
efra
ctor
y lo
w-g
rade
non
-H
odgk
in’s
lym
phom
a
20 m
Ci
10 m
Ci
20 m
Ci
1 m
Ci
0.1
mC
i5
mC
i
5 m
Ci
5 m
Ci
5 m
Ci
0.4–
0.6
mC
i0.
5–0.
8 m
Ci
1 m
Ci
10 m
Ci
5 m
Ci
0.2
mC
i
8–40
mC
i
3–4
mC
i2
mC
i
10–2
0 m
Ci
0.3–
0.4
mC
i/kg
IV IV IV Ure
thra
lEy
e dr
ops
IV IV IV IV Inte
rstit
ial
Intra
derm
alPO IV PO PO IV IV IV In
hala
tion
IV
12614-01_CH01-rev3.qxd 10/25/11 10:56 AM Page 6
Not for
Dist
ributi
on
7RADIOISOTOPES
TAB
LE 1
-2R
adio
nu
clid
es in
Nu
clea
r M
edic
ine
Phot
on M
eV
Hal
f-V
alue
Gam
ma
Ray
D
ecay
�
max
in M
eV
(�an
d x-
rays
) La
yer
Dos
e C
onst
ant
Nuc
lide
Mod
eaH
alf-
lifeb
(% I
nten
sity
)b,c
�m
ean
(MeV
)b(%
Int
ensi
ty)b
(mm
Pb)
(R/m
Ci-
hr/c
m)e
11C
β+20
.3 m
in0.
960
(100
)0.
386
0.51
1 (2
00)
4.0
5.91
13N
β+9.
97 m
in1.
198
(100
)0.
492
0.51
1 (2
00)
4.0
5.91
14C
β−57
00 y
r0.
156
(100
)0.
049
Non
eN
one
Non
e15
Oβ+
122
sec
1.73
2 (1
00)
0.73
50.
511
(200
)4.
05.
9118
Fβ+
109.
8 m
in0.
633
(97)
0.25
00.
511
(193
)4.
05.
7332
Pβ−
14.2
6 da
ys1.
710
(100
)0.
695
Non
eN
one
Non
e51
Cr
EC27
.7 d
ays
Non
eN
one
0.32
0 (1
0)1.
70.
1857
Co
EC27
1.7
days
Non
eN
one
0.12
2 (8
6)0.
21.
00.
136
(11)
58C
oEC
, β+
70.9
day
s0.
475
(15)
0.20
10.
811
(99)
9.0
5.5
64C
uEC
, β+ ,
β−
12.7
hr
β+0.
653
(17.
6)β+
0.27
80.
511
(35.
2)0.
41.
16β−
0.57
9 (3
8.5)
β−0.
191
67C
uβ−
61.8
hr
0.16
8 (1
)0.
141
0.09
1 (7
)7.
00.
520.
377
(57)
0.09
3 (1
6)0.
468
(22)
0.18
5 (4
9)0.
562
(20)
67G
aEC
3.26
day
sN
one
Non
e0.
093
(39)
0.66
0.8
0.18
5 (2
1)0.
300
(17)
0.39
4 (5
)68
Ga
β+67
.7 m
in0.
822
(1)
0.83
00.
511
(178
)4.
05.
371.
899
(88)
(con
tinue
d)
12614-01_CH01-rev3.qxd 10/25/11 10:57 AM Page 7
Not for
Dist
ributi
on
8 NUCLEAR PHARMACY QUICK REFERENCE
TAB
LE 1
-2R
adio
nu
clid
es in
Nu
clea
r M
edic
ine
(Co
nti
nu
ed)
Phot
on M
eV
Hal
f-V
alue
Gam
ma
Ray
D
ecay
�
max
in M
eV
(�an
d x-
rays
) La
yer
Dos
e C
onst
ant
Nuc
lide
Mod
eaH
alf-
lifeb
(% I
nten
sity
)b,c
�m
ean
(MeV
)b(%
Int
ensi
ty)b
(mm
Pb)
(R/m
Ci-
hr/c
m)e
82R
bβ+
76.4
sec
2.60
(13)
1.48
0.51
1 (1
91)
7.0
6.1
3.38
(82)
0.77
7 (1
5)81
mK
rIT
13.1
sec
Non
eN
one
0.19
0 (6
8)0.
019
1.6
89Sr
β−50
.5 d
ays
1.49
26 (1
00)
0.58
5N
one
Non
eN
one
90Y
β−64
hr
2.28
(100
)0.
934
Non
eN
one
Non
e99
Mo
β−65
.94
hr0.
437
(16)
0.38
90.
740
(12)
6.5
0.18
1.21
5 (8
2)0.
778
(4)
99mTc
IT6.
02 h
rN
one
Non
e0.
1405
(89)
0.17
0.78
99Tc
β−2.
11E+
5 yr
0.29
4 (1
00)
0.08
5N
one
Non
eN
one
111 I
nEC
2.8
days
Non
eN
one
0.02
3 (6
9), x
-ray
s0.
233.
210.
026
(13)
, x-r
ays
0.17
1 (9
1)0.
245
(94)
123 I
EC13
.22
hrN
one
Non
e0.
027
(70)
, x-r
ays
0.05
1.6
0.03
0–0.
032
(15)
, x-r
ays
0.15
9 (8
3)12
4 IEC
, β+
4.18
day
s1.
534
(12)
0.82
00.
027
(47)
, x-r
ays
8.0d
7.6d
2.13
7 (1
1)0.
511
(46)
0.60
3 (6
3)0.
723
(10)
1.69
1 (1
1)
12614-01_CH01-rev3.qxd 10/25/11 10:57 AM Page 8
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9RADIOISOTOPES
125 I
EC59
.4 d
ays
Non
eN
one
0.02
7 (1
14),
x-ra
ys0.
017
1.43
0.03
1–0.
032
(24)
, x-r
ays
0.03
5 (7
)13
1 Iβ−
8.02
day
s0.
248
(2)
0.18
20.
030
(5),
x-ra
ys2.
42.
270.
339
(7)
0.08
0 (3
)0.
606
(90)
0.36
4 (8
2)0.
637
(7)
133 X
eβ−
5.24
day
s0.
346
0.10
00.
031–
0.03
6 (4
9), x
-ray
s0.
035
0.51
0.08
1 (3
8)13
7 Cs
β−30
.08
yr0.
514
(95)
0.18
70.
032
(6),
x-ra
ys6.
03.
321.
175
(5)
0.66
2 (8
5)15
3 Sm
β−46
.5 h
r0.
635
(31)
0.22
40.
041
(48)
, x-r
ays
0.1
0.46
0.70
4 (4
9)0.
047
(9),
x-ra
ys0.
808
(18)
0.10
3 (2
9)18
6 Re
β−3.
72 d
ays
0.93
2 (2
2)0.
347
0.13
7 (9
)2.
50.
21.
070
(71)
201 T
lEC
3.04
day
sN
one
Non
e0.
069–
0.08
2 (7
5), x
-ray
s0.
006
4.7
0.13
5 (2
.6)
0.16
7 (1
0)
aEC
=el
ectr
on c
aptu
re, I
T =
isom
eric
tran
sitio
n.bV
alue
s ob
tain
ed fr
om N
atio
nal N
ucle
ar D
ata
Cen
ter,
Bro
okha
ven
Nat
iona
l Lab
orat
ory
(ww
w.n
ndc.
bnl.g
ov/c
hart
/reC
ente
r.js
p?z=
39&
n=51
).cβ m
axis
the
endp
oint
ene
rgy
for
the
deca
y.dSo
urce
: http
://hp
scha
pter
s.or
g/no
rthc
arol
ina/
NSD
S/12
4IPD
F.pd
f.eR
=ro
entg
en.
12614-01_CH01-rev3.qxd 10/25/11 10:57 AM Page 9
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ributi
on
10 NUCLEAR PHARMACY QUICK REFERENCE
TAB
LE 1
-3R
adio
nu
clid
e G
ener
ato
r Sy
stem
s
Pare
nt (
half-
life)
Pare
nt D
ecay
Mod
eD
augh
ter
Prod
uct
(hal
f-lif
e)C
olum
n Ty
peEl
uant
99M
o (6
5.94
hr)
82Sr
(25.
55 d
ays)
68G
e (2
71 d
ays)
81R
b (4
.57
hr)
90Sr
(28.
9 yr
)11
3 Sn
(115
.09
days
)
Bet
a m
inus
Elec
tron
cap
ture
Elec
tron
cap
ture
Elec
tron
cap
ture
Bet
a m
inus
Elec
tron
cap
ture
Alu
min
um o
xide
Stan
nic
oxid
e
Stan
nic
oxid
e
Cat
ion
exch
ange
res
in
90Sr
sol
utio
n
Zir
coni
um o
xide
0.9%
NaC
l
0.9%
NaC
l
0.1
M H
Cl
Wat
er
Air
/oxy
gen
Solv
ent e
xtra
ctio
n
0.05
M H
Cl
Na99
mTc
O4
(6.0
1 hr
)82
RbC
l (76
.4 s
ec)
68G
aCl 3
(67.
7 m
in)
81mK
r ga
s (1
3.1
sec)
90Y
Cl 3
(64
hr)
113m
InC
l 3(1
.7 h
r)
12614-01_CH01-rev3.qxd 10/25/11 10:57 AM Page 10
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11RADIOISOTOPES
99Mo
99mTc
99Tc
β– (14%)
β– (86%)
γ 0.140 MeV (88%)
(T½ 66 hours)
(T½ 6 hours)
Emax
1.357 MeV
(T½ 2.1 × 105 yr)
F I G U R E 1 - 1 Simplified decay scheme for99Mo.
1.0
0.5
0.2
0.110 20 30 40 50 60 70
Hours
Act
ivity
99Mo Decay
99mTc Ingrowth
99mTc Elution
F I G U R E 1 - 2 Decay of 99Mo and ingrowth and elution of 99mTcactivity over time in a 99mTc generator.
12614-01_CH01-rev3.qxd 10/25/11 10:57 AM Page 11
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12 NUCLEAR PHARMACY QUICK REFERENCE
TABLE 1-4 Expiration Times for 99mTc-Sodium Pertechnetate afterGenerator Elution
Initial Ratio Initial Ratio (microcuries of Expiration (microcuries of Expiration 99Mo/millicurie Time 99Mo/millicurie Time of 99mTc) (hr) of 99mTc) (hr)
0.135 1 0.072 7
0.122 2 0.065 8
0.109 3 0.058 9
0.098 4 0.052 10
0.089 5 0.047 11
0.080 6 0.042 12
Source: Ponto JA. Expiration times for Tc-99m. J Nucl Med Technol. 1981;9:40.
.
TABLE 1-5 Relationship between 99mTc and 99Mo in the Generator atVarious Times after Elution
Time Curies 99Mo × Ratio = Curies 99mTca
(hr) 99mTc:99Mo
0 1.000 — 0
1 0.990 0.094 0.093
2 0.979 0.179 0.175
3 0.969 0.255 0.247
4 0.959 0.324 0.311
5 0.949 0.386 0.366
6 0.940 0.441 0.414
12 0.883 0.677 0.598
18 0.829 0.803 0.666
24 0.779 0.870 0.678
36 0.688 0.924 0.636
48 0.607 0.940 0.571
60 0.533 0.944 0.506
72 0.473 0.946 0.448
78 0.445 0.946 0.421
a Actual 99mTc present based on 86.05% 99Mo decay to 99mTc.
12614-01_CH01-rev3.qxd 10/25/11 10:57 AM Page 12
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