young minds at work

Italian experiencein biomedical research:

Desenzano del Garda (BS) • Park Hotel

23-24 ottobre 2015

3rd

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FacultyGIULIA ABATEARIANNA BATTISTIMICHELA BERTUZZIIBRAHIM BITARSILVIA BOLZANI LEONARDO BONTEMPIGIULIA CACCIOTTIFRANCESCA CACCURILUNA COLAGROSSIMARIASOFIA CALTAGIRONEFEDERICA CAMPILONGOFRANCESCA CAPPELLETTIILARIA CARLIARNALDO CARUSONAGAIA CIACCICHIARA CIPRIANIMASSIMO CLEMENTIELENA CRISCUOLO ANTONIO CURTONIGIOVANNA DESOLEDOMENICO DI CARLOFRANCESCA FALASCALORENA FALLARINOROBERTO FERRARESEGIANLUIGI FRANCIDIEGO GALLIPAOLO GRUMATI MICHELA GUARIENTILUCIA HENRICI DE ANGELISMARIA LUISA IARIAGABRIELE IBBALAURA INFURNARIMICHELE LAI MARIAGRAZIA MARZIANOPIETRO MAZZUCALORENZO MESSADAVIDE MILETOBARBARA MONTICOFEDERICA MORELLIGIORGIO PALÙAURORA PIAZZAGIORGIO PICCINELLISTEFANO PICCOLOMARIKA PREMOLI MARGHERITA ROMEO ALDA SALDANFRANCESCO SANTOROELENA TIBALDIELENA TOSONIANDREA ZENDRINI

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Dear Colleagues,

We are pleased to announce the 3rd Annual Italian Experience in

Biomedical Research: Young Minds at Work, which will take place

in Desenzano del Garda (BS) on the 23rd and 24th of October, 2015.

This conference is open to young scientists from across all biomedi-

cal disciplines involved in innovative research (PhD students, po-

stgraduates, Post-Doctoral Scientists, etc.). This meeting presents a

unique opportunity for young scientists and researchers to gain ex-

posure and visibility, while exchanging knowledge and fostering

meaningful interactions that may facilitate future projects and col-

laborations. Furthermore, this experience may potentially inspire the

development of new programs such as the integration of PhD and

Specialization programs, the establishment of nationwide stan-

dards, and additional European funding.

In keeping with the tradition established in the first and second Edi-

tion of this meeting, students play a fundamental role in both the

organization of the conference and its scientific content. Once

again, the meeting will be conducted exclusively in English for both

oral and written communication. Each interested participant must

submit an English Abstract (300 words maximum) with the follo-

wing format: Title, Affiliation, Background, Methods, Results, Con-

clusion.

A committee will review submitted abstracts and select those to be

presented. Each presentation will be limited to 15 minutes, with 5

minutes for questions. Each presentation will be evaluated and the

top three presentations will be selected for recognition.

Registration is free, however, the conference will host a maximum

of 100 participants. The registration will include access to the pre-

sentations as well as coffee breaks, and lunch for the 24th of Octo-

ber. All additional costs (Hotel bookings etc.) will be at the expense

of the participants. There are affordable hotels available near the

Congress Center, and we will soon provide a list with respective pri-

ces. The deadline for both conference registration and abstract sub-

missions is October 2nd, 2015; and must be submitted via mail to:

elisabetta.rossi01@gmail.com.

We look forward to receiving submissions from across all biomedical

research divisions from young research scientists in your programs

and departments. Please feel free to share this invitation with

anyone who might be interested in attending.

Your participation in this conference is important to us, and we hope

to meet you in Desenzano del Garda!

Kind regards,

Prof. Arnaldo Caruso

Prof. Massimo Clementi

Prof. Giorgio Palù

PARTECIPANTS REGISTRATION

h 13.00-14.00

OPENING AND WELCOME

h 14.00-14.15Giorgio Palù, Massimo Clementi, Arnaldo Caruso

STEM CELLS

Chairman: Giorgio Palù

h 14.15-15.00 KN - Stefano Piccolo, University of PaduaYAP/TAZ in organ growth, somatic stem cells and cancer

h 15.00-15.15 Giovanna Desole, University of PaduaComparison of induced pluripotent stem cells (iPSCs) reprogrammingmethods based on retroviral vectors, Sendai virus vectors and episomalvectors

ANTICANCER THERAPY

Chairmen: Michele Lai and Diego Galli

h 15.15-15.30 Elena Tibaldi, University of PaduaNovel fingolimod analogues: a new tool for switching off Lyn-depen-dent oncogenic signals in Chronic Lymphcytic Leukemia

h 15.30-15.45 Francesca Caccuri, University of BresciaHHV-6 U94 inhibits motility, migration and invasiveness of human bre-ast cancer cells by modulation of Src signalling pathway

h 15.45-16.00 Michele Lai, S. Anna Institute of PisaAblation of Acid Ceramidase induces apoptosis, growth arrest and se-nescence in melanoma cells

h 16.00-16.15 Diego Galli, University of BresciaGenetic polymorphisms as a stratification factor that contributes toidentify patients at high risk of developing Anthracycline-induced car-diomyopathy

BREAKh 16.15-16.30

AUTOPHAGY AND APOPTOSIS

Chairmen: Paolo Grumati and Barbara Montico

h 16.30-16.45 Barbara Montico, IRCCS-National Cancer Institute of Aviano (PN)Phospholipid scramblase 1 at the cross-road between autophagy andapoptosis in mantle cell lymphoma4

Friday, October 23

h 16.45-17.00 Pietro Mazzuca, University of BresciaRole of HIV-1 matrix protein p17 and its variant in autophagy in lym-phatic endothelial cells (LECs)

h 17.00-17.15 Paolo Grumati, Goethe University School of Medicine, GermanyRegulation of endoplasmic reticulum turnover by FAM134B mediatedselective autophagy

PROTEIN MISFOLDING AND PATHOLOGY

Chairmen: Margherita Romeo and Francesca Caccuri

h 17.15-17.30 Margherita Romeo, Mario Negri Institute of MilanCardiac light chain amyloidosis: the key role for metal ions revealed bythe C. elegans model. New therapeutic perspectives

h 17.30-17.45 Federica Morelli, Mario Negri Institute of MilanHIV-1 matrix protein p17 and AIDS related dementia: correlation bet-ween protein misfolding and in vivo toxicity using the C. elegans model

h 17.45-18.00 Federica Campilongo, University of BresciaRole of HIV-1 matrix protein p17 variants in Lymphoma Pathogenesis

CELL-MICROBE INTERACTION

Chairmen: Gianluigi Franci and Chiara Cipriani

h 18.00-18.15 Gianluigi Franci, II University of NaplesPlasmodium falciparum: Invasion of erythocytes through mechanismsof protein export

h 18.15-18.30 Elena Tosoni, University of PaduaNucleolin stabilizes G-quadruplex structures folded by the LTR promo-ter and silences HIV-1 viral transcription

h 18.30-18.45 Chiara Cipriani, Tor Vergata University, RomeTranscriptional activity of different endogenous retrovirus (ERV) fami-lies and pro-inflammatory cytokines in a mouse model of Autis

h 18.45-19.00 Maria Luisa Iaria, University of BresciaPhosphatidylinositol-(4,5)-bisphosphate driven unconventional secretion of biologically active HIV-1 matrix protein p17

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GENERAL BACTERIOLOGY

Chairmen: Mariasofia Caltagirone and Lucia Henrici De Angelis

h 08.30-08.45 Ibrahim Bitar, University of Pavia

Acinetobacter baumannii ST78 Italian Clinical Strains: a hypothesis of

MDR to XDR evolution

h 08.45-09.00 Mariasofia Caltagirone, University of Pavia

Clinical Isolation of an Enterobacter cloacae Strain Producing the Novel

Plasmid-Borne AmpC ACT-24 Variant

h 09.00-09.15 Antonio Curtoni, University of Turin

MALDI-TOF MS application in direct identification of microorganisms

from positive blood culture

h 09.15-09.30 Aurora Piazza, University of Pavia

A Travel-Related Case of NDM-5-Producing Escherichia coli in Northen

Italy

h 09.30-09.45 Giorgio Piccinelli, University of Brescia

A cluster of invasive listeriosis in Brescia, Italy

h 09.45-10.00 Lucia Henrici De Angelis, University of Siena

Genotypic and virulence characterisation of the first hypermucoviscous

Klebsiella quasipneumoniae subsp. quasipneumoniae isolate from a

bloodstream infection

h 10.00-10.15 Laura Infurnari, University Vita-Salute San Raffaele, Milan

The fecal microbiome as risk stratification marker of enteric sepsis and

acute graft-versus-host disease (GVHD) in hemopoietic stem-cell allo-

transplanted patients

h 10.15-10.30 Roberto Ferrarese, University Vita-Salute San Raffaele,

Milan

Apolipoprotein E (ApoE) Modulates Systemic Inflammatory Profile and

Gut Microbiota in Response to “Western Diet” in Mice

BREAK

h 10.30-10.456

Saturday, October 24

DRUG DEVELOPMENT AND BIOMARKERS

Chairmen: Michela Bertuzzi and Ilaria Carli

h 10.45-11.00 Michela Bertuzzi, University of BresciaA proteomic approach to compare Erythropoietin and its biosimilars

h 11.00-11.15 Michela Guarienti, University of BresciaComputational and functional analysis of biopharmaceutical drugs inzebrafish: erythropoietin as a test model

h 11.15-11.30 Lorenzo Messa, University of PaduaThe homodimerization of Human Papillomavirus oncoprotein E6: a po-tential new druggable antiviral targe

h 11.30-11.45 Ilaria Carli, University of PaduaSennoside A from Rheum palmatum (L) affects HIV-1 replication atearly post-entry steps of the virus life cycle

h 11.45-12.00 Andrea Zendrini, University of BresciaPlasmonic Exosomes

NEURODEGENERATION

Chairmen: Marika Premoli and Giulia Abate

h 12.00-12.15 Marika Premoli, University of BresciaNF-κB p50 knock-out mice as animal model of neurodevelopmental di-sorders

h 12.15-12.30 Leonardo Bontempi, University of BresciaRole of nicotinic and dopamine D3 receptor crosstalk in the regulationof dopaminergic neurons plasticity

h 12.30-12.45 Mariagrazia Marziano, University of BresciaCorrelation between antioxidant enzymes, oxidative stress markersand conformational altered p53 protein in Alzheimer’s Disease

h 12.45-13.00 Giulia Abate, University of BresciaComparison of extracellular and intracellular blood compartments hi-ghlights redox alterations in Alzheimer’s and Mild Cognitive Impair-ment patients

LUNCHh 13.00-14.30 7

GENERAL VIROLOGY

Chairmen: Francesco Santoro and Gabriele Ibba

h 14.30-14.45 Francesco Santoro, University of SienaInduction and characterization of prophage Ф1207.3 in Streptococcuspneumoniae

h 14.45-15.00 Nagaia Ciacci, University of FlorenceMolecular and physiological characterization of a new lytic bacterio-phage against KPC-positive Klebsiella pneumoniae

h 15.00-15.15 Gabriele Ibba, University of SassariCodon usage optimization affects the tissue-specificity of the JC po-lyomavirus

CONTROL OF INFECTION AND MICROBIAL RESISTANCE

Chairmen: Silvia Bolzani and Luna Colagrossi

h 15.15-15.30 Alda Saldan, University of PaduaHuman cytomegalovirus infection in pregnancy: immune correlates toCMV vertical transmission

h 15.30-15.45 Silvia Bolzani, University of FerraraKIR2DL2 expressing NK cells: effect on HSV-1 infection control

h 15.45-16.00 Arianna Battisti, Tor Vergata University, RomeA high HBsAg genetic complexity can influence HBV immunogenicityin the setting of acute infection

h 16.00-16.15 Luna Colagrossi, Tor Vergata University, RomeA hyper-glycosylation of HBV surface antigen correlates with immuno-suppression-driven HBV reactivation and strongly affects HBsAg quan-tification in vitro

BREAKh 16.15-16.30

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Saturday, October 24

ANTIVIRAL THERAPY AND DRUG RESISTANCE

Chairmen: Elena Criscuolo and Domenico Di Carlo

h 16.30-16.45 Francesca Cappelletti, University Vita-Salute San

Raffaele, Milan

Human monoclonal antibody endowed with anti-HSV-1 and -2 activity

strongly inhibits virus replication

h 16.45-17.00 Elena Criscuolo, University Vita-Salute San Raffaele, Milan

In vivo protection conferred by human monoclonal antibody directed

against HSV-1 and 2

h 17.00-17.15 Lorena Fallarino, University of Padua

Anti HIV-1 gene therapy strategies combining multiple siRNA with the

membrane-anchored fusion inhibitor C-peptide “maC46”

h 17.15-17.30 Domenico Di Carlo, Tor Vergata University, Rome

Virological response and tropism evolution in pluri-experienced HIV-1

infected patients starting maraviroc in clinical practice

h 17.30-17.45 Francesca Falasca, Sapienza University, Rome

Full viral suppression, residual viremia and low level viremia in HIV-1

ART treated patients: risk of virological rebound/failure and association

with inflammation markers and HIV-1 DNA

h 17.45-18.00 Davide Mileto, Luigi Sacco Hospital, Milan

Clinical usefulness of drug resistance test at low viremia levels

h 18.00-18.15 Giulia Cacciotti, Sapienza University, Rome

Variation in interferon sensitivity and induction among Usutu and West

Nile (lineage 1 and 2)

DESENZANO AWARDS

h 18.15-18.30

TAKE HOME MESSAGE

h 18.30-18.45Massimo Clementi, Arnaldo Caruso, Giorgio Palù

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SEDE

PARK HOTEL****Lungolago C. Battisti 17 - 25015 Desenzano del Garda (Brescia) - Italia

COME RAGGIUNGERE DESENZANO

AUTOSTRADA MILANO-VENEZIAUscita Desenzano - 2 Km dal centro

FERROVIA MILANO-VENEZIAStazione Ferroviaria di Desenzano - 1 Km dal centro

AEROPORTI“G. D’Annunzio” (Brescia) - 15 Km da Desenzano

“V. Catullo” (Verona) - 24 Km da Desenzano

Linate-Malpensa (Milano) - 110 Km da Desenzano

Orio al Serio (Bergamo) - 70 Km da Desenzano

IN AUTOBUSUtilizzando le numerose linee disponibili

IN BATTELLOUtilizzando i traghetti presenti su tuttoil lago di Garda a cura della"NAVIGAZIONE LAGO DI GARDA"

Informazioni Generali

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ISCRIZIONI

La quota di iscrizione è gratuita e include: Partecipazione ai lavori congressuali

• Abstract book • Kit Congressuale • Attestato di frequenza • Coffee Break e Co-

lazione lavoro di sabato 24 ottobre.

Saranno accettate le prime 100 Iscrizioni sulla base della temporalità. Per infor-

mazioni e iscrizioni rivolgersi a:

Sig.ra Rossi ElisabettaLaboratorio di Virologia ed Indagini Microbiologiche

Piazzale Spedali Civili, 1 - 25123 Brescia - Tel. +39 030 3995652

Fax +39 030 395258 - E-mail: elisabetta.rossi01@gmail.com

PRENOTAZIONE ALBERGHIERA

Sono stati opzionati alberghi di diverse tipologie, di seguito in elenco. Ogni par-

tecipante deve prenotare e saldare direttamente la propria prenotazione con-

tattando direttamente l’hotel.

PARKhotel (4 stelle)Lungolago C. Battisti 17, Desenzano del Garda - Lago di Garda - Brescia

E-mail: booking@parkhotelonline.it

Tel +39 030 9143494 - Fax +39 030 9142280

Costi: Doppia Uso Singola € 90,00 - Doppia vista centro storico € 130,00

I prezzi si intendono per camera a notte con prima colazione

Non comprendono tassa di soggiorno € 1,00 per persona per notte.

HOTEL PIROSCAFO (3 stelle)Via Porto Vecchio 11, Desenzano del Garda - Lago di Garda - Brescia

Tel +39 030 9141128 - E-mail: info@hotelpiroscafo.it

Costi: SGL € 55,00 - Doppia Uso Singola € 65,00

Doppia € 85,00 - Tripla € 110,00

I prezzi si intendono per camera a notte con prima colazione

Non comprendono tassa di soggiorno € 0,80 per persona per notte.

HOTEL CITY (3 stelle)Via Nazario Sauro 29, Desenzano del Garda - Lago di Garda - Brescia

E-mail: info@hotelcity.it - Tel +39 030 9911704

Costi Comfort: Doppia Uso Singola € 58,00 - Doppia € 88,00

Costi Superior: Doppia Uso Singola € 68,00 - Doppia € 98,00

I prezzi si intendono per camera a notte con prima colazione

Non comprendono tassa di soggiorno € 0,80 per persona per notte.

SEGRETERIA ORGANIZZATIVA

Nadirex International srl

Congressi - Meeting - Comunicazione

Via Riviera, 39 - 27100 Pavia, ITALY

Tel. +39 0382 525735-14 - Fax +39 0382 525736

Cell. +39 347 8589333 - E-mail: info@nadirex.com - www.nadirex.com

Informazioni Generali

SEGRETERIA

ORGANIZZATIVA

Nadirex International srlCongressi - Meeting - Comunicazione

Via Riviera, 39 - 27100 Pavia, ITALYTel. +39 0382 525735-14 Fax +39 0382 525736E-mail: info@nadirex.comwww.nadirex.com

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