Reflects regulatory capacity of a cellular state

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JD Buenrostro et al, Nature Methods, 2013.

Tn5 adaptor insertion

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Sequencing

QC, read trimming

Alignment Processing

Peak calling

QC, data visualization

Downstream analysis

FastQC, Cutadapt, Trimmomatic etc.

BWA, Bowtie2

MACS2

ChIPQC, IGV

Alignment

SamTools, Bedtools, ATACseqQC

GREAT, Centipede, atactk, NucleoATAC

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Hosoya et al., Sci Rep. 2018