· pdf filesee relapse/refractqry disease ... bcr-abl1-like disease bois-sel al. oncol...

52

Upload: lycong

Post on 25-Feb-2018

215 views

Category:

Documents

2 download

Report

Download

Embed Size (px):

TRANSCRIPT

$Page 1: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 2: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 3: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 4: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 5: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 6: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 7: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 8: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 9: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 10: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 11: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 12: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 13: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 14: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 15: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 16: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 17: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 18: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 19: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 20: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 21: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 22: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 23: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 24: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 25: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 26: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 27: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 28: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 29: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 30: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 31: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 32: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 33: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 34: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 35: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 36: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 37: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 38: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 39: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 40: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 41: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 42: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 43: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 44: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 45: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 46: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 47: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 48: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 49: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 50: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 51: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

$Page 52: · PDF fileSee Relapse/RefractQry Disease ... BCR-ABL1-like disease Bois-sel al. oncol 20C3;2fr774 ... ETV6, NUP214, RCSDI, RANBP2, SNX2, ZMIZI$

La vie - SVHTAsvhta.info/recursos/jorcasos2019/presentaciones/Andrea...PCMI-JAK2 ETV6-JAK2 BCR-JAK2 NOS LEUCEMIA MIELOIDE CRÓNICA ATÍPICA aCML-Eo LEUCEMIA MIELO-MONOCÍTICA CRÓNICA

Behandlungsstrategien und Studien der … und Studien der Studienallianz Leukämie ... DEK-NUP214 . Multiplex PCR : ... Relapse . Y . RELAZA

Nous Tractamentsen la LLA-T - academia.cat Tractamentsen la LLA-T ... ABL1 (9q34) • NUP214 (9q34) ... About 30% relapse rate in MRD responsive/negative patients in both studies

Genetics of Adolescent/Young Adult ALL … of Adolescent/Young Adult ALL (Cytogenetics) ... NUP214-ABL1 3% 3%. ... Infection following BMT One BM relapse Post BMT 9yr, Female

Novel treatment approaches in (pediatric) Therapy selected Selection of clones or genetic events that confer resistance ... NUP214-ABL1 transient response RANBP2-ABL1 ZMIZ1-ABL1 RCSD1-ABL1

Assessment of fusion genes: pros and cons of the different ...€¦ · SECRETORY BC Abcam EPR17341 Optiview+ amplification ETV6-NTRK3 fusion nuclear staining Invasive BC nos Abcam

2 Progenitors are Affected by the ETV6-RUNX1 …mcr.aacrjournals.org/content/molcanres/early/2014/07/24/1541-7786...2 Progenitors are Affected by the ETV6-RUNX1 Rearrangement 3 Chiara

Tumor Cytogenetics - Welcome | Institute for Cancer … Cytogenetics Vundavalli Murty ... Short CR and prompt relapse Generally Poor t(11;19)(q23;p13.3) ... NUP214/ABL1*ampliﬁcaWon*

Review Article Genetic Aberrations in Childhood Acute ... of the entire human genome using high-density single nucleotide polymorphism array ... the amplification of the NUP214-ABL1

Clinical utility of DNA microarrays in acute … utility of DNA microarrays in acute lymphoblastic leukaemia Meg Wall, ... Relapse free survival in UK MRC ... ALL10 T 5 NUP214-ABL1

Nasopharyngeal carcinoma super-enhancer–driven ETV6 … · Nasopharyngeal carcinoma (NPC) most frequently occurs in south-ern China and southeast Asia. Epidemiology studies link

NUP214-ABL1 mediated cell proliferation in T-cell acute

Tumor Cytogenetics - icg.cpmc.columbia.edu Cytogenetics Vundavalli Murty ... Short CR and prompt relapse Generally Poor t(11;19)(q23;p13.3) MLL ... NUP214/ABL1 ampliﬁcaWon ABL1 and

Greater Manchester and Cheshire Cancer Network … Relapse ... DEK-NUP214 , (2) AML with inv(3)(q21q26.2) or t ... but should be treated as BCR-ABL1 –positive acute

Dissecting the role of the ETV6 transcriptional regulator ...dro.deakin.edu.au/eserv/DU:30073262/rasighaemi... · Dissecting the role of the ETV6 transcriptional regulator in development

Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell ... · Tumor and Stem Cell Biology Infection Exposure Promotes ETV6-RUNX1 Precursor B-cell Leukemia via Impaired H3K4 Demethylases

Genomic characterization of ETV6/RUNX1-positive acute

Case 0094 NUP214-ABL1 Fusion - sh-eahp.org SH PPT.pdfof part of the ABL1 and NUP214 genes. ... usually a late event, associated with early relapse Few cases of B-ALL ... NUP214-ABL1

Mammary Analogue Secretory Carcinoma of the Parotid Gland ...€¦ · However, only MASC shows ETV6 rearrangements and the presence of the ETV6-NTRK fusion transcript. Although histologically,

17. Updated Presentation - Bueso-Ramos, Carloscmesyllabus.com/wp-content/uploads/2017/10/4-Slides-Bueso-Ramos...AML with t(6;9)(p23;q34.1); DEK-NUP214 AML (megakaryoblastic) with t(1;22)(p13.3;q13

DOI: 10.1038/ncomms11790 OPEN Identiﬁcation of ETV6 ...liu.diva-portal.org/smash/get/diva2:946988/FULLTEXT01.pdfAnna K. Andersson1, Magnus Fontes2 & Thoas Fioretos1,6 Fusion genes

Importin beta and CRM1 control a RANBP2 spatiotemporal ...jcs.biologists.org/content/joces/early/2017/06/08/jcs.197905.full.pdf · Importin beta and CRM1 control a RANBP2 spatiotemporal

«Adverse Prognosis» Acute Myeloid Leukemia - sgh same factors likely underlie the decrease in non-relapse ... (p23;q34.1); DEK-NUP214 (frequently ... • t(9;22) (q34.1;q11.2); BCR-ABL1

Review - oaepublishstorage.blob.core.windows.net · 4 4 CEBPE 14q11.2 rs2239633 G A G B-ALL(ETV6-RUNX1) 22076464 2012 EllinghausE CEBPE 14q11.2 rs4982731 C T C ALL 23512250 2013 XuH

Case Report Clonal Hypereosinophilia with ETV6 ...downloads.hindawi.com/journals/crihem/2013/652745.pdfCaseReportsinHematology have been commonly associated with myelodysplastic syn-dromes

Using Mouse Models of Acute Lymphoblastic Leukemia …tumor-models.com/wp-content/uploads/sites/67/2017/07/David-Teachey.pdfDismal Outcome for 2nd+ Relapse of ALL ... PAKVKK NUP214-ABL1

Case Report Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 ...downloads.hindawi.com/journals/crim/2016/8324791.pdf · Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential

ets family transcription factor ETV6 - uni-muenchen.de · Zhang C.D. Ph.D. thesis Munich 2004 2 1. Introduction Chromosomal rearrangements, especially balanced chromosomal translocations,

Epidemiology of Acute ... · acute lymphoblastic leukemia genome. Beyond hyperdiploidy, ETV6-RUNX1 fusion, the other classical lesions, there is whole world somatic mutations, short

Short communicationCharacterization of the role of the ... · anti-Nup88 (green) and anti-Nup214 (re d) antibodies and anal yzed by confocal laser microscopy . Chromatin was visualized

Genomic characterization of ETV6/RUNX1-positive …lup.lub.lu.se/search/ws/files/3214386/1787229.pdf · Genomic Characterization of etv6/runx1-Positive Acute Lymphoblastic ... runx1-Positive

Comprehensive Analysis of Transcriptome … Analysis of Transcriptome Variation Uncovers Known and Novel ... al. (2013) Comprehensive Analysis of Transcriptome Variation ... NUP214-ABL1

ETV6 (TEL1) in Blood Cell Development and Malignancydro.deakin.edu.au/eserv/DU:30072293/rasighaemi-etv6tel1...of β-globin synthesis [25]. This may explain the observation that enhanced

Genomic characterization of ETV6/RUNX1-positive … · Genomic Characterization of etv6/runx1-Positive Acute Lymphoblastic Leukemia ... runx1-Positive Acute Lymphoblastic Leukemia

Mérieux 2017 public - fondation-merieux.org Predictive markers Molecular classification Functional understanding ... NUP214-ABL1 TCF3-PBX1 in vitro BCP-ALL T-ALL A …