ri (uk and ire) introduces the "ivf cube" drawer type incubator

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The new and innovative drawer type incubator for IVF and embryo culture. Introduced to the UK by Research Instruments to help innovation within Human Assisted Reproduction.

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Page 1: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Research Instruments

Page 2: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Drawer Type IncubatorAR-3100GC

IVF Cube

Page 3: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

History of trends RI have seen in incubation hardware for IVF clinics worldwide

1980 – 2009CO2 & later Low O2 and Premix Large volume30 – 48 Litres availableSmall alternation in overallenvironment

2009 – 2012Low O2 and Premix Tri-gas, Small volume Absolute purge

Large Volume incubators

Bench top style Incubator

2013 - Benefits of both without their disadvantages Additional new unique features

*NEW* Drawer Incubator

Page 4: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Key Features

IVF Cube -Drawers for Embryos- Drawers designed for Embryo Culture

Page 5: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Individual Drawer / Incubation Chamber

Culture Space: 780ml (Single Chamber)

Dishes: 35mm dish x 12

60mm dish x 6

4 well dish x 4

IVF Cube –AR-3100GC / Drawers for Embryos-

Page 6: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos-

CO2 SupplyAir Circulation In

Air Circulation Out

Air Circulation maintains the accurate Gas mixture in the Drawer

Constant air circulation through CO2 an O2 sensors

Individual Drawer Incubation Chamber

Page 7: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- Individual Control for CO2, O2 and Temperature for each drawer

☆   Each drawer has separated, independent control which makes the IVF cube more versatile.

Display/ControlDisplay/Control: Temperature

CO2   Concentration

O2 Concentration

AlarmsAlarms: Over Temperature

CO2 Over and Lower Alarm (±1.0 % )

O2 Over and Lower Alarm (±1.0 % )

☆   4 incubators in one single unit.

☆   Each drawer can be sorted by the patient or the stage of embryo culture.

Page 8: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Capable of culturing with wet or dry environment

IVF Cube –AR-3100GC / Drawers for Embryos-

Hybrid Type Incubator

Water Slot

Intra Red CO2 sensor for each incubation drawer makes it possible to culture either wet or dry for each drawer.

When water is used, sterilized cotton is recommended in the slot.

Page 9: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Heating from the top and bottom of each drawerIVF Cube –AR-3100GC / Drawers for Embryos-

Side View of the IVF Cube

Lid

Heating Elements

Very quick Temperature Recovery

Page 10: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- Drawers / intuitive access to the the embryos

Pull out the drawer Lift up the lid with your thumb

Page 11: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- The Lid can hold up itself

at any position Press down to close tight

and sealed

Page 12: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Hand held Chamber / Satellite Incubator

IVF Cube –AR-3100GC / Drawers for Embryos-

Hot Plate stage

Page 13: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Technical Aspects

IVF Cube -Drawers for Embryos- Drawers designed for Embryo Culture

Page 14: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- CO2 / O2 sensor, Solenoid valve, and air pump are separately equipped and protected under approx. 38oC heated box.

Avoids condensations in the tubes and air is always warmed up around 37oC.

Page 15: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

CO2 / O2 sensor, Solenoid valve, and air pump are separately equipped and protected under approx. 38oC heated box.

IVF Cube –AR-3100GC / Drawers for Embryos-

Close up view of gas sensor unit

Separated components are easy to be serviced when needed.

Page 16: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- Three Gas connection unit in the back of the drawer

The Gas connection unit is equipped with stainless springs that push the drawers when it is closed all the way back to make sure the tight sealing of the gas ports.

Tri-gas MixtureGas circulations

Silicon gasket for sealing the gas ports

Page 17: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- CPU board and other important electronics are located on the side.

Easily accessible by pulling out as one assembled plane for servicing.

Page 18: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube -Drawers for Embryos-

Performance

Page 19: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos-

Surface: 36.98

Surface: 37.06Surface: 37.04

Surface: 36.91Surface: 36.92

Temperature Distributions ①Drawer surface

Center: 36.93-36.99oC

- Surface: +0.1oC

Front

Back

Page 20: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- Temperature / In the Medium

Dish: 35mm dish

Volume: 20 micro liter (droplet)

With Oil overlaid

-Other factors-

Cover heater: 38oC or less

Cover heater: 37.1oC +0.1

Air: Approx. 38oC

Drawer surface: 36.93~36.99 (Center)

37.1oC 37.1oC

37.0oC

37.0oC

36.9oC 36.9oC

All these factors make the medium droplets equilibrated at optimum temp.

Page 21: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos- Gas Concentration Recovery

①   O2 Recovery after 30 sec lid openingCO2 recovery after 30sec Lid Open

0

5

10

15

20

25

00:00

02:30

05:00

07:30

10:00

12:30

15:00

Time(分)

O2 (

%)

O2

11 min 35 sec to recover

Page 22: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

IVF Cube –AR-3100GC / Drawers for Embryos-

CO2 recovery after 30sec Lid Open

0

1

2

3

4

5

6

7

00:00

02:30

05:00

07:30

10:00

12:30

15:00

Time (Minutes)

CO2 (

%)

CO2

3 min 35 sec to recover 96%

Gas Concentration Recovery

②   CO2 Recovery after 30 sec lid opening

Page 23: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Drawer Type IncubatorAR-3100GC

IVF Cube

Page 24: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

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Page 25: RI (UK and IRE) introduces the "IVF Cube" Drawer Type Incubator

Research Instruments